Time of Rec.CeAD

Studies with recurrent CeAD

Design Sample size

Time of Rec.CeAD

Recurrency

patients /Rate (%)

Mean follow- up (years)

Touzè et al

⁹

retrospective 457 13-39 mo 4 (0.9) 2.6

Schievink et al

¹⁴

prospective 200 2d -8,6 y 14 (7) 7.4

Arauz et al

¹³

130 0 (0) 1.6

Dziewas et al

²⁸

126 6 (4.8) 0.5

Leys et al

¹⁶

105 3 (2.9) 3

Beletsky et al

¹⁷

105 0 (0) 1

de Bray et al

¹⁸

103 5 (4.9) 4

Kremer et al

¹⁹

retrospective 92 12mo-3y 1 (1.1) 6.7

Bassetti et al

¹²

prospective 81 16-48 mo 3 (3.7) 2.8

d' Anglejan Chatillon et al

²⁰

62 2 (3.2) 3.4

Lee et al

²¹

retrospective 48 7,8y 0 (0) 7.8

Dittrich et al

¹⁰

prospective 36 1wk-7mo 9 (25) 0.6

Mokri et al

²²

36 0 (0) 4.9

Engelter et al

²³

33 0 (0) 2.3

Gonzales-Portillo et al

²⁴

27 0 (0) 4.8

Treiman et al

²⁵

24 2 (8.3) 9.3

Bogusslavsky et al

²⁶

23 1 (4.3) 3.2

Guillon et al

²⁷

16 0 (0) 3.1

Present study prospective 238 1d-7y All: 39 (16.4)/ late:

17 (7.1)

4.3

Table e-1: Publications with early and long-term CeAD recurrency.

1

_______________________________________________________________________________________________________________________

n initial event symptoms subsequent events symptoms delay

monophasic CeAD

64 ICAD-le 15 local; 4 TIA; 45 stroke

1 ICAD-le TIA ICAD-ri asympt 5 days

1 ICAD-le TIA ICAD-ri TIA 4 days

1 ICAD-le stroke ICAD-ri + bi-VA asympt 4 days

1 ICAD-le stroke ICAD-ri / bi-VA local / asympt 2 days / 7 days

62 ICAD-ri 14 local; 8 TIA; 40 stroke

1 ICAD-ri local ICAD-le asympt 3 weeks

1 ICAD-ri stroke ICAD-le asympt 10 days

1 ICAD-ri stroke ICAD-le local 4 days

1 ICAD-ri stroke ICAD-le stroke 7 days

1 ICAD-ri TIA ICAD-le asympt 1 day

1 ICAD-ri TIA ICAD-le asympt 3 days

1 ICAD-ri stroke VAD-ri local 1 day

1 ICAD-ri stroke bi-VAD local 1 day

41 VAD-le 2 local; 4 TIA; 35 stroke

1 VAD-le stroke ICAD-le asympt 3 days

1 VAD-le stroke ICAD-ri asympt <1 month

1 VAD-le stroke VAD-ri local 5 days

1 VAD-le stroke bi-ICAD asympt 1 day

20 VAD-ri 4 local; 2 TIA; 14 stroke

1 VAD-ri local ICAD-le local 3 days

1 VAD-ri local VAD-le asympt <1 month

1 VAD-ri stroke VAD-le asympt 11 days

1 VAD-ri stroke VAD-le asympt 3 days

1 VAD-ri stroke VAD-le asympt 7 days

1 VAD-ri stroke bi-ICAD stroke 13 days

4 bi-ICAD 1 local; 3 stroke

2

4 bi-VAD 1 local; 3 stroke

1 bi-CCAD stroke

1 bi-ICAD+bi-VAD stroke

2 bi-ICAD-VAD-le stroke

Two CeAD phases

1 ICAD-le local ICAD-ri asympt 2 months

1 ICAD-le local ICAD-ri local 2 years

1 ICAD-le local ICAD-ri local 3 years

1 ICAD-le stroke ICAD-ri local 6 years

1 ICAD-le stroke ICAD-ri TIA 41 days

1 ICAD-le TIA ICAD-ri asympt 3 months

1 ICAD-ri local ICAD-le local 4 years

1 ICAD-ri stroke ICAD-le asympt 12 months

1 ICAD-ri stroke ICAD-le local 3 years

1 ICAD-ri TIA VAD-ri local 3 months

1 VAD-le TIA ICAD-le stroke 4 months

1 VAD-ri stroke ICAD-le stroke 3 months

Multiple CeAD phases

1 ICAD-le local ICAD-le / ICAD-ri local / asympt 16 months / 4 months

1 ICAD-le local VAD-ri / A.renalis / ICAD-ri local / back pain / TIA 7 days / 3,5 years / 4 years

1 ICAD-ri local VAD-ri / ICAD-le local / asympt 4 months / 19 months

1 VAD-ri local ICAD-le / ICAD-ri local / local 3 months / 4 months

1 VAD-le local VAD-ri / ICAD-ri / ICAD-le local / local / TIA 12 months / 2 years / 4 years

_______________________________________________________________________________________________________________________

Table e-2. Description of vascular localization, symptoms and delay between events in 238 participants in the current study. CeAD Patients were classified as those with monophasic CeAD, with two CeAD phases and with multiple CeAD phases. n: number of patients; ICAD: internal carotid artery dissection; VAD: vertebral artery dissection; -le:

left side; -ri: right side; stroke: ischemic stroke; local: purely local symptoms; TIA: transient ischemic attack; asympt: asymptomatic; delay: time between subsequent CeAD events.