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Supplemental Table 1. Transfused Red Blood Cell units in the 48 hours prior to Critical Care initiation to date of Discharge RDW and 30-day mortality Discharge RDW

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Supplemental Table 1. Transfused Red Blood Cell units in the 48 hours prior to Critical Care initiation to date of Discharge RDW and 30- day mortality

Discharge RDW

≤ 13.3% 13.3-14.0% 14.0-14.7% 14.7-15.8% > 15.8%

Transfused PRBC units 0 units

no.(%) 9,200 (96.7) 9,235 (92.7) 6,265 (88.7) 6,034 (85.8) 8,251 (85.7)

30-day mortality 0.9% 2.0% 2.1% 3.0% 5.4%

1-3 units

no.(%) 233 (2.5) 548 (5.5) 601 (8.5) 737 (10.5) 985 (10.2)

30-day mortality 0.0% 2.7% 2.2% 4.6% 7.9%

4-6 units

no.(%) 47 (0.5) 113 (1.1) 116 (1.6) 146 (2.1) 214 (2.2)

30-day mortality 0.0% 0.9% 2.6% 4.8% 5.6%

>6 units

no.(%) 37 (0.4) 71 (0.7) 84 (1.2) 115 (1.6) 180 (1.9)

30-day mortality 2.7% 1.4% 1.2% 1.7% 1.1%

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Supplemental Table 2. Adjusted Associations between Discharge Red Cell Distribution Width and Mortality following Hospital Discharge

Discharge RDW

≤ 13.3% 13.3-14.0% 14.0-14.7% 14.7-15.8% > 15.8%

Congestive Heart Failure (n= 12,784) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 1.33 (0.85-2.10) 1.56 (1.00-2.44) 1.89 (1.23-2.92) 3.34 (2.20-5.05)

P-value 0.22 0.049 0.004 <.0001

Coronary Artery Disease (n= 11,939) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 1.46 (0.86-2.46) 1.68 (0.99-2.83) 2.32 (1.40-3.85) 4.12 (2.54-6.69)

P-value 0.16 0.053 0.001 <.0001

Myocardial Infarction (n= 7,770) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 1.58 (0.91-2.76) 2.30 (1.33-3.97) 2.29 (1.33-3.96) 4.09 (2.44-6.84)

P-value 0.11 0.003 0.003 <.0001

Stroke (n= 4,536) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 1.05 (0.68-1.61) 1.03 (0.65-1.66) 1.04 (0.64-1.70) 1.67 (1.06-2.65)

P-value 0.83 0.89 0.86 0.028

Pulmonary Embolism (n= 1,648) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 2.12 (0.57-7.86) 1.13 (0.27-4.68) 3.39 (0.97-11.82) 7.11 (2.14-23.65)

P-value 0.26 0.87 0.055 0.001

Cardiac Arrest (n= 863) Adjusted 30-day Mortality

OR (95%CI) 1.00 (Referent) 1.13 (0.30-4.21) 2.49 (0.75-8.28) 1.98 (0.56-6.99) 3.85 (1.24-11.99)

P-value 0.86 0.14 0.29 0.02

____________________________________________________________________________________________________________________________

Note: All estimates adjusted for age, gender, race (white, non-white), type (surgical versus medical), Deyo-Charlson index and Acute Organ Failure.

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Supplemental Table 3. Adjusted Associations between Discharge Red Cell Distribution Width and Mortality following Hospital Discharge

Discharge RDW

≤ 13.3% 14.7-15.8% > 15.8%

Adjusted 30-day Mortality a

OR (95%CI) 1.00 (Referent) 2.45 (1.95-3.09) 4.47 (3.60-5.55)

P-value <.0001 <.0001

Adjusted 30-day Mortality b

OR (95%CI) 1.00 (Referent) 2.37 (1.87-2.99) 4.28 (3.43-5.35)

P-value <.0001 <.0001

Adjusted 30-day Mortality c

OR (95%CI) 1.00 (Referent) 2.49 (1.98-3.14) 4.57 (3.68-5.68)

P-value <.0001 <.0001

Adjusted 30-day Mortality d

OR (95%CI) 1.00 (Referent) 2.45 (1.94-3.08) 4.45 (3.58-5.54)

P-value <.0001 <.0001

Adjusted 30-day Mortality e

OR (95%CI) 1.00 (Referent) 2.41 (1.91-3.04) 4.36 (3.51-5.42)

P-value <.0001 <.0001

Adjusted 30-day Mortality f

OR (95%CI) 1.00 (Referent) 2.40 (1.91-3.03) 4.27 (3.44-5.31)

P-value <.0001 <.0001

Adjusted 30-day Mortality g

OR (95%CI) 1.00 (Referent) 2.40 (1.91-3.03) 4.27 (3.44-5.31)

P-value <.0001 <.0001

Adjusted 30-day Mortality h

OR (95%CI) 1.00 (Referent) 2.38 (1.85-3.05) 4.59 (3.63-5.80)

P-value <.0001 <.0001

Adjusted 30-day Mortality i

OR (95%CI) 1.00 (Referent) 2.47 (1.96-3.11) 4.51 (3.63-5.60)

P-value <.0001 <.0001

Adjusted 30-day Mortality j

OR (95%CI) 1.00 (Referent) 2.44 (1.94-3.08) 4.44 (3.57-5.53)

P-value <.0001 <.0001

____________________________________________________________________________________________________________________________

a. Estimates adjusted for age, gender, race (white, non-white), type (surgical versus medical), Deyo-Charlson index and Acute Organ Failure.

b. Estimates adjusted for all covariates in (a.) and hematocrit.

c. Estimates adjusted for all covariates in (a.) and transfusion.

d. Estimates adjusted for all covariates in (a.) and creatinine.

e. Estimates adjusted for all covariates in (a.) and WBC.

f. Estimates adjusted for all covariates in (a.) and sepsis.

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g. Estimates adjusted for all covariates in (a.) and vasopressors/inotropes.

h. Estimates adjusted for all covariates in (a.) and mechanical ventilation.

i. Estimates adjusted for all covariates in (a.) and year of hospital discharge

j. Estimates adjusted for all covariates in (a.) and WBC, creatinine and transfusions.

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