VETERINARY PHARMACY SCIENCE

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COURSE CONTRACT

VETERINARY PHARMACY SCIENCE

STUDY PROGRAM VETERINARY MEDICINE /Bachelor

1. Course : Veterinary Pharmacy Science 2. Course Code : FAF 300

3. Study Load : 3 SKS

4. Semester : V

5. Major/ Study Program

: Bachelor Faculty of Veterinary Medicine

6. Pre-requisite : Phrmacology, Biochemistry, Physiology, Pharmacotherapy and toxicology, Anatomi, Histology

7. Course Description

: The courses were giving in class time and some cases will be exploring in e-learning interactive models, than giving more advances competence by laboratory practicing learning models. Teaching material will be given three major parts as a (1) general part, (2) special part and (3) capita selecta for veterinary pharmacy science.

The part of one will be preparing as follows; philosophy of veterinary pharmacy science, about medicines and veterinary medicine devices, prescription and latin abbreviation, than continuously with other material i.e dose regimented, GMP for veterinary medicines and generally preparing of the dispensing form. The part of two will be preparing as follows; solid preparing. Semi-solid and liquid dispensing form. The capita selecta will be given as follows; kinetics model relationship to dispensing form of medicines in healthy condition and sick condition, characterization of dispensing form pursuant to LADME profile at clinical subject condition, pharmacogenetics phenomenon, bio-availability and bio-equivalence, withdrawal time, incompatibility and interaction. The withdrawal time will be preparing three sub- material as a bio-analysis phenomenon, sample preparation, instrumentation. The incompatibility and interaction will be preparing at three sub-material as a interaction between medicine, interaction between medicine vs., feed or water to drink, risk assessment risk analysis. The laboratory learning models will be practicing three models standard medicine (solid, semi-solid and liquid standard medicine dispensing form) and also quality assay of the medicines. The teaching- learning process will be evaluate by three models evaluation as follows;

quiz and soft skill evaluation, multiple question exam as a theoritic evaluation and practice examination.

8. Person in Charge : Dr. Rahmi Sugihartuti, DVM., M.Sc

9. Lecturers

1. Prof. Dr. Mochamad Lazuardi, M.Pharm., Pharm. D 2. Dr. Lilik Maslachac, DVM., M, Sc.

3. Mohamad Sukmanadi, DVM., M.Sc

10. Days/ Meeting/ Time/

Room

Theory :

Wednesday for D Group at 10.00 to 11.50 a.m in Avian Class

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Room; Thursday for E Group at 07.00 to 08.50 a.m in IV C Class Room and of C Groups at 09.00 to 10.50 a.m in Postgraduate Class Room; Friday for A Group at 07.00 to 08.50 a.m in III A Class Room and other Group of B at 07.00 to 08.50 a.m in III B Class Room.

Practice in laboratory is doing for all groups each time of 13.00 to 15.00 p.m at The Veterinary Pharmacy Research Centre Faculty of Veterinary Medicine, Universitas Airlangga.

11. Soft Skills Attributes

1. Self-motivation/initiative 2. Work ethic/dependability 3. Critical thinking

4. Questioning skills 5. Academic/learning skills 6. Teaching/training skills

12. Learning Outcomes

of Graduates

: LO 4: Analyze various kinds of medicines based on chemical structures, pharmacokinetics, and pharmacodynamics, and the therapy to define drug of choice in line with caused agent of sick animals

13. Course Learning Outcomes

 Able to using of the medicines and veterinary medical devices by concept veterinary pharmacy philosophy

 Able to legal determinant by concept using medicine’s law and veterinary medical device’s law pursuant to veterinary

 Understand about the philosophy of prescribing and able to apply the Latin abbreviation pursuant to writing prescription

 Able to practicing of dose regimented pursuant to veterinary medicines services as a prescribed included measuring devices to apply the calculated using the medicine

 Able to to assessed the quality of the drug pursuant to veterinary services by concepts producing of the medicine at level Good Manufacturing Product (GMP) for Veterinary drug

 Able to described the generally of the drug dispensing form for apply the specific treatment pursuant to veterinary services.

