Hall Ticket No.
Entrance Examinations = 2016 M.Sc. Biochernistry
Time : 2 hours
Booklet Code : C
Max. Marks : 100
Please read
the following instructions carefully before answering:
1. Enter
HallTicket number in
the spaceprovided
above and also on OMRsheel
2. Paper contains three sections: Part A" Part B and Part C together with
85questions for 100 marks. Part A contains 25 questions, each question carries one mark Part B contains 45 questions, each question carries one mark
Part
Ccontains 15 questions, each question carries two marks.
Part
Awill
beused for tie breaking.
In Part A there is negative marking, 0.33 marks will be deducted for each wTong answer. In Part B there is no negative marking In Part
Cthere is negative marking. 0.66 marks will
bede$lcted for
eachwrong answer.
Answers have
to
bemarked
onthe
OMR sheet as perthe instructions provided' Apart from oMR sheet, the question paper contains 14 fFourteen)
pagesincluding the instructions.
7. Please return the
OMRanswer sheet at the end of examination.
B.
Noadditional
sheetwill
beprovided.
9.
Roughwork
can becarried out in the question paper itself in the
spaceprovided
atthe
endofthe booklet.
10. Non
programmable calculators
areallowed'
PART A
[Each Question has only one
right
answer.Mark
theright
answer]1.
When two heterozygous individuals are mated, the percentof
heterozygous offspringswill
bea) 0 b)50 c)25
3.
4.
5.
6.
2.
Thefotlowing
receptor(tlpe)
mediates odorants and bitter taste sigrrals:a)
G-protein coupledreceptors b)
EGFRc)
Nuclearreceptors d)
Receptonwith
tyrosine kinaseactivity
3.
In dicotyledonous leaves, stomata are arrangedin
a)
Epicarpc)
Mesocarpd)loo
b)
Parallel mannerd)
Radiallyb)
Seedcarpd)
Pericarpa)
Linear rowsc)
Scattered4. Coir
is made from which part of the coconut?5.
Which one of thefollowing
staternents is not true?K* L\
B"hkj G&4: c-
a)
Rateoffacilitated
transport is saturableb)
Facilitated fransport is specificwith
respect to the type of molecules transportedc)
Rate of transport by simplediffusion
is saturabled) Active
transport can take place against concentration gradient6.
Transfer ofDNA
from donor to recipient by a bacteriophage isa) Transformation b)
Transductionc) Conjugation d)
Transposition7. coliform
bacteria are used as indicatorsof
sewagepollution
because they:a)
Arenon-pathogenic b)
Survive bestin
sewagec)
Are abundant in humanintestine d)
Are easy to culture8.
Lichens are combinations of green algae and fturgi. They existin
a---
relationshipa) Opportunistic b)
Commensalc) Mutualistic d)
parasitic9.
Carpel, the female reproductive part of aflower consiststf
all these parts except:a) Stigma b)
Ovaryc) Sryle
d) Calyx10.
