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Courses » Multidimensional NMR Spectroscopy for Structural Studies of Biomolecules
Unit 3 - Two
dimensional NMR
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Introduction to Basics of NMR
Two dimensional NMR
Basic concepts in 2D NMR spectroscopy Principles of 2D correlation spectroscopy COSY Principles of 2D Total correlation spectroscopy (TOCSY) 2D Nuclear Overhauser Effect Spectroscopy 2D NOESY and 2D ROESY Quiz :
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Due on 2019-02-13, 23:59 IST.
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Which of the following is not an advantage of 2D NMR as compared to 1D NMR?
It is possible to correlate two different chemical shifts by 2D NMR
It is possible to observe multiple quantum coherences directly in a 2D spectrum
The sensitivity of 2D NMR spectrum is better than 1D NMR so it takes comparatively less time to acquire 2D NMR spectrum
2D NMR spectra have better resolution than 1D NMR spectrum
No, the answer is incorrect.
Score: 0
Accepted Answers:
The sensitivity of 2D NMR spectrum is better than 1D NMR so it takes comparatively less time to acquire 2D NMR spectrum
Which of the following is a homonuclear NMR experiment?
HSQC HMQC
COSY
HMBC
No, the answer is incorrect.
Score: 0
Accepted Answers:
COSY
What is the total number of peaks in the COSY spectra of CH3-CH2-CH2-Cl (Ignore the J-multiplet pattern)?
7 6 8 5
No, the answer is incorrect.
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Important 2D NMR
experiments for Biomolecules
3D NMR Spectroscopy
Basics of Protein Structure
Isotope Labelling
Resonance assignment of Proteins with NMR and Structure Determination
NMR
Experiments for Studying Protein-Ligand Interactions
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assignment solution page 4
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7) 1 point
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Accepted Answers:
7
What is the total number of peaks in the TOCSY spectra of CH3-CH2-CH2-Cl (Ignore the J-multiplet pattern)?
11 8 9 7
No, the answer is incorrect.
Score: 0
Accepted Answers:
9
In which of the following NMR experiments, the magnetization is transferred among all spins in a spin system having J-couplings to each other?
COSY
NOESY
TOCSY
ROESY
No, the answer is incorrect.
Score: 0
Accepted Answers:
TOCSY
There are two pairs of protons: A-B and C-D. In a 2D NOESY spectrum, the intensity of cross peak between A-B was 10 times more than the intensity of cross peaks between C-D. Which of the following is true about the distances: r(A-B) and r(C-D)?
r(A-B) is approximately 3 times greater than r(C-D) r(A-B) is approximately 1.5 times greater than r(C-D)
r(A-B) is approximately 3 times smaller than r(C-D)
r(A-B) is approximately 1.5 times smaller than r(C-D) No, the answer is incorrect.
Score: 0
Accepted Answers:
r(A-B) is approximately 1.5 times smaller than r(C-D)
Which of the following is true about the difference between 2D ROESY and 2D NOESY?
In 2D ROESY, magnetization is transferred through J-coupling, but not in 2D NOESY
In 2D NOESY, magnetization is transferred through J-coupling, but not in 2D ROESY
There is a mixing time in 2D NOESY and not in 2D ROESY
The cross peaks and diagonal peaks in 2D ROESY are opposite in sign but same sign in 2D NOESY
No, the answer is incorrect.
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9) 1 point
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Accepted Answers:
The cross peaks and diagonal peaks in 2D ROESY are opposite in sign but same sign in 2D NOESY
Which of the following is true about 2D NOESY?
The distance between two protons is directly proportional to the intensity of the cross peaks in 2D NOESY
The intensity of cross peaks in 2D NOESY does not keep increasing with increase in mixing time
A mixing time of 200-300 ms is used in 2D NOESY for proteins
A 2D NOESY spectrum can never contain more number of peaks than 2D TOCSY
No, the answer is incorrect.
Score: 0
Accepted Answers:
The intensity of cross peaks in 2D NOESY does not keep increasing with increase in mixing time
Which of the following mixing times is most likely used in a 2D homonuclear TOCSY?
30 ms 5 ms 40 ms
80 ms
No, the answer is incorrect.
Score: 0
Accepted Answers:
80 ms
In a 2D experiment, what is sandwiched between two evolution times?
Preparation period
Mixing period
Decoupling period Detection period
No, the answer is incorrect.
Score: 0
Accepted Answers:
Mixing period
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