ﺑﺴﻢ اﷲ اﻟﺮﺣﻤﻦ اﻟﺮﺣﻴﻢ

ƮǀůźƫřƲưůźƫřĽřƮƀŝ

id8243328 pdfMachine by Broadgun Software - a great PDF writer! - a great PDF creator! - http://www.pdfmachine.com http://www.broadgun.com

Ê¿Z»{Êf‹Y|Æ]cZ»|yÁÊ°‹‚a¹Â¸ŸÃZ´Œ¿Y{

€Æ‹Â]

Ê°‹‚aÃ|°Œ¿Y{

Ä»Z¿½ZËZaÊËZÆ¿‰Y‚³ ÃÁ{

ÉY€f¯{

ÉYħ€u Ê°‹‚a

ÉÁY{€ÌiZeʇ€]

Colofac

{Zu| ¬»©Z¬‹½Z»{{

ÉZŵZ‡{

ÂnŒ¿Y{

YĸuY

Zf¼»Êvf¨·YÂ]

Zf‡Y Z¼ÀÅY{

€f¯{

«Z—YÃ{Y‚̸ŸZ“|̼u



ʻ¼ŸÊuY€mŠz]ZË{Zf‡Y

{Zf‡Y

ÁZŒ»

ÊËY€Ì»½Y€»Z¯€f¯{

ÊËZ¼fmYÊ°‹‚aZË{Zf‡Y

»ÃÂuÊ·Z»dËZ¼uÁ\ːeZ]s€—¾ËY Ê°‹‚a¹Â¸ŸÃZ´Œ¿Y{ʌÅÁ„ad¿ÁZ 

d‡YÃ|Ë{€³Y€mY€Æ‹Â]Ê¿Z»{Êf‹Y|Æ]cZ»|yÁ

{Y{€»

Á|aÄ]ºË|¬e

¹YÃ{Â]½ZŒÅZÀa{ÃY¼Åį¹‚Ë‚Ÿ{Z»

İƳřŵŹŶƣƹźĪƄţ

Àm|À¼mY|ÌeZ‡Y¢Ë{Ê]cZ¼uY ÁÃ{Y‚̸Ÿ€f¯{ÉZ«M[Z

€f¯{

ÊËY€Ì»

Y€°ŒeµZ¼¯

¹Y{

Īģ ǀ ƵŶ

ƶƯŶƤƯ ŞƀƳŢǀƘƋƹĨƿŶƘƤƯơŚƤƃ ľŚŤ

ƮſŚĜſřƶŝźŬƴƯƭŹŵƺƳōŹŵƾĭŹŚěĨƿƱōŹŵƶĩŢſřƖƿŚƃ

ƾƯƾƸŤƴƯƭŹŵƺƳōƶŝƾƳŚſźƳƺųƂƷŚĩƹƾĭŹŚěƂƿřżƟřŵŹŵŵŚŬƿřƶŝŵƺųƶĩŵƺƃƾƯƩŚƳōƾƬųřŵźŤĮƴƠſř ŵƺƃ ƶĩƵŶƃŜſŚƴƯŚƳƮǀƯźţŚŝƾưųŻŵŚŬƿřŦƗŚŝƾưĪƀƿřƹƮſŚĜſřŵŹŵƪĪǀſ

ƾƯƲƯżƯơŚƤƃĨƿƶŝƪƿŶŞţ

ŵƺƃ ŚƯŹŵŹŵƾƬƇřƝŶƷ ŶƘƤƯƮſŚĜſřƂƷŚĩŵŚůŶƘƤƯơŚƤƃƱ

ŶƃŚŝƾƯ

řŹŵ ƿ ŧŚţƶŝƶƘƫŚƐƯƲ ǀ

ƹŹřŵź ƽ

Colofac

ƱřƺƴƗƶŝ ƿ

ŤƳōĨ ƾ ŵƺưſŚĜſř ƿ

ƯŵŚůŶƘƤƯơŚƤƃƱŚƯŹŵŹŵĨ ƾ

Żřŵźě ƿ Ʈ ŹŚĩƁƹŹ

źƋŚůƶƘƫŚƐƯ

ƾƴǀƫŚŝ ƾƿŚƯŻōŹŚĩ Ĩƿ

(clinical trial)

