Supplementary Table 1: Parameters and distributions regarding recurrence and mortality for additional factors
Parameter Level Total Recurrence Mortality
No. (%) No. (%) pa No. (%) pa
Health care region b
Region 1 2779 (19) 437 (16) 0.883 966 (35) 0.012
Region 2 3106 (22) 504 (16) 1126 (36)
Region 3 1661 (12) 253 (15) 630 (38)
Region 4 2761 (19) 449 (16) 1076 (39)
Region 5 2709 (19) 448 (17) 1039 (38)
Region 6 1309 (9) 214 (16) 503 (38)
Age group 0-40 years 184 (1) 27 (15) 0.038 23 (13) 0. 000
40-50 years 442 (3) 74 (17) 56 (13)
50-60 years 1335 (9) 223 (17) 221 (17)
60-70 years 3677 (26) 618 (17) 825 (22)
70-80 years 5176 (36) 865 (17) 2036 (39)
80-90 years 3261 (23) 460 (14) 1993 (61)
90+ years 250 (2) 38 (15) 186 (74)
BMI c Underweight (<18.5) 336 (2) 53 (16) 0.098 197 (59) 0.000 Normal (18.5-24.9) 5323 (37) 837 (16) 2026 (38) Overweight (25-29.9) 4302 (30) 696 (16) 1361 (32)
Obese (30-34.9) 1519 (11) 218 (14) 476 (31)
Morbid obesity (>35) 439 (3) 82 (19) 148 (34)
Missing 2406 (17) 419 (17) 1132 (47)
ASA d I 2085 (15) 357 (17) 0.011 373 (18) 0.000
II 7318 (51) 1187 (16) 2324 (32)
III 3927 (27) 636 (16) 2151 (55)
IV and V 328 (2) 49 (15) 252 (77)
Missing 667 (5) 76 (11) 240 (36)
Pretherapeutic staging
No tumor staging 4337 (30) 725 (17) 0.180 1821 (42) 0.000
Tumor staged 9987 (70) 1580 (16) 3519 (35)
No lung staging 1750 (12) 349 (20) 0.000 799 (46) 0.000
Lung staged 12574 (88) 1956 (16) 4541 (36)
No liver staging 1489 (10) 279 (19) 0.003 673 (45) 0.000
Liver staged 12835 (90) 2026 (16) 4667 (36)
Vascular
ligature Central 8465 (59) 1353 (16) 0.000 3049 (36) 0.000
Distal 4603 (32) 755 (16) 1740 (38)
Polypectomy patients e 313 (2) 6 (2) 64 (20)
Missing 944 (7) 191 (20) 487 (52)
CRM f <3mm 1541 (11) 310 (20) 0.000 678 (44) 0.000
3-10 mm 1988 (14) 332 (17) 734 (37)
≥10 mm 5492 (38) 814 (15) 1798 (33)
Missing 5304 (37) 849 (16) 2130 (40)
LRM g <50 mm 4025 (28) 679 (17) 0.235 1527 (38) 0.001
5-90 mm 3383 (24) 513 (15) 1183 (35)
≥90mm 3652 (25) 596 (16) 1336 (37)
Missing 3265 (23) 517 (16) 1294 (40)
Mucinous No 10172 (71) 1607 (16) 0.308 3687 (36) 0.000
Yes 2690 (19) 448 (17) 1079 (40)
Missing 1463 (10) 250 (17) 574 (39)
Postoperative complications
No 10948 (76) 1724 (16) 0.044 3799 (35) 0.000
Yes 3377 (24) 581 (17) 1541 (46)
Adjuvant treatment
Stage I No adjuvant 2682 (98) 110 (4) 0.000 760 (28) 0.252
Adjuvant 48 (2) 10 (21) 10 (21) Stage II No adjuvant 5545 (88) 555 (10) 0.000 2014 (36) 0.000
Adjuvant 769 (12) 127 (17) 146 (19)
Stage III No adjuvant 2014 (39) 572 (28) 0.646 1369 (68) 0.000
Adjuvant 3187 (61) 924 (29) 1014 (32)
a Proportions tested with Pearsons-χ2 test.
b Region: Location of patient surgery.
c BMI: Body mass index.
d American Society of Anesthesiologists’ classification (ASA) rated by an anesthesiologist before surgery.
e Patients who underwent endoscopic polypectomy
f CRM: Circumferential resection margin
g LRM: Longitudinal resection margin.
