Table S1. Characteristics of caregivers and children with glaucoma they care for (n = 85)
Caregiver characteristics Count %
Age*, years 42.5 ±7.5
Relation to patient Father 46 54.1
Mother 39 45.9
Current employment status Employed 54 63.5
Unemployed/retired 31 36.5
Formal school-based education Yes 75 88.2
No 10 11.8
Current marital status Married 79 92.9
Single 6 7.1
Number of additional children with glaucoma
None 61 71.8
≥ 1 24 28.2
Patient’s characteristics
Age*, years 12.9 ±3.8
Gender Male 32 37.6
Female 53 62.4
Diagnosis† Primary congenital glaucoma 64 75.3
Other type of glaucoma 21 24.7
Age at diagnosis At birth 54 63.5
Later 31 36.5
Laterality of glaucoma Unilateral 13 15.3
Bilateral 72 84.7
Glaucoma eye drops used per day 6.7 ± 4.2
Number of previous glaucoma surgeries 4.8 ± 4.5
VA better eye 20/20-20/50 31 36.5
20/60-20/200 28 32.9
< 20/200 26 30.6
*Data are presented as means and SD
†Other included Juvenile open-angle glaucoma, secondary childhood glaucoma.
Table S2. Rasch-scaled scores of the quality of life of caregivers of children with glaucoma by subgroups (n=81)
*Student’s t –test was used to compute significance unless stated otherwise.
**Mann-Whitney U test was used to compute significance.
Caregiver characteristics Count Rasch-scaled scores (logit units) P*
Mean SD Median IQR
All 81 0.63 1.05 0.58 1.22
Relation to patient Father 44 0.87 0.99 0.75 1.23 0.026
Mother 37 0.35 1.05 0.45 1.04
Current employment status Employed 51 0.81 0.98 0.69 1.23 0.044
Unemployed/retired 30 0.33 1.11 0.47 1.26
Formal school-based education
Yes 71 0.62 1.05 0.58 1.49 0.769
No 10 0.72 1.11 0.63 1.15
Current marital status Married 76 0.69 1.03 0.69 1.27 0.075
Single 5 -0.18 1.09 0.32 1.89
Number of additional children with glaucoma
None 59 0.88 0.95 0.80 1.28 <0.001
≥ 1 22 -0.04 1.02 0.09 1.27
Patient’s characteristics
Gender Male 31 0.69 1.06 0.58 1.36 0.699
Female 50 0.60 1.05 0.61 1.22
Diagnosis Primary congenital glaucoma 60 0.59 1.14 0.58 1.50 0.503
Other type of glaucoma 21 0.76 0.74 0.58 0.69
Age of diagnosis** At birth 51 0.55 1.17 0.69 1.50 0.618
Later 30 0.77 0.81 0.58 0.69
Laterality of glaucoma** Unilateral 13 0.69 0.73 0.45 0.41 0.964
Bilateral 68 0.62 1.10 0.69 1.60
VA better eye 20/20-20/200 57 0.85 0.95 0.69 1.03 0.003
< 20/200 24 0.11 1.09 0.09 1.56
Table S3. Bivariate linear regression analysis of factors associated with quality of life of caregivers of children with glaucoma (n=81)
a
= reference category
Caregiver characteristics Crude β 95%CI
PAge, years 0.002 -0.03, 0.03 0.914
Current employment status Employed
aUnemployed/ retired -0.48 -0.96, -0.01 0.044
Current marital status Married
aSingle -0.86 -1.81, 0.09 0.075
Formal school-based education
Yes
aNo 0.10 -0.6, 0.81 0.769
Relation to patient Father
aMother -0.52 -0.97, -0.06, 0.026
Number of additional children with glaucoma
None
a≥ 1 -0.92 -1.4, -0.43, <0.001
Patient’s characteristics
Age, years 0.01 -0.05, 0.07 0.712
Gender Male
aFemale -0.09 -0.57, 0.39 0.699
VA better eye 20/20-20/200
a< 20/200 -0.74 -1.23, -0.26 0.003
Diagnosis
Primary congenital glaucoma -0.18 -0.71, 0.35 0.503
Other type of glaucoma
aAge at diagnosis
At birth -0.22 -0.7, 0.26 0.369
Later
aLaterality of glaucoma Unilateral
aBilateral -0.07
-0.71, 0.560.824
Glaucoma eye drops used per day -0.02
-0.07, 0.040.475
Previous glaucoma surgeries -0.02
-0.14, 0.10.736
Table S4. Multiple linear regression analysis of factors associated with quality of life of caregivers of children with glaucoma (n=81)
Model 1 Model 1 Model 3
Characteristic β(95% CI) P β(95% CI) P β(95% CI) P
Additional children with glaucoma None a
≥ 1 -0.92 (-1.4, -0.43) <0.001 -0.89 (-1.36, -0.42) <0.001 -0.75 (-1.22, -0.27) 0.003 Relation to patient
Fathera
Mother -0.48 (-0.90, -0.05) 0.027 -0.46(-0.87, -0.04) 0.031
VA of child in better eye 20/20-20/200 a
< 20/200 -0.52 (-0.98,-0.05) 0.030
Constant 0.88 1.09 1.12
Model Summary
Adjusted R2 0.143 0.185 0.223
R2 0.153 0.205 0.252
F 14.318 10.051 8.661
P-value <0.001 <0.001 <0.001
∆ R2 0.153 0.051 0.047
∆ F 14.318 5.049 4.880
Sig∆ F <0.001 0.027 0.030
a