ƾƏ ƶĩ Ţſř ƵŚĮƳŚƯŹŵ ƶŝ ƵŶƴƴĩ ƶƘūřźƯ ƱřŹŚưǀŝ Źŵ ƩŚſ Ĩƿ šŶƯ

Ŵţ ƩŚſ ƾƏ źƸƃƺŝ ƪƌƠƫřƺŝř ƾůřźū ƾƈƈ

íî æèíí Ŷƃ ƭŚŬƳř

ƲŤƟźĭ Żř žě ƱřŹŚưǀŝ ƶƘƫŚƐƯ Ʋƿř Źŵ

ƵƹźĭƹŵƶŝƾƟŵŚƈţšŹƺƈŝŵŚůŶƘƤƯơŚƤƃŵƺūƹŶǀƿŚţƹƶƴƿŚƘƯŢƿŚƋŹ çå

ƹŶƳŶƃƮǀƀƤţƵźƠƳ

Ĩƿƶŝƹ

ƽƹŹřŵƵƹźĭ

Colofac

šŹƺƈŝ

ƅźƣ æèêmg

ŹŚŝƹŵ ŻƹŹŹŵ ƹƾƘƋƺƯƲǀŗŚĩƹŶǀƫƩĥƩźŤƴĩƵƹźĭƶŝƹ

ƩƺƀĜĩ

Celecoxib

ŶƿŵźĭƭźĭśōƲĮƫƹźŞǀƟƝźƈƯƶŝƶǀƇƺţƵƹźĭƹŵźƷƶŝƹŶƃƵŵřŵ

ŹŵšŚƴƿŚƘƯŻřžě

ƽƹŹřŵźǀŧŚţƽŶƘŝšŚƘūřźƯ

Colofac

ŢƟźĭŹřźƣƾſŹźŝŵŹƺƯŵŚůŶƘƤƯơŚƤƃƱŚƯŹŵŹŵ

ƽźǀĭƶŬǀŤƳƹŦŰŝ

ƶūƺţŚŝ ŚŝƱŚƯŹŵƲǀŝƽŹřŵƾƴƘƯƽŹŚƯōšƹŚƠţƶƘƫŚƐƯƲƿřŹŵƵŶƯōŢſŶŝƽŹŚƯōŪƿŚŤƳƶŝ

Colofac

ƱŚƯŹŵƹ

ƹŵŹřŵŵƺūƹŵŚůŶƘƤƯơŚƤƃƲǀţƹŹƽŚƷ

ƶƴƿżƷƂƷŚĩƹƽŹŚưǀŝƲƿřƱŚƯŹŵƱřƺƴƗƶŝƹŹřŵƲƿřŻřƱřƺţƾƯ

ŵźĩƵŵŚƠŤſřƱŚƯŹŵƹƽźŤƀŝ

ŢǀƇŚųŹŵƾƄƤƳžƴūƹƲſŶƃƆŴƄƯƶƘƫŚƐƯƲƿřŹŵ

ĨƿŵƺưſŚĜſřƾŤƳō

Colofac

ƾŤůřŹƶŝƹŵŹřŶƳ

ŵƺưƳżƿƺŬţřŹƱōƱřƺţƾƯ

ŚƷƵĥřƹŶǀƬĩ

ĨƿŵƺưſŚĜſřƾŤƳōƱŚƯŹŵŵŚůŶƘƤƯơŚƤƃ

Colofac

ŜƫŚƐƯŢſźƸƟ

ƱřƺƴƗ

ƶŰƠƇ

ϝϭ΍Ϟμϓ

æ æ šŚǀƬĩ ...

...

...

...

ç

æ ç ƶƬŘƀƯƱŚǀŝ ...

...

...

é...

æ è šŚǀƋźƟƹƝřŶƷř ...

...

...

ææ

ϡϭΩϞμϓ

ç ƱƺŤƯźŝƽŹƹźƯ ...

...

...

ÎÐ

ϡϮγϞμϓ

è ŹŚĩƁƹŹƹŵřƺƯ ...

...

...

æë

ϡέΎϬ̩Ϟμϓ

Ñ ŪƿŚŤƳ ...

...

...

...

ÎÕ

ϢΠϨ̡Ϟμϓ

Ò ƽźǀĭƶŬǀŤƳƹŦŰŝ ...

...

...

çê

ƖŝŚƴƯ ...

...

...

...

çë

ƶƇLjų ƽ

ƬĮƳř ǀ ƀ ƾ ...

...

...

çí

ěǀ ŚƷŢſƺ ...

...

...

...

