Supplementary Table 1: The criteria for dengue with or without warning signs and severe dengue.
Categories Dengue with or without warning signs
Severe dengue Probable dengue Warning signs
Characteristic s
Live in/travel to dengue endemic area, fever and 2 of the following:
Nausea, vomiting
Rash
Aches and pains
Leukopenia
Tourniquet test positive
Abdominal pain
Persistent vomiting
Clinical fluid accumulation
Mucosal bleeding
Lethargy, restlessness
Liver enlargement
>2cm
Increase in HCT concurrent with rapid increase in platelet count
Severe plasma leakage:
Shock (DSS)
Fluid accumulation with respiratory distress Severe bleeding
Severe organ involvement:
Liver: AST or ALT ≥ 1000
CNC: Impaired consciousness
Heart and other organs
Supplementary Table 2: List of Protein Markers (pg. 1 of 5)
A1BG AKD2 ATG12 BRSK2 CAPG CDK2 COPB2 CXCR6
AAK1 AKT1 ATG7 BTF3 CARD8 CDK3 COPEB CXorf48
AARS AKT2 ATIC BTG1 CARD9 CDK4 COPG2 Cxorf61
ABCF1 AKT3 ATP5B BTG3 CARHSP1 CDK5 COPS6 CXXC1
ABCF3 ALDOA ATXN3 BTRC CASP1 CDK5R1 COTL1 CYCS
ABI1 ALOX15 AURKA BUB1 CASP10 CDK7 COX6B2 CYLD
ABL2 ALOX15B AURKB BUB1B CASP3 CDK8 COX6C CYP1B1
ABT1 ALPK1 AXIN1 BUD31 CASP4 CDK9 CPA4 DAPK1
ACAT2 ALX1 AXL_int C10orf119 CASP6 CDKN1A CPM DAPK2 ACPP AMD1 AXUD1 C19orf50 CASP7 CDKN2A CPXCR1 DBNL
ACRBP AMOTL2 BACH1 C1D CASP9 CDKN2B CRADD DCAF12
ACSL6 AMT BAD C1orf174 CASS4 CDKN2C CREB1 DCBLD2
ACTA1 ANKRD13A BAG3 C1orf216 CBFA2T3 CDKN2D CREB5 DCDC2
ACTB ANKRD45 BAG4 C1orf57 CBFB CDO1 CRISP2 DCLK1
ACTL7B ANXA1 BAGE2 C20orf43 CBLC CEACAM1 CROT DCLK2 ACTL8 ANXA11 BANK1 C21orf2 CBX5 CEACAM7 CRX DCT ACTR2 ANXA2 BASP1 C21orf33 CCDC110 CEACAM8 CRYAB DDB1
ACVR1 AP2M1 BATF C4BPA CCDC33 CEBPG CSAG1 DDB2
ACVR1C APCS BCKDK C6 CCDC36 CEP55 CSAG2 DDIT3
ACVR2A APEX1 BCL10 C6orf106 CCM2 CFL1 CSK DDR1
ADAM2 API5 BCL2A1 C9orf86 CCNA1 CHEK1 CSNK1D DDR1_ext ADAM29 APOBEC3G BCL2L14 C9orf96 CCNA2 CHEK2 CSNK1G1 DDR1_int
ADCK1 APP BCR CA1 CCNB1 CHI3L1 CSNK1G2 DDX43
ADCK4 APPL1 BDNF CA4 CCNB1IP1 CHIC2 CSNK2A1 DDX5