 Understand at level LO 3 about medicines of solid dispensing form’s group including able to determination quality product by design producing and apply their prescription to veterinary services.

 Understand at level LO 3 about medicines of semi-solid dispensing form’s group including able to determination quality product by design producing and apply their prescription to veterinary services.

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 Understand at level LO 3 about medicines of semi-solid dispensing form’s group including able to determination quality product by design producing and apply their prescription to veterinary services.

 Able to apply the medicine pursuant veterinary services using exactly determine parameters as follows ; (a) indicated of the diseases, (b) dispensing form of the medicine, (c) active substance and excipient substances, (d) dose, (e) route and time of apply (f) condition of the clinical subject.

 Able to assessment and apply the learning outcomes courses at CAPITA SELECTA‘s Topic as follows: (a) kinetics model in animal bodies, (b) fate of the medicine in healthy condition and sick

condition, (c) characterization of dispensing form pursuant to liberation - absorption- distribution - metabolism - excretion (LADME) profile to pathology and physiology of the clinical subject, (d) inter and intra-variability species response of the medicine, (e) bio-availability and bio-equivalence, (f) withdrawal time and apply the calculation, (g) incompatibility and interaction of the medicine

14. Sub-Learning Outcomes :

1. After learning the 1^st material of the courses, student university to be able to explain about the rules of teaching-learning veterinary pharmacy science method, and able to explained about (1)

Philosophy of veterinary pharmacy science, (2) drug discovery, and principles of therapeutics services using natural bio-active and synthetics bio-active.

2. After learning about 2^nd material of the course, student university to be able to explain (1) philosophy of prescription, and good excellency to apply the latin language for prescription, (2) description about prescription, (3) regulation and ethic of prescription, (4) technique of writing prescription, and also (5) the kinds of medicine (patent, generic, standard, etc), (6) expiration date, (7) criteria for determined remedium cardinale.

3. After learning about 3^rd material of the course, student university to be able to explained basic theoritical GMP and apply practicing of GMP for veterinary drug.

4. After learning about 4^th material of the course, student university to be able to apply dose regimented as follows; (1) description about dose regimented, (2) preparation of dose regimented, (3) properly for apply the medicines (tablespoon, teaspoon, cochlear pultis, medicine dropper,cup slocki, drench oral medicines), (4) description of % and their application, (5) calculated dose regimented base on of body weight, age, body surface area, chest size, (6) calculated dose for apply the oral medicine.

5. After learning about 5^th material of the course, student university to be able to apply the general classification of the drug dispensing form (solid, semi-solid and liquid) pursuant to veterinary services.

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6. After learning about 6^th material of the course, student university to be able to apply the preparation of solid dispensing form ( pulvis, pulveres, tablet, capsule, pilulae, bolus, granula, suppositoria, bacilla, pellets, crubles, briquette, block) and also the apply of prescribing

7. After learning about 7^th material of the course, student university to be able to apply the preparation of semi-solid dispensing form (unguentum, pasta, cream, linimentum, sapo, emplastrum, electuarium, gelly ) and also the apply of prescribing

8. After learning about 8^th material of the course, student university to be able to apply the preparation of semi-solid dispensing form (solutio, mixtura, mixtura agitanda, suspension, emulsion.

Saturatio, guttae, syrupus, galenica preparations, injection, aerosol, intra mammary infusion, linctusis, oleoresin ) and also the apply of prescribing. Especial this material to be added with material of sterilization for medicine substances and the student university must to be apply technique application at excellence level.

9. After learning about 9^th material of the course, student university to be able to apply concepts of (1) the right identification indication of the diseases,. (2) the right of dispensing form, (3) the right of actives substances and excipient, (4) the right of amount as a dose regimented, (5) the right of route and time of apply, (6) application depends on condition subject clinics.

10. After learning about 10^th of the course, student university to be able to apply the writing prescription for standard medicine of solid dispensing form, semi-solid dispensing form and liquid dispensing form.