èå

ϣΪϘϣ Ϫ

æ æ šŚǀƬĩ

ŶƘƤƯơŚƤƃ ƿ

ƘƋƹĨ ǀ

ŞƀƳŢ ľŚŤ Śƃ ƿ ƯƹƱřƺūŵřźƟřŹŵƶĩŢſřƖ ǀ

ƭƺºſƶºƷŚƯƶºſŹŵŜºƬƛřƹƩŚƀƳŚ

ŹřŵŹŚŝ ƽ ƵŹƹŵŹŵƹ

post partum

ŵƿ ƯƵŶ ƾ ŵƺƃ æ

ŶƘƤƯơŚƤƃ ƿ

ĭŹŚºěĨ ƾ

ŵŹŵƖºƣřƹƭŹŵƺºƳōŹŵ ƿ

ƩŚŤºƀ ƳŵƎºų řƶºƳřŶ ƽ ºƯ ƾ ŶºƃŚŝ ºƯŹƺºƈţ ƾ

ŵƺºƃ

ƟƺţŚě ǀż ƿ ĥƺƫƺ ƽ ƃŚƳŚƯƹźţŚŝŶƘƤƯơŚƤƃ ƾ

ŢƠſƕƺƟŶƯŹƺŞƗŻř ƿ

ƳLJƺƏƩŚƸſřŚ ƾ

ŶºƃŚŝƎŞţźƯ

ºƿ ĭŹŚºěĨ ƾ

Źŵ

ƬųřŵźŤĮƴƠſřƮſŚĜſřƶŝźŬƴƯƭŹŵƺƳō ƾ

ƯƩŚƳō ƾ řƶŝŵƺųƶĩŵƺƃ ƿ

řżƟřŵŹŵŵŚŬ ƿ

ĭŹŚěƂ ƾ ƳŚſźƳƺųƂƷŚĩƹ ƾ

ƸŤƴƯƭŹŵƺƳōƶŝ ƾ

Ư ƾ ŵƺƃ ſ ǀ ĜſřŵŹŵƪĪ řƹƮſŚ

ƿ ưĪƀ ƾ řŦƗŚŝ ƿ ưųŻŵŚŬ ƾ

ƯźţŚŝ ǀ ŶŞţƶĩƵŶƃŜſŚƴƯŚƳƮ ƿ

ƶŝƪ

ƿ ƯƲƯżƯơŚƤƃĨ ƾ

ŵƺƃ ç

ŚƷƶƳŚƄƳ ƽ

ĭŹŚěŽŚƀůřŚŝŵŹŵƪƯŚƃƱōƶƈŴƄƯ ƾ

ŵƹũřżƯŢŝŚūřƩŚŞƳŵƶŝ ƿ

ºƯƲºƃƹŹƱƺºųƱŶ ƾ

ŶƃŚŝ ŝǀ ŻřŢſřƲĪưƯƱřŹŚư ƿ

ŶƃƩŚƳōƮſŚĜſřĨ ƿ

ŶƴģŚţƶĩħŚƳŵŹŵƹŶ ƿ

ŻřŶƘŝŢƗŚſƲ ƿ

ƹŹŢĩźůĨ ƶŝƵŵ

ƯƩƺƏ ƾ ƳŶƯŚŬƳř ǀ ŚĪƃż ƿ ŶƴƴĩŢ ç ř ƿ ĩƕƺƳŹŵƮŗLjƗƲ ǀƠ

ǀ ĭŶƳŻŢ ƾ

ƯƮƸƯŵřźƟř ƾ

ŶƃŚŝ ŤƳŹŵ ǀ ƢƟƺƯƱŚƯŹŵƶŬ

ĩŵƺŞƸŝŹŵŶƘƤƯơŚƤƃ ǀƠ

ǀ ĭŶƳŻŢ ƾ

 ƀŝ ǀ ƯźŧƺƯŹŚ ƾ

ŶƃŚŝ æ

ŚƷƵŶƴƴĩƭźƳřŻƮŬůƪƯřƺƗƪƯŚƃŶƘƤƯƶŝŚƯƹźţƂƷŚĩŹƺƔƴƯƶŝƩƹřƎųƱŚƯŹŵ ƽ

ƕƺƟŶƯ ƹ ƲŤƀƄƳ

śōƲĮƫŹŵ Ưƭźĭ

ƾ ŶƃŚŝ ůřźūƱŚƯŹŵ ƾ

řźŝ ƽ ŚƷơŚƤƃ ƽ

ƴƯżƯ ƾ ŞƏƱŚƯŹŵƶŝƶĩ ƾ

ƇƺţŶƳřƵŵřŶƳŲſŚě ǀ

ºƯƶ ƾ

ŵƺƃ ç ƟƺţŚěŶƃƶŤƠĭƶĩŹƺƐƳŚưƷ ǀż

ƿ ĥƺƫƺ ƽ ƃŚƳŚƯƹźţŚŝŶƘƤƯơŚƤƃ ƾ

ŢƠſƕƺƟŶƯŹƺŞƗŻř ƿ

ƳLJƺƏƩŚƸſřŚ ƾ

ƯƎŞţźƯ ƾ řƹŶƃŚŝ ƿ

ƘƋƹƲ ǀŤ ƾ źŰţƵŵƹŹƭƹŹŶƴſŹŵƶĩŢſř ºƿ

ŸºěĨ ƿ ź

IBS

˺

ŵ ºƿ ºƯƵŶ ƾ ŵƺºƃ IBS

ºƿ Ĩ

ŵźĪƬưƗƩLjŤųř ƽ

řƵŵƹŹ ƽ ų ǀƬ ƾ Śƃ ƿ šŹƺƈŝƶĩŢſřƖ çê

æå Ƙưū ǀ ƯƺưƗŢ ƾ

ưŴţ ǀ ƯƵŵŻƲ ƾ ŵƺƃ è

Ɯţ ǀǀ źţŢŝŚŧũřżƯŢŝŚūřŹŵź ƿ

ƫŚŝźƷŚƔţƲ ǀƴ

ƾ Źŵ IBS

Ţºſř Śºƃ ƿ źŤƘ ƿ ƺºĮƫřƲ ƽ

Ɯţ ºǀǀ ũřżºƯŢºŝŚūřź

ƿ ľLJƺưƘƯƶĩŢſřśƹŚƴŤƯƩŚƸſřƹŢſƺŞ ƿ

Ī ƾ ƮŗLjƗŻř ŢſřŜƫŚƛơƺƟ

é ƃŻƹźŝ ºƴƘƯšŹƺºƈŝŶƘƤƯơŚƤ ƾ

ϭIrritable Bowle Syndrom

Źřŵ ƽ Źŵ IBS

ƶŞƬƛŚŝ ƿ ŚŤƳƹŢſřƵŵƺŝƩźŤƴĩƵƹźĭŻřźŤĭŹżŝŢſƺŞ ƿ

ěƵŶƯōŢſŶŝŪ ǀ

ƱŚºƯŹŵƶºĩŶƳŵźĩŵŚƸƴƄ

żƷƂƷŚĩƹƉŹřƺƗƂƷŚĩŜūƺƯ ƿ

ŶƃŶƷřƺųŚƷƶƴ

ê

ŹŵƱŚƯŹŵ IBS

ƪƯŚƃ ĥŹ ƿ ƟźěƮ ǀ ŽźŤºſřƂƷŚºĩƵƺƸƣƪŨƯŚƸĩźŰƯƝźƈƯŻřśŚƴŤūřźŞ ƹƵŹƹŚºƄƯ

ƮƔƴƯƁŻŹƹ ŚƷƹŹřŵ

ƽ ƬƯƩŚƸſřŶƋ ǀ

řźºŝƲ ƽ ƿ ĭŵźºƀƟřŶºƋŢſƺŞ ƾ

ŚºƷ ë ƪƯŚºƃƮºſŚĜſřŶºƋƪºƯřƺƗƹ

Colofac

ƹ ƿ Ś

Hyoscin

ƿ ŤƳōĨ ƾ ŹŚĪſƺƯ ƿƴ ƾ Ư ƾ ěřƂƷŚĩŹŵƶĩŶƃŚŝ ǀ

ŚƷŵƹż ƽ ŹŵŵŹŵ IBS

ºƯƁŻŹřŚºŝ ƾ

ŶƃŚŝ ì

Colofac

ƪĪƃƶſƶŝ

suspension(10mg/ml)

 ŶƴƣƂƃƺěŚŝƅźƣ ƽ

(100mg,135mg)

ƩƺºƀĜĩƹ

modified release

(200mg)

