Total = (100%)

(1)

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU PEER REVIEW KARYA ILMIAH : PROSIDING

Judul Karya Ilmiah : The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

Jumlah Penulis : 3 Orang

Status Pengusul : Penulis ke-1

Identitas Prosiding : a. Judul Prosiding : IOP Conference Series: Materials Science and Engineering, 11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

b. ISBN/ISSN : Online ISSN: 1757-899X, Print ISSN: 1757-8981 c. Thn Terbit, Tempat Pelaks. : 2017, Purwokerto - Indonesia

d. Penerbit/Organiser : IOP Publishing Ltd

e. Alamat Repository/Web : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029

Alamat Artikel : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029/pdf

f. Terindeks di (jika ada) : Scopus Kategori Publikasi Makalah :

√ Prosiding

Forum Ilmiah Internasional (beri

pada kategori yang tepat) Prosiding

Forum Ilmiah Nasional Hasil Penilaian

Peer Review

:

Komponen Yang Dinilai

Nilai Reviewer

Nilai Rata- Reviewer I Reviewer II rata

a. Kelengkapan unsur isi prosiding (10%) 2,00 2,00 2,00

b. Ruang lingkup dan kedalaman pembahasan (30%) 7,40 7,50 7,45

c. Kecukupan dan kemutahiran data/informasi dan metodologi (30%)

6,50 7,50 7,00

d. Kelengkapan unsur dan kualitas terbitan/prosiding(30%) 8,50 7,50 8,00

24,40 24,50 24,45

Nilai Pengusul = (60% x 24,45) = 14,67

Reviewer 2

Prof. Dr. Hadiyanto, S.T., M.Sc.

NIP. 197510281999031004

Unit Kerja : Teknik Kimia FT UNDIP

Reviewer 1

Prof. Dr. Widayat, S.T., M.T.

NIP. 197206091998031001

Unit Kerja : Teknik Kimia FT UNDIP

Semarang, 2 Mei 2020

(2)

(3)

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU PEER REVIEW KARYA ILMIAH : PROSIDING

Judul Karya Ilmiah : The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

Jumlah Penulis : 3 Orang Status Pengusul : Penulis ke-1

Identitas Prosiding : a. Judul Prosiding : IOP Conference Series: Materials Science and Engineering, 11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

b. ISBN/ISSN : Online ISSN: 1757-899X, Print ISSN: 1757-8981 c. Thn Terbit, Tempat Pelaks. : 2017, Purwokerto - Indonesia

d. Penerbit/Organiser : IOP Publishing Ltd

e. Alamat Repository/Web : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029

Alamat Artikel : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029/pdf

f. Terindeks di (jika ada) : Scopus Kategori Publikasi Makalah : √ Prosiding Forum Ilmiah Internasional (beri Ppada kategori yang tepat) Prosiding Forum Ilmiah Nasional Hasil Penilaian Peer Review :

Komponen Yang Dinilai

Nilai Maksimal Prosiding Nilai Akhir Yang Diperoleh Internasional Nasional

a. Kelengkapan unsur isi prosiding (10%) 3,00 2,0

b. Ruang lingkup dan kedalaman pembahasan (30%)

9,00 7,5

c. Kecukupan dan kemutahiran data/informasi dan

metodologi (30%) 9,00 7,5

d. Kelengkapan unsur dan kualitas

terbitan/prosiding(30%) 9,00 7,5

Catatan Penilaian Paper oleh Reviewer :

1. Kesesuaian dan kelengkapan unsur isi paper: Kelengkapan unsur artikel sudahs esuai dengan author guidelines dari IOP 2. Ruang lingkup dan kedalaman pembahasan: Kedalaman pembahasan cukup baik namun masih meemrlukan sitasi untuk

jurnal yang lebih banyak

3. Kecukupan dan kemutakhiran data/informasi dan metodologi: Jumlah pustaka 5 tahun terakhir masih kurang

4. Kelengkapan unsur dan kualitas terbitan: IOP merupakan prosiding terindex Scopus dan memiliki standar yang baik dalam publikasi

Semarang, 2 Mei 2020 Reviewer 2

Prof. Dr. Hadiyanto, S.T., M.Sc.

NIP. 197510281999031004

Unit Kerja : Teknik Kimia FT UNDIP

Total = (100%) 30,00 24,5

Nilai Pengusul = (60% x 24,50)= 14,70

(4)

Document details

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The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

(Conference Paper) (Open Access)

, ,

Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, Semarang, Indonesia Physiology and Microanatomy Division, Faculty of Veterinary Medicine, Gadjah Mada University, Jogjakarta, Indonesia

