Supplementary Table 1. Baseline characteristics of COVID-19 patients with different severity.
Baseline Characteristics Total (N=42)
Mild type(N=14)
Moderate type(N=22)
Critical type(N=6)
Pvalue
Age, years, median (IQR) 62 (51
–
68) 52 (37–58) 64 (57–
71) 67 (63–80) 0.004 Sex,n(%)Female 21 (50) 5 (35.7) 11（50） 5 (83.3) 0.225
Male 21 (50) 9 (64.3) 11（50） 1 (16.7)
History of exposure to
COVID-19 confirmed patients, n(%)
12 (28.6) 7 (50) 5 (22.7) 0 0.039
Comorbidities,n(%) 23 (54.8) 4 (28.6) 16 (69.6) 3 (50) 0.051
Hypertension 14 (33.3) 3 (21.4) 9 (39.1) 2 (33.3) 0.595
Cardiovascular disease 3 (7.1) 0 3 (13.6) 0 0.282
Diabetes 8 (19) 2 (14.3) 5 (22.7) 1 (16.7) 0.898
Malignancy 3 (7.1) 0 2 (9.1) 1 (16.7) 0.386
COPD 1 (2.4) 0 1 (4.5) 0 0.670
Gout 3 (7.1) 1 (7.1) 1 (4.5) 1 (16.7) 0.475
Chronic liver disease 2 (4.8) 1 (7.1) 1 (4.5) 0 0.782
Systemic sclerosis 1 (2.4) 0 1 (4.5) 0 0.670
Smoke,n(%) 5 (11.9) 1 (7.1) 4 (18.2) 0 0.468
Signs and symptoms,n(%)
Fever 29 (69) 7 (50) 17 (77.3) 5 (83.3) 0.259
Dry cough 27 (64.3) 8 (57.1) 17 (77.3) 2 (33.3) 0.323
Anorexia 31 (73.8) 11 (78.6) 15 (68.2) 5 (83.3) 0.491
Myalgia 2 (4.8) 1 (7.1) 1 (4.5) 0 0.782
Dyspnea 32 (76.2) 7 (50) 19 (86.4) 6 (100) 0.030
Expectoration 6 (14.3) 1 (7.1) 2 (9.1) 3 (50) 0.009
Fatigue 10 (23.8) 3 (21.4) 3 (13.6) 4 (66.7) 0.027
Diarrhea 8 (19) 3 (21.4) 4 (18.2) 1 (16.7) 0.918
Chills 4 (9.5) 1 (7.1) 3 (13.6) 0 0.642
Onset of symptom to hospital admission, median (IQR), d
11 (8
–
17) 12 (8–
14) 14 (7–
20) 8 (7–
12) 0.167Heart rate, median (IQR), bpm 89 (78
–
103) 81 (75–89) 93 (88–106) 88 (81–102) 0.113 Respiratory rate, median (IQR),breaths/min
23 (21–27) 21 (20–24) 24 (22–28) 26 (22–37) 0.026
Mean arterial pressure, median (IQR), mm Hg
92 (85–99) 90 (84–95) 94 (87–102) 93 (87–97) 0.437 COVID: Corona virus disease; IQR: Interquartile range; COPD: Chronic obstructive pulmonary disease.
Supplementary Table 2. Baseline characteristics of survival and non-survival patients with COVID-19.