which
of thefollowing
blood cell types isNor
in the same group as others?a) Lymphocyte b)
Eosinophilc) Neutrophils d)
Basophil1 I ' Leeches feed on blood
for
whichtheir
saliva contains an anticoagulant. Whichof
thefollowing
is secreted by leeches in their saliva?a) Heparin b) Hirudin
c) Hematin d)
Hemoglobin12' The portion
of
the nervous systern that is responsiblefor
thebodily
functionswithout
any conscious directions, such as breathing, heartbeat, and digestive processes etc are called:a)
Somatic neryoussystem b)
Sensory nervous systemc) Aulonomic
nervoussystem d) Motor
nervous system 13. Oleic acid has which of thefollowing
functional groups?a)
Carboxylic acid,alcohol
b) Alkene, carboxylic acidc)
Alkene, alcohol and carboxylicacid
d) Alkene and alcohol 14. Deaminationof
cytosine leads to the formationof
a) Thymine
b)Uridine c) 5-Methylcyrosine
d)Uracil
15. When 150 g
of
ureaO{W
60) wa.s dissolvedin
1.35 kg of waterit
gave a solutionof
density 1.2 glmL. What would be the molarity
(M)
of thesolutionf
a) 1.85 b)2.22
c)1.54
d) 2.00 16.which
of thefollowing
proteins is an ATpasein
the skeletal muscle?a) Actin
b)Myosin c) Troponin d)
TropomyosinK- tr
g"rt"trf b&e'. a
17. Which of the
following
characteristics best defines gynrnospenns:a)
Exposed seeds, vasculor, r,ni591Euu1no*".,
oJ--grvsvvr'rb)
Exposed segdg,.bjsexyal flowers, haploid endospermc)
Vascular,triploid
endosperm, flatleaves
--r
---d) cone like
leaves,triptoid
endospenn, hard wood producing 18. The major site ofregulaion
of glycolysis iswith
a) foruvate kinase L;
fhosptrofiuctokinasec) Hexokinase d)
AlJoiase19. Starch is best defined as
a) PolysacchT*
of grucose and galactosein
1,6-glycosidic linkageb) Polysacc{{" of
glucosein t,I
andr,o_gty.o;;;iirk;g"
c) PolvsacchTg"
exclusivelyof
grucosein l,r-"00" *rr.ilioi. tintug.
d)
Polysaccharide of galactoie in -1,4_glycosi&.lililg?, -""
20. The cause ofdisease scurvy is due to the deficiency
af
a) Vitamin 86 b)
Ascorbic acidc) Niacin d)
pantothenic acid 21. What is concentration ofH-
a)
10-r3Mc)
10-iM
ion in a solution of 0.1
M
NaOH?b) l0-toY d) 10rM 22.
All prokaryotic organisms are classified undera)
Archaebacteria, Eubacteri4 and protistsb)
Archaebacteria and protistsc)
Protists and Eubacteriad)
Eubacteria and Archaebacteria23' which
(most inclusive) of thefollowing tolowest
is the correct taxonomicar sequence graderr"*t
showingin"fi,riu"-ir'-
rhe highest taxonomical gradea)
Kingdom,llyl*,
f)omain,Orier,
Class,F;ily;c;;us,
SpeciesbJ
Kingdom,fhyl.o*, Ipily,
Class,Order,'d;s, Sp;;
c) f)omain,
Kingdom, phylum, Class, Order,F;ly,G;;.,
Speciesd)
Species, Genus, Family, Class, Order,philrrr {i;il;*
24. Which of the
following
is a poor immunogen?a) Enzymes b)
dntiUoOiesc) Glycogen
d) Whole yeast cell25. Antigenic determinants
of
an antibody consistof 3f
_Varialte regionsof light
chainsonly
bJ ]/,arialle
regions of hJavy chainsonly
c)
Variable regions of both heavy andlight
chainsd)
Constant regionsof
both heavy andfW
"frui",
K- tt
Eoo\trbt."&: C
PART
BfTbese
ouestioru nrY
havenore tha Ygf
all the correct answers'For
articular question,
all
three options must be marked otherwiseit wilt
be considered incorrect]26. Which of the
following
are trueof
sphingolipids?a)
Cerebrosides and langliosides are sphingolipids'b)
Phosphatidylcholine is a typical sphingolipid'c)
They always contain glycerol and fatty acids'd)
Sphingomyelin is a phosphosphingolipid27. Which of the enzymatic reactions in the
citric
acid cycle produces high energy containing phosPhate comPound?a) SuccinylcoAsynthetase b)
succinatedehydrogenasec)
Isocitratedehydrogenase d)
Citrate synthetase28.
Which of the following
bonds/interactionsis (are) NOT
responsiblefor
binding antibody to its cognate rJgion on anantigen? -
a) ionic interactions b)
Hydrophobic forcesc)
Hydrogenbonds d)
Disulfrde bonds29. Which of the
following
statement(s) about antibodies is (are)NOT
correcta)
They serve {ts the specific receptors on B and T lymphocytes'b)
They axe composed of trvo heavy(H)
chains and twolight (L)
chains.c) Thetwo lightll)
chains alone have the variable regions that can bind antigen'aj ffre
amino acid sequencewithin
the variable(V)
regions varieswidely
from one clone ofB-cell to
another31. Which of the statements about
point mutrtions
are correct? They can bea)
Induced by chemicalsb)
Responsiblefor
a genetic diseaseci
Mapped by a technique similar to Maxam-Gilbert sequencingd)
Detected easily by Southernblotting
32.