11. After learning about 11^th material of the course, student university to be able to explain (1) the kinetics profile of medicines in animal body’s and their technology for assessment, (2) fate of medicines in animal body’s with healthy and pathology conditions, (3) characterized dispensing form of the LADME medicines pursuant to safety and efficacy, (4) variably response inter and intra species.

12. After learning about 12^th material of the course, student university to be able to apply the concepts of (1) bio-availability and bio-equivalence, (2) bio-analysis and sample preparation and also instrumentation, (3) calculation of withdrawal time.

13. After learning about 13^th material of the course, student university to be able to apply the concepts of (1) incompatibilities pharmaceutics theory, (2) interactions between medicines, (3) interaction medicines and feed or water for drink, (4) risk analysis and risk management.

15. Function of Course

The medicines is a professional tools of veterinarian for giving services and that tools

(including with veterinary medical devices) is a area working of veterinarian. That tools can

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be usefully if that area will be controlled veterinarian. The control of medicines and veterinary medical devices will be effective if the veterinarian have a competence of the veterinary pharmacy science. The competence must be advances start at area of drugs discovery until principles using of the drug via prescriptions. Competence of the veterinarian for area of medicines doesn’t stop just doing the medicine for veterinarian services, but must be added with other knowledge as follows; (1) production of the drug, (2) dispensing form in unit of prescribing services and (3) quality test and control regulation in drug store. All of that competence as descried at above will be indicated that veterinary pharmacy science is important to giving start in student university.

16. Lecture Strategies

In the lecture, students are expected to learn course of pre-requisite first and read learning materials/reference book, than the lecturer only gives outline of study topic or sub study topic or gives examples the true of the fact in real practising. The last of explaining, lecture giving statements for discussion in e-learning and giving assignment. The assignment must be collecting to the lecture about three days after giving assignment.

Especial for learn activities in laboratory, the student must prepared one of the medicines dispensing form as describe in guidance of practice of compounding. After finished the activities of dispensing form, student must discussion to their supervision explored about their product.

There are six model evaluations in veterinary pharmacy science as follows; (1) quiz, (2) mid test and (3) final test, (4) assignment and (5) laboratory examination, (6) evaluation soft skill. Each evaluation have a criteria assessment with proportion described in point 19 at below. For evaluation all the leaning and teaching processing for obtained the excellency competence level, all of point evaluation will be calculate as proportion in point 19 in below.

17. Materials and Text books of Lecture

1. Farmakope Obat Hewan Indonesia Farmasetik Edisi IV, 2009. Direktorate Jenderal Peternakan dan Kesehatan Hewan Kementerian Pertanian,

2. Farmakope Obat Hewan Biologik Edisi IV, 2013. Direktorate Jenderal Peternakan dan Kesehatan Hewan, Kementerian Pertanian

3. Lazuardi M. 2009. Biopharmaceutics and Clinical Pharmacokinetics for Medical Veterinary, 1^st.

Ed^.Ghalia Indonesia.

4. Lazuardi M, 2016. The Generally of veterinary pharmacy science. 1^st Ed. Ghalia Indonesia.

5. British Pharmacopoeia (Veterinary), 2017. Medicines Commission pursuant to the Medicine Act 1985. London Her Majesty’s Stationary Office. UK.

6. Lazuardi M. Rahmi S, Lilik M, Sukmanadi M, 2018. Guideline of the practice veterinary drug standard compounding. 1^st Ed. Airlangga University Press.

7. Lazuardi, M, 2019. The special part of veterinary pharmacy science. 1^st Ed. Airlangga University Press, Surabaya Indonesia.

18. Learning Assignment

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Personal ASSIGNMENT

There are three personal assignment on 1 semester, and each student must be make a three assignment as with template of assignment as describe in part of appendix of

Guideline of the practice veterinary drug standard compounding.

19.

Assessment Criteria

1. ASSESSMENT SYSTEM

Every test is given in raw score of 0 upto 100. But for final score, assessment is given in 7 grades, that is, A, AB, B, BC, C, D and E.

Final score of a course is determined by result of all test evaluation combined conducted by respective lecturer. The example of test load (quiz), (structured assignment), (soft-skill), (mid- term test), (final test) and practice of laboratory is 1 : 1 : 1 : 2 : : 2: 3.

