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Supplemental Tables

Supplemental Table 1.Hardware and software of the system

Modules Hardware Software

Workstation CPU: Intel Core i7-8700 CPU (3.7GHz)

GPU: NVIDIA GeForce GTX

OS: Window 10

IDE: Visual Studio 2015 Navigation CBCT

NDI navigation Customized application based on the API of OpenGL (4.5) , VTK (6.3),Qt5.12

Robot KUKA iiwa med800 Customized application based on the API of Kuka,java

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Supplemental Table 2. Drilling Accuracy Measurement

No.= Number,mm= millimeter, SD= Standard Deviation Model

No. Points Position error- upper surface(mm)

Position error- lower surface(mm)

01 1 0.34 1.6

2 1.59 0.12

3 0.67 0.79

4 1.17 0.42

Mean±SD 0.94± 0.55 0.73± 0.64

02 1 1.39 0.24

2 0.86 0.39

3 1.12 1.36

4 0.33 0.69

Mean±SD 0.93± 0.45 0.67± 0.49

03 1 0.19 1.02

2 1.61 0.21

3 0.78 1.56

4 0.56 0.62

Mean±SD 0.79± 0.60 0.85± 0.58

04 1 1.06 0.91

2 0.82 1.14

3 1.01 0.87

4 0.52 1.11

Mean±SD 0.85± 0.24 1.01± 0.14

05 1 0.29 1.57

2 0.18 0.37

3 1.29 0.15

4 1.13 0.39

Mean±SD 0.72± 0.57 0.62± 0.64 Total Mean±SD 0.85± 0.45 0.78± 0.49

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Supplemental Table 3.Milling Accuracy Measurement

No.= Number, mm= millimeter, SD= Standard Deviation Model No.

Mean (mm) SD (mm)

01 0.98 0.51

02 0.89 0.51

03 0.91 0.52

04 0.93 0.49

05 0.95 0.54

Total 0.93 0.50

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Supplemental Table 4.Overall skull window overlapped percentage

No.= Number, mm3= cubic millimeter, SD= Standard Deviation Model No.

Vactual(mm3) Vdesign(mm3)

O

verall skull window coincidence

rate(%)

01 11799.01 12007.26 98.27

02 13653.61 14052.05 97.16

03 15909.68 16215.93 98.11

04 14882.96 15416.22 96.54

05 11980.57 12379.56 96.78

Mean±SD 13645.17±1791.61 14014.20±1838.11 97.37±0.78

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