Abstract

Plants from Lamiaceae family has almost entirely reported having physiological activities. One of them is Hyptis pectinata Poit plant. Research on the toxicity of Hyptis pectinata needs to be done to protect people from the possibility of its harmful effects. This study aim to know the acute toxicity effects of Hyptis pectinata extract (HPE) on liver of Balb/c mice. This research was a laboratory experimental study using the post test only controlled group design. Balb/c mice were randomly divided into 4 groups. K (control group), P1, P2 and P3 (treatment groups; given HPE 200mg/kgBW, 1000 mg/kgBW, and 5000 mg/kgBW, respectively). The extract was orally given with gastric tube on the first day and the mice were terminated at the 8th day then the livers were observed. The Kruskal-Wallis test for macroscopic morphological and volume of the liver showed there were no significant difference with p=0.406 and p=0.054. The highest liver histopathological score was in P3 group. The Kruskal-Wallis test showed significantly difference (p=0.000). Continued with Mann-Withney test that showed a significant difference in K-P1 (p=0.009), K-P2 (p=0.009), K-P3 (p=0.009), P1-P2 (p=0.028), and P1-P3 (p=0.009). In conclusion, the HPE is safe to use which has no complication with liver of mice. © Published under licence by IOP Publishing Ltd.

SciVal Topic Prominence

Topic:

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Indexed keywords

Engineering controlled terms:

Testing Toxicity

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Acute toxicity test Control groups Harmful eﬀects Kruskal-Wallis tests Lamiaceae family Methanolic extracts Physiological activity Treatment group

Engineering main heading:

Mammals

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IOP Conference Series: Materials Science and Engineering Volume 172, Issue 1, 17 February 2017, Article number 012029

11th Joint Conference on Chemistry, JCC 2016, in Conjunction with the 4th Regional Biomaterials Scientiﬁc Meeting; Purwokerto; Indonesia; 15 September 2016 through 16 September 2016; Code 126603

Suzery, M.^a  Cahyono, B.^a Astuti, P.^b

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References (10)

Bispo, M.D., Mourão, R.H.V., Franzotti, E.M., Bomﬁm, K.B.R., de Arrigoni-Blank, M.F., Moreno, M.P.N., Marchioro, M., (...), Antoniolli, A.R.

(2001) Journal of Ethnopharmacology, 76 (1), pp. 81-86. . doi: 10.1016/S0378-8741(01)00172-6

Boalino, D.M., Connolly, J.D., McLean, S., Reynolds, W.F., Tinto, W.F.

(2003) Phytochemistry, 64 (7), pp. 1303-1307. . doi: 10.1016/j.phytochem.2003.08.017

Malan, K., Pelissier, Y., Marion, C., Blaise, A., Bessiere, J.M.

(1988) Planta medica, 54 (6), pp. 531-532. .

Martinez, M.

(1989) , p. 508.

(: Editorial Botas Mexico) Las Plantas Medicinales de Meacute;xico

Rojas, A., Hernandez, L., Pereda-Miranda, R., Mata, R.

(1992) Journal of Ethnopharmacology, 35 (3), pp. 275-283. . doi: 10.1016/0378-8741(92)90025-M

ISSN: 17578981

Source Type: Conference Proceeding Original language: English

DOI: 10.1088/1757-899X/172/1/012029 Document Type: Conference Paper Sponsors:

Publisher: Institute of Physics Publishing

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Antinociceptive and antiedematogenic eﬀects of the aqueous extract of Hyptis pectinata leaves in experimental animals

Cited 66 times

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α-Pyrones and a 2(5H)-furanone from Hyptis pectinata

Cited 33 times http://www.journals.elsevier.com/phytochemistry/

View at Publisher

3

The essential oil of Hyptis pectinata.

4

5

Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants

Cited 191 times

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Melo, G.B., Silva, R.L., Melo, V.A., Antoniolli, Â.R., Jordani Souza, M.E., Jordani, M.C., Castro-e-Silva Jr., O.

(2005) Phytomedicine, 12 (5), pp. 359-362. . doi: 10.1016/j.phymed.2004.02.009

Darmansjah, I., Wiria, M.S.S.

(2007) Farmakologi Dan Terapi, pp. 820-825.

Darmansjah I and Wiria MSS 5 ed SG Gunawan, R Setiabudy and Elysabeth Nafrialdi (Jakarta: Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia) Dasar Toksikologi

Robins, S.L., Kumar, V.

(1995) , 3, p. 18.

Robins SL and Kumar V 4 ed Alih bahasa and BU Pendit (Jakarta: EGC) Buku Ajar Patologi II

Junqueira, L.C., Carneiro, J.

(1997) , p. 354.

Junqueira LC and Carneiro J 3 ed Alih bahasa and A. Hartono (Jakarta: EGC) Histologi Dasar

Suzery, M., Cahyono, B.

Evaluation of Cytotoxicity Eﬀect of Hyptis pectinata Poit (Lamiaceae) extracts using BSLT and MTT methods (2014) Jurnal Sains Dan Matematika, 22, pp. 82-86. .