To process final score (raw score/numeric) to be Value Score in letter is devided into 7 grades.

From final score (raw score) can be process into mean score (X). Score classification is conducted using PENILAIAN ACUAN PATOKAN (PAP)/STANDARD REFERRING ASSESSMENT as follows :

Raw Score Letter Score

≥ 75 70 – 74.9 65 – 69.9 60 – 64.9 55 – 59.9 40 – 54.9

< 40

A AB

B BC

C D E

Score resulted from score processing above is presented in 7 grades as follows :

Letter Score Value Score

A AB

B BC

C D E

4 3.5

3 2.5

2 1 0

2. Others

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

Students are allowed to take final test if their attendance reaches 75 % (minimally they attend the class 9 meetings for new students) and 50 % (for students who retake the course )

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If students fail to jon quiz, mid-term test, final test, they must have doctor’s certification and must take make up test 1 week later

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Submission of structured assignment and practicum report is maximally 1 week from assignment or practicum activity given.

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Question type for quiz : essay

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For mid-term and final test : multiple choice

21. SCHEDULE OF LECTURE

SCHEDULE OF LECTURE VETERINARY PHARMACY SCIENCE FACULTY OF VETERINARY MEDICINE – UNIVERSITAS AIRLANGGA

ACADEMIC YEAR ……….

No. NAME LECTURE

ABBREVIATION 1. Prof. Mochamad Lazuardi, DVM., M. Pharm., Pharm D LZ

2. Dr. Rahmi Sugihartuti, DVM., M.Sc RH

3. Dr. Lilik Maslachah, DVM., M.Sc LL

4. Mohamad Sukmanadi, DVM., M.Sc SK

SCHEDULE TEACHING-LEARNING PROCCESS OF VET. PHARMACY SCIENCE

No Activities (The Topic Material

described in LSP)

Groups D Wednesday 10.00-11.50

a.m

Groups E Thursday 07.00-8.50

a.m

Groups C Thursday 09.00-11.50

a.m

Groups A Friday 07.00-08.50

a.m

Groups B Friday 07.00-08.50

a.m

1 1^st Topic RH LL RH LZ SK

2 2^nd Topic LL RH SK LZ RH

3 3^rd Topic LZ SK SK RH LL

4 4^th Topi SK LL RH LZ LL

5 5^th Topic RH LZ LZ SK LL

6 6^th Topic RH SK SK LL LZ

7 7^th Topic LZ RH LL SK LZ

8 8^th Topic LL SK LZ RH SK

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9 9^th Topic LZ LL LZ LZ RH

10 10^th Topic LL RH LZ SK RH

11 11^th Topic LZ RH SK LL LZ

12 12^th Topic LZ LL LZ SK LZ

13 13^th Topic RH LZ LL LZ SK

Note :

1. Quiz, Mid-Test and Final Test will be arranger in special schedule.

2. The 1

^st

, 2

^nd

and 3

^rd

Assignment were arrangement at special schedule after contact by each groups of Student University

SCHEDULE LEARNING OF COMPOUNDING IN LABORATORY

No Practices in Laboratory Groups and Time Supervision

1 - Technique of laboratory pursuant to veterinary pharmacy science

- Describe of role of the game practice in laboratory

A to E at 13.00-15.00 p.m

LZ, RH, LL, SK

2. - Compounding for R/ Solid preparation A to E 13.00 - 15.00 p.m

LZ,RH,LL, SK

LZ, RH,LL, SK

5. - Compounding for R/ Semi-solid preparation A to E 13.00 - 15.00 p.m

LZ, RH,LL, SK

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LZ, RH,LL, SK

8. - Compounding for R/ liquid preparation A to E 13.00 - 15.00 p.m

LZ, RH,LL, SK

11. - Compounding for R/ Pills A to E

13.00 - 15.00 p.m

LZ, RH,LL, SK

12. - Compunding for R/ Pills A to E

13.00 - 15.00 p.m

LZ, RH,LL, SK

Note : Evaluation at special schedule :

VETERINARY PHARMACY SCIENCE

COURSE CONTRACT