Supplementary Table 2. PDGF (Platelet-Derived Growth Factor)
Author,
Year PMID, Title Model Donor
site Recipient site LOE Technique Follow-
up Result Concl.
Animal Studies
Craft, 2009
18178534 Effect of local, long-
term delivery of platelet-derived growth factor (PDGF) on injected fat graft survival in severe combined immunodeficient (SCID) mice [51]
Mice with SCID
Human subcuta neous adipose
tissue from the
abdome n
Pericranial region 5
Group 1: fat + PDGF bound to microspheres (n=8)
Group 2: fat + free PDGF (n=8) Control: fat + blank microspheres (n=8) Control: fat graft
(n=8)
12 weeks
The group with PDGF bound to microspheres had an
increased weight maintenance and preservation of
adipose tissue architecture, as compared to the control groups
+
Human Studies
Fontdevila, 2014
25068344 Double-blind clinical trial to compare autologous fat grafts versus autologous fat grafts with PDGF:
no effect of PDGF [52]
Human
Various dependi ng on patient
Face 2b Group 1: fat +
PDGF Control: fat 2 and 12 months
Both groups exhibited significant increase of volume in the facial area and improvement in clinical facial atrophy grade after treatment. There was no statistically significant difference in the volume gain between the groups.
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