Identify
the statements that describe conectly the events in transcriptiona) RNA
synthesis initiates denovo (no requirernent for primer)b) 'U'
is inserted oppositeto 'T'
duringtarscription
"j
Sigmu factor in bacterial polymerase is required for accurateinitiation
d)
EukaryoticmRNA
are cappedwith
amodified 'C'
33.
Identify
the events that occur in the cytoplasma)
PolyadenYlation ofmRNA
c) fusembly
of small and large ribosomal subunits 34. Degenerate codons are30.
Which of
thefollowing
genes code(s)for
foreign antigens onlY?a)
Class IMHC c)
ClassIII MHC
receptors
that recopize(s)
and present(s)b)
ClassIIMHC d)
CD4 receporsModification
ofIRNA
Synthesis of protein b)d)
4
K-tt
Eoohlof c&a: c
a) Usually
different in thethird
baseb) Third
base is invariantc)
Recognized by the sameIRNA
d) Different DNA
sequences that encode the same amino acid 35.Which
of thefollowing
statements about viruses are true?a)
I{aveDNA orRNA
as genetic materialb)
Encode their complete replication machineryc)
Require a host cellfor
propagationd) Do
not infect plants36.
A buffer
solution can be preparedfrom
amixture of a)
Sodium acetate and acetic acidin
waterb) Sodium
acetrte andhydrochloric
acidin
waterc)
Ammonia and ammonium chloridein
waterd) Ammonia
and sodium hydroxidein
water37.
Which
of thefollowing
is true for the rate constantof
a chemical reaction?a)
Depends only on temperature andcatalyst r
b) Always
increaseswith
temperaturec) Linearly
related to rateofreaction
d)
Same for both directionsin
a reversible reaction 38.H
1. HCN2. MeOH/HC|
cr o
a) b) c)
d)cr oH cr cN cl cN cN
oHq) .oo*" q) "oo*" q) "o"' E) 'o",
39.
Which
of thetbllowing
compound(s) can reactwith
PClsto
give POCI:.a) Oz
b)COz
c)SOz
d)H:O
40.
Which
of thefollowing
pairs are enantiomers?OHHoHH ltll
Ph/lJl pn'\'oH c'H'45o, n'"133,
(D cN cN 0D
K- \t
$.dr trt co&p', .
9Ht F
oH(rrr) "'15-,, "'4.,"{' ,rr:Y ^'4t
a) I b) II c) III d) IV
41. Which of the
following will
exemplify passiveimmunity?
a) A
personrecovershom
aninfection
b) A
person receives immune serum during treatmentfor
hepatitisc) A
fetus receives maternal antibodies that cross the placentad) A
person given BCG vaccine against tuberculosis42.
Which
of thefollowing
is CORRECTfor differentiating
Crustaceans and Insects?a)
Crustaceans alone have fused head and thorax making cephalothoraxb)
Crustaceans have three pairsof
legs in their thorax regionc) Oniy
insects have tri-segmented bodyd)
lnsects have omatidia as photoreceptors43.
Which
of thefbllowing
statements are truefor
inUreeting?a)
Leads tohomozygosity b)
Improves hybridvigour
c)
Lossof heterosis d) Always
increasesproductivity
44.Which
of thefollowing
statements about photorespiration isNOT
true?a)
Convertslixed
carbon back into COzb)
C4 photosynthesis counteru photorespirationc)
Ribulosel,5-bisphosphate is oxidizedto
COzwithout
production ofATp
d)
Photorespiration producesNADPII
45. Which of the
fbllowing
events happen in telophaseof
mitosis?a)
Dis-assemblyof
spindle apparatusb) Alignment of
chromosomesin
the centreof
the nucleusc)
Decondensingof
chromosomesd)
Cell plate is formed46.
