Table S1. Effects of BP-lowering in trials in hypertensive patients stratified by level of cardiovascular risk and achieved SBP
Outcome
Achieved SBP (mmHg)
Trials (n)
Follow-up (years)
SBP/DBP difference
(mmHg)
Events (n/patients) RR
(95%)
Outcome risk
Active Control
A. High-very high cardiovascular risk
Stroke ≥ 140
130-139
< 130
21 15 6
3.4 4.0 4.5
-9.5/-4.6 -5.3/-2.6 -7.4/-3.7
1104 / 25258 2502 / 47091 415 / 18574
1403 / 23365 2987 / 47063 525 / 18606
0.73 (0.66-0.80) 0.79 (0.72-0.87) 0.79 (0.66-0.83)
6.0 6.3 2.8
CHD ≥ 140
130-139
< 130
21 15 6
3.3 4.0 4.5
-9.4/-4.5 -5.3/-2.6 -7.4/-3.7
743 / 24607 1987 / 47091 1110 / 18574
798 / 22526 2272 / 47063 1291 / 18606
0.81 (0.73-0.90) 0.87 (0.81-0.94) 0.86 (0.78-0.96)
3.5 4.8 6.9
HF ≥ 140
130-139
< 130
15 12 4
3.3 3.9 4.5
-10.3/-4.5 -5.0/-2.4 -6.0/-2.7
525 / 15488 1928 / 42402
288 / 13170
657 / 14054 2249 / 42492
368 / 13165
0.66 (0.56-0.77) 0.86 (0.76-0.97) 0.80 (0.64-0.99)
4.7 5.3 2.8
Stroke + CHD ≥ 140
130-139
< 130
20 15 6
3.3 4.0 4.5
-9.5/-4.6 -5.3/-2.6 -7.4/-3.7
1815 / 24218 4489 / 47091 1525 / 18574
2107 / 22325 5269 / 47063 1820 / 18606
0.78 (0.72-0.84) 0.83 (0.78-0.89) 0.84 (0.76-0.93)
9.4 11.2
9.8 Stroke +CHD + HF ≥ 140
130-139
< 130
17 12 4
3.7 3.9 4.5
-10.8.-5.0 -5.0/-2.4 -6.0/-2.7
2021 / 17731 6180 / 44321 1306 / 13170
2338 / 16327 7181 / 44343 1569 / 13165
0.76 (0.70-0.83) 0.83 (0.77-0.90) 0.84 (0.73-0.97)
14.3 16.2 11.9
CV death ≥ 140
130-139
< 130
20 15 8
3.3 4.0 4.4
-9.5/-4.6 -5.2/-2.6 -7.3/-3.7
1309 / 24218 2519 / 47091 605 / 19171
1384 / 22325 2779 / 47063 691 / 19181
0.85 (0.77-0.93) 0.87 (0.80-0.95) 0.89 (0.77-1.02)
6.2 5.9 3.6
All death ≥ 140
130-139
< 130
23 16 8
3.4 4.0 4.4
-9.4/-4.5 -5.2/-2.6 -7.3/-3.7
2608 / 25707 4334 / 47298 1216 / 19171
2611 / 23626 4601 / 47265 1355 / 19181
0.92 (0.86-0.98) 0.91 (0.86-0.97) 0.91 (0.82-1.01)
11.1 9.7 7.1 B. Low-moderate cardiovascular risk
Stroke 130-139
< 130
12 5
4.4 3.1
-6.6/-3.8 -8.1/-4.8
336 / 25847 91 / 11121
545 / 32174 98 / 10446
0.77 (0.65-0.91) 0.84 (0.61-1.15)
1.7 0.9
CHD 130-139
< 130
12 6
4.4 3.1
-6.6/-3.9 -8.1/-4.8
480 / 25683 184 / 11789
583 / 32007 192 / 10680
0.94 (0.84-1.07) 0.80 (0.65-0.98)
1.8 1.8
HF 130-139
< 130
7 4
