Fig.1: FTIR spectra of the drug, pure polymers and compact formulation.
400 600
800 1000
1200 1400
1600 1800
2000 2400
2800 3200
3600
4000 1/cm
50 55 60 65 70 75 80 85 90
%T
3959.59 3942.23 3855.44 3803.36 3722.36 3670.28 3651.00 3639.43 3612.42 3488.99 3255.62 3234.40 3218.97 3122.54 2810.09 2659.65 2416.64 2293.20 2146.62 1834.18 1811.03 1778.25 1699.17 1620.09 1539.09 1404.08 1303.79 1193.85 1029.92 983.63 904.55 869.84 725.18 595.96 534.25 493.74 486.03 449.38
PAMIDRONATE
Figure: FTIR spectrum of Pamidronate disodium
400 600
800 1000
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1600 1800
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3600
4000 1/cm
-30 -20 -10 0 10 20 30 40 50 60 70 80 90
%T
3969.23 3938.37 3884.37 3786.01 3718.50 3681.86 3666.43 3633.64 3606.64 3284.55 3220.90 3045.39 2883.38 2815.88 2680.87 2410.85 2333.71 2206.41 2104.19 1824.53 1770.53 1689.53 1608.52 1535.23 1409.87 1299.93 1213.14 972.06 906.48 862.12 786.90 730.97 655.75 609.46 514.96 437.81
THYOLATED CHITOSAN
Figure: FTIR spectrum of Thiolated chitosan
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55 60 65 70 75 80 85 90 95 100
%T
3564.21 3500.56 3479.34 3463.92 3444.63 3421.48 3367.48 3348.19 3328.91 3294.19 3224.76 3161.11 2979.82 2943.17 2889.17 2879.52 2831.31 1650.95 1639.38 1458.08 1442.66 1373.22 1334.65 1313.43 1265.22 1193.85 1107.06 1080.06 1058.85 1035.70 1022.20 945.05 891.05 838.98 788.83 756.04 738.69 694.33 644.18 595.96 572.82 536.17 514.96 491.81 457.10 420.45
PURE HPMC K4M
Figure: FTIR spectrum of HPMC- K4M
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4000 1/cm
7.5 15 22.5 30 37.5 45 52.5 60 67.5 75 82.5 90
%T
3851.58 3813.01 3569.99 3485.13 3271.05 2972.10 2908.45 2860.24 2671.23 2526.57 2337.56 2142.77 1764.75 1674.10 1541.02 1402.15 1299.93 1188.07 1031.85 964.34 925.77 827.41 624.89 599.82 540.03 445.53
PAMIDRONATE + THYOLATED CHITOSAN +HPMC K4M
Figure: FTIR spectra of pamidronate disodium+ thiolated chitosan+HPMC-4KM
Fig. 2: DSC thermogram of the drug, pure polymers and polymeric film formulations.
Figure: DSC curve of pamidronate disodium
Figure: DSC curve of thiolated chitosan
Figure: DSC curve of HPMC-4KM
Figure: DSC curve of Ethyl cellulose
100.00 200.00 300.00 Temp [C]
-20.00 -10.00 0.00 mW DSC
133.88x100C Onset
143.55x100C Endset
139.44x100C Peak
-113.04x100J/g -162.03x100mcal Heat
213.58x100C Onset
232.12x100C Endset
223.35x100C Peak
-37.15x100J/g -53.25x100mcal Heat
D14
Figure: DSC curve of pamidronate disodium+ thiolated chitosan+HPMC-4KM+ethyl cellulose
Fig. 3: X-ray diffraction patterns of the drug, pure polymers and polymeric film formulations. PAMIDRONATE DISODIUM
Operations: Smooth 0.150 | Background 2.138,1.000 | Import
File: SAIFXR140205D-12(PAMIDRONATE DISODIUM).raw - Step: 0.020 ° - Step time: 32.8 s - WL1: 1.5406 - kA2 Ratio: 0.5 - Generator kV: 40 kV - Generator mA: 35 mA - Ty
Lin (Counts)
0 1000 2000 3000 4000
2-Theta - Scale
3 10 20 30 40 50 60 70 80
Figure: X-ray diffraction pattern of Pamidronate disodium
Figure: X-ray diffraction pattern of Thiolated chitosan
HPMC-4KM
Operations: Smooth 0.150 | Background 2.138,1.000 | Import
File: SAIFXR140205D-11(HPMC-4KM).raw - Step: 0.020 ° - Step time: 32.8 s - WL1: 1.5406 - kA2 Ratio: 0.5 - Generator kV: 40 kV - Generator mA: 35 mA - Type: 2Th/Th lock
Lin (Counts)
0 1000 2000 3000 4000
2-Theta - Scale
3 10 20 30 40 50 60 70 80
Figure: X-ray diffraction pattern of HPMC-4KM
ETHYL CELLULOSE
Operations: Smooth 0.150 | Background 46.774,1.000 | Import
File: SAIFXR140205D-13(ETHYL CELLULOSE).raw - Step: 0.020 ° - Step time: 32.8 s - WL1: 1.5406 - kA2 Ratio: 0.5 - Generator kV: 40 kV - Generator mA: 35 mA - Type: 2T
Lin (Counts)
0 100 200 300 400 500 600 700 800 900 1000 1100
2-Theta - Scale
3 10 20 30 40 50 60 70 80
Figure: X-ray diffraction pattern of Ethyl cellulose
Figure: X-ray diffraction pattern of Pamidronate + Thiolated chitosan+HPMC-4KM+Ethyl cellulose