ŢſřŵƺūƺƯ

ƪƯŚƃƱōƵŵŚƠŤſřŵŹřƺƯ IBS

řƵŶƘƯƮſŚĜſřƹ ƽ

řƵŵƹŹ ƽ ƺƳŚŧ ƿ ƶºŝƶ

ŝǀ ŹŚư ƽ ŚƷ ƽ ƳŚĭŹř ǀ Ĩ Ư ƾ ŶƃŚŝ í ŶūƉŹřƺƗ ƽ

ºƃŚƳ ƾ ºŤƳōŻřźºŤưĩƁřƉŹřƺºƗƹŵŹřŶºƳŵƺºūƹƱōŻř ƾ

ŹŚĪſƺƯ ƿƴ ƾ ŢſŚƷ î

ŶƘƤƯơŚƤƃŶƃƵŹŚƃřƶĩŹƺƐƳŚưƷ ƿ

ƘƋƹĨ ǀ

ŚƃľŚŤŞƀƳŢ ƿ

ƯƖ ƾ Śŝ ĩƶĩŶƃ ǀƠ

ǀ ĭŶƳŻŢ ƾ

źŧŚºŤƯřŹŵřźºƟř

Ư ƾ ƬƇřƝŶƷƹŵŻŚſ ƾ

ƯŶƘƤƯƮſŚĜſřƂƷŚĩƱōƱŚƯŹŵŹŵ ƾ

ŶƃŚŝ řźŝŚƴŝ ƿ ƹŶºƘƤƯơŚƤºƃƍŚŞţŹřƶŝƶūƺţŚŝƲ

ŧŚţ ǀ ƹŹřŵź ƽ

Colofac

řŹŵƮſŚĜſřƂƷŚĩŹŵ ƿ

ŶƃƱōźŝƶƘƫŚƐƯƲ ƿ

ŧŚţƶĩƮ ǀ řź ƿ ƤŤƀƯŹƺƐŝřŹƹŹřŵƲ ǀ

ƱŚƯŹŵźŝƮ

ſŹźŝŵŹƺƯŵŚůŶƘƤƯơŚƤƃ ƾ

ƣ ƷŵŹřź ǀ Ʈ

æ ç ǀŝ ƶƬŘƀƯƱŚ

ơŚƤƃ

ŶƘƤƯ

ƿ ĭŹŚěĨ ƾ ƭŹŵƺƳōŹŵ

ŵŹŵƖƣřƹ ƿ

řƶƳřŶƳŵƎųƩŚŤƀ ƽ

Ư ƾ ŶºƃŚŝ Źƺºƈţ ºƯ ƾ ŵƺºƃ

ƟƺţŚě ǀż ƿ ĥƺƫƺ ƽ ƃŚƳŚƯƹźţŚŝŶƘƤƯơŚƤƃ ƾ

ŢƠſƕƺƟŶƯŹƺŞƗŻř ƿ

ƳLJƺƏƩŚƸſřŚ ƾ

ŶºƃŚŝƎŞţźƯ

ŹŵƾĭŹŚºěĨºƿ

ƶĩŵƺƃƾƯƩŚƳōƾƬųřŵźŤĮƴƠſřƮſŚĜſřƶŝźŬƴƯƭŹŵƺƳō

ƾƳŚſźƳƺųƂƷŚĩƹƾĭŹŚěƂƿřżƟřŵŹŵŵŚŬƿřƶŝŵƺų

ŵƺƃƾƯƾƸŤƴƯƭŹŵƺƳōƶŝ

ƶŝƪƿŶŞţƶĩƵŶƃŜſŚƴƯŚƳƮǀƯźţŚŝƾưųŻŵŚŬƿřŦƗŚŝƾưĪƀƿřƹƮſŚĜſřŵŹŵƪĪǀſ

ŵƺƃƾƯƲƯżƯơŚƤƃĨƿ

ç

ŚƷơŚƤƃźŨĩř

ƽ ƠƬųƎſƹƎųŹŵŶƘƤƯ ƾ

řƿ ƯŵŚŬ ƾ ŶƳƺƃ æê æå řƭřŶƣƎſƹƎųŹŵŚƸƳō ƿ

ºƯŵŚŬ ƾ

ƺƃ ŻřźŤưĩƹŶƳ æ

ŶěƎſƹƎųŻřũŹŚųŚƷơŚƤƃ ƿ

ƯŶ ƾ ō ƿ Ŷƴ ç

ŶƘƤƯơŚƤƃ ƿ

ƘƋƹĨ ǀ

ŚƃŢ ƿ ƬƇřŢƯLjƗƹŢſřƖ ƾ

źƳƺºųƹƩŚƳōŵŹŵƪƯŚƃƱō ƿż

ƽ Ţºſř æå ŵŹŵ

Ŷƃ ƿ ƃŹƺŞƗšŹƺƈŝľLJƺưƘƯƹŢſřŶ ǀ

ƇƺţƶŤƀĪƃƶƄ ǀ

Ưƞ ƾ ŵƺƃ řƿ ºƃŻƺſŵŹŵƲ ƾ

ŶºƴģŢºſřƲºĪưƯ ƿ

Ʋ

ųźŝŹŵũřżƯŢŝŚūřŻřŶƘŝŢƗŚſ ƾ

ŝǀ ŹŚư ƶƯřŵřƱř ƿ

ŶŝŚ źƳƺų ƿż ƽ ƲºƃƹŹƱƺºųƍŚºƤƳšŹƺƈŝƹŢſřƎſƺŤƯ

ƹŹ ƽ ƕƺƟŶƯ ƿ ƯơŚƠţřŢƫřƺţƩŚưŤſŵŚ ƾ

ŶŤƟř æ ŝ ǀ ŻřŢſřƲĪưƯƱřŹŚư ƿ

ŶƃƩŚƳōƮſŚĜſřĨ ƿ

ƶºĩħŚºƳŵŹŵƹŶ

ŶƴģŚţ ƿ ŻřŶƘŝŢƗŚſƲ ƿ

ƯƩƺƏƶŝƵŵƹŹŢĩźůĨ ƾ

ƳŶƯŚŬƳř ǀ ŚĪƃż ƿ ŶƴƴĩŢ ç

ƯŚţƱřƺūƱLJŚƀĭŹżŝŹŵŶƘƤƯơŚƤƃ ǀ

ƀƳŚ ĮƬƯŚºůƭƺſƶƷŚƯƶſŹŵŜƬƛřƹƩŚ ƾ

ƵŹƹŵƹ

post partum

ƯơŚƠţř ƾ ŶŤƟř æ

ŚƘƯŹŵ ƿ Ɵƶƴ ǀż ƿĪ ƾ ƯřŹơŚƤƃľŚŞƫŚƛ ƾ

LjƯƱŵźĩřŶūŚŝƱřƺţ ƿ

źſƮ ƿ ŵƺưƳƵŶƷŚƄƯƭŹŵƺƳōŹŵŚƷƲ

ľLJƺưƘƯ

Ŷůƶŝ ƽ ſŚƀů ǀ ŚƘƯƪưŰţƶĩŶƳŹřŵŢ ƿ

ŤƄĮƳřƶƴ ƾ

ěƺĪſƺƳōƭƺŤĩŹ ƾ

ƿ ěƺĪſƺţƹźěŚ ƾ

ŶƳŹřŶƳřŹ

ŵŚůơŚƤƃ ºƿ

Ĩ

ĭŹŚě ƾ ŰƐſ ƾ ŵƭŹŵƺƳōŹŵ ƿ

ƯƩŚŤƀ ƾ źƤţƹŶƃŚŝ ƿ

ưƷľŚŞ ǀ ºŞƏšŚƯřŶºƣřŚºŝƶºƄ ƾ

ºƯŵƺºŞƸŝ ƾ

ƿ ŶºŝŚ ŚºƷơŚƤºƃ ƽ

ƃŚůƹƮųŻƲƯżƯ ǀ

ŚƷƶ ƽ ŚƷƶŤƃŹƵřźưƷƶŝƵŶƯōźŝ ƽ

Ơſ ǀ ƬųřŵźŤĮƴƠſřŶ ƾ

ƮºųŻƵŶºƗŚƣŹŵƵŶƷŚƄƯƪŝŚƣƩŚƳō

řƿ ƯŵŚŬ ƾ ŚưƳ ƿ Ŷƴ ľŚŞƫŚƛ ƿ ŤſƺěƵŶŗřŻĨ ƾ

(skin tag)

