ﺪﻧﺩ ﻡﻮﻠﻋ ﺭﺩ ﻖﻴﻘﺤﺗ ﻪﻠﺠﻣ ﻩﺭﻭﺩ /ﻲﻜﺷﺰﭙﻧﺍ
ﻢﻫﺩﺯﺎﻳ ﻩﺭﺎﻤﺷ / ﻝﻭﺍ / ﺭﺎﻬﺑ 1393 ﻲﭘﺎﻴﭘ / 39
7
:ﺕﺎﺒﺗﺎﻜﻣ ﻝﻮﺌﺴﻣ ﻩﺪﻨﺴﻳﻮﻧ# ﺮﺘﻛﺩ
ﻠﻋ ﻲ ﻠﺳﺮﻣ ﻲ ﺮﻫﺍ ﻱ ، ﻥﺎﻬﻔﺻﺍ - ﻧﺍﻮﻏﺭﺍ ﻴﻪ - ﻣﻼﺳﺍ ﺩﺍﺯﺁ ﻩﺎﮕﺸﻧﺍﺩ ﻲ
ﻩﺪﻜﺸﻧﺍﺩ– ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﺼﺼﺨﺗ ﺶﺨﺑ ﻲ ﺘﻧﺍﺩﻭﺪﻧﺍ ﻴ ﺲﻜ :ﻦﻔﻠﺗ 09143139198
:ﻚﻴﻧﻭﺮﺘﻜﻟﺍ ﺖﺴﭘ [email protected]
ﺘﻧﺁ ﺮﺛﺍ ﻪﺴﻳﺎﻘﻣ ﻲ
ﻝﺎﻳﺮﺘﻛﺎﺑ ﺮﺗ ،ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ﺐﻴﻛﺮﺗ ،ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ
ﻱ ﺘﻧﺁ ﻲ ﻭ ﻚﻴﺗﻮﻴﺑ
ﻭﺭ ﺮﺑ ﺪﻳﺎﺴﻛﻭﺭﺪﻴﻫ ﻢﻴﺴﻠﻛ ﻱ
ﻧﻮﺧﺭﺎﮔﺁ ﻂﻴﺤﻣ ﺭﺩ ﺲﻴﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻢﻠﻴﻓﻮﻴﺑ ﻲ
ﺮﺘﻛﺩ ﻠﻋ ﻲ ﻠﺳﺮﻣ ﻲ ﺮﻫﺍ ﻱ
P
1#
P ﺮﺘﻛﺩ ﺒﺧ ﺩﻮﻌﺴﻣ ﻴ
ﺮ ﻱ
P
2
P ﺮﺘﻛﺩ ﺭﻮﭘ ﺙﺭﻮﻤﻬﻃ ﻭﺯﺭﺁ
P
3
P ﺮﺘﻛﺩ ﺮﻣ ﻳ ﻢ ﻣﺮﻬﺟ ﻉﺭﺍﺯ ﻲ
P
2
1 - ﺩ ﺘﺳ ﻴ ﺭﺎ ﺼﺼﺨﺗ ﻩﻭﺮﮔ ﻲ ﺘﻧﺍﺩﻭﺪﻧﺍ ﻴ ﺲﻜ ﻥﺎﻬﻔﺻﺍ ،ﻥﺎﮕﺳﺍﺭﻮﺧ ﻲﻣﻼﺳﺍ ﺩﺍﺯﺁ ﻩﺎﮕﺸﻧﺍﺩ ،ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻩﺪﻜﺸﻧﺍﺩ
2 - ﺩﺎﺘﺳﺍ ﻳ ﺭﺎ ﻩﻭﺮﮔ ﺘﻧﺍﺩﻭﺪﻧﺍ ﻴ ﺲﻜ ﻥﺎﻬﻔﺻﺍ ،ﻥﺎﮕﺳﺍﺭﻮﺧ ﻲﻣﻼﺳﺍ ﺩﺍﺯﺁ ﻩﺎﮕﺸﻧﺍﺩ ،ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻩﺪﻜﺸﻧﺍﺩ
3 - ﺩﺎﺘﺳﺍ ﻳ ﺭﺎ ﻣ ﻴ ﺑﻭﺮﻜ ﻴ ژﻮﻟﻮ ﻱ ﻣﻼﺳﺍ ﺩﺍﺯﺁ ﻩﺎﮕﺸﻧﺍﺩ ﻲ
ﻥﺎﮕﺳﺍﺭﻮﺧ
،ﻥﺎﻬﻔﺻﺍ ﻩﺪﻜﺸﻧﺍﺩ ﻱﺭﺎﺘﺳﺮﭘ
ﻪﺻﻼﺧ : :ﻑﺪﻫ ﻭ ﻪﻘﺑﺎﺳ
ﻌﺗ ﻑﺪﻫ ﺎﺑ ﻪﻌﻟﺎﻄﻣ ﻴﻴ
ﻦ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ
،ﻢ ﻛﺮﺗ ﻴ ﺐ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ
ﻳ ﺴ ﻴ
،ﻦ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻭ
ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻭﺭ ﺮﺑ ﻱ ﺑﻴ ﻓﻮ ﻴ ﻢﻠ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ .ﺪﺷ ﻡﺎﺠﻧﺍ