Which
of thefollowing
steps occurin
one or more models of recombination?a)
Single-strand cleavage(nicking) b)
Double-strand cleavage.c) Excision of
damagednucleotide. d)
Resolution.47. Which of the
following
experimentswill
detect the presenceof
intronsin mRNA?
a) A
comparison of the protein sequencewith mRNA
sequenceb) A
comparison of the genomicDNA
andcDNA
sequences.c) A
hybridizatton betweenDNA
andmRNA
molecules.d)
Density-gradient centrifugation of totalRNA
48. Which of the
following
is truefor
enzyme catalyzedreaction?Enzymesa)
Force reactions to proceedin
only one direction.b) Do
not alter theequilibrium
of the reactionc) Alter
the standard free energy.of the reactiond)
Can couple energetically unfavorable reactionsto
favorable onesK- tt
Ba*-tcj,cr&: c
49. Which of the statements are true for HbF (Fetal
Hb)
a)
Fetal Hb has higheraffinity
for Oz than does maternal bloodb)
Fetal hemoglobin (FIbF) is a tetramer that contains two o- and two y'chainsc)
The FIbF have alow affinity
for BPGd)
Oxygen partial pressure Pso forHbA
(Hemoglobin inAdults)
is less than FIbF 50. Which of thefollowing
statements are true for pollen tubes:a) It
showstip fowth b)
Transports male garnetesc)
Holds the antherlobes d)
Requiredfor pollination
51.
Amino
acids that containhydroxyl
group in their side chains area) Serine b) Threonine
c)Tyrosine
d)Histidine
52. The common acceptor
for
amino groupin
transamination reactions are (is)a)
a-ketoglutarate b)
Oxaloacetatec) Acetoacetate d)
Citrate53. Which of the
following
structures mediate comrngurication between cells?a) Gapjunction b) Laminat c) Desmosomes d)
Microtubules 54. Gastric glands secrete gastric juicerich in HCI
in response toa)
Dietary ibod available in the stomachb)
Stimulation by gastrins the parietal cells in gastric glands secreteHCI
c)
Stimulation of chief cellsin
gastric glandsd)
Stimulation of neck cells in the gastric glands55. Thiamine pyropohosphate is the prosthetic group
in
which of thefollowing
enzyrnesa)
Pyruvatedecarboxylase b)
Pyruvate carboxylasec) Transketolase d)
Transaldolase56.
The conduction of a nerve impulse is an
electro-chemicalimpulse. Which of
thefollowing
is (are) truein
the context of conduction of a nerve impulse through a nerve fibre?a)
The neurilemma permits onlyK*
ion to diffrrse freely into and outside a neuronb)
The sodium pumps of the neurons are resting during resting potentialc)
T'he sodium pumpsactively
transportNa* ions to the
outsideof the
neuron under resting conditiond)
Depolarization causespositive
chargeslike
Ca2* andNa* to rush
inside the neuron57. Which of the
following
compounds has a higher group transfer potential for phosphate than ATP?a)
Glucose6-phosphate b)
2-Phosphoenolpyruatec)
Creatinephosphate d)
Ribose S-phosphate58. Oxygenated and deoxygenated blood gets mixed
in
the heart of which of thefollorving
organisms?a) Fish b) Frog.