ūŹŚų ƾ ƹ ƿ Ś ƿ ěŚěĨ ǀ Lj ƽ ƷƩŚºƳō ǀ ºƟƹźţźĜ ƾ ƪºųřŵŹŵƵŶºƃ

ŵŹřŵŵƺūƹ

řƱŚƯŹŵ ƿ ůřźūƶŝŢſřƲĪưƯƹŢſřźţŹřƺƃŵơŚƤƃƲ ƾ

Ƴǀ ŶƃŚŝŻŚ ç

ƿ ƘƣƺƯŹŵƶĩƲƯżƯŶƘƤƯơŚƤƃĨ ǀ

ŞƳŚūŢ ƾ ŝźŝƩřŵŢſřƲĪưƯŢſřƶŤƟźĭŹřźƣ ǀ

ŹŚư ƽ ƯŻ ǀ řƶºƴ ƽ Żř

Şƣǀ ŝƪ ǀ ŹŚư ƽ ƹƱƹźĩ ƿ řƆƤƳŽƹź ƿ

ƴư ƾ ƳŚƀƳř ƾ ſ

ǀ ƬƠ ǀ ƪſž ƿ

ưĩƺƫŚ ƾ ŶƃŚŝ ƇŹŵ ţŹƺ ƾ ŴƄţƶĩ ǀ ħƺĪƄƯƆ

ŶƃŚŝ ƿ Ś ƿ ŤƬƗŵƺūƹƶŝĨƃĨ ƾ

ŵ ƿ řźŝźĮ ƽ źěŵŹŵ ƽ ŞƣŻřƩŚƳō ǀ

ƶƀŝōƪ ƿ

ƟŚ ǀ ƲĪưƯŶºƃŚŝƶŤºƃřŵŵƺºūƹƩƺŤºƀ

ŚƘƯƶŝŢſř ƿ

Żƶƴ ƿ ŝź ǀ ƃƺƸ ƾ Ƴǀ ŶƃŚŝŻŚ ç

ººſƖººƐƣźººŝƱŚººƯŹŵ ǀ

řƹƮººſŚĜſřŵŹŵƪĪ ƿ

ưĪººƀ ƾ řƩƺŘººƀƯƶººĩ ƿ

ŹƺººƈţŶººƘƤƯŹŵơŚƤººƃŵŚººŬ

Ư ƾ ƯżĩźưŤƯŵƺƃ ƾ

ŶƃŚŝ ƱŚƯŹŵ ŹƺƔƴƯƶŝƩƹřƎų ƽŚƷƵŶƴƴĩƭźƳřŻƮŬůƪƯřƺƗƪƯŚƃŶƘƤƯƶŝŚƯźţƂƷŚĩ

ŶƃŚŝƾƯƭźĭśōƲĮƫŹŵƲŤƀƄƳƹƕƺƟŶƯ

ƲǀŗŚĩƹŶǀƫƩĥƱŵƹżƟř ç

ƭźºĩźƿŚſŚƿ ƾºƯƲĪºƀƯƽŚºƷ

ƸŝƾŤƯLjƗƱŚƯŹŵŶƳřƺţ ŶƿŚưƳŵŚŬƿřƽźŤ

ƳŵŚưěŻř ǀ

ƬĭƹźŤ ǀ źƀ ƿ Ʋ ç ƘƋƺƯŹƺƏƶŝ ƾ

źūŵƺºŞƸŝŢºƸū ºƿ

ƱƺºųƱŚ

ƵŶƃƵŵŚƠŤſř

ƫƹŢſř ƾ ŶƃŵŹŵźſľŚŞƫŚƛ ƿŶ

ƽ řƿ ƯŵŚŬ ƾ ŚưƳ ƿŶ ŚºƷƵŶºƴƴĩħƺºƬŝŻř ƽ

ºƀƬĩƩŚºƳŚĩ ǀ

Ʈ Ƴǀ ŶºƠ ƿĜǀ ƹƲ

ŵƿ ŤƬǀ ƭŻŚ ĩřŹƺų ƾ ƘƋƺƯƹ ƾ Ƴǀ ƄŴŝŵƺŞƸŝŹƺƔƴƯƶŝż ǀ

ŢºſřƲºĪưƯƹŢºſřƵŶºƃƵŵŚƠŤºſřŚºƷơŚƤºƃƶŝƱŶ

ŞƳŚūƉŹřƺƗ ƾ

źŤưĩ ƽ ƳƶŝŢŞƀƳ ǀ

ŚƷšřźŤ ƽ

ƘƋƺƯ ƾ ŶƴƃŚŝƶŤƃřŵ

ŚƷƹŹřŵŻř ƽ

Ŷū ºƿ ŞƣŻřźţŶ ºǀ

Źōƪ ºƳĥ ǀ Ʋ ŚºƷŹ

ƳƵŶƴƴĩ ǀ źŤ ƿ ƀĩřĨ ǀ Ŷ ƘƋƺƯƩƺĪƳŚŤŝƹ ƾ

ƿ ƳƺĭŚŤƳōĨ ǀ

ŹŚĪſƺƯŢƀ ƿƴ

ƾ Ƴǀ řźŝż ƽ ƵŶºƃƵŵŚƠŤºſřơŚƤºƃƱŚºƯŹŵ

Ţſř ŞƏƱŚƯŹŵ ƾ

ƫƹŢſřźŧƺƯŵŚůơŚƤƃŵŹřƺƯźŨĩřŹŵ ƾ

ŵƹŶůŚƸƴţ ëå

êå ŚƷơŚƤƃŶƇŹŵ ƽ

ŵƺŞƸŝřŹƲƯżƯ

Ư ƾ ŶƄŴŝ ƫƺţƺŝƮſ ǀƴǀ

ĭƺƬūŚŝƮ ǀź

ƽ ŻŚſŵřŻōŻř ƽ

Ťſř ǀ ƫƺĩƪ ǀ ěŻřƲ Śƿ ŚƷƶƳŚ ƽ ŞƈƗ ƾ ºě ǀ ſƂ ǀ ºƀěŚƴ ƾ

ƿ ŪºƬƟĨ