ADD1 AR BID CA9 CCND1 CHN1 CSNK2A2 DDX53
ADRBK1 ARAF BIRC2 CAB39L CCND2 CHST4 CST4 DDX55
ADRBK2 AREG BIRC3 CABC1 CCNH CIDEB CSTB DEDD
ADSL ARHGDIA BIRC5 CABYR CCNI CIDEC CT45A1 DEK
AFF4 ARHGDIB BIRC7 CAGE1 CCR5 CISH CT47A1 DFFA
AFP ARHGDIG BLK CALM2 CCRK CITED1 CT62 DGKA
AGR2 ARIH2 BLZF1 CALM3 CCT3 CKB CTAG1A DGUOK
AHSG ARL1 BMP7 CALML4 CCT5 CKM CTAG2 DKK1
AICDA ARMC3 BMPR1A CALR CD276 CKMT2 CTAGE1 DKKL1
AIF1 ARNT BMPR1B CALR3 CD5L CKS1B CTAGE5 DLX1
AIFM1 ARRB1 BMPR2 CALU CD96 CLK1 CTBP2 DLX3
AIFM2 ARX BMX CAMK1 CDC2 CLK2 CTCFL DLX4
AIFM3 ASB1 BOLA3 CAMK1G CDC20 CLK3 CTNNA2 DMAP1
AIM2 ASCL1 BOP1 CAMK2A CDC25A CLUAP1 CTNNB1 DMPK
AK1 ASNA1 BPI CAMK2B CDC25C CMPK1 CTNNBL1 DMRTB1
AK2 ASPSCR1 BRAF CAMK2D CDC2L1 CNN1 CTSD DMRTC2
AK3 ATF1 BRD2 CAMK2G CDC2L6 CNOT2 CTSE DNAJA1
AK3L1 ATF2 BRD3 CAMK4 CDC42 CNOT8 CTTN DNAJA2
AK7 ATF3 BRD8 CAMKK1 CDH19 CNRIP1 CUL4A DNAJB1
AKAP3 ATF4 BRDT CAMKK2 CDK10 COL4A3BP CUL5 DNM1L
AKAP4 ATF5 BRSK1 CAMKV CDK14 COMMD3 CXCR4 DNM2
List of Protein Markers (pg. 2 of 5)
DNMT3L ELF5 FAM50B FTH1 GPAT2 HMG20B IFITM1 JAK3
DNTT ELK1 FANCC FTHL17 GPATCH2 HMGB2 IGF2 JUNB
DOM3Z ELK3 FANCG FTSJ3 GPC3 HNF1B IGF2BP1 JUP
DPF2 ELL3 FAP FUS GPHN HNRNPA2B1 IGF2BP3 KAT2A
DPPA2 ELMOD1 FAS FYN GPX1 HNRPUL1 IGHG1 KATNB1
DR1 ELMOD3 FASTK FZD1 GRAP2 HOMER2 IGSF11 KCMF1
DRD2 ELOVL4 FASTKD1 G6PD GRB10 HOOK1 IKBKB KCNIP3
DSTYK ENO1 FATE1 GADD45G GRB2 HOPX IKBKE KIAA0101
DTYMK ENO2 FBXO9 GAGE1 GRB7 HORMAD1 IKZF1 KIAA1984
DUSP10 EPAS1 FEN1 GAGE2C GRK5 HOXA1 IKZF3 KIF9
DUSP11 EPCAM FES GALK1 GRK6 HOXA9 IL13RA1 KIT
DUSP12 EPHA10 FGF1 GAPDH GRM3 HOXB13 IL13RA2 KIT_ext
DUSP13 EPHA2 FGF13 GAS2 GSK3B HOXB6 IL18 KIT_int
DUSP14 EPHA3_ext FGFR1 GAS7 GSTT1 HOXB7 IL1A KLF10 DUSP18 EPHB3_int FGFR1_ext GATA1 GTF2A2 HOXC10 IL1B KLF12 DUSP4 EPHB4 FGFR1_int GATA3 GTF2B HOXC8 IL1F5 KLF4 DUSP6 EPS15 FGFR10P GATAD2A GTF2E2 HPCAL1 IL1F7 KLF7
DVL2 ERBB2 FGFR2 GCLC GTF2F1 HPRT1 IL1RN KLHL12
DYNC1LI2 ERBB3_ext FGFR2_ext GDF15 GTF2F2 HRAS IL21R KLK3 DYRK2 ERBB3_int FGFR2_int GEM GTF2H1 HRH1 IL24 KRAS DYRK3 ERCC2 FGFR4_ext GFAP GTF2H2D HRH2 IL8RB KRT14 DYRK4 ERCC3 FGFR4_int GGPS1 GTPBP1 HRSP12 ILF2 KRT15