6

Eﬀect of the aqueous extract of Hyptis pectinata on liver mitochondrial respiration

Cited 8 times www.urbanﬁscher.de/journals/phytomed

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JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering172(2017) 011001 doi:10.1088/1757-899X/172/1/011001

Content from this work may be used under the terms of theCreative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

Published under licence by IOP Publishing Ltd 1

(9)

4/7/2020 11th Joint Conference on Chemistry – Better things for better living through chemistry

jcc.fmipa.unsoed.ac.id 9/12

(http://jcc.fmipa.unsoed.ac.id/wp-content/uploads/2016/03/POSTER-SEMINAR.jpg)

Feb 04

11th Joint Conference on Chemistry 2016

(http://jcc.fmipa.unsoed.ac.id/2016/02/04/hello-world/)

(10)

4/7/2020 11th Joint Conference on Chemistry – Better things for better living through chemistry

jcc.fmipa.unsoed.ac.id 2/12

Please be reminded that the 11th JCC 2016 only published its proceeding in the online form. Presenters and participants whose interested in obtaining printed copies of the proceeding should contact the IOP Publishing directly, extra cost will be incurred for request of the printed copies of the proceeding.

Thank you for your support for the 11th Joint Conference on Chemistry 2016 in Conjunction with the 4th Biomaterials Meeting and we look forward to your participation in the upcoming 12th JCC 2017 at 19-20 September 2017 in Universitas Negeri Semarang, Semarang, Jawa Tengah (http://kimia.unnes.ac.id/jcc2017/).

Best Regards,

—

Amin Fatoni, Ph.D

Sep 02

Conference Schedule (http://jcc.fmipa.unsoed.ac.id/2016/09/02/conference- schedule/)

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i

Welcome Message From Chairman of Conference

On behalf of the Committee, I am very pleased that the 11

^th

Joint Chemistry Conference in Conjunction with The 4

^th

Regional Biomaterials Scientific Meeting has attracted many scientist from Indonesia, Malaysia, Thailand, Bangladesh, Egypt, Japan as well as other countries.

This international conference is attended by more than 150 participants covering wide variety subject grouped as theoretical chemistry and educational, material synthesis and modification, bioscience and analysis, and also Industrial and environmental chemistry. The given oral and poster presentation would showing outputs for future need as indicated in the conference theme of “Material Chemistry Development for Future Medicine, Industry, Environmental and Biomaterial Application”

The success of the Conference would not have been attained without strong supports from contributing scientists and our partner institutes including Diponegoro University, Semarang State University, Sebelas Maret University, Satya Wacana Christian University and Indonesian Biomaterial Society. I would like to thank all of them for helping to make a very successful conference.

Chairman,

Amin Fatoni, Ph.D

JCC2016 IOP Publishing

IOP Conf. Series: Materials Science and Engineering172(2017) 011001 doi:10.1088/1757-899X/172/1/011001

2

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ii

Committee

Chairman : Amin Fatoni, Ph.D (Universitas Jenderal Soedirman, Indonesia) Secretary : Anung Riapanitra, M.Sc. (Universitas Jenderal Soedirman, Indonesia)

Dr. Hartiwi Diastuti (Universitas Jenderal Soedirman, Indonesia) Treasurer : Senny W, M.Si. (Universitas Jenderal Soedirman, Indonesia)

Dian Riana N, M.Si. (Universitas Jenderal Soedirman, Indonesia) Dian Windy Dwiasi, M.Sc. (Universitas Jenderal Soedirman, Indonesia) Moch. Chasani, M.Si. (Universitas Jenderal Soedirman, Indonesia) Kapti Riyani, M.Si. (Universitas Jenderal Soedirman, Indonesia) Scientific : Uyi Sulaiman, Ph.D. (Universitas Jenderal Soedirman, Indonesia)

Dadan Hermawan, Ph.D. (Universitas Jenderal Soedirman, Indonesia) Dr. Suwandri (Universitas Jenderal Soedirman, Indonesia)

Puji Lestari, M.Si. (Universitas Jenderal Soedirman, Indonesia) Mardiyah K, M.Sc. (Universitas Jenderal Soedirman, Indonesia) Zusfahair, M.Si. (Universitas Jenderal Soedirman, Indonesia) Program : Ari Asnani, Ph.D. (Universitas Jenderal Soedirman, Indonesia)

Dr. Ponco Iswanto (Universitas Jenderal Soedirman, Indonesia) Roy Andreas, Ph.D. (Universitas Jenderal Soedirman, Indonesia) Suyata, M.Si. (Universitas Jenderal Soedirman, Indonesia)

Tien Setyaningtyas, M.Si. (Universitas Jenderal Soedirman, Indonesia) Eva Vaulina, M.Si. (Universitas Jenderal Soedirman, Indonesia)

Purwati, M.Si. (Universitas Jenderal Soedirman, Indonesia) Publication : Dwi Kartika, M.Sc. (Universitas Jenderal Soedirman, Indonesia)

Ely Setiawan, M.Si. (Universitas Jenderal Soedirman, Indonesia) Irmanto, M.Si. (Universitas Jenderal Soedirman, Indonesia)

3

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iii

International Scientific Board 1. Prof. Dr. Hadi Nur (Universiti Teknologi Malaysia)

2. Prof. Dr. Hassan Y. Aboul-Enein (National Research Centre, Cairo, Egypt) 3. Prof. Dr. Ahmad Zuhairi Abdullah (Universiti Sains Malaysia, Malaysia)

4. Assoc. Prof. Dr. Panote Thavarungkul (Prince of Songkla University, Thailand) 5. Assoc. Prof. Dr. J. Yan Mulyana (Tokyo Metropolitan University, Japan)

6. Dr. Oki Muraza (King Fahd University of Petroleum and Minerals, Saudi Arabia) 7. Assoc. Prof. Dr. Imran Parvez (Hajee Mohammad Danesh Science and

Technology University (HSTU), Bangladesh)

8. Dr. Danjuma Solomon (Ibrahim Badamasi Babangida University, Nigeria) 9. Uyi Sulaiman, Ph.D (Universitas Jenderal Soedirman, Indonesia)

10. Dr. Dwi Hudiyanti, M.Sc (Diponegoro University, Indonesia) 11. Dr. Khairul Anam (Diponegoro University, Indonesia)

12. Ismiyarto, Ph.D (Diponegoro University, Indonesia) 13. Adi Darmawan, Ph.D (Diponegoro University, Indonesia)

14. Dr. rer.nat Maulidan Firdaus, M.Sc (Sebelas Maret University, Indonesia) 15. Venty Suryanti, Ph.D (Sebelas Maret University, Indonesia)

16. Dr. Eddy Heraldy (Sebelas Maret University, Indonesia)

17. Dr.rer.nat. Witri Wahyu Lestari (Sebelas Maret University, Indonesia) 18. Dr. Dian M. Widjonarko, M.Si (Sebelas Maret University, Indonesia) 19. Dr. Hartati Soetjipto (Satyawacana Christian University, Indonesia) 20. Ir. Sri Hartini, M.Sc (Satyawacana Christian University, Indonesia) 21. Dr. Risfidian Mohadi (Sriwijaya University, Indonesia)

22. Dr. Mokosuli Yermia S (Manado State University, Indonesia)

4

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4/7/2020 IOP Conference Series: Materials Science and Engineering, Volume 172, 2017 - IOPscience

https://iopscience.iop.org/issue/1757-899X/172/1 1/11

 _NOTICE : Ensuring subscriber access to content on IOPscience throughout the coronavirus outbreak - see our remote access guidelines.

Balb/c mice. This research was a laboratory experimental study using the post test only controlled group design. Balb/c mice were randomly divided into 4 groups. K (control group), P1, P2 and P3 (treatment groups; given HPE 200mg/kgBW, 1000 mg/kgBW, and 5000 mg/kgBW, respectively). The extract was orally given with gastric tube on the first day and the mice were terminated at the 8th day then the livers were observed. The Kruskal-Wallis test for macroscopic morphological and volume of the liver showed there were no significant difference with p=0.406 and p=0.054. The highest liver histopathological score was in P3 group. The Kruskal-Wallis test showed significantly difference (p=0.000). Continued with Mann-Withney test that showed a significant difference in K-P1 (p=0.009), K-P2 (p=0.009), K-P3 (p=0.009), P1-P2 (p=0.028), and P1-P3 (p=0.009). In conclusion, the HPE is safe to use which has no complication with liver of mice.

1. Introduction

There are at least 295 genera and 7775 species of plants from Lamiaceae family and most widely found in Mexico, Senegal, Brazil, Spain and in Asia such as India, Malaysia and Indonesia. Some species of this genus of plants, namely Hyptis pectinata Poit, Hyptis suaveolens, Hyptis oblingofolia, Hyptis tumentosa, Hyptis verticillata, Hyptis capitata, Hyptis brevives Poit, Hyptis fruktikosa and Hyptis urticoide, almost entirely reported to have physiological activities. The activities shown by this plant: anti-inflammatory, antipyretic, cancer [1, 2], ease breathing, skin diseases [3], disorders of the stomach, fever [4], and infections by bacteria [5].

In India, Hyptis pectinata Poit leaves are made in the form of tea which used as a beverage prevent abdominal pain [2]. Water extract of this plant has also been reported to increase liver regeneration [6].

Currently, in society the issue back to nature is growing and thus influence use of traditional medicine tends to increase. Meanwhile, many people assume that the use of herbs or traditional medicines are relatively safer than synthetic drugs. However it does not mean herbs or traditional

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012029 doi:10.1088/1757-899X/172/1/012029

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

Published under licence by IOP Publishing Ltd

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Interlayer free – nickel doped silica membranes for desalination

A Darmawan

^1,*

, L Karlina

¹

, Y Astuti

¹

, Sriatun

¹

, D K Wang

²

, J Motuzas

²

, J C D da Costa

²

1

Diponegoro University, Department of Chemistry, Semarang 50275, Indonesia.

2

The University of Queensland, FIM2Lab-Functional Interfacial Materials and Membranes Laboratory, School of Chemical Engineering, Brisbane Qld 4072, Australia.

*corresponding author e-mail: adi_darmawan@undip.ac.id Tel.:+62-8222-121-9817

Abstract. This work shows for the first time the potential of nickel oxide silica membranes for

desalination applications. Nickel oxide silica xerogels were synthesised via a sol–gel method including TEOS, nickel nitrate with and without addition of hydrogen peroxide. The effects of nickel addition (5% - 50 mol %) on the structure–property relationship of the silica materials were systematically studied. The membrane performance were tested as a function of feed salt concentration (0.3–3.5 wt% NaCl) and temperature (27–60 °C). The membranes which were prepared using equal sol–gel conditions to the xerogel samples showed the raised feed temperatures resulted in increased water fluxes, whilst increasing the salt concentration resulted in decreased water fluxes. The membranes with addition of hydrogen peroxide exhibited better performances than their H

2

O

2

absence counterpart. The salt rejection was in excess of 90% and the maximum flux observed was 7.3 kg m

^-2

h

^-1

at 60°C for a 0.3 wt% NaCl feed concentration.

Introduction

The world is facing a global water crisis due to population growth and climate change [1]. With increasingly limited water resources, the use of infinite number of sea water becomes one choice in the provision of clean and fresh water, hence the desalination technology is one of solution[2]. Currently, approximately 43.5% of the desalination systems in the world are still using thermal technology.

Membrane technology becomes an alternative instead of thermal desalination [3] because it uses less energy and produce greater water fluxes. In commercial applications, the polymeric membrane are still dominating the market despite of the polymeric membranes have some limitations, especially in their thermal and chemical stability, hence some researchers tried to find a new alternative using inorganic membranes [4-10]

There are two types of inorganic membranes that have been tested for molecular sieve application, zeolite membranes and silica membranes. In general, silica membranes are developed primarily for gas separation [11, 12]. However, some studies have shown that silica membranes coated on alumina support could reject salt ranging from 92% to 99% [8, 10, 13-15]. However, one of the main obstacles in using silica membranes for water purification is due to their hydro instability. To overcome this

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012001 doi:10.1088/1757-899X/172/1/012001

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

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Development of high performance liquid chromatography method for miconazole analysis in powder sample

D Hermawan

¹

, Suwandri

¹

, U Sulaeman

¹

, A Istiqomah

¹

and H Y Aboul-Enein

²

1

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

2

Department of Pharmaceutical and Medicinal Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt

Email: dadanphd@gmail.com

Abstract.

A simple high performance liquid chromatography (HPLC) method has been developed in this study for the analysis of miconazole, an antifungal drug, in powder sample.

The optimized HPLC system using C

₈

column was achieved using mobile phase composition containing methanol:water (85:15, v/v), a flow rate of 0.8 mL/min, and UV detection at 220 nm. The calibration graph was linear in the range from 10 to 50 mg/L with r

²

of 0.9983. The limit of detection (LOD) and limit of quantitation (LOQ) obtained were 2.24 mg/L and 7.47 mg/L, respectively. The present HPLC method is applicable for the determination of miconazole in the powder sample with a recovery of 101.28 % (RSD = 0.96%,

n

= 3). The developed HPLC method provides short analysis time, high reproducibility and high sensitivity.

1. Introduction

Many types of drugs are produced synthetically and commercially available in dosage forms. One example of important drugs used as a medication is antifungal drugs. An antifungal drug is used to treat deep infections caused by a fungus. This drug can be divided into several classes, including triazoles and imidazoles. Miconazole is an imidazole antifungal agent (figure 1). It is commonly used to the skin or to mucous membrane to cure fungal infections, due to its high therapeutic properties. It has been extensively applied in the management of dermal, oral and vaginal mycosis. It is used in a variety of pharmaceutical formulations such as injections, tablets, oral gels, creams, ointments, topical powders and vaginal suppositories. The most usual application forms include creams, ointments or gels at 2.0 % concentration level, alone or associated with anti-inflammatory steroids, or other antimicrobials such as gentamicin for the treatment of dermatitis. Diaper dermatitis, a common dermatologic disorder in infancy, frequently associated with Candida albicans infections, is currently treated with ointments containing 0.25 % miconazole nitrate [1-2].

Chromatographic methods have achieved a great reputation in separation science; mainly using high performance liquid chromatography (HPLC) method [3-10]. The chromatographic process can be described as a separation technique that includes mass-transfer between stationary and mobile phase.

HPLC uses a liquid mobile phase to separate the components in a mixture. The stationary phase can be in a liquid phase or a solid phase. These components are forced to flow through a chromatographic column under high pressure after being dissolved in a solvent. The mixture is then separated into its

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012011 doi:10.1088/1757-899X/172/1/012011

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

(22)

Surface modifications of chalcopyrite CuInS ₂ thin films for photochatodes in photoelectrochemical water splitting under sunlight irradiation

Gunawan,

¹

A Haris,

¹

H Widiyandari,

²

W Septina

³

and S Ikeda,

⁴

1

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Semarang Indonesia

2

Physics Department, Faculty of Sciences and Mathematics, Diponegoro University, Semarang Indonesia

3

University of Zurich, Switzerland

4

Konan University, Osaka, Japan

E-mail: gunawan_undip@yahoo.com

Abstract. Copper chalcopyrite semiconductors include a wide range of compounds that are of

interest for photoelectrochemical water splitting which enables them to be used as photochatodes for H

₂

generation. Among them, CuInS

₂

is one of the most important materials due to its optimum band gap energy for sunlight absorption. In the present study, we investigated the application of CuInS

₂

fabricated by electrodeposition as photochatodes for water splitting. Thin film of CuInS

2

chalcopyrite was formed on Mo-coated glass substrate by stacked electrodeposition of copper and indium followed by sulfurization under H

₂

S flow. The films worked as a H

₂

liberation electrode under cathodic polarization from a solution containing Na

₂

SO

₄

after loading Pt deposits on the film. Introduction of an n-type CdS layer by chemical bath deposition on the CuInS

₂

surface before the Pt loading resulted appreciable improvements of H

₂

liberation efficiency and a higher photocurrent onset potential. Moreover, the use of In

₂

S

₃

layer as an alternative

n-type layer to the CdS significantly improved the H₂

liberation performance: the CuInS

₂

film modified with In

₂

S

₃

and Pt deposits worked as an efficient photocathode for photoelectrochemical water splitting.

1. Introduction

The shortage of fossile sources has made an effort to get alternative energies such as hydrogen through its conversion to energy by direct combustion in conventional engines or reaction with pure oxygen in a fuel cell. Hydrogen can be produced by natural gas reforming, electrolysis, biomass, thermochemical, thermophysical, photoelectrochemical (PEC) methods, and photo-biological process [1]. Hydrogen (H

2

) production by PEC water splitting is considered to be an attractive in view of energy and environmental issues.

Since the first report of a TiO

2

thin-film photoelectrode [2], a variety of semiconductor electrodes and devices have been investigated. To date, performances with conversion efficiency as high as 12.4% have been demonstrated for electrodes based p-GaInP

2

/GaAs cells grown by atmospheric- pressure organometallic vapor-phase epitaxy [3]. However, due to limited corrosion resistance in aqueous electrolytes and expensive cost for production of these electrodes, these systems are not feasible for practical applications. Meanwhile, corrosion-resistant and inexpensive transition metal oxides are well-studied, but conversion efficiencies for these electrodes are not sufficiently high yet

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012021 doi:10.1088/1757-899X/172/1/012021

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

(23)

Unsaturated 15 and 16 Membered Appended Naphthalene Macrocyclic Molecules for The Development of Fluorometric Chemosensors

S Hasan

¹

,S Salleh

¹

, S Hamdan

¹

, and B Yamin

¹

1

Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

e-mail:sharizal187@perlis.uitm.edu.my

Abstract.

Unsaturated macrocyclic molecules have got an interest due to their potential in catalysis, ion exchange and electron transfer. Salicaldehyde derivatives macrocyclic molecules have a broad range in synthesis. In this study, two unsaturated macrocyclic molecules (L1 and L2) have been synthesized. The preparation of unsaturated macrocyclic ligands involve two steps; the reaction of salicylaldehyde with 1,2-dibromoethane or 1,4-dibromobutane to produce precursor, then cyclisation were completed using schiff base technique by adding diamines (naphthalene diamine). The ligands were characterized spectroscopically. In FT-IR spectrums, the form of the ligands mainly can be observed on the disappearance of the carbonyl group of aldehyde at approximately 1650cm

^-1

that was readily assigned to C=O group of salicylaldehyde with the replacement of C=N peak at 1684.13cm

^-1

. The success in producing macrocyclic ligands have been further characterized using fluorescence emission spectroscopy (FES) and revealed the typical emission of naphthalene at ~430nm. Fluorescence changes of L1 and L2 showed high selectivity for Fe3

⁺

and Cu2

⁺

respectively in the presence of other common metal ions, such as Zn2

⁺

, Ni2

⁺

and Co2

⁺

. Besides, the ligand was sensitive enough to detect the concentration of ferric ion with the detection limit down to 1.08 x 10

^-6

M and fluorescence change that was unaffected by the presence of other common coexisting metal ions.

Complexation with Co(II) was also attempted.

Keywords: Macrocyclic Schiff base, Macrocyclic complexes. 1,2-bis(2-carboxyaldehyde phenoxy)ethane, Cobalt(II)complexes,1,8- Naphthalenediamine, Fluorophore.

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012054 doi:10.1088/1757-899X/172/1/012054

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

(24)

Dimethylaminodiethylenetriamine Derivatives of Fluorescence Chemosenso for Detection of Zn ²⁺ In Aqueous Solution

S N A M Adnan

¹

, S Hasan

¹

, S Zakaria

¹

and Y M Yusof

¹

1

Faculty of Applied Sciences Universiti Teknologi MARA 40450 Shah Alam, Selangor, Malaysia

Email: sharizal187@perlis.uitm.edu.my

Abstract.

Fluorescent chemosensors for the detection and measurement of metal ions, especially for cations environmental interest such as Fe

³⁺

, Co

²⁺

, Mn

²⁺

, Cu

²⁺

, and Zn

²⁺

are actively investigated because it shows simplicity, high sensitivity and fast response. New benzenyl derivative bearing pyridine group has been synthesized and studied as fluorescent chemosensor for Zn

²⁺

ion. Chemosensor N-{2-[(4-Dimethylamino-benzylidene)-amino]- ethyl}-N'-pyridin-2-ylmethylene-ethane-1,2-diamine was synthesized by condensation of

p-

dimethylaminobenzaldehyde, diethylenetriamine and o-pyridinecarbaldehyde and characterized by FT-IR,

¹

H-NMR and elemental analysis (CHN). FT-IR showed the appearance of peak azomethine (C=NH) at 1639.46 cm

^-1

, pyridine (C-N) at 1591 cm

^-1

and disappearance of NH

2

peak at 3278.78 cm

^-1

after the condensation reaction in between aldehyde and amine.

¹

H-NMR signal at 8.19 ppm, 3.12 ppm and 8.08 ppm was assigned to C=NH, N(CH

3

)

2

and C-N respectively, confirmed the formation of N-{2-[(4-Dimethylamino-benzylidene)-amino]- ethyl}-N'-pyridin-2-ylmethylene-ethane-1,2-diamine. The elemental analysis was found closed to the theoretical value and the percent composition of A is 91.82%. Sensor A exhibits high selectivity and sensitivity towards Zn

²⁺

. Other metal ions such Cu

²⁺

, Fe

³⁺

, Co

²⁺

and Ni

²⁺

had no such significant effect on the fluorescence. The detection limit of N-{2-[(4-Dimethylamino- benzylidene)-amino]-ethyl}-N'-pyridin-2-ylmethylene-ethane-1,2-diamine for Zn

²⁺

was 3.5 x 10

^-5

M. M. This sensor exhibits a very good fluorescence sensing ability to Zn

²⁺

over a wide range of pH. Therefore it is capable of being a practical system for the monitoring of Zn

²⁺

concentrations in real water sample.

1. Introduction

Zinc is the second most abundant transition metal ion in the human body, it plays an indispensable role in various biological activities such as gene expression, neural signal transmission, regulation of metalloenzymes, and DNA binding or recognition [1]. However, excessive amounts of zinc in human cause many severe diseases such as Alzheimer’s disease [2], ischemic stroke [3] and epilepsy [4].

Hence it is very important to develop highly selective and sensitive chemosensors for the detection of Zn

²⁺

in the environment as well as biological samples.

Owing to its essential roles in biological nutrition systems, the measurement of Zn

²⁺

is an active field in analytical chemistry. Compared with numerous traditional analytical techniques, fluorescence molecule sensor display high sensitivity, selectivity, simplicity, and tunability thus have been developed as a powerful tool for detecting the trace amount of analytes. Chemosensors are commonly composed of two parts, a receptor (recognition element) responsible for the molecular recognition of

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012051 doi:10.1088/1757-899X/172/1/012051

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

(25)

Synthesis and characterization of p-

dimethylaminobenzaldehyde benzoylthiourea and study

towards selective and sensitive fluorescent sensor for detection of iron (III) cation in aqueous solution.

S Hasan

¹

, N A Hamedan

¹

, A A A Razali

¹

, N H Uyup

¹

, and H M Zaki

¹

1

Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

Email: sharizal187@perlis.uitm.edu.my

Abstract. Benzoyl thiourea derivatives ligand backbones contain Oxygen (O), Nitrogen (N),

and Suphur (S) donor atoms can react with transition metal ions and form stable metal complexes. A new ligand was synthesized by the reaction of benzoyl isothiocyanate with diethylenetriamine and characterized by using Elemental Analysis (EA), Infrared (IR) spectroscopy and proton Nuclear Magnetic Resonance (

¹

H NMR) spectroscopy. The monofunctionalize ligand were synthesized using 1:1 condensation of

p-

dimethylaminobenzaldehyde with diethylenetriamine and confirmed by disappearance of carbonyl group, C=O at 1656 cm

^-1

with the appearance of peak C=N in the range 1633 - 1638 cm

^-1

in the IR spectrum. This monofunctionalize ligand was synthesis by using Schiff base technique. Benzoyl thiourea derivatives,

HN are synthesis from the 1:1 condensation of

benzoyl isothiocyanates with monofunctionalized ligand.

HN ligand was verified by the

presence of peaks

v(N-H), v(C=O), v(C=N) v(C-N) and v(C=S) at 3317 - 3336 cm-1, 1612 -

1660 cm-1, 1550 -1589 cm-1, 1234-1366 cm-1 and 709-767 cm-1 respectively while

¹

H NMR show peaks of alkane (CH

2

), benzene (Ar-H), CONH, CSNH at 3.75, 6.73 – 7.33, 8.19, and 8.25 respectively. The total percent composition of C, H, N, O, and S using Elemental Analysis for

HN, C21

H

27

N

5

OS found was 85.23%. For application, further study on selectivity and sensitivity of

HN ligand was conducted on several metal ions. The fluorescent emission

spectroscopy shown that HN is a selective fluorescent sensor for Fe

³⁺

and Cu

²⁺

ions but not for other metal ions such as Co

²⁺

, Ni

²⁺

, Mn

²⁺

, Cr

³⁺

and Zn

²⁺

. However,

HN ligand shows more

sensitive towards Fe

³⁺

ions than Cu

²⁺

ions which provide rapid detection of Fe

³⁺

ions at concentrations as low as 4.5 x 10

^-7

M than 2.9 x 10

^-6

M of Cu

²⁺

ions. As conclusion, HN ligand was expected to be useful as efficient chemical sensor for detection of Fe

³⁺

ion.

1. Introduction

Nowadays, the development of chemosensors for selectivity and sensitivity quantification of environmentally and biologically for heavy and transition metal ions, has attracted a high attention [1].

They usually represent an environmental concern when present in uncontrolled amounts, but at the same time some of them such as iron, zinc, manganese, copper and cobalt are present as essential elements in biological systems. Among biologically important metal ions, iron is the most abundant transition metal ion present in the human body. As one of the most essential trace elements in

1

JCC2016 IOP Publishing IOP Conf. Series: Materials Science and Engineering 172

(2017) 012050 doi:10.1088/1757-899X/172/1/012050

International Conference on Recent Trends in Physics 2016 (ICRTP2016) IOP Publishing Journal of Physics: Conference Series 755 (2016) 011001 doi:10.1088/1742-6596/755/1/011001

(26)

Total = (100%) - Undip Repository

Judul Karya Ilmiah : The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

Jumlah Penulis : 3 Orang

Status Pengusul : Penulis ke-1

Identitas Prosiding : a. Judul Prosiding : IOP Conference Series: Materials Science and Engineering, 11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

b. ISBN/ISSN : Online ISSN: 1757-899X, Print ISSN: 1757-8981 c. Thn Terbit, Tempat Pelaks. : 2017, Purwokerto - Indonesia

d. Penerbit/Organiser : IOP Publishing Ltd

e. Alamat Repository/Web : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029

Alamat Artikel : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029/pdf

f. Terindeks di (jika ada) : Scopus Kategori Publikasi Makalah :

Forum Ilmiah Internasional (beri

Forum Ilmiah Nasional Hasil Penilaian

:

a. Kelengkapan unsur isi prosiding (10%) 2,00 2,00 2,00

b. Ruang lingkup dan kedalaman pembahasan (30%) 7,40 7,50 7,45

c. Kecukupan dan kemutahiran data/informasi dan metodologi (30%)

6,50 7,50 7,00

d. Kelengkapan unsur dan kualitas terbitan/prosiding(30%) 8,50 7,50 8,00

Total = (100%)

Reviewer 2

Prof. Dr. Hadiyanto, S.T., M.Sc.

NIP. 197510281999031004

Unit Kerja : Teknik Kimia FT UNDIP

Reviewer 1

Prof. Dr. Widayat, S.T., M.T.

NIP. 197206091998031001

Unit Kerja : Teknik Kimia FT UNDIP

Semarang, 2 Mei 2020

LEMBAR

HASIL PENILAIAN SEJAWAT SEBIDANG ATAU PEER REVIEW KARYA ILMIAH : PROSIDING

Judul Karya Ilmiah : The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

Jumlah Penulis : 3 Orang Status Pengusul : Penulis ke-1

Identitas Prosiding : a. Judul Prosiding : IOP Conference Series: Materials Science and Engineering, 11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

b. ISBN/ISSN : Online ISSN: 1757-899X, Print ISSN: 1757-8981 c. Thn Terbit, Tempat Pelaks. : 2017, Purwokerto - Indonesia

d. Penerbit/Organiser : IOP Publishing Ltd

e. Alamat Repository/Web : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029

Alamat Artikel : https://iopscience.iop.org/article/10.1088/1757- 899X/172/1/012029/pdf

f. Terindeks di (jika ada) : Scopus Kategori Publikasi Makalah : √ Prosiding Forum Ilmiah Internasional (beri Ppada kategori yang tepat) Prosiding Forum Ilmiah Nasional Hasil Penilaian Peer Review :

Komponen Yang Dinilai

Nilai Maksimal Prosiding Nilai Akhir Yang Diperoleh Internasional Nasional

a. Kelengkapan unsur isi prosiding (10%) 3,00 2,0

b. Ruang lingkup dan kedalaman pembahasan (30%)

9,00 7,5

c. Kecukupan dan kemutahiran data/informasi dan

metodologi (30%) 9,00 7,5

d. Kelengkapan unsur dan kualitas

terbitan/prosiding(30%) 9,00 7,5

Semarang, 2 Mei 2020 Reviewer 2

Prof. Dr. Hadiyanto, S.T., M.Sc.

NIP. 197510281999031004

Unit Kerja : Teknik Kimia FT UNDIP

Total = (100%) 30,00 24,5

Nilai Pengusul = (60% x 24,50)= 14,70

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The Acute Toxicity Test of Methanolic Extract of Hyptis pectinata Poit on Liver Balb/c Mice

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Antinociceptive and antiedematogenic eﬀects of the aqueous extract of Hyptis pectinata leaves in experimental animals

α-Pyrones and a 2(5H)-furanone from Hyptis pectinata

The essential oil of Hyptis pectinata.

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