ƳLjƌƗ ƾ ŤƣƺƯ ƾ řƿ ƯŵŚŬ ƾ Ŷƴĩ Źżţ ƿ ƫƺţƺŝƮſƢ ǀƴǀ

Ʈ ŚūƱřƺƴƗƶŝ ƿ

żĮ ƿƴ ƾ řźŝ ƽ ƯƺţƹźŤĮƴƠſř ƾ

ºůřźū ƾ ƱŚºƯŹŵŹŵ

ěƲƯżƯơŚƤƃ ǀ

ŢſřƵŶƃŵŚƸƴƄ

ůřźūƱŚƯŹŵƶŝ ƾ

řźŝ ƽ ŚƷơŚƤƃƱŚƯŹŵ ƽ

ƴƯżƯ ƾ ŞƏƱŚƯŹŵƶŝƶĩ ƾ

ƵŵřŶºƳŲºſŚě

ƇƺţŶƳř ǀ řźŝƹŢſřƵŶƃƶ ƽ

źūźŨĩř ƯƺţƹźŤĮƴƠſřƱŚůř ƾ

Ƭųřŵ ƾ ŞƳŚū ƾ ŝŚŴŤƳřƭřŶƣř ƾ

ŶƃŚŝƾƯ

ŻřƝŶºƷ

ƶƬƌƗŻřƾŤưƀƣƁźŝƢƿźƏŻřƾƬųřŵźŤĮƴƠſřƮſŚĜſřƂƷŚĩƭřŶƣřƲƿř

ŶƃŚŝƾƯ

ŹŵŵƺƗ æå

ƱřŹŚºưǀŝ

ƽŹŚǀŤųřƾŝźƐųƹŵƺƃƾƯŵŚŬƿř

ŻŚĭƶŝľLJƺưƘƯ

Żř æê ê ŶƃŚŝƾƯźǀƜŤƯ

ç

Mebeverine hydrochloride(Colofac) ƿ

ƭƹŹŶƴºſŹŵƵŵźŤºƀĭƵŵŚƠŤºſřŚŝƹŹřŵĨ

źŰţƵŵƹŹ ƿ

ŸěĨ ƿź

(IBS)

Ţſř ææ

ƪƯŚºƃƱōƱŚưŤųŚºſ

4-[ethyl-[2-(4-methoxyphenyl)-1-methylethyl] aminobutyl veratrate

hydrochloride

ƴƟŻřƵŶƃƢŤƄƯ

ǀ ƪ ţř ǀ Ưōƪ ǀ Ʋ Ţſř æç

řƿ ƹŹřŵƲ ƪĪƃƶſƶŝ

suspension(10mg/ml)



ƽŶºƴƣƂƃƺěŚŝƅźƣ

(100mg,135mg)

ƩƺºƀĜĩƹ

modified release

(200mg)

ŢſřŵƺūƺƯ

ææ

ĥƺƫƺĩŚƯŹŚƟ ƽ

Mebeverine ƿ

ƛƵŶƴƴĩƪƃźŧřĨ ǀ

ƇŚƈŤųřź ƾ

ƤŤƀƯ ǀ ƹŹƮ ƽ ŵƹŜƬƣơƹźƗ ƿ

ƷŚƯźĮ ǀ ŚƷƶĤ ƽ ƝŚƇ

ŵŹřŵ ŤƳōźŧřƶĩŵřŵƱŚƄƳšŚƘƫŚƐƯ ƾ

ŵƺưſŚĜſř ƿ

řĨ ƿ ſƅƺƈŴƯƹŹřŵƲ ǀ

ƇŚųƮŤƀ ƾ

ưƳƱŶŝŻř ƾ

ƶſŚŝƹŶƃŚŝ

ƳŚĪƯ ǀ ŻƮƀ ƿ ƯƪưƗź ƾ

Ŷƴĩ

ƺƘţ  ƿ Ɗ ƿ ƀƬĩƱƺ ǀ ƤŤƀƯźŧřŚŝŚƷŚƄƛƭŚĪŰŤſřƹƮ ǀ

ƷŚƯźŝƮ ǀ

ŚƷƶĤ

řŹřŵ  ƽ ƇŚų ǀ ŤŝŚƣŹŢ ƾ ŤƳō ƾ ŹŚĪſƺƯ ƿƴ ƾ ŵƹŶůŹŵ æ

å åê å ěƹźţōźŝřźŝ ǀ

Ʋ

řŹřŵ  ƽ ƇŚų ǀ ŝŢ ƾ ƀů ƾ ƘƋƺƯ ƾ ƀƳŚŤěŚŝ ǀ ţŚĜưſŹŚƸƯƪ ǀ

ŹŵƱŵźĩŹŚƸƯŢƬƗƶŝĨ ƿ

ƫŚºƳŹŵōŹƺƳŢºƟŚ ǀ

Ʋ

ŚěŹŵ ƿƳŚ ŚƷƶ ƽ ţŚĜưſŜƈƗ ǀ

Ĩ

šŚººƘƫŚƐƯŹŵ

in vitro

ŶººƃƵŵřŵƱŚººƄƳ

Mebeverine

řŹřŵ ƽ źººŧř ƽ ººŤƳō ƾ ŵƺưººſŚĜſř ƿ

޺ºƃĨ ǀ

ƶ

ŹƹŚěŚě ƿ Ʋ

(Papaverine)