E2F6 ERCC5 FH GIPC1 GUK1 HSBP1 ILK KRT19
E6 ERG FHOD2 GK H2AFY HSF1 IMP3 KRT4
E7 ESR2 FIGF GK2 HAGH HSFY1 IMPA1 KRT8
EAPP ESRRG FIP1L1 GLRX3 HAGHL HSP90AA1 IMPDH1 L3MBTL2
EEF1A1 ETNK2 FKBP1B GLS2 HAND1 HSP90AB1 INA LAD1
EEF1A2 ETS2 FKBP3 GMEB1 HBG1 HSPA1A ING4 LASP1
EEF1D ETV4 FKBP5 GMEB2 HCFC2 HSPA5 INHBA LASS2
EEF1G ETV6 FLCN GMPS HCLS1 HSPB8 INPP1 LATS1
EEF2K ETV7 FLI1 GNA15 HDAC1 HSPB9 INPP5B LCK
EFHD2 EWSR1 FLT1 GNAI2 HDAC3 HSPD1 IP6K1 LCP1
EFS EXOSC10 FMR1NB GNAI3 HDAC4 HSPE1 IP6K2 LDB1
EGFR_ext EXOSC4 FN3K GNAO1 HES6 HTATIP2 IPMK LDB2
EGFR_int EXOSC8 FOLH1 GNAZ HEXIM1 HTR1D IRAK1 LDHA
EGR2 EXT1 FOS GNB1 HEYL HTR2B IRAK4 LDHB
EHF EXT2 FOSL1 GNB3 HIF1A HUS1 IRF4 LDHC
EHMT2 EZH2 FOSL2 GNG11 HIF3A ID1 IRF5 LEF1
EIF4A2 EZR FOXA3 GNG2 HINFP ID2 ISG20 LEMD1
EIF4A3 FADD FOXI1 GNG3 HIPK1 IDI1 IST1 LEPREL4
EIF4E FAF1 FOXN2 GNG4 HIPK4 IDO1 ITGB6 LGALS1
EIF4EBP1 FAIM FOXR2 GNGT2 HIST1H1C IFI16 ITGBL1 LGALS7
ELF1 FAM133A FOXS1 GOT1 HIST1H4I IFI35 ITK LGMN
ELF2 FAM46D FRK GP2 HK2 IFIT1 ITPK1 LHFP
ELF4 FAM48A FSCN1 GPA33 HLX IFIT5 ITPKB LIMK2
List of Protein Markers (pg. 3 of 5)
LIMS1 MAP3K7 MGC42105 MYC NLK ODF4 PDGFRL PKNOX1
LIN28 MAP4 MIF MYCBP NLRP2 OGG1 PDIK1L PLAC1
LIPI MAP4K3 MITF MYCBPAP NLRP4 OIP5 PDK1 PLAGL2
LMNA MAP4K5 MKNK1 MYCL1 NME4 OLIG3 PDK2 PLD2
LMO2 MAPK1 MKNK2 MYCN NME5 OSBPL9 PDK3 PLEKHA5
LNX1 MAPK10 MLANA MYD88 NME6 OTOA PDK4 PLK1
LRDD MAPK11 MLF1 MYF6 NME7 OVOL1 PDPK1 PLK2
LRRFIP2 MAPK12 MLH1 MYNN NMRAL1 OXSR1 PDXK PLK4
LSM1 MAPK13 MLKL MYOG NOL4 P4HB PEBP1 PLUNC
LTA4H MAPK14 MLLT11 MYOZ2 NPM1 PABPC1 PECI PMEL
LTV1 MAPK3 MLLT3 MYST2 NPY5R PACSIN3 PELO PMF1
LUZP4 MAPK6 MLLT6 NAB1 NR0B2 PAGE1 PFKFB3 PMVK
LY6K MAPK7 MLPH NAE1 NR1D2 PAGE2B PFKFB4 PNPT1
LY86 MAPK8_tv1 MLX NAGK NR1H2 PAGE5 PFKP POLR2I
LY96 MAPK8_tv2 MMP11 NAP1L1 NR1I2 PAK2 PFN2 POTEE
LYL1 MAPK9 MMP14 NAP1L3 NR2C1 PAK4 PHB2 POTEH
LYN MAPKAPK3 MMP2 NAP1L4 NR2C2 PAK6 PHF1 POU2AF1