ﺩﺍﻮﻣ ﻭ ﺵﻭﺭ :ﺎﻫ ﺍ ﺭﺩ ﻳ ﻦ ﺑﺮﺠﺗ ﻪﻌﻟﺎﻄﻣ ﻲ
- ﺎﻣﺯﺁ ﻳ ﻫﺎﮕﺸ ﻲ
، ﺴﻧﺎﭙﺳﻮﺳ ﻴ ﻥﻮ ﺮﺘﻛﺎﺑ ﻳﺎ ﻲﻳ ﻭﺮﺘﻧﺍ ﻟﺎﻜﻓ ﻙﻮﻛ ﻴ
ﺲ ﺤﻣ ﺭﺩ ﻴ ﻂ ﻧﻮﺧ ﺭﺎﮔﺁ ﻲ
، ﻭﺭ ﻱ 56 ﺩ ﻳ ﻚﺴ
ﺮﺘﺳﺍ ﻳ ﻞ ﻭﺭ ﻱ ﺩ .ﺖﻓﺮﮔ ﺭﺍﺮﻗ ﺭﺎﮔﺁ ﺢﻄﺳ ﻳ
ﻚﺴ ﺎﻫ ﺭﺩ 7 ﺖﺸﻫ ﻩﻭﺮﮔ ﻲﻳﺎﺗ
ﺕﺪﻣ ﻪﺑ ﻳ ﻚ ﺩ ﺮﺑﺍﺮﺑ ﺭﺩ ﺖﻋﺎﺳ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ
،ﻢ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ
،ﻦ ﺮﺗ ﻱ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ
،ﻚ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ - ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ
،ﻦ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻐﺗ ﻴﻴ ﺮ ﻳ ﻪﺘﻓﺎ
، ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺎﻣﺮﻧ ﻭ ﻦﻴﻟﺎﺳ ﻝ ﺽﺮﻌﻣ ﺭﺩ
ﺭﺍﺮﻗ
ﺪﻨﺘﻓﺮﮔ ﺍ ﺯﺍ ﺪﻌﺑ . ﻳ
ﻦ ﻟﺎﻌﻓ ،ﺕﺪﻣ ﻴ
ﺖ ﻣﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﺮﻃ ﺯﺍ ﺎﻫﻭﺭﺍﺩ ﻳ
ﻖ ﻮﺸﺘﺴﺷ ﻱ ﺩ ﻳ ﻚﺴ ﺎﻫ ﻟﺎﺳ ﺭﺩ ﺭﺎﺑ ﺞﻨﭘ ﺩﺍﺪﻌﺗ ﻪﺑ ﻴ
ﻦ ﻭ ﻩﺪﺷ ﻊﻄﻗ ﺭﺍﺩﺮﻓﺎﺑ
ﺎﻫﺪﺣﺍﻭ ﻱ ﻜﺸﺗ ﻴ ﻞ ﻧﻮﻠﻛ ﺓﺪﻨﻫﺩ ﻲ
) CFU ﺮﺘﻛﺎﺑ( ﻱ ﺎﻫ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻗﺎﺑ ﻴ ﻩﺪﻧﺎﻤ ﺩ ﺭﺩ ﻳ ﻚﺴ ﺎﻫ ﺩﺮﮔ ﺵﺭﺎﻤﺷ ﻳﺪ
ﻩﻭﺮﮔ ﺭﺩ ﻭ ﺎﻫ
ﻱ ﺎﺑ ﻒﻠﺘﺨﻣ
ﻥﻮﻣﺯﺁ ﺎﻫ ﻱ kruskal wallis ﻭ
Mann-U-Whitney
ﺰﺠﺗ ﻳﻪ ﻠﺤﺗ ﻭ ﻴ ﻞ .ﺪﺷ
ﻳ ﻪﺘﻓﺎ :ﺎﻫ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻳ
ﺴ ﻴ
،ﻦ ﻠﻛ ﻴ ﺔ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺑ ﺯﺍ ﺍﺭ ﻴ ﻦ ﺮﺗ ؛ﺎﻬﻧﺁ ﺯﺍ ﺪﻌﺑ ﻭ ﻩﺩﺮﺑ ﻱ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻐﺗ ﻴﻴ ﺮ ﻳ
؛ﻪﺘﻓﺎ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ
؛ﻦ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺴﻠﻛ ﻭ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺑﻴ ﺸ ﺮﺘ ﻳ ﻦ ﺎﻧﺍﻮﺗ ﻲﻳ ﺮﺘﻛﺎﺑ ﻱ ﺸﻛ ﻲ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﺍﺭ ﻭ
ﺎﻬﻧﺁ ﻦﻴﺑ
ﻲﻨﻌﻣ ﺕﻭﺎﻔﺗ .ﺪﺷ ﻩﺪﻳﺩ ﻱﺭﺍﺩ
) 004 /0 p<
( ﺎﺟ ﻳ ﺰﮕ ﻳﻨ ﻲ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺎﻣ ﺎﺑ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﻛﺮﺗ ﺭﺩ ﻴ ﺐ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺶﻫﺎﻛ ﺐﺟﻮﻣ
ﻲﻨﻌﻣ ﻱﺭﺍﺩ ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺩﺮﮔ ﻭﺭﺍﺩ ﻳﺪ . ) 002 /0 P<
(
ﺘﻧ ﻴ ﻪﺠ ﮔ ﻴ ﺮ ﻱ : ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺘﻧﺁ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﻭﺭﺍﺩ ﻱ ﻬﺘﻟﺍﺪﺿ ﺑﺎ ﻲ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺎﻘﻣ ﺭﺩ ﻳ ﻪﺴ ﺴﻠﻛ ﺎﺑ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻠﻋﺮﺑ ﻴ ﻪ ﺑﻴ ﻓﻮ ﻴ ﻢﻠ ﻙﻮﻛﻭﺮﺘﻧﺍ
ﻟﺎﻜﻓ ﻴ ﺲ ﺭﺎﻜﺷﺁ ﺕﺭﻮﺻ ﻪﺑ ﻱ
ﺑﻴ ﺮﺘﺸ ﻩﺩﻮﺑ ﻲﻣ ﻭ ﻂﻳﺍﺮﺷ ﺭﺩ ﻥﺍﻮﺗ ﻠﻛ
ﻴﻨ ﻴ ﻜ ﻲ ﺍﺭ ﻥﺁ ﺎﺟ ﻳ ﺰﮕ ﻳ ﻦ ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳ .ﺩﻮﻤﻧ ﺪ
ﻠﻛ ﻴ ﺪ ﻩژﺍﻭ :ﺎﻫ
،ﻪﺸﻳﺭ ﻝﺎﻧﺎﻛ ﻥﺎﻣﺭﺩ ،ﺲﻴﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺁ ،ﺪﻳﺎﺴﻛﻭﺭﺪﻴﻫ ﻢﻴﺴﻠﻛ ،ﻝﺎﻳﺮﺘﻛﺎﺑ ﻲﺘﻧﺁ ﻞﻣﺎﻋ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ
:ﻪﻟﺎﻘﻣ ﻝﻮﺻﻭ 21
/2 / 92 :ﻲﻳﺎﻬﻧ ﺡﻼﺻﺍ 8
/6 / 92 :ﻪﻟﺎﻘﻣ ﺵﺮﻳﺬﭘ 12
/9 / 92
ﻪﻣﺪﻘﻣ : ﻣ ﻑﺬﺣ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﻱ ﺭ ﻝﺎﻧﺎﻛ ﻞﺧﺍﺩ ﻳ
ﻪﺸ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ
ﺵﻭﺭ ﺎﻫ ﻱ ﻧﺎﻜﻣ ﻴ ﻜ ﻲ ﺷ ﻭ ﻴ ﻤ ﻴﺎ ﻲﻳ ﻢﻬﻣ ﺯﺍ ﺮﺗ ﻳ ﻦ ﻝﺎﻧﺎﻛ ﻥﺎﻣﺭﺩ ﻑﺍﺪﻫﺍ
ﺭﻳ ﻪﺸ ﻣ ﻲ ﺪﺷﺎﺑ
).
