Supplementary data
Authors
Country
Sex Age
Etiology
Malignant or Non malignant
Palliative
Allodynie Initial MEQ
before OIH management
oMED after OIH management
Pain before
Pain after
OIH strategy
Drugs used
Ali USA 2 63 Pelvic cancer Malignant Palliative care no 20520 NA Rotation
methadone, amitriptyline and NSAID
Axelrod USA 2 45 Myeloma Malignant Palliative care no 14400 810 10
adequate pain
control Rotation
Axelrod USA 2 29
Sickle cell disease chronic
pain Non malignant no 12240 720 10 7 Adjuvant therapies ketamine
Belgrade case 1 USA 1 14 Leukaemia Malignant no 1000 0 NA Adjuvant therapies dexmedetomidine IV
Belgrade case 10 USA 1 33 Hemophilia A / hepatite C Non malignant no 900 900 NA NA Adjuvant therapies dexmedetomidine IV
Belgrade case 11 USA 1 16 Leukemia Malignant no 850 260 NA NA Adjuvant therapies dexmedetomidine IV
Belgrade case 2 USA 1 9 Hemorrhagic cystitis Non malignant no 1000 0 NA Adjuvant therapies dexmedetomidine IV
Belgrade case 3 USA 2 26
Chronic pancreatitis/
pancreatectomy Non malignant no 1000 40 7.5 5.2 Adjuvant therapies dexmedetomidine IV
Belgrade case 4 USA 2 31 na no 150 30 3.5 3.5 Adjuvant therapies dexmedetomidine IV
Belgrade case 5 USA 2 34 Vascular necrosis no 200 250 10 10 Adjuvant therapies dexmedetomidine IV
Belgrade case 6 USA 1 35 Hemophilia A Non malignant no 720 80 NA Adjuvant therapies dexmedetomidine IV
Belgrade case 7 USA 2 49
Chronic pain, methadone
maintenance Non malignant no 320 340 NA Adjuvant therapies dexmedetomidine IV
Belgrade case 8 USA 2 35 Lung transplantation Non malignant no 120 160 6 1 Adjuvant therapies dexmedetomidine IV
Belgrade case 9 USA 1 21 Pancreatectomy Non malignant yes 1000 90 10 4.5 Adjuvant therapies dexmedetomidine IV
Bennitz Canada 1 46
Chronic pancreatitis, neuropathy HIV,
fibromyalgia, Non malignant yes 90 60 worsening
significant
reduction Adjuvant therapies
dextromethorphan and clonidine
Berthelot France 2 43 Joint Pain Non malignant yes 180 severe NA na
Bitar USA 1 56 Back pain Malignant Palliative care no 288 144 severe died peacefully Rotation methadone
Chauhan USA 2 31 Headache Non malignant no 270 90 10 2 Adjuvant therapies lorazepam et Mexiletine
Appendix A
Supplementary data
chazan case 4 Israel 2 52
Breast cancer with bone
metastasis Malignant yes 3000 0 extreme mild Adjuvant therapies ketamine
Chung USA 1 63
Metastatic neuroendocrine
tumor Malignant Palliative care no 7200 696
Substantial decrease in pain
Rotation followed by Adjuvant therapies
(methadone,oxymorphe, hydromorphe, )failure then propofol
De conno Italy 1 49 Malignant Palliative care yes 8000 5000 8 5.5 Opioid cessation 37% reduction
Forero Canada 1 52
Postoperative Lumbo
radiculopathy Non malignant yes 1200 200 severe no pain Adjuvant therapies ketamine
Garuba USA 2 NA
Complex regional pain
syndrome Non malignant yes 135 40 severe mild Opioid cessation
reduction then oxycodone stopped
Hallet Australia NA infant
Gastroschisis and multiple
surgical operation Non malignant yes severe mild Adjuvant therapies
hydromorphone, ketamine, dexmedetomidine
Juba USA 2 43 Metastatic lung cancer Malignant Palliative care yes 1920 720 6 4 Rotation
oxycodone+ hydromorphone then sufentanyl
Junker Germany 1 13 Metastatic pancreatic cancer Malignant Palliative care yes 3000 1440 worsening
Pain significantly reduced, died
peacefully Adjuvant therapies S-ketamine
kalaydjian USA 2 60 Laminectomy Non malignant no 270 22.5 worsening improved Opioid cessation
reduction and cessation of fentanyl IT
Kaneria UK 2 44 Temporal Glioma Malignant Palliative care yes 285 45 not controlled improved Opioid cessation Reduction + benzodiazepine
Kaye USA 1 63
Metastatic neuroendocrine
tumor Malignant Palliative care no 7920 736 severe mild Adjuvant therapies propofol
Lawlor Canada 2 52 Malignant Palliative care yes 28800 450 8 2 Rotation methadone
Lee South korea 1 67 Postherpetic neuralgia Non malignant yes 80 0 7 2 Adjuvant therapies ketamine
Lee South korea 2 57 Joint Pain Non malignant no 40 0 6 2 Adjuvant therapies ketamine
Mercadante Italy 1 48 Thoracic Sarcoma Malignant Palliative care no 86520 168 8 5 Rotation methadone
Mercadante/case 1 Italy 1 54 Lung Cancer Malignant Palliative care no 600 600 10 4
Rotation followed by Adjuvant therapies
methadone (failure), ketamine (failure), midazolam, epidural bupivacaïne.,
