Table S13. Description of TCOF1 related proteins analysed by STRING database
Gene Name
Reference
Number Description
HBG2
9606.ENSP0000 0338082
hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains
POLR1 C
9606.ENSP0000 0361465
polymerase (RNA) I polypeptide C, 30kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precu
CDT1
9606.ENSP0000 0301019
chromatin licensing and DNA replication factor 1; Cooperates with CDC6 to promote the loading of the mini- chromosome maintenance complex onto chromatin to form the pre- replication complex necessary to initiate DNA replication. Binds DNA in a sequence-,
NOP56
9606.ENSP0000 0370589
microRNA 1292; Required for 60S ribosomal subunit biogenesis
ANXA6
9606.ENSP0000 0346550
annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores
RFC1
9606.ENSP0000 0261424
replication factor C (activator 1) 1, 145kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B
FEN1
9606.ENSP0000 0305480
flap structure-specific endonuclease 1; Endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Also possesses 5' to 3' exonuclease
CDKN1 A
9606.ENSP0000 0244741
cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phos
RFC3
9606.ENSP0000 0369411
replication factor C (activator 1) 3, 38kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1
NDST1
9606.ENSP0000 0261797
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharid
RFC4
9606.ENSP0000 0296273
replication factor C (activator 1) 4, 37kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved i
CDK4
9606.ENSP0000 0257904
cyclin-dependent kinase 4; Probably involved in the control of the cell cycle
MKLN1
9606.ENSP0000 0323527
muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin 1 (By similarity)
UBTF
9606.ENSP0000 0302640
upstream binding transcription factor, RNA polymerase I; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specif
RFC2
9606.ENSP0000 0055077
replication factor C (activator 1) 2, 40kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By sim
CCND1
9606.ENSP0000 0227507
cyclin D1; Essential for the control of the cell cycle at the G1/S (start) transition
GADD4 5G
9606.ENSP0000 0252506
growth arrest and DNA-damage-inducible, gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
MSH6
9606.ENSP0000 0234420
mutS homolog 6 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields
PCNA
9606.ENSP0000 0368438
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similar
LIG1
9606.ENSP0000 0263274
ligase I, DNA, ATP-dependent; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair
TBL1X
9606.ENSP0000 0217964
transducin (beta)-like 1X-linked; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors.
MSH2
9606.ENSP0000 0233146
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA
POLD1
9606.ENSP0000 0262266
polymerase (DNA directed), delta 1, catalytic subunit 125kDa; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins
GADD4 5A
9606.ENSP0000 0360025
growth arrest and DNA-damage-inducible, alpha; Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S ph
DNMT1
9606.ENSP0000 0352516
DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epige
TCOF1
9606.ENSP0000 0406888
Treacher Collins-Franceschetti syndrome 1; May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex (By similarity)
POLD3
9606.ENSP0000 0263681
polymerase (DNA-directed), delta 3, accessory subunit; Required for optimal DNA polymerase delta activity
DYNC1 H1
9606.ENSP0000 0348965
dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release o
POLD2
9606.ENSP0000 0379148
polymerase (DNA directed), delta 2, regulatory subunit 50kDa; The function of the small subunit is not yet clear
POLR1 D
9606.ENSP0000 0302478
polymerase (RNA) I polypeptide D, 16kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA
RFC5
9606.ENSP0000 0408295
replication factor C (activator 1) 5, 36.5kDa; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1