LYPD6B MAPKAPK5 MMP24 NCK1 NR2E1 PAK7 PHF11 POU2F2
LZTR1 MAPKSP1 MNAT1 NCOA4 NR2E3 PANK3 PHF17 POU5F1
MAEL MARK2 MNDA NCOA5 NR3C1 PAPSS2 PHF5A PPARD
MAFG MARK3 MOBKL2A NDE1 NR4A1 PASD1 PHF7 PPARG
MAGEA10 MARK4 MORC1 NDRG1 NR4A2 PATZ1 PHIP PPIC
MAGEA4 MAST1 MPP1 NDRG2 NR6A1 PAX3 PHKG1 PPID
MAGEB1 MASTL MPP3 NDUFAB1 NRAS PAX5 PHKG2 PPM1A
MAGEB2 MATK MPP5 NDUFV3 NRBF2 PAX8 PHLDA1 PPP1CB
MAGEB3 MATN3 MPZL2 NEDD9 NRBP2 PBX1 PHLDA2 PPP1R14A
MAGEB4 MAX MRPL45 NEK11 NRF1 PBX3 PHTF1 PPP1R2P9
MAGEB5 MAZ MRPL55 NEK3 NRIP1 PC PIAS2 PPP2CB
MAGEB6 MCM5 MRPS26 NEK7 NRIP3 PCBD PIK3C3 PPP2R1A
MAGEC1 MDM2 MRPS30 NEUROD1 NSBP1 PCBP2 PIK3R1 PPP2R1B
MAGEC2 ME2 MRT4 NEUROD4 NSF PCGF2 PIM1 PPP2R2B
MAGEC3 MECP2 MSC NF2 NTRK3_ext PCK2 PIM2 PPP2R2C
MAK MED16 MSH2 NFATC4 NUAK2 PCTK1 PIN1 PPP2R4
MAL MED17 MSLN NFE2 NUBP2 PCTK2 PIP PPP2R5A
MALL MED21 MSN NFE2L2 NUCB1 PCTK3 PIP4K2B PPP2R5C
MAP1S MED22 MST4 NFIA NUDT2 PDCD2L PIP4K2C PPP3CA
MAP2K1 MED24 MTCP1 NFIB NUF2 PDCD5 PIP5K1B PPP3CC
MAP2K3 MED30 MTERF NFIL3 NUP50 PDCD6 PIR PPP3R1
MAP2K5 MED4 MTMR2 NFKBIA NXF2 PDCL3 PITRM1 PPP4C
MAP2K6 MEF2A MTO1 NFX1 NXF2B PDE4A PITX2 PPP4R1
MAP2K7 MEF2C MUSK NFYA OAS2 PDGFB PIWIL2 PQBP1
MAP3K13 MEIS2 MUTYH NFYB ODC1 PDGFRA PKDCC PRAME
MAP3K14 MEIS3 MX1 NHLH1 ODF1 PDGFRA_ext PKLR PRC1
MAP3K2 MEOX2 MX2 NICN1 ODF2 PDGFRB PKM2 PRCC
MAP3K6 METTL3 MYBL2 NKX2-5 ODF3 PDGFRB_ext PKMYT1 PRDM4 List of Protein Markers (pg. 4 of 5)
PRDX1 PTK7_ext RBPJ RPL30 SDCCAG10 SMN2 SSX2 TACC1 PRDX6 PTK7_int RCAN1 RPL31 SDCCAG3 SNCA SSX2b TACSTD2 PRELID1 PTP4A1 RCC2 RPL32 SDCCAG8 SNX6 SSX3 TADA2L PRKAA1 PTP4A2 RDBP RPL34 SDHB SOCS2 SSX4 TADA3L PRKAA2 PTP4A3 REG3A RPL37A SDHC SOCS3 SSX4B TAF5L PRKACA PTPN1 RERG RPL5 SEC14L2 SOCS5 SSX5 TAF6L PRKACB PTPN11 RET RPL7A SECISBP2 SOCS6 SSX7 TAF7L PRKACG PTPN2 RET_ext RPLP1 SEMG1 SOD1 STAM TAF9 PRKAG3 PTPN20A RET_int RPS15A SEPT4a SOD2 STAM2 TAGLN PRKAR1A PTPN22 REXO4 RPS2 SEPT5a SORD STAP1 TAOK3 PRKCB PTPN4 RFK RPS27A SEPT6a SOX10 STARD7 TARDBP PRKCH PTPN6 RFX3 RPS6KA1 SEPT9a SOX15 STAT1 TBC1D2 PRKCI PTRH1 RG9MTD1 RPS6KA2 SERPINB5 SOX2 STAT3 TBC1D5 PRKCZ PTTG1IP RGS5 RPS6KA3 SERPINE2 SP1 STAT4 TBCB PRKD2 PXK RHOA RPS6KA4 SERPINF2 SP110 STAT5A TBK1