1
ﺎﺘﻧ ﺱﺎﺳﺍﺮﺑ (
ﻳ ﺞ ﻘﺤﺗ ﻴ ﺕﺎﻘ ﻒﻠﺘﺨﻣ
، ﺮﺜﻛﺍ
ﻨﻜﺗ ﻴ ﻚ ﺎﻫ ﻱ ﻩﺩﺎﻣﺁ ﺯﺎﺳ ﻱ ﺯﺎﺴﻛﺎﭘ ﻭ ﻱ ﻞﻣﺎﻛ ﻑﺬﺣ ﺚﻋﺎﺑ ﻝﺎﻧﺎﻛ
ﺖﻓﺎﺑ ﻣ ﻭ ﺎﻫ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﻩﺭﺍﻮﻤﻫ ﻭ ﻩﺪﺸﻧ ﺖﺳﺩ ﻖﻃﺎﻨﻣ
ﻩﺩﺭﻮﺨﻧ ﺍ ﻱ ﺭ ﻝﺎﻧﺎﻛ ﺭﺩ ﻳ
ﻪﺸ ﻗﺎﺑ ﻲ ﻣ ﻲ ﺪﻧﺎﻣ
).
2
ﺩ ﻑﺮﻃ ﺯﺍ (
ﻳ ﺮﮕ
، ﺮﺜﻛﺍ
ﺵﻭﺭ ﺎﻫ ﻱ ﻮﺸﺘﺴﺷ ﻱ ﺪﺻ ﻑﺬﺣ ﺚﻋﺎﺑ ﻝﺎﻧﺎﻛ ﺭﺩ
ﺪﺻ
ﻣﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﻗﺎﺑ ﻭ ﻩﺪﺸﻧ ﻝﺎﻧﺎﻛ ﺯﺍ ﻲ
ﻥﺪﻧﺎﻣ ﻣ ﻴ ﻭﺮﻜ ﻧﺎﮔﺭﺍ ﻴ ﻢﺴ ﺎﻫ ﻣ ﻝﺎﻧﺎﻛ ﺭﺩ
ﻲ ﺪﻧﺍﻮﺗ ﺍ ﻪﺑ ﺮﺠﻨﻣ ﻳ
ﺩﺎﺠ ﺗﻼﻜﺸﻣ ﻲ ﺑ ﺪﻨﻧﺎﻣ ﻴ ﺭﺎﻤ ﻱ
ﺮﭘ ﻱ ﭘﺍﻴ ﻝﺎﻜ ﺩﺩﺮﮔ
) .
