Supplementary Tables
Table S1: Variables Used for Multivariate Survival Analysis Variables Considered for Analysis
Transplanted MELD Level Functional Status at Transplant
MELD at Transplant 6-11 10
MELD at Transplant 12-14 20
MELD at Transplant 15-17 50
Etiology of Liver Failure 60
Primary Biliary Cirrhosis 70
Primary Sclerosing Cholangitis 80
Autoimmune Cirrhosis 90
Hepatocellular Carcinoma 100
Non-alcoholic Steatohepatitis INR at Transplant
Viral Hepatitis 2-2.5
Alcoholic Cirrhosis 2.5-3
Incompatible Blood Type 3-3.5
Age of Transplant Recipient 3.5-4
18-30 >4
60-65 Life Support for Transplant Patient
>65 ICU Stay Prior to Transplant
Albumin Level at Transplant (g/dL) Hospitaliztation Prior to Transplant
<1.5 Timing of Retransplant 1.5- 2 More Than 3 Transplants
2-2.5 Patient on Ventilator
BMI Portal Venous Thrombosis
30-35 Payment Method
35-40 Private Insurance
>40 Medicaid
Cold Ischemia Time (h) Previous Abdominal Surgery
<6 UNOS Region
12-14 Region: CT, ME, MA, NH, RI
>14
Region: DE, DC, MD, NJ, PA, N. VA, WV Donation after Circulatory Death Region: AL, AR, FL, GA, LA, MS, PR
Dialysis Prior to Transplant Region: OK, TX
Distance of Donor to Transplant Center (miles) Region: AZ, CA, NV, NM, UT 500-100 Region: AK, HI, ID, MT, OR, WA
>1000 Region: IL, MN, ND, SD, WI
Highest Education Level Region: CO, IA, KS, MO, NE, WY
High School Dropout Region: NY, VT
High School Education Region: IN, MI, OH
Technical Degree Region: KY, NC, SC, TN, VA Bachelors Degree Transplant Location
Doctorate Degree Regional
Encephalopathy National
African American Recipient Foreign
Pretransplant Serum Sodium Level (mEq/L) Total Bilirubin (mg/dL)
<125 <2
125-130 8-16
130-135 16-32
145-150 >32
150-155 TIPSS
>155 Employment Status
Table S2: Sensitivity Analysis: High Transplant MELD Region, Low Transplant MELD Region, Dropped Exceptions
Region 9
MELD 6-11 12-14 15-17 18-20 21-23 24-26 27-29 30-32 33-35 36-39 >40
Hazard Ratio (95% CI)
0.70 0.68 0.47 0.45 0.41 0.54 0.45 0.49 0.40 0.45 0.27
(0.62- 0.80)
(0.58- 0.79)
(0.40- 0.57)
(0.37- 0.55)
(0.34- 0.51)
(0.43- 0.68)
(0.35- 0.58)
(0.38- 0.62)
(0.31- 0.51)
(0.36- 0.57)
(0.22- 0.33)
p-values <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Region 3
MELD 6-11 12-14 15-17 18-20 21-23 24-26 27-29 30-32 33-35 36-39 >40
Hazard Ratio (95% CI) 0.68 0.59 0.54 0.55 0.55 0.48 0.48 0.50 0.48 0.40 0.34
(0.60- 0.77)
(0.51- 0.67)
(0.48- 0.60)
(0.48- 0.62)
(0.48- 0.63)
(0.41- 0.56)
(0.40- 0.58)
(0.41- 0.61)
(0.39- 0.61)
(0.32- 0.50)
(0.28- 0.41)
p-values <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Excluding Exceptions
MELD 6-11 12-14 15-17 18-20 21-23 24-26 27-29 30-32 33-35 36-39 >40
Hazard Ratio (95% CI) 0.69 0.54 0.49 0.42 0.48 0.42 0.43 0.43 0.39 0.36 0.23
(0.64- 0.75)
(0.50- 0.58)
(0.46- 0.52)
(0.40- 0.45)
(0.45- 0.51)
(0.39- 0.45)
(0.40- 0.47)
(0.40- 0.47)
(0.36- 0.43)
(0.33- 0.39)
(0.21- 0.24)
p-values <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