PRKD3 PXN RHOB RPS6KA5 SET SP2 STAU1 TBL1X
PRKRA PYCR1 RHOH RPS6KA6 SFN SPA17 STIP1 TBPL1
PRKX PYGB RHOT2 RPS6KB1 SFRS5 SPACA3 STK10 TBX5
PRL PYGO2 RHOXF2 RPS6KB2 SGK1 SPAG4 STK11 TBX6
PRM1 RAB38 RING1 RPS6KL1 SGK196 SPAG9 STK16 TCEA2 PRM2 RABEP1 RIOK2 RPS7 SGK2 SPANXN1 STK17B TCEAL1 PRPF4 RAC1 RIOK3 RQCD1 SGK3 SPANXN2 STK24 TCEB3 PRPS2 RAC2 RIPK1 RRAGC SGOL1 SPANXN4 STK25 TCF12
PRSS50 RAD21 RIPK2 RRAS SGSM3 SPARC STK3 TCF21
PRSS54 RAD23A RIPK3 RRAS2 SH2B1 SPARCL1 STK32A TCF4 PSCA RAD23B RNASEL RUFY1 SH2D1A SPATA19 STK32B TCL1A PSG1 RAD51 RNF38 RUNX1T1 SH3BGRL3 SPATA25 STK32C TDRD1 PSG11 RAD51L1 RNF40 RUVBL1 SH3GL1 SPDEF STK33 TDRD3 PSIP1 RAD51L3 RNF6 RXRB SH3GLB1 SPEG STK38 TDRKH
PSMA6 RAF1 RNF7 S100A6 SHPK SPG20 STK38L TEAD2
PSMB10 RAG1 RNGTT S100A7 SIAH1 SPIB STK4 TEAD3
PSMB3 RAGE ROPN1 S100A8 SIK2 SPIC STMN1 TEK
PSMB8 RALBP1 RORC S100A9 SIVA1 SPINLW1 STRADA TERT
PSMB9 RAN RPA2 S100P SIX1 SPO11 STRADB TEX101
PSMD4 RAP1GDS1 RPL10 SAGE1 SKAP1 SQSTM1 STUB1 TEX14
PSMD9 RAPGEF4 RPL10A SART3 SLA SRM STYX TFAP4
PSME1 RARA RPL11 SAV1 SLA2 SRP19 STYXL1 TFCP2
PSME2 RARB RPL13A SBDS SLC25A6 SRPK1 SUB1 TFCP2L1 PSME3 RB1 RPL15 SCAND1 SLCO6A1 SRPK2 SUCLA2 TFDP1
PTEN RBKS RPL17 SCEL SMAD2 SRPX2 SUFU TFDP2
PTGDR RBM28 RPL18 SCFD1 SMAD4 SS18L1 SUMO2 TFDP3 PTGER3 RBM46 RPL18A SCGB1D2 SMAD5 SSB SUPT4H1 TFE3 PTK2_iso1 RBM6 RPL22 SCMH1 SMAD9 SSBP4 SYCE1 TFEB PTK2_iso2 RBM7 RPL27A SCP2 SMARCD1 SSNA1 SYCP1 TFEC
PTK6 RBMS1 RPL28 SCYL3 SMARCE1 SSX1 SYK TFG
List of Protein Markers (pg. 5 of 5)
TFPT TRIB2 ULK2 ZBTB32 ZNF70
TFRC TRIB3 ULK4 ZBTB7B ZNHIT3 TGFBR2 TRIM32 UQCRC1 ZC4H2 ZNRD1
TGIF1 TRIM37 USF1 ZFP36L1 ZSCAN12 TGIF2 TRIP11 USF2 ZHX2 ZSCAN16 THEG TROVE2 USH1C ZKSCAN1 ZSCAN18 THRA TSC22D1 USP10 ZKSCAN3 ZSCAN21 THRB TSC22D4 UTP14A ZKSCAN4 ZZ_con1 THUMPD1 TSG101 UXT ZKSCAN5 ZZ_con2 TIE1_ext TSGA10 VAV1 ZMAT2 ZZ_con3 TIE1_int TSPY1 VAX2 ZMAT3 ZZ_con4