2،
1 (
ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻭﺭﺍﺩ ﻥﺍﻮﻨﻋ ﻪﺑ ﻱ
ﺭ ﻝﺎﻧﺎﻛ ﻞﺧﺍﺩ ﻳ
ﻪﺸ ﺑ ﺭﺩ ﻴ ﻦ
ﻧﺎﻣﺭﺩ ﺕﺎﺴﻠﺟ ﻲ
؛ ﺑﻮﻠﻄﻣ ﺹﺍﻮﺧ ﻲ
ﻟﻼﺣ ﺪﻨﻧﺎﻣ ﻴ
ﺖ ،ﻩﺯﻭﺮﻜﻧ ﺖﻓﺎﺑ
ﮔﻮﻠﺟ ﺭﺩ) ﻻﺎﺑpH ﻴﺮ
ﻱ ﭘ ﺯﺍ ﻴ ﺖﻓﺮﺸ ﻠﺤﺗ ﻴ ﻞ ﺪﺿ ﺹﺍﻮﺧ ﻭ (
ﻣﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ .ﺩﺭﺍﺩ
) 3
ﺍ ﺎﺑ(
ﻳ ﻦ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﺔﻧﻮﮔ ﻭﺩ ؛ﻝﺎﺣ ﻴ
ﺲ
ﺪﻧﺎﻛ ﻭ ﻳ ﺍﺪ ﺒﻟﺁ ﻴ ﺲﻧﺎﻜ ﺭ ﻥﺎﻣﺭﺩ ﺖﺴﻜﺷ ﺩﺭﺍﻮﻣ ﺭﺩ ﻳ
ﻩﺪﺷ ﻩﺪﻫﺎﺸﻣ ﻪﺸ
ﻟﻭ ﻲ ﻫ ﻴ ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ ﻭﺭ ﻱ ﺍﻳ ﻦ ﺑﻮﻠﻄﻣ ﺕﺍﺮﺛﺍ ﻪﻧﻮﮔ ﻭﺩ ﻲ
.ﺩﺭﺍﺪﻧ
) 4
ﺍﻳ (
ﻦ ﻨﭽﻤﻫ ،ﻭﺭﺍﺩ ﻴ
؛ﻦ ﻣﺎﻤﺗ ﻲ ﻣ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﺯﺍ ﺍﺭ
8
ﺘﻧﺁ ﺮﺛﺍ ﻪﺴﻳﺎﻘﻣ ﻲ
ﻝﺎﻳﺮﺘﻛﺎﺑ ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ﺐﻴﻛﺮﺗ ،ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ...
ﺳ ﻴ ﻢﺘﺴ ﺭ ﻝﺎﻧﺎﻛ ﻳ ﻪﺸ ﻧ ﻭ ﻩﺩﺮﻜﻧ ﻑﺬﺣ ﻴ
ﺯﺎ ﺯ ﺕﺪﻣ ﻪﺑ ﻳ
ﺩﺎ ﻱ ﺑ ﺍﺮ ﻱ
ﻣﺪﺿ ﺕﺍﺮﺛﺍ ﻝﺎﻤﻋﺍ ﻴ
ﺑﻭﺮﻜ ﻲ ﺩﺭﺍﺩ
).
5 (
،ﻥﺎﻣﺰﻤﻫ ﻣ
ﻴ ﻥﺍﺰ ﺎﻧﺍﻮﺗ ﻲﻳ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﻱ ﻈﻧ ﻒﻠﺘﺨﻣ ﻴﺮ
ﺴﻛﻮﻣﺁ ﻲ ﺳ ﻴﻠ ﻴ
،ﻦ ﺎﻣﻮﻜﻧﺍﻭ ﻳ ﺴ ﻴ
،ﻦ ﺭﺍ ﻳ ﺎﻣﻭﺮﺘ ﻳ ﺴ ﻴ
،ﻦ ﺰﻨﺑ ﻳ ﻞ ﻨﭘ ﻲ ﺳ ﻴﻠ ﻴ ﻦ ﻭ
ﺴﻛﺍﺩ ﻲ ﺎﺳ ﻳ ﻠﻜ ﻴ ﻦ ﻠﻋﺮﺑ ﻴ ﻪ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺧﺮﺑ ﺭﺩ ﻲ
ﻘﺤﺗ ﻴ ﺕﺎﻘ ﺯﺭﺍ ﻳﺑﺎ ﻲ ﺖﺳﺍ ﻩﺪﺷ
)6.
