ACCENT JOURNAL OF ECONOMICS ECOLOGY & ENGINEERING
Peer Reviewed and Refereed Journal, ISSN NO. 2456-1037Available Online: www.ajeee.co.in/index.php/AJEEE
Vol. 06, Issue 06, June 2021 IMPACT FACTOR: 7.98 (INTERNATIONAL JOURNAL) 13 EFFECT OF TULSI (OCIMUM SANCTUM) IN METABOLIC RELATED DISORDER
RESULTING AS ADAPTOGEN Dr. Rishina Natu
(Department of Chemistry), P.M.B. Gujrati Science College
Abstract - Tulsi is indigenous to the Indian Continent within the Ayurvedic and Siddha medical system it has multiple therapeutic actions including anti microbial cardio protective etc. effects.
The practical conducted to review human studies that reported on a clinical outcome after ingestion of Tulsi. These practicals reported theraptic effects on metabolic disorder, cardio vascular disease, immunity etc. identified.
All studies and practical reported favorable clinical outcomes with no studies reporting any significant adverse events the reviewed of our studies suggest that Tulsi is an effective treatment for many diseases including diabetes, metabolic syndrome and psychological stress.
These practical and studies explore mechanisms of action of Tulsi.
Keywords: Antimicrobial, Cardio productive, cardio vascular diabetes, metabolic syndrome, psychological stress.
1 INTRODUCTION
The Sanskrit name of Tulsi is Tulasi and in English it is holy basil. It is a medicinal aromatioharb from the family lamiaceae that is indigenous to the Indian subcontinent and been used within Ayurvedic medicine more than 3000 years. In the Indian material medica Tulsi leaf extracts for the treatment purpose the juice of the leaf are also helpful in many diseases the roots and stems were also used to treat mosquito and snake bites and for the malaria.
2 THREE TYPES OF TULSI ARE COMMONLYDESCRIBE
1. Ocimumlencuilorum
2. Rama or Sri Tulsi and Krishna or ShayamaTulsi.
3. Gralissimum.
Tulsi leaf having potent pharmacological actions that include adaptogenic, metabolic, immuno- modulatory, anticancer, anti
inflammatory, antioxidart,
hepatoprotective, radiopropective, antimicrobial and antidibetic effects that have been extensively reviewed previously.
The studies have demonstrated that Tulsi prevents stress induced ulcers in rats comparable to antidepressant drugs Tulsi is more effective.
3 METHODS AND MATERIDLS
Many clinical studies were identified through searching Google scholar, Science direct, many libraries and Indian
medical data bases. The terms in the title in combination search were "Tulsi", "Holy basil", "Ocimumsanctum", "Ocimum Tenuiflorum", "Ocimumgratissimum",
"Ocimum", "Albahaca Morada", or combined with "Clinical Trial", "Clinical"
or "Human".
3.1 Quality Assessment:
In full text of each article was reviewed to assess suitability of the study with duplications remove. The references of selected articles were manually search to identify further studies a where appropriate. Study authors were contacted to request further information.
4 RESULT AND DISCUSSION
The reviewed studies involved a total of 1222 participants with ages ranging from 10 to 80 years old with eight clinical trials limiting participants to ≥ 40 years old.
The study durations ranged from 2 to 16 weeks and Tulsi dosage and frequency varied from 500 mg to 500 mg given as 1- 5 times per day as Tulsi leaf aqueous extract : 500 mg - 100 mg once or twice per day and as tincture solution 30 drops a day as 3 equal does daily.
Most studies looked at clinical populations with specific acute or chronic illnesses such as viral infection, Psychological stress diabetes, or metabolic synclrome.
Most common outcome
measurements were related to blood glucose levels lipid profile and blood
ACCENT JOURNAL OF ECONOMICS ECOLOGY & ENGINEERING
Peer Reviewed and Refereed Journal, ISSN NO. 2456-1037Available Online: www.ajeee.co.in/index.php/AJEEE
Vol. 06, Issue 06, June 2021 IMPACT FACTOR: 7.98 (INTERNATIONAL JOURNAL) 14 pressure which result no harmful effect in humans.
The Practice report is as follows.
Table - 01 Clinical
Domain Study design Participants
(Age range) Tulsi
Extract Duration Doses Outcome Adverse effect 1. Clinical trial
control parallel group
40 Adults T
2DM Tulsi
Powder Leaves
4 Weeks 3 gm/day Post prandial glucose and tansing blood.
Not reported
In 2. Randomized
control clinical trial
70 Male Adults T2DM (50-60 years)
Tulsi Leaves Caps
9 Weeks 7 gm/day Before male
Post prandial glucose and tasting blood
Not reported Metaboli
sm 3. Randomized
placebo controlled clinical trial
200 Adults (≥
50 years) AquaseTul
si Leaves 15 Weeks 10 ml/ x 3 days before meals
Improve lipid profile and B.P. Not
reported
4. Clinical Trial 20 Adults (60-
85 years) Power Whole plant Tulsi
20 Weeks 6gm x 2 /
day Improvement in
lipid profile None 5. Clinical study
case report 6 Adults T2
DM Fresh
Tulsi Leaves
4 Weeks Fresh Leaves 4 x daily
Glucose reaching near normal level Not
reported
The studies identified in this review could be classified according to four man clinical domains including metabolic disorder (15 studies) mood conditions (5 studies) and immunity and infections (7 studies). Which suggest that Tulsi May indeed be an effective adaptogen. The anti inflammatory effects of Tulsi have been previously documented in many vitro and divot studies. The most commonly use part of the Tulsi plant is the leaf which is non to contain several bioactive compounds all reviewed studies reported fever able clinical effect or no side effect irrespective of those dose.
5 CONCLUSION
34 human studies published to date suggest that Tulsi is a safe herbal intervention which normalizing glucose blood pressure and lipid profile and dealing with psychological and immunological stress. There is no side effect of daily addition of Tulsi to the diet.
REFERENCE
1. R.C. Saxena, R. Singh, P. Kumar "Efficacy of an extract of ocimumtenuifloram in the management of general stress". Volume 2012, Artical ID 894509 7 Pages.
2. S. Das, A. Chandra, A. Sagarwal and N. Singh (A Preliminary clinical trial) (Volume 80) 1983, P.P. 323 - 327.
3. G. Sharma. "Antiasthmatic efficacy of ocimum sanctum". Sachitra Ayurved Volume 35, P.P. 665 - 668. 1983.
4. A. K. Varma, G.P. Dubey and A. Agrawal.
"Biochemical Studies on serum Hb, Sugar, urea and lipid profile in aged patients Research general of pharmacy and technology. "Volume 5, P.P. 791 - 794, 2012.
5. R. Gandhi, B. Chohan and G. Jadej "Effect of Tulsi powder on hyperglyeemic patient Indian general of applied research. Volume 5 number 6, 2016.
