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Tables:

Supplemental Table 1: Characteristics of IMA levels on day 0 and day 1in patients with TBI

Data are presented as mean (sd), or number (percentage) as appropriate.

IMA D0: ischemia modified albumin on day 0, IMA D1: ischemia modified albumin on day 1, ABSU: absorbance unit.

Number (percentage)

Mean(SD)

IMA D0 (ABSU)

elevated

Mild TBI 11

49(90.7%) 1.08(0.28)

Moderate TBI

6 Severe TBI 32

normal

Mild TBI 5

5(9.3%) 0.55(0.026)

Moderate TBI

0 Severe TBI 0

IMA D1 (ABSU)

elevated

Mild TBI 12

43(79.6%) 1.1 (0.36)

Moderate TBI

10 Severe TBI 21

normal

Mild TBI 10

11(20.4%) 0.58(0.047)

Moderate TBI

1 Severe TBI 0

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Supplemental Table 2: Patients characteristics. Hemodynamic and lab variables

Data are presented as mean (sd), or number (percentage) as appropriate.

Variables All patients

(n=54)

Age (years) 37.67(13.36)

Gender (M/F) 32/22( 59.3/40.7)

BMI 23.52 (2.46)

GCS D0 7.85 (4.68)

GCS D1 9.39 (5.06)

Length of stay(in days) 3.39 (1.19)

HR admission 100.37(15.05)

HR 24hrs 84.91( 9.24)

systolic_0 128.15 (21.64)

systolic_24 118.24 (22.31)

diastolic_0 77.59 (11.96)

diastolic_24 67.78 (17.12)

CVP admission 5.96 (3.28 )

CVP 24hrs 7.7 ( 2.4 )

Temp admission 37.1 ( 0.6 )

Temp 24hrs 37.15 (0.05)

HB D0 11.28 ( 2.4 )

Creat D0 1 (0.27 )

ALT D0 37.5 ( 24.65 )

Albumin D0 3.52 ( 0.6 )

Albumin D1 3.57 ( .16 )

INR D0 1.06 ( 0.2 )

Na+ D0 145.7 ( 3.6 )

K + D0 4.81 ( 0.25 )

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BMI:body mass index , GCS D0: glascow coma scale day zero

Supplemental Table 3: Correlation between IMA and GCS

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IMA D0 IMA D1

Correlation Coefficient(a) .762 .703

GCS D0 P value < .001* < .001*

N 54 54

Correlation Coefficient(a) .498 .797

GCS D1 P value < .001* < .001*

N 54 54

A Spearman's correlation was run to assess the relationship between IMA levels on day 0 and day 1 and GCS on day 0 and day 1

(a) The magnitude of the observed correlation coefficient is interpreted as follows:

 0.00 - 0.10 is a negligible correlation

 0.10 - 0.39 is a weak correlation

 0.40 - 0.69 is a moderate correlation

 0.70 - 0.89 is a strong correlation

 0.90 - 1.00 is a very strong correlation

* Denotes that the correlation is statistically significant (P < .05)

IMA D0: ischemia modified albumin on day 0, IMA D1: ischemia modified albumin on day 1, GCS D0: Glasgow coma scale on day 0, GCS D1: Glasgow coma scale on day 1

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