ƹŹ

ƽ řƿ ĩƹƮůŹƭƺŘƬ ǀ

řŹřŵƹŢſřřźƠƇƶƀ ƽ

ƿ ƫŚƘƟĨ ǀ ƺºƣŢ ƽ ºŝ ƾ ºƀů ƾ ƘºƋƺƯ ƾ

Ţſř æç ŚƯŻōŹŵ ƿ šŚƄ

in vivo

ŚºƷƶƳƺĭźŝ ƽ

ŵƞºƬŤŴƯ ºƿ

šŹŶºƣŶºƃƵŶ

Mebeverine

ê è ŝźºŝřźŝ ǀ ŻřźŤºƄ

ŹƹŚěŚě ƿ źŤĮƴƠſřƮſŚĜſřƱŵźĩƝźƏźŝŹŵƹŢſřƝŚƇšLjƌƗƮſŚĜſřŹŚƸƯŹŵƲ Oddi

Źŵ

Rabbit

ƂƤƳŚƷ

ŵŹřŵ ƴĤưƷ ǀ ŶƃƆŴƄƯƲ

Mebeverine

ĩŶƳřšřźŧř ƾ

źěźºŝ ƿ ŤƫŚŤºƀ ǀ ŞƏž ǀ ºƘ ƾ ºƫƹŵŹřŵƵŵƹŹ ƾ

ºŤƳōšřźºŧř ƾ

ŵƺưſŚĜſř ƿ

řƵŵƹŹšŚĩźůƱŶƃŚƤƫřŚŝƱōĨ ƽ

řżƟřƹ ƿ Ƃ ƯƕƹźƃšŚĩźů ƾ

ŵƺƃ šřźºŧřŶƃƶŤƠĭƶĩŹƺƐƳŚưƷ

ŤƳō ƾ ŵƺưſŚĜſř ƿ

ŚƸŤưƀƣƶưƷźŝƱōĨ ƽ

ƫƹŢſřƁŹřƺĭƵŚĮŤſŵ ƾ

ųźŝŹŵ ƾ ŚƯŻō ƿ ƶĩŶƃƆŴƄƯšŚƄ šřźŧř

ƷŚƯźŝƱō ǀ

ŝƱƺƫƺĩƝŚƇƶĤ ǀ

ŢſřźŤƄ

æç

ƅźƣźŝƶƘƫŚƐƯ

æååmg Mebeverine

řƶĩŵřŵƱŚƄƳ ƿ

ŤƳōšřźŧřƹŹřŵƲ ƾ

ƫƺĩ ǀ ĥźƴ ƿ żĩźƯĨ ƽ

ƹŵŹřŶºƳ

ŰƯšřźŧř ǀ

Ɛ ƾ ŻřźŤưĩƱō ååæ

å ěƹźţōŻřźŝřźŝ ǀ

ŢſřƲ ƴĤưƷ ǀ żĩźƯšřźŧřƲ ƽ

ŵŹŵŶƋ ƿ

Ś

depressant

ŵŹřŶºƳ

ŚƷŻƹŵŹŵƎƤƟƹ ƽ

źŰţšřźŧřLJŚŝ ƿ

żĩźƯĨ ƽ

ŵŹřŵ ř ƿ ƬĮƳŚĭŹŚƸƯŜūƺƯƹŹřŵƲ ǀ

ŚºƷƱƺ ºƿ ƩŚºƤŤƳřŹŵƪųřŶºţŚ

ƷŚƯ ǀ řƶĤ ƽ ŞƈƗ ƾ ưƳ ƾ ŵƺƃ Źżţ ƿ ŹƹƪųřŵƢ ƿŶ

ƽ řƿ ůŹŵƹŹřŵƲ ǀ

řŜºūƺƯšŚºƳřƺ ƿ

ŹōŵŚºŬ ƿ

ºưŤ ƾ ŞƬƣ ƾ ŵřźºŝ

ƽ

ŵŹŚĩ ƽ Ɯţƹ ǀǀ šřź ECG

Ư ƾ ŵƺƃ æç

ĩƺĩŚƯŹŚƟ ǀŤƴ

ǀ Ĩ

ƯźŨĩřŶů ǀ

ŻřŶƘŝƹŹřŵƱřż è

æ řƝźƈƯŻřŢƗŚſ ƿ

ƯŵŚŬ ƾ ŵƹŶůƹŵƺƃ ìê

ƯƺŞƫōŚŝƱō ǀ

ŶƳŚŝƭźſƲ

Ư ƾ ŵƺƃ źŤĭŹżŝ ƿ ƫƺŝŚŤƯŮƃźţƵřŹƲ ǀ

ŚƷŢ ƽ

Mebeverine

źƏŻř ºƿ ŹřŹŵřƢ îê ºƯ ƾ ºƏľLJƺºưƘƯƹŶºƃŚŝ ƾ

ç

ƯűŹŢƗŚſ ƾ

ŶƷŵ æç

ŶƳř ƿ ſŚĪ ǀ ŚƸƳƺ ƽ ƝźƈƯ

Mebeverine

ƱŚººƯŹŵŹŵ IBS

źŰţƱƺººƫƺĩ ººƿ

ŸººěĨ ƿ ŤººſŚĜſřƱƺƫƺĩź ǀ

ŝĨ ǀ ŹŚư ƽ ŚººƷ ƽ ŵźººĪƬưƗ ƽ

ƵŵƹŹ ƿ ŤſŚĜſřŢººſƺŞ ǀ

޺ºƈƗƩŚƸººſřĨ ƾ

ŶƳř ƿ ººſŚĪ ǀ ĚººƯřźĩƹŵŹŵƶººƬưūŻřƱōƮººŗLjƗƱŚººƯŹŵŹŵƹŵŹřŵƱƺ

ưĪƃ ƾ ƩŚƸſř

Śŝ ƿ ŚƷƵŹƹŵƱƹŶŝŚ ƽ

ƿ ŢſƺŞ ưĪƃŲƠƳƹ ƾ

ŧŚţ ǀ ŵŹřŵź

ŶƳřźŤƴĩ ƿ

ſŚĪ ǀ Ʊƺ

ſŚƀů  ǀ ĪƄţŌřżūřƶŝŢ ǀ

ƱōƵŶƴƷŵƪ

ŻŵŹřƺƯŹŵƱōƝźƈƯ  ƿ

Śŝź ƿ ŤůřŚŝŶ ǀ ŶƃŚŝƍŚ ŵ

ƿ Źž ƿ ưŤ ƾ ŚƷ ƽ ŞƬƣ ƾ ƺŝ ƿ ŝŹŵƵĦ ǀ ħLjŝŚŝƱřŹŚư

ƬƷŵ ǀż ƽ ƴƐŝ ƾ ŞƀƳ ƾ ƿ ƹƪƯŚĩŚ ƿ

ŝŚ ǀ ŹŚư ƽ řƿ ưĪƀ ǀ ŞƬƣĨ ƾ Ŷƃ ƿ Ŷ ƿ ĦƳōŚ ƿ ŚƷƲ ŶºŞĩšLJLjŤųř ƽ

ŝƶƬưūŻř ǀ

ŝŚŝƱřŹŚư ǀ

ŹŚư ƽ ŚƷ ƽ ŶŞĩ ƽ ěǀ ſƪŨƯƶŤƟźƄ ǀ

Żƹź ƫƺŝŚŤƯƵřŹ ǀ

ƹŹřŵƮƀ

ŝ ǀ ŹŚư ƽ ŚƷ ƽ

Ƭĩ ǀƺ ƽ ěǀ ƶŤƟźƄ ƹŹřŵŮƃźţƵřŹ

