Table S1. Predictive performance in the entire cohort.
AUC (standard deviation in five-fold cross-validation)
1-year OS 1-year PFS 1-year relapse/progression 1-year NRM
RSF 0.76 (0.07) 0.75 (0.09) 0.75 (0.11) 0.72 (0.12)
Cox PH model 0.76 (0.07) 0.72 (0.08) - -
DRI-R1 0.70 (0.09) 0.71 (0.09) 0.73 (0.11) 0.50 (0.12) HCT-CI2 0.59 (0.06) 0.57 (0.07) 0.55 (0.08) 0.63 (0.09)
HCT-CR3 0.71 (0.10) 0.71 (0.10) 0.74 (0.11) 0.55 (0.16)
HCT-CI/Age4 0.62 (0.06) 0.58 (0.07) 0.56 (0.08) 0.64 (0.12)
EBMT risk score5 0.69 (0.06) 0.68 (0.06) 0.68 (0.07) 0.58 (0.12)
Abbreviations: AUC, area under the receiver-operating characteristic curve; Cox PH, Cox proportional hazard; DRI-R, refined Disease Risk Index; EBMT, European Group for Blood and Marrow Transplantation; HCT-CI, Hematopoietic Cell Transplantation Comorbidity Index;
HCT-CI/Age, hematopoietic stem-cell transplant comorbidity/age index; HCT-CR, hematopoietic cell transplant-composite risk; NRM, non-relapse mortality; OS, overall survival; PFS, progression-free survival; RSF, random survival forest.
Table S2. Predictive performance in the training cohort per hyperparameter in the RSF model.
The number of variable candidates
(hyperparameter)
AUC
1-year OS 1-year PFS 1-year
relapse/progression 1-year NRM
1 0.7710 0.7482 0.7394 0.6124
2 0.7774 0.7606 0.7542 0.6502
3 0.7806 0.7600 0.7504 0.6684
4 0.7828 0.7582 0.7452 0.6712
5 0.7866 0.7548 0.7422 0.6838
6 0.7856 0.7548 0.739 0.6776
7 0.7878 0.7544 0.7348 0.6740
8 0.7864 0.7540 0.7330 0.6794
Bold letters indicate the hyperparameter that showed the highest predictive performance for each outcome.
Abbreviations: AUC, area under the receiver-operating characteristic curve; NRM, non-relapse mortality; OS, overall survival; PFS, progression free survival; RSF, random survival forest.
Table S3. Predictive performance in the test cohort.
Predictive model
AUC 1-year OS
[95% CI]
1-year PFS [95% CI]
1-year relapse/progression
[95% CI]
1-year NRM [95% CI]
RSF 0.70 [0.60-0.80] 0.72 [0.62-0.82] 0.73 [0.63-0.83] 0.77 [0.64-0.90]
Cox PH 0.71 [0.60-0.81] 0.70 [0.59-0.80] - -
DRI-R1 0.65 [0.55-0.75] 0.67 [0.57-0.77] 0.72 [0.62-0.81] 0.39 [0.24-0.53]
HCT-CI2 0.55 [0.44-0.66] 0.54 [0.44-0.65] 0.51 [0.40-0.62] 0.59 [0.43-0.75]
HCT-CR3 0.66 [0.56-0.76] 0.70 [0.61-0.79] 0.75 [0.67-0.84] 0.38 [0.21-0.54]
HCT-CI/Age4 0.58 [0.47-0.70] 0.54 [0.43-0.64] 0.50 [0.39-0.61] 0.60 [0.42-0.78]
EBMT risk score5 0.71 [0.61-0.81] 0.65 [0.55-0.75] 0.61 [0.51-0.72] 0.61 [0.42-0.79]
Abbreviations: AUC, area under the receiver-operating characteristic curve; Cox PH, Cox proportional hazard; DRI-R, refined disease risk index; EBMT, European Group for Blood and Marrow Transplantation; HCT-CI, hematopoietic cell transplantation comorbidity index;
HCT-CI/Age, hematopoietic stem-cell transplant comorbidity/age index; HCT-CR, hematopoietic cell transplant-composite risk; NRM, non-relapse mortality; OS, overall survival; PFS, progression free survival; RSF, random survival forest.
References
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3. Kongtim P, Parmar S, Milton DR, et al. Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome. Bone Marrow Transplant.
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Figure S1. Schema of the assessment method for the predictive models.
Figure S2. The change of AUCs for OS and PFS as the patient number of the training cohort are increased.
Abbreviations: AUC, area under the receiver-operating characteristic curve; OS, overall survival; PFS, progression free survival.