،5
ﻟﺎﺳ ﻝﻮﻃ ﺭﺩ (
ﻴ ﻥﺎ ﺩﺎﻤﺘﻣ ﻱ
،
ﺩﺎﻔﺘﺳﺍ ﺳ ﻩ ﻴ ﺗﺎﻤﺘﺴ ﻴ ﻚ ﻌﺿﻮﻣ ﻭ ﻲ
ﺘﻧﺁ ﺯﺍ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﺭﺩ
ﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻲ
ﻜﺷﺰﭘ ﻭ ﻲ ﻥﺍﻮﻨﻋ ﻪﺑ ﻳ
ﻚ ﺬﭘ ﻝﻮﻤﻌﻣ ﺵﻭﺭ ﻳ
ﻪﺘﻓﺮ ﻩﺪﺷ
).ﺖﺳﺍ
1
ﺍﺰﻓﺍ ﺭﻮﻈﻨﻣ ﻪﺑ (
ﻳ ﺶ ﻣ ﻴ ﻥﺍﺰ ﺮﺘﺳﺍ ﻳ ﻞ ﻝﺎﻧﺎﻛ ﻥﺩﻮﺑ ﻤﺧ ؛ﺎﻫ
ﻴﺮ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻪﺳ ﺎﺗ ﻲﻳ ﻮﺘﺤﻣ ﻱ ﺘﻧﺁ ﻪﺳ ﺭﺩﻮﭘ ﻁﻮﻠﺨﻣ ﻲ
ﺑﻴ ﺗﻮ ﻴ ﻚ
ﻧﻭﺮﺘﻣ ﻴ
،ﻝﻭﺯﺍﺪ ﺳ ﻴ ﺳﺎﺴﻛﻮﻠﻓﻭﺮﭙ ﻴ
ﻦ ﺎﻣ ﻭ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﺖﺒﺴﻧ ﻪﺑ
ﺴﻣ ﻭﺎ ﻱ ﺲﭙﺳ ﻭ
، ﻛﺮﺗ ﻴ ﺐ ﺍﻳ ﻦ ﻟﺎﺳ ﻝﺎﻣﺮﻧ ﺎﺑ ﺭﺩﻮﭘ ﻴ
ﻦ ﺭﺩ ﻢﻫ
ﺩﺭﺍﻮﻣ ﻱ ﻣ ﺮﻈﻧ ﻪﺑ .ﺖﺳﺍ ﻩﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ ﻲ
ﺪﺳﺭ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻭﺭﺍﺩ ﻥﺍﻮﻨﻋ ﻪﺑ ﻱ
ﺭ ﻝﺎﻧﺎﻛ ﻞﺧﺍﺩ ﻳ
ﻪﺸ ﺭﺩ ﺪﻧﺍﻮﺘﺑ
ﺍﺰﻓﺍ ﻳ ﺶ ﻣ ﻴ ﻥﺍﺰ ﺮﺘﺳﺍ ﻳ ﻞ ﺳ ﻥﺩﻮﺑ ﻴ ﻢﺘﺴ .ﺪﺷﺎﺑ ﺮﺛﺆﻣ ﻝﺎﻧﺎﻛ
) 4 (
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﻳ ﻚ ﻭﺭﺍﺩ ﻱ ﻏ ﺏﺎﻬﺘﻟﺍﺪﺿ ﻴ
ﺋﻭﺮﺘﺳﺍﺮ ﻴ ﺪ ﻱ ﺖﺳﺍ
ﺭﺩ ﻪﻛ ﺑﺎﻬﺘﻟﺍ ﺕﻻﻼﺘﺧﺍ ،ﺎﻫﺩﺭﺩ ﻉﺍﻮﻧﺍ ﻥﺎﻣﺭﺩ ﻲ
ﺩ ﻭ ﻳ ﺲ ﻩﺭﻮﻨﻣ
ﺪﻧﺍ ﻳ ﺳﺎﻜ ﻴ ﻥﻮ ﺳ ﺕﺍﺮﺛﺍ ﻭ ﻪﺘﺷﺍﺩ ﻴ
ﻤﺘﺴ ﻴ ﻚ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺶﻫﺎﻛ ﺭﺩ
ﺎﻫﺩﺭﺩ ﻱ ﻧﺍﺪﻧﺩ ﻲ ﺄﺗ ﻪﺑ ﻴﻳ ﺪ ﺳﺭ ﻴ ﻩﺪ ﺖﺳﺍ
)6.
(
ﺭﺩ ﺧﺮﺑ ﻲ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ؛ﺕﺎﻌﻟﺎﻄﻣ ﻲ
ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﻭﺭ
ﻱ ﻡﺎﻤﺗ
ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻡﻭﺎﻘﻣ E.coli ﺖﺳﺍ ﻩﺪﺷ ﺵﺭﺍﺰﮔ
).
