Supplemental Digital Content 1. Univariable Logistic Models of Mortality
Hospital Mortality Characteristic
Odds ratio
(95% CI) P-value Average Daily Platelet Transfusion Volume (mL/kg) 1.06 (1.04, 1.08) <.001 Average Daily Platelet Count
(per 109/L up to 115x109/L)
0.98 (0.97, 0.99) <.001
Age <.001
Pre-Term Neonate 3.71 (1.96, 7.31)
Full-Term Neonate Reference
Infant 1.75 (1.11, 2.74)
Child 1.39 (0.82, 2.34)
Adolescent 1.67 (0.86, 3.23)
Primary ECMO Indication <.001
Respiratory Reference
Cardiac 1.95 (1.33, 2.87)
ECPR 3.11 (1.79, 5.47)
Mode of ECMO 0.001
VA Reference
VV 0.45 (0.26, 0.74)
Baseline PRISM III 1.02 (0.99, 1.05) 0.144
Highest pH within 48 Hours Post-ECMO Initiation 0.01 (0.00, 0.11) <.001 ECMO directly from Cardiopulmonary Bypass 1.31 (0.80, 2.14) 0.287 Average Daily RBC Transfusion Volume (mL/kg) 1.01 (1.01, 1.02) <.001 Lowest Lactate in 48 hours Post-ECMO Initiation (mmol/L) 1.48 (1.32, 1.70) <.001
New Neurologic Event 4.21 (2.84, 6.30) <.001
Bleeding Event 1.89 (1.28, 2.82) 0.001
Thrombotic Event 1.61 (1.12, 2.31) 0.010
Hepatic Failure 2.98 (2.05, 4.36) <.001
Renal Failure 2.19 (1.52, 3.17) <.001
Average Daily Heparin Dose (units/kg/min) 0.20 (0.08, 0.48) <.001 Acute Diagnoses
Airway Abnormality 0.87 (0.25, 2.76) 0.813
Immune Dysfunction 1.58 (0.80, 3.16) 0.188
Cardiac Arrest 1.50 (0.83, 2.75) 0.182
Cardiovascular Disease (Acquired) 1.35 (0.80, 2.29) 0.261
Cardiovascular Disease (Arrhythmia) 1.23 (0.47, 3.20) 0.666
Cardiovascular Disease (Congenital) 1.61 (1.12, 2.31) 0.010
Hypoxic/Anoxic Injury 0.50 (0.16, 1.36) 0.180
Gastrointestinal Disorder 1.62 (0.70, 3.87) 0.258
Pertussis or Sepsis 0.90 (0.57, 1.42) 0.648
Pneumonia or Bronchiolitis 0.60 (0.24, 1.38) 0.233
Supplemental Digital Content 1. Univariable Logistic Models of Mortality
Hospital Mortality Characteristic
Odds ratio
(95% CI) P-value
Shock (Non-Septic) 0.91 (0.30, 2.67) 0.869
Respiratory Distress/Failure 1.09 (0.75, 1.58) 0.639
Neurologic Condition 0.27 (0.06, 0.86) 0.025
Meconium Aspiration Syndrome 0.10 (0.03, 0.25) <.001
Congenital Diaphragmatic Hernia 2.04 (1.17, 3.65) 0.012
Persistent Pulmonary Hypertension of the Newborn 0.46 (0.28, 0.74) 0.001 Chronic Diagnoses
Chronic Lung Disease 1.39 (0.52, 3.76) 0.505
Immune Dysfunction 2.08 (0.76, 6.21) 0.154
Congenital Anomaly or Chromosomal Defect 1.62 (1.07, 2.46) 0.022
Neurologic Condition 0.63 (0.26, 1.42) 0.269
Cardiovascular Disease (Congenital) 0.89 (0.57, 1.39) 0.615
ECMO = extracorporeal membrane oxygenation; ECPR = extracorporeal cardiopulmonary resuscitation;
VA = veno-arterial; VV = veno-venous; PRISM = Pediatric Risk of Mortality score.