Mercadante/case 2 Italy 1 47 Hepatic Carcinoma Malignant NA no 270 270 10 0
Rotation then Adjuvant therapies
methadone Bupivacaïne and morphine IT
Mercante case 1 Italy 1 65
Breast cancer, with bone
metastase Malignant NA NA 200 180 7 4 Rotation methadone
Mercante case 2 Italy 1 62
cancer ORL metastatic bone
cancer Malignant NA NA 90 135 7 4 Rotation methadone
Supplementary data
Mercante case 3 Italy 1 58 Pancreatic cancer Malignant NA NA 900 540 7 4 Rotation methadone
Mercante case 4 Italy 2 50
breast cancer metastasic
bone Malignant NA NA 120 150 7 4 Rotation methadone
Mercante case 5 Italy 1 55
Lung cancer with nerve
compression Malignant NA NA 30 105 7 4 Rotation methadone
Mercante case 6 Italy 2 75 Pancreatic cancer Malignant NA NA 90 105 7 4 Rotation methadone
Mercante case 7 Italy 1 55 Metastatic blader cancer Malignant NA NA 1200 1200 7 4 Rotation methadone
Mercante case 8 Italy 1 47 Bone metastasis Malignant NA NA 120 540 7 4 Rotation methadone
Mercante case 9 Italy 2 62 Metastatic breast cancer Malignant NA NA 160 270 7 4 Rotation methadone
Mercante case 10 Italy 2 76 cancerpancreas Malignant NA NA 120 480 7 4 Rotation methadone
Mercante case 11 Italy 1 64
Lung cancer with nerve
compression Malignant NA NA 150 105 7 4 Rotation methadone
Mercante case 12 Italy 2 51
cancer uterus with
neurological compression Malignant NA NA 45 70 7 4 Rotation methadone
O'Donnell USA 1 34
Abdominal and Pelvis
trauma Non malignant Palliative care yes NA
Could not be
mobilized 4 Adjuvant therapies Lidocaïne
Pirbudak Turkey 1 40
Colon cancer after visceral
surgery Malignant Palliative care no 300 4 9 2 Adjuvant therapies
IV dexmedetomidine puis SC ketamine(10 mg/day, IT clonidine (90 µg/day)
Ricart Spain 2 81 Vertebral collapse Non malignant no 1300 250 severe moderate Rotation methadone
Rivera USA 2 45
Chronic pelvic pain and
fibromyalgia Non malignant no 242 7 4 Adjuvant therapies
ketamine alone failed then ketamine+naltrexone
Singla USA 1 49
Complex regional pain syndrome 1/ Multiple
oeration of knee Non malignant no 6300 NA severe mild Adjuvant therapies
IT bupivacaïne + opioid (bupicacaine ) then ketamine boli then IVSE
Siniscalchi Italy 2 27 Neuropathy Non malignant no 300 0 10 2 Adjuvant therapies
general anesthesia propofol clonidine 3 mcg/kg and nalaxone
Sjogren case 1 Denmark 2 19 Gliosarcoma Malignant yes 60000 90 severe pain- free Rotation methadone
Sjogren case 2 Denmark 2 55 Spinal metastasis Malignant yes 180 60 severe
touch evoked
pain disapeared Opioid cessation reduction
Sjogren case 3 Denmark 2 68 Spinal metastasis Malignant Palliative care yes 1920 1200 severe pain relief Rotation sufentanil
Sjogren case 4 Denmark 1 10
Cerebral and medullary
metastasis Malignant Palliative care yes 600 60 severe 0 Rotation methadone
Varney USA 1 23
Abdominal trauma and leg
amputation Non malignant no 506 NA 10 NA Adjuvant therapies ketamine
Supplementary data
Vijayan USA 2 9 Idiopathic juvenile arthritis Non malignant yes 216 0 10 2 Opioid cessation opioid cessation
Vorobeychik USA 1 56 Metastatic lung cancer Malignant Palliative care no 50700 28860 10 3 Rotation methadone
Waldfogel Australia 1 28 Metastatic pancreatic cancer Malignant Palliative care no 48540 872 10 5 Adjuvant therapies ketamine
Wall UK 2 76 Metastatic breast cancer Malignant Palliative care yes 120 60 severe has improved Opioid cessation
Willeford USA 2 38 Neuroendocrine tumor Malignant no 1200 522 10 5 Adjuvant therapies ketamine
Wilson USA 1 39 Metastatic testicular cancer Malignant Palliative care no 115000 1700 extreme pain-free Adjuvant therapies ketamine
Sjogren2 case 1 Denmark 2 28 Uterine cancer Malignant Palliative care NA 86000 NA extreme NA NA NA
Sjogren2 case 2 Denmark 1 42 Visceral cancer Malignant Palliative care yes 122000 NA extreme NA NA NA
Sjogren2 case 3 Denmark 2 31 Melanoma Malignant Palliative care NA 129000 NA extreme NA NA NA
Sjogren2 case 4 Denmark 2 67 Breast cancer Malignant Palliative care NA 144000 NA extreme NA NA NA
Sjogren2case 5 Denmark 1 56 Rectal cancer Malignant Palliative care NA 72000 NA extreme NA NA NA
Sjogren2 case 6 Denmark 2 52 Rectal cancer Malignant Palliative care NA NA NA extreme NA NA NA
Sjogren 2 case 7 Denmark 1 71 Rectal cancer Malignant Palliative care NA 144000 NA extreme NA NA NA
Sjogren2case 8 Denmark 2 61 Chordoma Malignant Palliative care yes 86000 NA extreme NA NA NA