Supporting Information
Synthesis of alkaloids 3,3’-(pyridin-2-yl)methylene)bis(1H-sustituted-indole) via infrared irradiation as heating and their evaluation antifungal against Candida albicans, Cryptococcus neoformans and
Aspergillus fumigatus
José Abraham Rojas-Jaramilloa, José Guillermo Penieres-Carrilloa*, Francisco Pérez-Floresb, Tonatiuh Alejandro Cruz Sánchezc, Francisco Barrera-Télleza, Alejandro Martínez Zaldivarc, &
Ricardo-Alfredo Luna-Moraa*
aFacultad de Estudios Superiores Cuautitlán-Universidad Nacional Autónoma de México, Sección de Química Orgánica, FESC, Campo 1, Cuautitlán Izcalli, C. P. 54740, México.
bInstituto de Química-Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de México, C.P. 04510, México.
cFacultad de Estudios Superiores Cuautitlán. Universidad Nacional Autónoma de México.
Carretera Cuautitlán-Teoloyucan Km. 2.5, San Sebastián Xhala, Cuautitlán Izcalli, C.P. 54714, México.
E-mail: [email protected]; [email protected]
Table of Contents
FT-IR 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)………... S1 MS-DART 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)……….….. S1 HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)………..…… S2 1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)………. S2 13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)………. S3 FT-IR 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)……….. S3 MS-DART 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)……….……. S4 HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)………. S4 1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)…... S5 13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)…… S5 FT-IR 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)………. S6 MS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)……….…. S6 HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)……… S7 1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)….... S7 13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)…… S8 FT-IR 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)……….. S8 MS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)……….……….. S9 HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)……… S9 1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)…… S10 13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)…… S10
S1
FT-IR 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)
MS-DART 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)
S2
HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)
1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)
S3
13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1H-indole) (15)
FT-IR 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)
S4
MS-DART 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)
HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)
S5
1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)
13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(1-methyl-1H-indole) (16)
S6
FT-IR 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)
MS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)
S7
HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)
1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)
S8
13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-methyl-1H-indole) (17)
FT-IR 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)
S9
MS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)
HRMS-DART 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)
S10
1H NMR (300 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)
13C NMR (75 MHz, DMSO-d6) 3,3’-(pyridin-2-yl)methylene)bis(2-phenyl-1H-indole) (18)