ŝ ǀ ŝŻƺŤĩLJƪưŰţƭŶƗŚŝƱřŹŚư ǀ

ŧŹřšLjĪƄƯŚŝƱřŹŚư ƾ

ƭŶºƗ

ŻƺŤĩLJŚĭƪưŰţ ƿ

żĩƺºƬĭśŸºūŌƺſŚ B

ŻƺºŤĩLJƂºƃƺěŵƺºūƹŢºƬƘŝŻƺŤĩLJŚºĭ ƽ

ƅźºƣ

ŚººƷ íåmg ƅźººƣźººƷ

ŝ ǀ ººŧŹřšLjĪººƄƯŚººŝƱřŹŚººư ƾ

śŸººūŌƺººſŻƺŤĩƹźƟƪººưŰţƭŶººƗ

ƺƬĭ ĩ ż B ŻƺŤĩLJŚĭ ƿ

ŻƹŹŚĩŚſŚ B

ŚƷƅźƣƂƃƺěŹŵŻƹŹŚĩŚſŵƺūƹŢƬƘŝŻŚŤƫŚƯ

æç

ŹřŵŹŚŝŹŵƵŵŚƠŤſř ƽ

Ƶƹźĭ B6

ƠƴƯźŧř ƾ ºƴūŶƃŹźŝ ǀ

ŵƲ ºƿ ºƫƹƵŶºƄƳƵŶ ƾ

ƱōƝźºƈƯ ºƇƺţƩƹřƶºƷŚƯƶºſƩƺºƏŹŵ

ǀ ƶ ºưƳ ƾ

ŵƺƃ Ƴĥƺţřźţšřźŧř ƾ

ĥƺƫƺţřźţšŚƘƫŚƐƯŹŵ ƽ

Źŵ Rat

ƹŚƷ

Rabbit

ŵŚƷ ƿ ŢſřƵŶƄƳƵŶ

æç

ƝźƈƯ

ƃƩƺƏŹŵ ǀ

Ʒŵź ƾ

Mebeverine

ººƃŹŵ ǀ ººƯŮººƃźţź ƾ

ŵƺººƃ ŻřźººŤưĩ

mcg/ml

æå ĩřŹƺººųƝźººƈƯŹŵ ƾ

æååmg

Mebeverine hydrochloride

ĩŹŶƯŶƴģźƷ ƾ

ŧŚţźŝ ǀ ƠƴƯź ƾ ƳŽźŤſŵŹŵŵřŻƺƳźŝƱō ǀ

ƫƹŢƀ ƾ ƩŚºůźºƷƶŝ

ƠƴƯƹŢŞŨƯšřźŧřŢſřźŤƸŝ ƾ

ůŹŵƱō ǀ

ƃƲ ǀ Ʒŵź ƾ ŵƺƃƶŤƟźĭźƔƳŹŵ

æç

ƹŹřŵƉŹřƺƗ

ƋŹřƺƗ ƾ ƫŚŝšŚƘƫŚƐƯŹŵƶĩ ǀƴ

ƾ ŵ ƿ ĭźſƪƯŚƃƵŶƃƵŶ ǀ

ƶưƋŚƷŌƺſƩŵźſƁŻƺſƶŬ

ŝ ƾ ŝřƺų ƾ ŝ

ƾ

ŚƸŤƃř ƾƿ

ƊŞƳŵřŶƘţƂƷŚĩŵŹŵźſ

ƿ ƯƺưƗƞƘƋƹŢſƺŞ ƾ

ųŵŹřƺƯŹŵ ǀƬ

ƾ ŚƷƂƴĩřƹŹŵŚƳ ƽ

ĥźƫō ƿ ƸĩƶƬưūŻřŢſřƵŶƃƁŹřżĭĨ ǀ

ĦƳōź ƿ ƮŤƳřżĭřƹƭŵřƺ

æç

ƝźƈƯŹřŶƤƯ

ƠŤſřŵŹƺƯƱLJŚƀĭŹżŝŻƹŵ ŹŵƵŵŚ

IBS

ƅźƣ æèêmg

ƪºŞƣŻƹŹŹŵŹŚºŝƶſ ºƿ

ºůŚ ǀ řŸºƛƲ ºƿ

ƩƺºƀĜĩŚ

çååmg

ƯŻƹŹŹŵŹŚŝƹŵ ƾ

řƹƝźƈƯƶŤƠƷŶƴģŻřŶƘŝƶĩŶƃŚŝ ƿ

ŧŚţŵŚŬ ǀ ŹŶºţƶŝŻƹŵŢſřƲĪưƯƭŻLJšřź ƿ

Ū

ŵƺƃƵŵřŵƂƷŚĩ

æç

ƹŹřŵƵŻřŶƳřŻřƂǀŝƝźƈƯ

ŵƹŹřŵƵŻřŶƳřŻřƂǀŝƝźƈƯŻřƾţŚƗLjƏř ŢƀǀƳŽźŤſŵŹŵƱŚƀƳřŹ

ŘţƑŚŰƫŻř ŹŵŢºſřƲĪưƯƽŹƺ

ĨƿźŰţŜūƺƯŵŚƿŻƽŚƷŻƹŵ CNS

ŵƺƃ ºƷƱŚºƯŹŵƾºƫƹŵŹřŶºƳŵƺūƹLJŚŝƽŚƷŻƹŵƱŚƯŹŵŢƸūƾţŚƗLjƏř ƽŚ

ƙřźƠŤſřŌŚƤƫřƪƯŚƃƶǀƫƹř

ŵŚƸƴƄǀěƾŤƿŚưůƽŚƷƱŚƯŹŵƹƵŶƘƯƽƺƄŤƀƃ

ŵƺƃƾƯ

æç

è ƋźƟƹƝřŶƷř ǀ

šŚ

ƬƇřƝřŶƷř ƾ

ŭźƏ

ſŹźŝ ƾ ŧŚţ ǀ ź

Colofac

Źŵ ŹŵŵŚůŶƘƤƯơŚƤƃƱŚƯŹŵ ŝǀ

ƪƌƠƫřƺŝřƵŚĮƳŚƯŹŵƶŝƵŶƴƴĩƶƘūřźƯƱřŹŚư

ƏźƸƃƺŝ ƾ

ƈŰţƩŚſ ǀƬ

ƾ íî æèíí

ƗźƟƝřŶƷř ƾ

ŭźƏ

æ ƾƯƺưƗƾůřźūƵŚĮƳŚƯŹŵƶŝƵŶƴƴĩƶƘūřźƯƱřŹŚưǀŝŹŵŵŚůŶƘƤƯơŚƤƃƾƳřƹřźƟƲǀǀƘţ

ç ƲǀǀƘţ ŹŚưǀŝŹŵźĩŸƯŵřźƟřƶŝŢŞƀƳŦƳƺƯŵřźƟřŹŵŵŚůŶƘƤƯơŚƤƃƾƳřƹřźƟ ƶŝƵŶƴƴĩƶƘūřźƯƱř

ƾƯƺưƗƾůřźūƵŚĮƳŚƯŹŵ

ŵźŝŹŚĩƝřŶƷř ƽ

ŭźƏ

æ ĭƺƬū ǀź ƽ ŶŞţŻř ƿ ŤƳŹŵƹƲƯżƯơŚƤƃƶŝŵŚůơŚƤƃƪ ǀ

żƷƂƷŚĩƶŬ ƿ

ŚƷƶƴ ƽ źŤƀŝ ƽ ƱŚƯŹŵƹ

ŝǀ ƱřŹŚư

ç ƃŚƳƉŹřƺƗŻřƂƷŚĩ ƾ

ƲƯżƯŶƘƤƯơŚƤƃƱŚƯŹŵŻř