7
ﻨﭽﻤﻫ (
ﻴ ﻦ
، ﺭﺩ
ﻮﻨﻤﻟﺎﺳ ﺖﻧﻮﻔﻋ ﻻ
ﻱ ﺵﻮﻣ ﺍ ؛ﺎﻫ ﻳ ﻦ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻭﺭﺍﺩ ﻲ
ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩﺭﺍﺩ
).
8 (
ﺘﻧﺁ ﺮﺛﺍ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﻭﺭ ﺮﺑ
ﻱ ﺎﻣ ﻳ ﺮﺘﻛﺎﺑﻮﻜ ﻳ ﻡﻮ ﺯﻮﻠﻛﺮﺑﻮﺗ ﻳ ﺲ
ﻧﻴ ﺰ ﺄﺗ ﻪﺑ ﻴﻳ ﺪ ﺳﺭ ﻴ ﻩﺪ ﺖﺳﺍ
).
9
ﺩﻭﺪﺣ (
50 ﺎﺗ 100 ﻣ ﻴﻠ ﻲ ﻡﺮﮔ ﺮﺑ
ﻣﻴ ﻠ ﻲ ﻟﻴ ﺮﺘ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﻭﺭ
ﻱ ﻪﻧﻮﮔ ﺮﺜﻛﺍ ﺎﻫ
ﻱ ﻔﻨﻣ ﻭ ﺖﺒﺜﻣ ﻡﺮﮔ ﻲ
ﻧﺎﻜﻣ ﻭ ﻩﺪﺷ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﺮﺛﻮﻣ ﻴ
ﻢﺴ ﺍﻳ ﻦ ﺕﺍﺮﺛﺍ ﻂﺳﻮﺗ ﻢﻫ DNA
synthesis inhibition ﺿﻮﺗ
ﻴ ﺢ ﺖﺳﺍ ﻩﺪﺷ ﻩﺩﺍﺩ
).
9 ، 8
ﻩﻭﻼﻋ (
ﺍ ﺮﺑ ﻳ
؛ﻦ ﻣ ﺮﻈﻧ ﻪﺑ ﻲ ﺪﺳﺭ ﺍﻳ ﻦ ﻛﺮﺗ ﺭﺩ ﻭﺭﺍﺩ ﻴ
ﺐ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﺎﺑ ﻳ
ﺴ ﻴ ﻦ
ﻣﺪﺿ ﺕﺍﺮﺛﺍ ﺪﻧﺍﻮﺘﺑ ﻴ
ﺑﻭﺮﻜ ﻲ ﺑﻴ ﺮﺘﺸ ﻱ ﺎﺸﻧ ﺩﻮﺧ ﺯﺍ ﺪﻫﺩ ﻥ
).
9
ﺧﺍ (
ﻴ
ًﺍﺮ
ﺩ ﻩﺪﺷ ﺵﺭﺍﺰﮔ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﻟﺎﻌﻓ
ﻴ ﺖ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺑﻴ ﺮﺘﺸ ﻱ ﺎﻘﻣ ﺭﺩ ﻳ ﻪﺴ
ﺴﻠﻛ ﺎﺑ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺭﺩ ﻥﺎﻣﺭﺩ ﺎﻫ ﻱ ﺭ ﻝﺎﻧﺎﻛ ﻳ ﻪﺸ ﻟﻭ ﻪﺘﺷﺍﺩ ﻲ
ﻠﻋﺮﺑ ﻥﺁ ﺕﺍﺮﺛﺍ ﻴ
ﻪ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺧﺮﺑ ﺯﺍ ﺮﺘﻤﻛ ﻲ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﺖﺳﺍ ﻩﺩﻮﺑ
.) 10 (