.c)
Houselizard d)
ManK-t\
e*b[d r'ea-: c
59. Under normal conditions,
which
of thefollowing
substances shouldNOT
be foundin
urine?a)
Ureab) Glucose c)
Proteind)
Creatinine60. Which
of following
hormones are glycoproteinin
nature?a) PRL b) FSH c) TSH d)
B-endorPhin61. Beadle and Tatum isolated sevsral mutants that were defective in arginine
biosynthesis. However they found that they could group them into three classes based on complementation analysis. This suggested that
a)
Arginine biosynthesis required 3 enzymesb)
Three different pathways exist for arginine biosynthesisc)
Three different amino acids have to be provided as precursorsd)
Many different mutations were isolatedin
each of the genes 62. Identifu the methods that arelikely
to be bactericidal:a)
Ionizingradiation b)
Membranefiltration c)
Autoclavingd) Refrigeratiql
63. Which of the
following
features are unique to plasmids but not true for transposansa)
Become inserted into chromosomesb)
Replicated autonomously outside of the chromosomec)
Depend on the host cell machinery for their propagationd)
Move from chromosome to chromosome64. Sedimentation velocity
of
a proteinin
a centrifugalfield
depends on which of thefollowing
properties:a)
Charge of proteinc)
Molecular mass of the Protein65. Which of the
following
phenomena conlribute to variety and combination of matemal and paternal traitsin
offsprings?a)
Recombinationb)
Random assortnent of chromosomes during MetaphaseI
c)
Errors duringDNA
rePlicationd)
Semi-conservative replication66.
\I/hich
of thefollowing
coenzymes are involvedin
enzymatic reduction reactions?b)
Shape of the proteind) pI
of the proteina)
Thiamine pyrophosPhatec) FAD+
67.
Unit
of k""t of an enz)rme cannot bea)
Ir4-tt-tb)
s-t68. Which of the
following
biomolecules have only C,H
and O?b)
NADH
d)
NADPH
c) M-l d) min'
b)
Glycerold) Palimitic
acida)
Glucosec)
Glycine69. Advantage(s) of cis double bonds (as opposed to trans double bonds)
in
tbtty acids is that theyK-tt
a)
Maintain membrane symmetry.c)
Decrease membranefluidity.
E*fUf c'&. c
b)
Increase membranerigidity.
d)
Increase membranefluidity
70. Choose all the statements that areTRUE
about telomeresa)
Telomeres contain regionswith
a high G contentb)
Telomeres solve end-replication problemc)
Telomerescontain short repetitive
sequences,which are invariant
among different organismsd)
Telomeres coatain non-Watson-Crick base pairingPART
C[Each Question has only one
right
answer. Mark theright
answer]71. Which option represents all the right
pain?
P. Eukaryotic
genome D
104 bpQ. Bacterial
genome II)
10s bp R. Chloroplastgenome III)
106 bp S.Viral genome IV)
108bp =
a)
P-I,Q-II, R-IIL S-IV
b)
P-IV,Q-III, R-II,
S-Ic)
P-V,Q-II, R-III,
S-Id) P-tv.
Q-Ir,R-IIL
S-ITL.Youtook
three tubesof
immunoglobulin G(IgG),
one was digestedwith
papain, anolher was digestedwith
pepsin and the last tube was digestedwith
pepsinfollowed by
reductionwith Dithiothreitol (DTT). You,
however,forgot to
label the tubes.To
resolvethe problem,
thedigested IgG were fractionated on a denafuring PAGE (Poly-Acrylamide
Gel Electrophoresis), tubeI
was loadedin
lanel,
tube 2loadedin
lane 2 and tube 3 was loadedin
lane 3. Based on the schematic gel pictureof
the denaturing PAGE,identifr
the tube digestedwith
pepsin followed by reductionwith dithiothreitol (DTT).
l5O kDri 110 kDa
a)
TubeI
b) Tube 2c)Tube 3 d)
TubeI orTube
3p
\ .\, r", o*"
^oeL.c(J
.:- S S N-!o
\ 4._
55 kDa 50 kDa
L(- t(
B*b-tof cAQ'.C
73. Given
below
is the oxygen-hemoglobin dissociation curve.If
thep0z in
the lungis
100ton
and pQ2 in the tissues
is
20torr, from
the graph below, what percentageof
oxygen picked up by hemoglobin in the lungwill
be released in the tissues?L ur ris
I
a) About
50%1;{) I
b) About60%
c) About 80% d) About 20%74. Given below is a Spirogram labeled to show the subdivisions of the total lung capacrty
(TLC),
which is OObOmt. The amountof
airinspiref
during normal, relaxed 6teathing, that is, thetidal
volume(TV) is
about 500mL,
the inspiratory reserye volume(IRV) or the additional air that can be forcibly inhaled after normal inspiration, is
about 3,100mL,
and the expiratory reserve volume(ERV),
is about 1,200mL.
