Supplementary Table 2: Univariable Cox proportional hazards model for TTR and OS for additional factors
Parameter Level TTR 95% CI b OS 95% CI b
HR a Lower Upper p HR a Lower Upper p
Health care
region c Region 1 1.0 (Ref) 1.0 (Ref)
Region 2 1.0 0.9 1.2 0.477 1.1 1.0 1.2 0.144
Region 3 1.0 0.8 1.1 0.825 1.1 1.0 1.2 0.031
Region 4 1.1 0.9 1.2 0.465 1.2 1.1 1.3 0.002
Region 5 1.1 0.9 1.2 0.268 1.2 1.1 1.3 0.001
Region 6 1.1 0.9 1.3 0.457 1.2 1.0 1.3 0.008
Age group 0-40 years 1.0 (Ref) 1.0 (Ref)
40-50 years 1.2 0.7 1.8 0.518 1.0 0.6 1.7 0.896
50-60 years 1.2 0.8 1.7 0.462 1.3 0.9 2.1 0.175
60-70 years 1.2 0.8 1.7 0.396 1.9 1.3 2.9 0.002
70-80 years 1.2 0.8 1.8 0.294 3.8 2.5 5.7 0.000
80-90 years 1.1 0.8 1.6 0.596 7.3 4.8 11.0 0.000
90+ years 1.4 0.8 2.2 0.210 11.6 7.5 17.9 0.000
BMI d Normal weight 1.0 (Ref) 1.0 (Ref)
Underweight 1.1 0.8 1.5 0.430 1.9 1.6 2.2 0.000
Overweight 1.0 0.9 1.1 0.880 0.8 0.8 0.9 0.000
Obese 0.9 0.8 1.0 0.085 0.8 0.7 0.9 0.000
Morbid obesity 1.2 0.9 1.5 0.188 0.9 0.7 1.0 0.063
Missing 1.2 1.0 1.3 0.019 1.2 1.2 1.3 0.000
ASA e ASA I 1.0 (Ref) 1.0 (Ref)
ASA II 1.0 0.9 1.1 0.696 2.0 1.8 2.2 0.000
ASA III 1.1 1.0 1.2 0.215 4.4 3.9 4.9 0.000
ASA IV and V 1.2 0.9 1.6 0.235 8.2 7.0 9.7 0.000
Missing ASA 0.7 0.5 0.9 0.003 2.3 1.9 2.7 0.000
Pretherapeutic
staging No staging 1.0 (Ref) 1.0 (Ref)
Tumor staged 0.9 0.8 1.0 0.077 0.8 0.8 0.9 0.000
Lung staged 0.7 0.6 0.8 0.000 0.7 0.7 0.8 0.000
Liver staged 0.8 0.7 0.9 0.000 0.8 0.7 0.8 0.000
Vascular ligature
Central 1.0 (Ref) 1.0 (Ref)
Distal 1.0 0.9 1.1 0.553 1.1 1.0 1.1 0.097
Polypectomy patients f 0.1 0.0 0.2 0.000 0.5 0.4 0.7 0.000
Missing 1.3 1.2 1.6 0.000 1.4 1.3 1.6 0.000
CRM g <3mm 1.0 (Ref) 1.0 (Ref)
3-10 mm 0.8 0.7 0.9 0.007 0.8 0.8 0.9 0.001
>10 mm 0.7 0.6 0.8 0.000 0.8 0.7 0.8 0.000
Missing 0.8 0.7 0.9 0.000 0.9 0.8 1.0 0.003
LRM h <50 mm 1.0 (Ref) 1.0 (Ref)
50-90 mm 0.9 0.8 1.0 0.042 0.9 0.9 1.0 0.026
>90 mm 1.0 0.9 1.1 0.473 1.0 0.9 1.0 0.219
Missing 0.9 0.8 1.0 0.190 1.0 0.9 1.0 0.310
Year of
surgery Each year after 2007
1.0 1.0 1.0 0.225 1.0 1.0 1.0 0.075
Mucinous No 1.0 (Ref)
Yes 1.1 1.0 1.2 0.274 1.1 1.1 1.2 0.000
Missing 1.1 0.9 1.2 0.287 1.0 0.9 1.1 0.716
Postoperative complications
No 1.0 (Ref)
Yes 1.2 1.1 1.3 0.000 1.5 1.4 1.6 0.000
a Unadjusted hazard ratio (HR)
b 95% confidence interval (CI).
c Region: Location of patient surgery.
d Body mass index (BMI) calculated before surgery.
e American Society of Anesthesiologists’ classification (ASA) rated by an anesthesiologist before surgery.
f Patients who underwent endoscopic polypectomy
g CRM: Circumferential resection margin
h LRM: Longitudinal resection margin.
h LRM: Longitudinal resection margin.