Supplementary Table 1

Supplementary Table 1

Target Action Drug Number of Trials

Actin binding protein Inhibitor Rhu-pGSN 1

CD73 Inhibitor AK119 1

CPI-006 1

DAMPs Inhibitor CD24Fc 1

C1 esterase Inhibitor Conestat Alfa 1

Ruconest 1

C3 Inhibitor AMY-101 1

APL-9 1

NGM621 1

C5 Inhibitor Zilucoplan 1

C5a Inhibitor Avdoralimab 1

BDB-001 1

Eculizumab 1

IFX-1 1

Ravulizumab 3

Cells CAR-Cells NK Cells 4

Immune Cells Donor Immune Cells 7

T-cells RAPA-501-Allo 1

Stem cells 46

CCR2/5 Inhibitor Cenicriviroc 1

CCR5 Inhibitor Leronlimab 2

Maraviroc 1

CD14 Inhibitor IC14 1

CD146 Inhibitor Meplazumab 1

CD6 Inhibitor Itolizumab 2

CD80/86 Inhibitor Abatacept 2

CD95 Inhibitor Asunercept 1

CSF-1R Inhibitor Axatilimab 1

CTGF Inhibitor Pamrevlumab 1

Cytokines Adsorption CytoSorb 5

oXiris 1

Hemopurifier 1

Seraph 100 1

DHODH Inhibitor Brequinar 1

IMU-838 2

Exosomes EXO 1 1

EXO 2 1

Organicell 1

Free Iron Chelation Desferal 2

Lactoferrin 4

Factor XIIa Inhibitor Garadacimab 1

Galectin-3 Inhibitor TD139 1

G-CSFR Inhibitor CSL324 1

GM-CSF Activator Sargramostim 3

Inhibitor Molgramostim 1

Gimsilumab 1

Lenzilumab 2

Mavrilimumab 5

Otilimab 1

TJ003234 1

GPCR19 Activator NuSepsin 1

HEF Activator ANG-3777 1

HIF-PI Inhibitor Desidustat 1

HSP Inhibitor MPT0B640 1

IL-1 Inhibitor Anakinra 12

Canakinumab 3

RPH-104 1

IL-15 Activator N-803 1

IL-17A Inhibitor Secukinumab 1

IL-2 Activator ILT101 1

IL-22 Activator F-652 1

UTTR1147A 1

IL-33 Inhibitor Astegolimab 1

IL-6 Inhibitor BLD-2660 1

Clazakizumab 5

Levilimab 1

Olokizumab 2

Sarilumab 9

Siltuximab 2

Sirukumab 1

Tocilizumab 32

IL-7 Activator CYT107 4

IL-8 Inhibitor BMS-986253 1

ILT7 Activator VIB7734 1

IMDPH Inhibitor Merimepodib 1

Immunoglobulins IVIG 16

Interferons Activators Inteferon alpha 1

Interferon alpha-2b 2

Inteferon beta-1a 7

Interferon beta-1b 3

Interferon Lambda 6

Interferon type 1 1

Inhibitor Emapalumab 1

IRAK4 Inhibitor PF-06650833 1

JAK Inhibitor Baricitinib 8

Ruxolitinib 8

TD-0903 2

Tofacitinib 5

Kallikerin Inhibitor Lanadelumab 1

MAPKAPK2 Inhibitor ATI-450 1

MAS Activator BIO101 1

Monoclonal COVID antibody ADM03820 1

anti-SARS-CoV-2 IgY 1

AZD7442 1

BGB DXP593 2

BRII-196 2

COVI-AMG 1

CT-P59 3

HFB30132A 1

HLX70 1

HLX71 1

INM005 1

Kamada Anti-SARS-CoV-2 1

LY3819253 2

MW33 1

REGN10933 1

REGN10987 1

SAB-185 2

SCTA01 1

Trimodulin 1

VIR-7831 1

JS016 1

LY3127804 1

LY3819253 2

REGN10933 1

REGN10987 1

STI-1499 1

TY027 1

XAV-19 1

Neutrophil Elastase Inhibitor Alvelestat 1

NF-kB Inhibitor Bardoxolone methyl 1

NLRP3 Inflammasome Inhibitor Dapansutrile 1

DFV890 1

NRP2 Activator ATYR1923 1

Other Dialyzable Leukocyte Extract 1

Amniotic Fluid 1

Nebulized Platelet Lysate 1

Vesicles 1

PD-1 Inhibitor PD-1 blocking antibody 1

Nivolumab 2

Pembrolizumab 1

PDE3/4 Inhibitor Ensifentrine 1

PDE4 Inhibitor Apremilast 2

PI3-Kinase Inhibitor Duvelisib 1

Piclidenson 1

Plasma Convalescent Plasma 87

Plasma Exchange 3

Prekallikrein Inhibitor ISIS 721744 1

Prostaglandin Activator Prostaglandin E1 1

Proteinase Inhibitor Liquid Alpha1-Proteinase Inhibitor 1

P-Selectin Inhibitor Crizanlizumab 1

IL-7 Activator NT-I7 2

RIPK1 Inhibitor SAR443122 1

S1P Activator Ozanimod 1

SK2 Inhibitor Opaganib 3

SUMO Inhibitor TAK-981 1

TGF-b1 Inhibitor PLN-74809 1

TIM3 Inhibitor MAS825 1

Tyrosine kinase Inhibitor BIO 300 1

Fostamatinib 2

Nintedanib 1

TLR-2/6/9 Activator PUL-042 2

TLR-4 Inhibitor EB05 1

TLR-7/8 Inhibitor M5049 1

TNF Inhibitor CERC-002 1

Infliximab 1

BAT2020 1

XPro1595 1

TORC1 Inhibitor RTB101 1

TPO Activator Eltrombopag 2

TREM-1 Inhibitor Nangibotide 1

TRPC6 Inhibitor BI 764198 1

Trypsin Inhibitor TAK-671 1

Tyrosine Kinase Activator Plitidepsin 1

Inhibitor Abivertinib 2

Acalabrutinib 4

Ibrutinib 3

Imatinib 5

Nintedanib 1

Pacritinib 1

TL-895 1

Zanubrutinib 1

Unknown Lenalidomide 1

RLS-0071 1

XC221 1

VEGF Inhibitor Bevacizumab 2

PTC299 1

VE-PTP Inhibitor Razuprotafib 2

Supplementary Table 1- Immunomodulatory targets in COVID-19