What are the Residual volume(RV),
thevital
capacity(VC)
and the inspiratory capacity(IC) oithe
lung?
E lscc)
a) RV=
1200 ml,VC--
3600ml
andIC:
2600ml
b) RV=
1200 ml,VC:4800 ml
andIC:3600 ml
c) RV:
1900 ml,VC:4300 ml
andIC:3600 ml
d) RV:
1200 ml.VC:3600 ml
andIC:4800 ml
75.
pKr
(-COOH), pKzCNH:.),
and pK3 (side chain)of
aspartic acid are: 1.88, 9.6 and 3.65 respectively.At
which pH Aspwill
not movein
an elecfric field?a)
5.74b) 2.77
c)6.6 d)
6.076. The standard cell potential (80..u) of the reaction below is +0.126
V. l'he
valueof
AGo
for the reaction shown below isX
(s) +2H*(aq) ---+
Xl2(aq) + Hz(g)!,-'
? E:o
!c
'i il
:
10
L<- t\
WFa*r^&e: C
a) -24kJlmol b) +24kJlmol
c)
-12kJ/mol d)
+12kJ/mol
77.
A
population ofDNA
letters consists of equal numbers of each letter(A,
T, G and C).The
probability
that a randomly selected letterfrom
this population being eitherA or
T is:a) 0.1 b)'0.5 c) 0.25 d)0.4
78.ln
a sample consistingof
lysine, leucine, andglutamic
acid,which will
be elutedfirst from
a cation exchange resin atpH
1?a) Ail
threewill
be eluted at the sametime
b)Lysine
c) Leucine
d) Glutamic acid79. What would be the structure o1'1l;rlidine at
pH
8.0??o 9o
H2N*'-rc-o H,N-9H.-E ,?*-9#f
".fi-9#-3 9Hz ul"'
9H,
gHz.,j.N'\II
N,
\) -Lil N\ "R\
a) Liln b) c) t-r'in d) Lr.ll
;
80. What is the length and molecular mass
of
a polypeptide chain having 60 amino acidsin
a single contiguous ahelix?
a) 60
d
20kDa
b) 90A, 22W)a
c) 90d
6.6kDa
d) 60A,6.6 kDa
81.Which
option best represents the orderin which
the proteinsbelou'are
adCedduring
formation of the
replication-initiation
complex in prokaryotes?P. DnaB Q. Primase R. Pol
III
S. Ssb protein T.
DnaA
a)
P-T-S-Q-R.c)
P-T-Q-S-R.b) r-P-s-Q-R.
d)
T-P-Q-S-R.82. Which of the
following
equation holds truefor
an enzyme's Michaelis-Menten equation when the substrate concentration is verylow
compared to its michaelis constant km?a) r'": H b) ,r-*:# 4
LL
K-il
O""Fkl. c"&', c
' kcat t2
^l -=-
er Km
[s].tEl83. Match proteins to their functions.
-.
kcotd).- 'Km
utEl tsl
i)
haemoglobinii) y-globulin
iii)
collageniv)
lipase1) enzyme
2) mechanical strength 3) oxygen transPort 4) immrine protection
a) i-3. iil, iii-2, iv-4
b) i-2, ii-4, iii-4, iv-l
c) i-3, ii-4, iii-2, iv-l d) i-3, ii4, iii-l, iv-2
g4. Colour blindness is a recessive,
non-X
linked inherited disorder.A
man whose father istotally
colourblind
marries a woman whose mother istotally
colour blind. What is theprobability
that their offspringwill
be colour blind?a)
100% boYs and 50%ofgirls b)
50% of boYs and girlsc) 25%of girls
and50Yo ofboYsd)
25% of boYs and girls85. Imagine you are having a delicious
fruit
salad' From you select 3 items?il 72a b)
60c)
12010 items,
in
how many waYS cand)
None of the aboveL2
K- [l