TIMP3 TSPY2 VCL ZMYM2
TIRAP TSPY3 VDR ZMYND11
TK1 TSSK1B VEGFB ZMYND8
TKT TSSK2 VGLL1 ZNF136
TLK1 TSSK3 VHL ZNF165
TLK2 TSSK6 VIM ZNF169
TLX2 TTBK2 VPS24 ZNF174 TMEFF1 TTF2 VPS45 ZNF187
TMEFF2 TTK VPS4A ZNF19
TMEM108 TTRAP VPS54 ZNF193 TNFAIP6 TUBA4A VPS72 ZNF202 TNFAIP8 TUBB VRK3 ZNF207 TNFRSF11B TUBGCP3 WAS ZNF256 TNIP1 TULP2 WDR45L ZNF274
TNK2 TWF1 WDR46 ZNF276
TOLLIP TWF2 WISP3 ZNF277
TOM1 TWIST2 WT1 ZNF282
TP53 TXN2 WWOX ZNF3
TP53RK TXNDC3 WWTR1 ZNF323 TP63 TXNRD1 XAGE1D ZNF331
TP73 TYMS XAGE2 ZNF346
TPBG TYR XAGE4 ZNF35
TPI1 TYRO3 XBP1 ZNF354A
TPM1 TYRO3_int XIAP ZNF37A
TPM3 TYRP1 XYLB ZNF384
TPM4 UBA1 YARS ZNF394
TPTE UBA3 YEATS4 ZNF398 TRAF1 UBE2I YTHDF2 ZNF41 TRAF2 UBE2Q1 YWHAE ZNF444 TRAF3IP1 UBE2V1 YWHAG ZNF449
TRAF4 UBP1 ZAK ZNF45
TRAF5 UCHL3 ZAP70 ZNF496 TRAF6 UCKL1 ZBTB16 ZNF593 TRAIP UHMK1 ZBTB25 ZNF645
Supplementary Table 3: Differential expression of proteins in DWS-, DWS+ and SD
DWS- DWS+ SD
Protein Fold change Protein Fold change Protein Fold change
ABCF3 3.42182 AKT1 2.54059 C20orf43 4.10941
ASNA1 4.32359 ARHGDIA 3.55182 CBX5 2.17204
DBNL 2.38189 BAD 2.23713 CDK14 3.58687
FAF1 8.66919 CAB39L 2.11176 CITED1 3.89461
FOSL2 2.05668 CCNA2 2.17988 DNMT3L 2.28745
MAP2K1 6.33328 ELK1 2.23016 FTH1 2.28249
MED21 4.66629 ERG 3.39654 HAGH 2.31145
METTL3 9.12489 GLRX3 2.46133 HSPD1 2.52285
MLANA 2.46726 LIMS1 2.11657 MATN3 2.08038
MPP5 2.82633 MAGEB1 9.83793 MKNK1 3.32360
PQBP1 4.15831 MED22 3.45470 MPP5 3.58229
TRAF3IP1 2.67523 MRT4 2.75577 NCK1 2.02803
MSH2 5.30824 NHLH1 5.20698
NAP1L3 8.20689 PAGE2B 3.45506
PAPSS2 2.56028 PDCL3 2.67852
PDPK1 2.20943 PRKAR1A 3.08855
PECI 2.68833 PRKD2 2.89989
PFKFB3 2.31419 PYGO2 2.44676
PTPN11 2.32997 RAB38 2.31192
RDBP 2.78881 RBM46 2.34464
RUNX1T1 3.76604 RGS5 2.01645
SDCCAG8 5.89752 RPA2 2.22193
SH3GL1 3.65074 SEPT9a 2.14070
SPG20 3.67984 TSC22D1 2.04442
STK33 7.59839 TWF2 2.02197
TCEAL1 2.11831 TXNDC3 2.37644
ZBTB16 2.53054 USP10 3.76321
ZSCAN18 2.39479 YARS 2.27684
ZNRD1 2.24910