Variation and correlation of potential unintended consequences of antipsychotic reduction in Ontario nursing homes over time
Daniel A. Harris, MPH, Laura C. Maclagan, MSc, Priscila Pequeno, MSc, Andrea Iaboni, MD, DPhil, Peter C. Austin, PhD, Laura C. Rosella, PhD, Jun Guan, MSc, Colleen J. Maxwell, PhD, Susan E. Bronskill, PhD
Supplemental Table 6. Correlation between intercepts and time trends from a multivariate model of overall antipsychotic use, antidepressant use, and relevant indications among all nursing homes in Ontario, Canada between April 1, 2010 and December 31, 2019 (N=649)
Intercept overall antipsychotic use
Intercept antidepressant use
Intercept relevant diagnoses
Time trend overall antipsychotic use
Time trend antidepressant use
Time trend relevant indications Intercept overall
antipsychotic use1 1.0 0.1639 0.2578 -0.6712 0.06086 -0.04302
Intercept
antidepressant2 1.0 0.07116 -0.09149 -0.4676 -0.00401
Intercept
relevant indications3 1.0 -0.1596 0.01377 -0.6399
Time trend overall
antipsychotic use1 1.0 0.06957 0.2565
Time trend
antidepressant use2 1.0 0.09287
Time trend
relevant indications3 1.0
Notes: Multivariate random effects models with random intercepts and slopes for time (time trends) were used to estimate changes in overal antipsychotic use, antidepressant use, and relevant indications over time. A total of 649 unique nursing homes were represented over the study period, reflecting the opening, closing and merging of facilities over time.
1) Overall antipsychotic use was measured by dividing the total number of residents receiving at least one orally administered antipsychotic medication by the total number of residents living in each nursing home in every quarter over the study period.
2) Antidepressant use was measured by dividing the total number of residents receiving at least one orally administered antidepressant by the total number of residents living in each nursing home in every quarter over the study period.
3) Relevant indications were measured by dividing the total number of residents with documented delusions, hallucinations,
schizophrenia, or Huntington’s disease indicated in their assessment was by the total number of residents living in each nursing home in every quarter over the study period.
1
2
