Table S1.
Predictive value of donor, operative and post-operative factors in predicting graft and patient survival
Graft survival Patient survival Donor factors
Siskind, 2014 (3) --- ---
Muthusamy, 2012 (29) --- ---
Bellingham, 2011 (9) --- ---
Salvalaggio, 2006 (40)^ --- ---
Fernandez, 2005 (8)# --- ---
D’Alessandro, 2004 (30) --- ---
Chandolias, 2013 (42) --- ---
Qureshi, 2012 (31) --- ---
Teraoka. 1995 (32) Primary non-function in grafts from 59 year old donor, 52 year old donor and 13 year old donor.
---
Teraoka, 1998 (33) Cases 4, 8, and 9 developed vascular thrombosis in the pancreatic graft, in which pancreatic graft was exposed to 14 minutes of warm ischemia after 30 minutes of closed cardiac massage (case 4), poor tissue perfusion by massive dose of
catecholamine for prolonged hypotension (case 8), or hypoxemia due to transient cardiopulmonary arrest (case 9)
---
Tojimbara, 1998 (36)# Three of four patients whose pancreas graft survived more than 5 years, had received the graft from NHBC donors whose organs were procured after sustaining
cardiopulmonary arrest following discontinuation of mechanical ventilation in the operating room.
---
Tojimbara, 1999 (37)# --- ---
D’Alessandro, 1995 (35)# --- ---
Farney, 2008 (27) --- ---
Ishida-Oku, 2010 (25) --- ---
Johnson, 2005 (26) --- ---
Naim, 2008 (28) --- ---
Ablorsu, 2009 (19) --- ---
Harbell, 2008 (20) --- ---
Ishida-Oku (21) --- ---
Jeon, 2002 (22) --- ---
Moon, 2004 (23) --- ---
Suh, 2009 (24) --- ---
Operative factors
Siskind, 2014 (3) --- ---
Muthusamy, 2012 (29) DCD survival compared to DBD SPK (88% vs. 87%, p = 0.9) and PA (76% vs. 73%, p
= 0.6)
DCD survival compared to DBD SPK (95% vs. 96%, p = 0.9); and PA (94% vs. 98% in PA, p = 0.4)
Bellingham, 2011 (9) --- ---
Salvalaggio, 2006 (40)^ DGF of the kidney in SPK transplant recipients of organs from DCD donors was almost four times higher than that with DBD allografts, 28.2%
versus 7.6% respectively (p <
0.01)
---
Fernandez, 2005 (7)# --- ---
D’Alessandro, 2004 (30) --- ---
Chandolias, 2013 (42) --- ---
Qureshi, 2012 (31) --- ---
Teraoka. 1995 (32) --- ---
Teraoka, 1998 (33) --- ---
Tojimbara, 1998 (36)# --- ---
Tojimbara, 1999 (37)# --- ---
D’Alessandro, 1995 (35)# --- ---
Farney, 2008 (27) --- ---
Ishida-Oku, 2010 (25) --- ---
Johnson, 2005 (26) --- ---
Naim, 2008 (28) --- ---
Ablorsu, 2009 (19) --- ---
Harbell, 2008 (20) --- ---
Ishida-Oku (21) --- ---
Jeon, 2002 (22) --- ---
Moon, 2004 (23) --- ---
Suh, 2009 (24) --- ---
Post Operative factors
Siskind, 2014 (3) --- ---
Muthusamy, 2012 (29) Numerically more DCD grafts lost to thrombosis (8% vs. 5%, p = NS)
Other causes for graft loss in
---
DCD compared with DBD (rejection: 6% vs. 4%;
bleeding: 1% vs. 1% and other causes: 9% vs. 9%)
Bellingham, 2011 (9) Rate of acute cellular pancreas rejection was 27% at 10 years in the DBD group, compared with 20% for the DCD cohort (P = .63)
94.4% of the DBD group were free of thrombosis at 1 year and 89.2% of the DCD group (P=0.1)
---
Salvalaggio, 2006 (40)^ SPK 10% of DBD and 17% of SPK recipients whose
pancreas failed, acute cellular rejection (9%), bleeding (18%) and chronic rejection (9%) were common causes in the DCD group and chronic allograft rejection (14%) and infection (6%) in the DBD group. DCD had oral hypoglycemic resumed.
PTA 18% of DBD and 30% of DCD had oral hypoglycemic resumed
---
Fernandez, 2005 (7)# Fasting blood glucose was 98.3 +/- 40.5 mg/dL for the DBD group and 98.7 +/- 20.0 mg/dL for the DCD group (P
= 0.51)
DCD group 8.1%were receiving oral hypoglycemic agents or insulin to treat mild hyper-glycemia. DBD 9.3%
received oral hypoglycemics (p=n.s.)
Seven episodes of pancreas graft thrombosis were noted in the immediate postoperative period (less than 1 week) in the DBD group (1.3%) and 0 in the DCD group (P = 1.00).
---
D’Alessandro, 2004 (30) --- ---
Chandolias, 2013 (42) --- ---
Qureshi, 2012 (31) Three grafts failed in the DCD group owing to venous graft thrombosis, acute antibody- mediated rejection and chronic rejection. Two pancreas transplants from DBD donors failed, both as a result of venous thrombosis.
HbA1c similar between DCD and DBD grafts 5·4 (4·9–7·7) versus 5·4 (4·1–6·2) per cent at 12 months (P = 0·910) Postoperative length of
hospital stay was similar, with a median of 17 (10 – 54) days for recipients of DCD organs and 17 (9 – 36) days for recipients of DBD organs (P = 0·535).
---
Teraoka. 1995 (32) --- ---
Teraoka, 1998 (33) In case that serum C-peptide elevated up to 10 ng/mL immediately after the
revascular- ization, immediate function and long-standing good graft function were attained, while patients with C-peptide within 5 to 10 ng/mL became insulin-free 3 to 18 days after the
transplantation.
---
Tojimbara, 1998 (36)# --- ---
Tojimbara, 1999 (37)# --- ---
D’Alessandro, 1995 (35)# --- ---
Farney, 2008 (27) --- ---
Ishida-Oku, 2010 (25) --- ---
Johnson, 2005 (26) --- ---
Naim, 2008 (28) --- ---
Ablorsu, 2009 (19) --- ---
Harbell, 2008 (20) --- ---
Ishida-Oku (21) --- ---
Jeon, 2002 (22) --- ---
Moon, 2004 (23) --- ---
Suh, 2009 (24) --- ---