Baseline Characteristics Total (N=42)
Survivor (N=37)
Non-Survivor(N
=5)
Pvalue
Age, years, median (IQR) 62 (51–68) 59 (49–67) 68 (63–81) 0.046 Sex,n(%)
Female 21 (50) 17 (45.9) 4 (80) 0.153
Male 21 (50) 20 (54.1) 1 (20)
History of exposure to COVID-19 confirmed patients,n(%)
12 (28.6) 12 (32.4) 0 0.125
Comorbidities,n(%) 23 (54.8) 20 (54.1) 3 (60) 0.853
Hypertension 14 (33.3) 12 (32.4) 2 (40) 0.768
Cardiovascular disease 3 (7.1) 3 (8.1) 0 0.503
Diabetes 8 (19) 7 (18.9) 1 (20) 0.977
Malignancy 3 (7.1) 2 (5.4) 1 (20) 0.245
COPD 1 (2.4) 1 (2.7) 0 0.706
Gout 3 (7.1) 2 (5.4) 1 (20) 0.245
Chronic liver disease 2 (4.8) 2 (5.4) 0 0.589
Systemic sclerosis 1 (2.4) 1 (2.7) 0 0.706
Smoke,n(%) 5 (11.9) 5 (13.5) 0 0.374
Signs and symptoms,n(%)
Fever 29 (69) 24 (64.9) 5 (100) 0.125
Dry cough 27 (64.3) 25 (67.6) 2 (40) 0.193
Anorexia 31 (73.8) 26 (70.3) 5 (100) 0.175
Myalgia 2 (4.8) 2 (5.4) 0 0.589
Dyspnea 32 (76.2) 27 (73) 5 (100) 0.206
Expectoration 6 (14.3) 4 (10.8) 2 (40) 0.087
Fatigue 10 (23.8) 6 (16.2) 4 (80) 0.002
Diarrhea 8 (19) 7 (18.9) 1 (20) 0.977
Chills 4 (9.5) 4 (10.8) 0 0.433
Onset of symptom to
hospital admission, median (IQR), d
11 (8–17) 14 (7–19) 8 (8–12) 0.190
Heart rate, median (IQR), bpm 89 (78–103) 88 (77–100) 96 (81–109) 0.508 Respiratory rate, median (IQR),
breaths/min
23 (21–27) 23 (21–27) 26 (23–41) 0.009
Mean arterial pressure, median (IQR), mmHg
92 (85–99) 92 (85–100) 92 (84–95) 0.418
COVID: Corona virus disease; IQR: Interquartile range; COPD: Chronic obstructive pulmonary disease.
Supplementary Table 3. The LUS scores of COVID-19 patients with different severity (total score 30).
LUS scores Moderate (n=14) Severe (n=22) Critical (n=6) Pvalue
Upper anterior 0 0.0 (0.0, 1.0) 3.5 (1.0, 4.0) <0.01
Lower anterior 0 0.0 (0.0, 2.0) 4.0 (0.75, 4.0) <0.01
Upper lateral 0.0 (0.0, 0.5) 2.5 (2.0, 4.0) 4.0 (4.0, 4.25) <0.01 Lower lateral 0.0 (0.0, 0.25) 1.0 (0.0, 3.0) 4.0 (4.0, 4.0) <0.01 Posterior 0.0 (0.0, 1.25) 4.0 (2.75, 4.0) 4.0 (4.0, 6.0) <0.01 Right lung 0.0 (0.0, 0.5) 5.0 (2.75, 6.0) 10.0 (6.75, 11.0) <0.01 Left lung 0.5 (0.0, 1.25) 5.0 (2.75, 5.0) 9.5 (8.5, 10.25) <0.01 Total 1.0 (0.0, 3.0) 9.0 (6.0, 12.25) 19.5 (15.25, 21.25) <0.01 COVID: Corona virus disease; LUS:
Lung ultrasound.
Supplementary Table 4. The LUS scores of survival and non-survival patients with COVID-19 (total score 30).
LUS scores Survivors (n=37) Non-suvivors (n=5) Pvalue
Upper anterior 0.0 (0.0, 1.0) 4.0 (2.0, 4.0 <0.001
Lower anterior 0.0 (0.0, 1.0) 4.0 (2.0, 4.0) 0.002
Upper lateral 2.0 (0.0, 4.0) 4.0 (4.0, 4.5) 0.005
Lower lateral 0.0 (0.0,2.0) 4.0 (4.0, 4.0) 0.001
Posterior 3.0 (0.0, 4.0) 4.0 (4.0, 5.0) 0.016
Right lung 3.0 (0.5,6.0) 10.0 (8.0,11.0) 0.001
Left lung 2.0 (0.0, 5.0) 10.0 (8.0,10.5) <0.010
Total 6.0 (1.5, 10.5) 20.0 (16.0, 21.5) 0.001
COVID: Corona virus disease; LUS:
