Univariate and multivariate analysis for seroconversion using binary logistic regression in the 705 patients who were seronegative immediately before the fourth dose

Table S1. Univariate and multivariate analysis for seroconversion using binary logistic regression in the 705 patients who were seronegative immediately before the fourth dose.

Univariate analysis Multivariate analysis

Factors P OR (95% CI) P OR (95% CI)

Age at fourth dose 0.010 0.95 (0.92–0.99) 0.031 0.96 (0.93–0.99)

Male gender 0.441 1.17 (0.79–1.73) -

Diabetes mellitus 1.000 1.10 (0.52–2.36) -

Time from transplantation to fourth dose 0.131 1.04 (0.99–1.09) -

Deceased donor (vs living donor) 0.002 0.33 (0.17–0.66) 0.005 0.36 (0.18–0.73)

Tacrolimus (vs cyclosporine) 0.636 0.84 (0.38–1.83) -

Mycophenolate (vs AZA/mTORi, in patients on calcineurin inhibitors) 0.447 0.89 (0.69–1.16) - mTORi (vs AZA/MPA, in patients on calcineurin inhibitors) 0.666 0.83 (0.42–1.64)

Time from third to fourth dose 0.426 0.99 (0.97–1.01) -

AZA, azathioprine; CI, confidence interval; MPA, mycophenolic acid; mTORi, inhibitor of the mammalian target of rapamycin; OR, odds ratio.