MSCCH-09
June - Examination 2019
M.Sc. (Final) Chemistry Examination Drugs and Pharmaceuticals
Paper - MSCCH-09
Time : 3 Hours ] [ Max. Marks :- 80
Note: The question paper is divided into three sections A, B and C.
Write answers as per the given instructions.
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IÊS> Ho$ {ZX}emZwgma àíZm| Ho$ CÎma Xr{OE&
Section - A 8
×
2 = 16 (Very Short Answer Questions)Note: Answer all questions. As per the nature of the question delimit your answer in one word, one sentence or maximum up to 30 words. Each question carries 2 marks.
IÊS> - "A' (A{V bKw CÎmar¶ àíZ)
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1) (i) Define Pro-drug and Types of Pro-drug.
àmo S´>J H$s n[a^mfm VWm àH$ma {b{IE&
420
MSCCH-09 / 1400 / 4 (1) (P.T.O.)
420
MSCCH-09 / 1400 / 4 (2) (Contd.)
(ii) What is meant by Agonist and Antagonist?
EJmo{ZñQ> VWm EÝQ>mJmo{ZñQ> go Amn ³¶m g‘PVo h¡?
(iii) Define Blood Pressure and types of blood pressure.
a³VXm~ H$s n[a^mfm VWm àH$ma {b{IE&
(iv) Give two examples of Local Anesthetic Drugs.
ñWm{ZH$ EoÝgWr{g¶m Am¡fYr Ho$ Xmo CXmhaU {b{IE&
(v) Define Xenobiotics with two examples.
{OZmo~m¶mo{Q>³g H$s n[a^mfm Xmo CXmhaUmo g{hV Xr{OE&
(vi) What is meant by Disposition and Distribution?
{S>ñnmo{OeZ VWm {dVaU go Amn ³¶m g‘PVo h¡?
(vii) What is ADME?
ADME
³¶m h¡?
(viii) Give two examples of b-Adrenoceptor Blockers drugs.
b
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Section - B 4
×
8 = 32 (Very Short Answer Questions)Note: Answer any four questions. Each answer should not exceed 200 words. Each question carries 8 marks.
(IÊS> - ~) (bKw CÎmar¶ àíZ)
{ZX}e : {H$Ýht Mma àíZm| Ho$ CÎma Xr{OE& Amn AnZo CÎma H$mo A{YH$V‘
200 eãXm| ‘| n[agr{‘V H$s{OE& à˶oH$ àíZ 8 A§H$m| H$m h¡&
2) Discuss the basic concepts of ‘Pro-drugs’ with the help of suitable examples of parent drug molecule(s). Write various applications of Pro-drug.
àmo S´>J H$s ‘yb n[aH$ënZm Cn¶w³V CXmhaU (OZH$ Am¡fYr AUw H$s)
Ûmam g‘PmBE& àmo S´>J Ho$ AZwà¶moJm| H$s {b{IE&
MSCCH-09 / 1400 / 4 (3) (P.T.O.) 420
3) Discuss the various ‘factors governing drug-design’.
S´>J {S>Om¶Z H$mo à^m{dV H$aZodmbo {d{^ÝZ H$maH$ g‘PmBE&
4) Enlist cardiac disorders. Explain cardiac arrhythmias.
öX¶ {dH$mam| H$s gyMr Xr{OE& öX¶ A[aX{‘¶m H$mo g‘PmBE&
5) What are antineoplastic agents? Explain classification of antineoplastic agents.
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6) Explain the classification and structure Activity Relationship of Benzodiazepine.
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7) Define Sedative - Hypnotics and give their Classification.
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8) Write short note on ANY TWO:
{H$Ýht Xmo na bKw ZmoQ> {b{IE…
(a) Inhalational anesthetics /
BÝhoboeZ EoÝgWr{g¶m
(b) Dopamine Hypothesis of Schizophrenia
S>monm{‘Z n[aH$ënZm (gmBOmo{’«${Z¶m)
(c) Synthesis of Diltiazem /
{S>pëQ>¶mOo‘ g§íbofU
(d) Synthesis of Quinidine /
³¶y{Z{S>Z g§íbofU
9) Classify antipsychotic drugs. Explain mechanism of action, effects and uses of Barbiturates.
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à^md VWm AZwà¶moJ {b{IE&
420
MSCCH-09 / 1400 / 4 (4)
Section - C 2
×
16 = 32 (Long Answer Questions)Note: Answer any two questions. You have to delimit your each answer maximum up to 500 words. Each question carries 16 marks.
(IÊS> - g) (XrK© CÎmar¶ àíZ)
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10) Describe and write the synthesis of the following drugs.
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(i) Methyl Dopa /
{‘WmBb S>monm
(ii) Chloroquin /
³bmoamo³¶yZ
11) What do you understand by Depression? Write the classification of antidepressants drugs. With help of suitable diagram explain the general mode of action of Anti depression drugs.
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12) What is Antibiotic? Classify b-Lactum antibiotics and give uses and Mechanism of action of Penicillin G.
à{VO¡{dH$ ³¶m h¡?
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13) Write notes on Renal Clearance and Distribution in the Excretion process.