4.3 3.0
-4.2/-3.0 -9.4/-5.6
139 / 14544 82 / 8889
148 / 20821 110 / 8231
1.00 (0.59-1.71) 0.94 (0.46-1.91)
0.7 1.3
Stroke + CHD 130-139
< 130
13 5
4.4 3.1
-6.5/-3.8 -8.1/-4.8
854 / 26282 249 / 11121
1147 / 31881 271 / 10446
0.85 (0.78-0.93) 0.84 (0.71-1.01)
3.6 2.6 Stroke +CHD + HF 130-139
< 130
8 4
4.6 3.0
-6.7/-4.0 -9.4/-5.6
908 / 23094 300 / 8889
1228 / 29333 342 / 8231
0.87 (0.80-0.95) 0.81 (0.69-0.94)
4.2 4.2
CV death 130-139
< 130
13 5
4.4 3.1
-6.5/-3.8 -8.1/-4.8
410 / 26282 75 / 11121
476 / 31881 81 / 10446
1.05 (0.80-1.38) 1.03 (0.64-1.66)
1.5 0.8
All death 130-139
< 130
14 5
4.3 3.1
-6.5/-3.8 -8.1/-4.8
896 / 26658 230 / 11121
1104 / 32854 268 / 10446
0.99 (0.89-1.09) 0.84 (0.70-1.02)
3.4 2.6
Outcome risk is expressed as percent incidence of a given outcome during the follow-up in the control group.
BP, blood pressure; CHD, coronary heart disease; CV, cardiovascular; HF, heart failure; RR, risk ratio.
Table S2. Effects of BP-lowering in trials in hypertensive patients with diabetes, stratified by level of cardiovascular risk and achieved SBP
Outcome
Achieved SBP (mmHg)
Trials (n)
Follow-up (years)
SBP/DBP difference
(mmHg)
Events (n/patients) RR
(95%)
Outcome risk
Active Control
A. High-very high cardiovascular risk
Stroke ≥ 140
130-139
< 130
10 11 2
3.5 4.1 4.5
-3.9/-1.9 -5.2/-2.3 -13.6/-6.1
288 / 5896 786 / 14433
94 / 2957
310 / 5834 873 / 14252
131 / 2882
0.89 (0.74-1.07) 0.85 (0.75-0.96) 0.66 (0.49-0.88)
5.5 6.1 4.5
CHD ≥ 140
130-139
< 130
9 10
1
3.5 4.5 ---
-3.4/-1.7 -5.6/-2.3
---
223 / 5889 771 / 11593
---
273 / 5670 837 / 11349
---
0.72 (0.60-0.85) 0.86 (0.78-0.94)
---
4.8 7.4 ---
HF ≥ 140
130-139
< 130
5 8 2
3.5 4.5 4.7
-3.0/-1.4 -5.7/-2.4 -11.3/-5.2
330 / 4647 400 / 10599
104 / 3096
304 / 4096 446 / 10353
113 / 3021
0.86 (0.70-1.05) 0.82 (0.69-0.97) 0.89 (0.65-1.23)
7.4 4.3 3.7
Stroke + CHD ≥ 140
130-139
< 130
9 11
1
3.6 4.5 ---
-3.6/-1.7 -5.5/-2.3
---
519 / 5813 1411 / 12652
---
600 / 5755 1568 / 12408
---
0.80 (0.71-0.90) 0.85 (0.78-0.91)
---
10.4 12.6 --- Stroke +CHD + HF ≥ 140
130-139
< 130
7 12
1
3.4 4.1 ---
-3.4/-1.6 -5.2/-2.3
---
789 / 4781 2589 / 15111
---
776 / 4222 2800 / 14921
---
0.85 (0.74-0.97) 0.87 (0.80-0.94)
---
18.4 18.8 ---
CV death ≥ 140
130-139
< 130
10 7 2
3.5 4.5 4.7
-3.2/-1.7 -5.6/-2.3 -11.3/-5.2
348 / 5217 567 / 11593
85 / 3096
339 / 5169 678 / 11349
75 / 3021
0.92 (0.75-1.13) 0.79 (0.67-0.93) 1.12 (0.77-1.63)
6.6 6.0 2.5
All death ≥ 140
130-139
< 130
9 11
2
3.5 4.5 4.7
-3.4/-1.7 -5.7/-2.5 -11.3/-5.2
766 / 5889 1031 / 11957
194 / 3096
727 / 5670 1149 / 11757
190 / 3021
0.98 (0.89-1.07) 0.85 (0.78-0.92) 1.00 (0.82-1.21)
12.8 9.8 6.3 B. Low-moderate cardiovascular risk
Stroke 130-139
< 130
3 2
3.3 3.2
-5.3/-1.8 -3.9/-2.3
15 / 597 11 / 2484
19 / 677 8 / 2462
0.89 (0.45-1.78) 1.36 (0.55-3.39)
2.8 0.3
CHD 130-139
< 130
3 2
3.3 3.2
-5.3/-1.8 -3.9/-2.3
9 / 597 23 / 2484
17 / 677 34 / 2462
0.67 (0.29-1.55) 0.67 (0.40-1.14)
2.5 1.4
HF 130-139
< 130
1 1
--- ---
--- ---
--- ---
--- ---
--- ---
--- ---
Stroke + CHD 130-139
< 130
5 2
3.5 3.2
-3.5/-1.9 -3.9/-2.3
70 / 1754 34 / 2484
61 / 1104 42 / 2462
0.73 (0.51-1.04) 0.80 (0.51-1.26)
5.5 1.7 Stroke +CHD + HF 130-139
< 130
1 2
--- 2.6
--- -8.7/-4.2
--- 61 / 485
--- 42 / 377
--- 0.84 (0.60-1.19)
--- 11.1
CV death 130-139
< 130
4 2
3.6 3.2
-3.5/-2.1 -3.9/-2.3
13 / 1543 16 / 2484
12 / 916 4 / 2462
0.61 (0.15-2.47) 2.95 (0.43-20.2)
1.3 0.2
All death 130-139
< 130
4 2
3.4 3.2
-4.4/-1.9 -3.9/-2.3
26 / 850 29 / 2484
33 / 804 20 / 2462
0.81 (0.49-1.35) 1.44 (0.81-2.57)
4.1 0.8
Outcome risk is expressed as percent incidence of a given outcome during the follow-up in the control group.
BP, blood pressure; CHD, coronary heart disease; CV, cardiovascular; HF, heart failure; RR, risk ratio.
Table S3. Effects of BP-lowering in trials in hypertensive patients without diabetes, stratified by level of cardiovascular risk and achieved SBP
Outcome
Achieved SBP (mmHg)
Trials (n)
Follow-up (years)
SBP/DBP difference
(mmHg)
Events (n/patients) RR
(95%)
Outcome risk
Active Control
A. High-very high cardiovascular risk
Stroke ≥ 140
130-139
< 130
9 6 2
4.0 3.8 4.2
-11.6/-5.5 -5.5/-2.7 -5.8/-2.5
436 / 11284 1140 / 22510
106 / 5929
656 / 11270 1415 / 22405
108 / 5881
0.66 (0.57-0.76) 0.76 (0.67-0.86) 0.98 (0.72-1.32)
5.8 6.3 1.8
CHD ≥ 140
130-139
< 130
6 5 2
4.0 4.4 4.2
-14.1/-6.3 -6.0/-2.8 -5.8/-2.5
357 / 7930 694 / 15204
283 / 5929
450 / 7916 831 / 15122
363 / 5881
0.82 (0.69-0.97) 0.82 (0.70-0.95) 0.78 (0.60-1.01)
5.7 5.5 6.2
HF ≥ 140
130-139
< 130
3 4 3
2.7 4.2 44
-13.0/-6.0 -6.0/-2.8 -4.5/-2.0
75 / 2926 497 / 13048
171 / 9353
105 / 2890 678 / 13038
229 / 9363
0.73 (0.54-0.97) 0.74 (0.67-0.83) 0.76 (0.62-0.92)
3.6 5.2 2.4
Stroke + CHD ≥ 140
130-139
< 130
7 6 2
3.9 4.4 4.2
-11.8/-5.4 -5.8/-2.8 -5.8/-2.5
862 / 10094 1484 / 17099
389 / 5929
1109 / 10090 1894 / 17035 471 / 5881
0.78 (0.71-0.86) 0.79 (0.73-0.85) 0.82 (0.70-0.97)
10.9 11.1 8.0 Stroke +CHD + HF ≥ 140
130-139
< 130
6 7 2
3.0 3.9 4.2
-13.0/-6.3 -5.4/-2.6 -5.8/-2.5
654 / 6461 2880 / 24405
465 / 5929
831 / 6337 3553 / 24318
574 / 5881
0.77 (0.68-0.87) 0.81 (0.75-0.87) 0.82 (0.69-0.98)
13.1 14.6 9.8
CV death ≥ 140
130-139
< 130
5 5 4
3.8 4.4 4.4
-14.6/-7.1 -6.0/-2.8 -4.4/-2.0
324 / 5850 571 / 15204
231 / 9520
408 / 5847 644 / 15122
341 / 9531
0.76 (0.57-0.99) 0.86 (0.67-1.11) 0.65 (0.45-0.93)
7.0 4.3 3.6
All death ≥ 140
130-139
< 130
7 6 6
4.1 4.6 4.4
-13.4/-6.2 -7.0/-3.6 -4.4/-2.0
859 / 8970 1321 / 20325
597 / 9520
929 / 8956 1453 / 20169
665 / 9531
0.93 (0.85-1.02) 0.91 (0.85-0.98) 0.90 (0.81-1.01)
10.4 7.2 7.0 B. Low-moderate cardiovascular risk
Stroke 130-139
< 130
7 4
4.5 3.2
-6.8/-4.0 -10.2/-5.6
298 / 23057 123 / 8683
484 / 28824 144 / 8602
0.76 (0.63-0.92) 0.81 (0.60-1.07)
1.7 1.7
CHD 130-139
< 130
8 4
4.5 3.3
-6.7/-3.9 -9.7/-5.6
442 / 23615 151 / 8338
527 / 29377 149 / 7935
0.95 (0.84-1.08) 0.89 (0.71-1.12)
1.8 1.9
HF 130-139
< 130
5 2
5.0 3.2
-5.8/-3.0 -11.2/-6.6
101 / 7736 74 / 7301
110 / 7752 104 / 7329
0.76 (0.37-1.58) 1.04 (0.44-2.47)
1.4 1.4
Stroke + CHD 130-139
< 130
7 3
4.5 3.2
-6.8/-4.0 -9.9/-5.7
736 / 23057 194 / 7670
1005 / 28824 219 / 7701
0.86 (0.79-0.95) 0.89 (0.73-1.07)
3.5 2.8 Stroke +CHD + HF 130-139
< 130
5 4
5.1 3.1
-9.0/-4.7 -9.2/-5.3
680 / 15878 462 / 8773
792 / 15853 421 / 8226
0.86 (0.75-0.99) 0.89 (0.76-1.05)
5.0 5.1
CV death 130-139
< 130
6 3
4.6 3.2
-6.8/-4.1 -9.9/-5.7
368 / 21641 51 / 7670
405 / 27379 77 / 7701
1.11 (0.96-1.27) 0.67 (0.47-0.97)
1.5 1.0
All death 130-139
< 130
8 3
4.5 3.2
-6.7/-3.9 -9.9/-5.7
817 / 23615 194 / 7670
989 / 29377 251 / 7701
1.00 (0.91-1.10) 0.77 (0.64-0.93)
3.4 3.3