View of STUDIES ON SOME 1:1:1, MIXED LIGAND COMPLEXES OF COPPER (II), NICKEL (II) AND COBALT (II)

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ACCENT JOURNAL OF ECONOMICS ECOLOGY & ENGINEERING

Peer Reviewed and Refereed Journal, IMPACT FACTOR: 2.104, (INTERNATIONAL JOURNAL) ISSN No. 2456-1037

Vol. 02, Issue 01,January2017 Available Online: www.ajeee.co.in/index.php/AJEEE

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STUDIES ON SOME 1:1:1, MIXED LIGAND COMPLEXES OF COPPER (II), NICKEL (II) AND COBALT (II)

Jagjivan Ram

Assistant Professor, Department of Chemistry, Dr. B. R. Ambedkar Govt Degree College, Mainpuri (U.P.)

Abstract- This article describes the synthesis and characterization of mixed ligand complexes of Co (II), Ni (II), and Cu (II) with phthalimides and heterocyclic amines.

Elemental analysis, IR, UVv and 1H NMR spectral analysis, color, molar conductivity, and magnetic properties suggested that the complex was formulated as [M (Phimide) 2 (L) 2-4]. Where M = Co (II), Ni (II) and Cu (II); Phimid = Phthalimide; L = quinoline, isoquinoline, 2-picoline and pyridine. The prepared complex of Co (II) and Ni (II) was an octahedron, and Cu (II) was a square planar geometry.

Keywords: Mixed ligand complex, phthalimide, heterocyclic amine.

1. INTRODUCTION

Organic compounds containing imide groups have both salt formation and coordination properties. The resulting imide complex is generally insoluble in polar solvents and soluble in non- polar solvents, which is very important from an analytical point of view. Phthalimides have structural characteristics-CON (R) CO and imide rings help to be biologically active and pharmaceutically useful. Phthalimides are attracting attention for their antibacterial, antifungal, analgesic, antitumor, anxiolytic, and anti-HIV1 activity. There is little detail in the literature on the study of simple metal imide complexes, but little research has been done on their mixed ligand complexes.

We recently investigated several mixed ligand complexes containing heterocyclic amines as secondary ligands and some Schiff base- containing complexes [615]. Here, several new mixed ligand complexes composed of Co (II), Cu (II), and Ni (II) with phthalimide as the primary ligand and heterocyclic amine base as

the Secondary ligand. Report on synthesis and characterization.

Nickel is one of the essential trace elements in biological systems.

It occurs primarily as an essential cofactor for nickel-based enzymes. It forms a coordination complex with amino acids in the enzyme. Nickel is also found in nucleic acids, but the function of nickel in DNA and RNA is not yet clearly understood. In this study, the tendency of Ni (II) to complex with adenine and certain linoic acids such as aspartic acid, glutamic acid, asparagine, leucine, phenylalanine and tryptophan was investigated in an aqueous medium.

Potential difference equilibrium measurements showed that both the binary and ternary complexes of Ni (II) were formed with adenine and the above linoic acid. The ternary complex of Ni (II) adenine amino acids is formed by a stepwise mechanism. The relative stability of the ternary complex is compared to the relative stability of the corresponding binary complex with respect to the Δlog10𝐾,

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2 log10𝑋, and% RS values. It has been shown that Ni (II): Ade: LAsn is the most stable ternary complex, while Ni (II): Ade: LPhe is the weakest in aqueous solution. Furthermore, the results of this study clearly show that different binary and ternary Ni (II) complexes are formed at different concentrations depending on the pH in the aqueous solution. In studies prior to Krause et al we investigated the interaction and stability of Ni (II) with amino acids containing a dipeptide consisting of asparagine cysteine (also known as NCC peptide) instead of the all-enzyme nickel superoxide dismutase (NiSOD). This study showed that the coordination of Ni (II) within the active site of NiSOD can be mimicked by NCC tripe tides.

Biological systems have a large set of target molecules for metal ion interactions. In addition to nickel, metal ions such as sodium, potassium, magnesium, calcium, manganese, iron, cobalt, copper, zinc and molybdenum are also present in different types of living cells and compete with each other for different metal-ligand complexes. Form a biological polymer. In some cases, as in the case of metal ion transporters, metal ions should interact relatively weakly with proteins. In contrast, metal ions interact very strongly with amino acids in the active center of metal enzymes. Therefore, it is important to analyze the strength of the metal-ligand interaction in aqueous solution using a mixed ligand system.

In this study, the stability of the binary and ternary complexes of nickel and adenine and the free amino acids LAsp, LGlu, LAsn, LLeu, LHe, LTrp in aqueous solution was

investigated using potentiometric titration. The results of this study show that the stability of the binary and ternary complexes of Ni (II) and these ligands depends on the pH of the aqueous solution and the structure of the linonic acid. The results of this study can be used to evaluate the interaction of nickel ions in aqueous solution with DNA bases and linoic acids in the presence of mixed ligands at the molecular level.

2. EXPERIMENTAL

2.1. Chemicals & Regents

All the chemicals and regrind used were of the quality of the chemicals and regrind. The solvent was purified using conventional methods.

2.2. Physical Measurements

Analysis of carbon, hydrogen and nitrogen was performed at the University of Liverpool in Liverpool, England. The magnetic moment was measured using the Sherwood Scientific magnetic susceptibility scale. The infrared spectrum as a KBr disc was recorded with a 4000400 cm1 Shimadzu FTIR8400 infrared spectrophotometer (Japan). The absorbance of the complex was recorded with a SHIMUDZU spectrophotometer (model UV1800).

The metal was determined by weighing it as an oxide produced by direct ignition.

2.3. General Method for the Preparation of the Complexes of the Type [M(X)(L)]

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3 Heterocyclic amine bases such as X = phthalimide, L = pyridine, quinoline, isoquinoline, 2- minopyridine, 2picoline. Mix an ethanol solution of M (II) chloride salt (2 mmol) (just dissolved) and an ethanolic potassium hydroxide solution of "X" acid (4 mmol) (just dissolved) and gently stir for 30 minutes. No precipitate was observed, then a secondary ligand was added at the calculated ratio and stirred until the complex settled. The precipitate was filtered off, washed several times with alcohol and then dried in a vacuum desiccators with phosphorus pentoxide (P2O5).

3. STRUCTURE OF THE COMPLEXES

The IR spectrum shows that the nitrogen atom of the imide ring is involved in the metal imide bond, and the electron spectrum provides information about the nature of this bond. 1 HNMR showed that 4 pyridines and 2 phthalimides are involved in complex formation. Based on elemental analysis, metal estimation, conductivity measurements, magnetic moment data, spectroscopic studies, and literature studies, you can assign octahedral structures to the structure of complex 2. The proposed structure of complex 2 is shown below.

Figure 1 Proposed structure of complex [Co(Ph-imide) 2(Py)].

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