ﻘﺤﺗ ﻴ ﻖ ﻌﺗ ﻑﺪﻫ ﺎﺑ ﺮﺿﺎﺣ ﻴﻴ
ﻦ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ
ﺪﺳ ﻳ
،ﻢ ﻛﺮﺗ ﻴ ﺐ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ
ﻳ ﺴ ﻴ
،ﻦ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻭ
ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻭﺭ ﺮﺑ ﻱ ﺑﻴ ﻓﻮ ﻴﻠ ﻢ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺭﺩ
ﻝﺎﺳ 1391 ﻭ ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻩﺪﻜﺸﻧﺍﺩ ﺲﻜﻴﺘﻧﻭﺩﻭﺪﻧﺍ ﺶﺨﺑ ﺭﺩ
ﻱﺭﺎﺘﺳﺮﭘ ﻩﺪﻜﺸﻧﺍﺩ ﻱژﻮﻟﻮﻴﺑﻭﺮﻜﻴﻣ ﺶﺨﺑ ﻲﻣﻼﺳﺍ ﺩﺍﺯﺁ ﻩﺎﮕﺸﻧﺍﺩ
.ﺪﺷ ﻡﺎﺠﻧﺍ ﻥﺎﮕﺳﺍﺭﻮﺧ ﺪﺣﺍﻭ
:ﺎﻫ ﺵﻭﺭ ﻭ ﺩﺍﻮﻣ ﻘﺤﺗ ﻴ ﻖ ﺑﺮﺠﺗ ﺕﺭﻮﺻ ﻪﺑ ﻲ
- ﺎﻣﺯﺁ ﻳ ﻫﺎﮕﺸ ﻲ ﺍﺮﺑ .ﺪﺷ ﻡﺎﺠﻧﺍ ﻱ
ﺍﻳ ﻦ
ﺑ ؛ﺭﻮﻈﻨﻣ ﻴ ﻓﻮ ﻴ ﻢﻠ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺮﺘﺳﺍ ) ﻳ ﻦ ﺮﻣﺍ ﻳ ﺎﻜ ﻲﻳ
ATCC 11700) ﻭﺭ
ﻱ 56 ﺩ ﻳ ﻚﺴ ﻧﻴ ﺕﺍﺮﺘ ﺰﻟﻮﻠﺳ ﻱ ﺖﻔﻫ ﺭﺩ
ﺎﺗ ﺖﺸﻫ ﻩﻭﺮﮔ ﻲﻳ
ﺮﺘﺳﺍ ﻳ ﻞ ﻓ ﺶﺷﻮﭘ ﺎﺑ ﻴ
ﺮﺘﻠ ﻬﺗ ﻴ ﻪ ﺪﺷ . ﺖﻣﺎﺨﺿ
ﺍﻳ ﻦ ﻻ ﻳﻪ ﺎﻫ ﻝﺩﺎﻌﻣ 2/
0 ﻣ ﻴ ﺮﺘﻣﻭﺮﻜ ﺕﺭﻮﺻ ﻪﺑ ﻭ ﻩﺩﻮﺑ
ﺩﻳ ﻚﺴ ﺎﻫ ﻲﻳ ﺮﻄﻗ ﻪﺑ 13 ﻣ ﻴﻠ ﻲ ﺮﺘﻣ .ﺪﻧﺪﺷ ﻪﻴﻬﺗ ﺴﻧﺎﭙﺳﻮﺳ
ﻴ ﻥﻮ
ﺮﺘﻛﺎﺑ ﻳﺎ ﻲﻳ ﻣ ﻩﺩ ﺯﺍ ﻴﻠ ﻲ ﻟﻴ ﺮﺘ ﻟﺎﺳ ﻝﺎﻣﺮﻧ ﻴ
ﻦ ﺮﺘﺳﺍ ﻳ ﻞ ﺮﻃ ﺯﺍ ﻭ ﻳ ﻖ
ﻨﻠﻛ ﺭﺎﺸﺘﻧﺍ ﻲ
ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻩﺪﻣﺁ ﺖﺳﺩ ﻪﺑ
ﺤﻣ ﺭﺩ ﻪﻧﺎﺒﺷ ﺖﺸﻛ ﺯﺍ ﻴ
ﻂ Blood Agar ﻬﺗ
ﻴ ﻪ ﺴﻧﺍﺩ .ﺪﺷ ﻴ ﺔﺘ
ﺴﻧﺎﭙﺳﻮﺳ ﻴ ﻥﻮ ﻌﺒﺗ ﺪﻨﻟﺭﺎﻓ ﻚﻣ ﺩﺭﺍﺪﻧﺎﺘﺳﺍ ﺯﺍ ﻴ
ﺖ ﻣ ﻲ ﺩﺮﻛ ﻪﻛ ﻪﺑ
ﻱﺩﻭﺪﺣ ﺩﺍﺪﻌﺗ CFU/ml
10
P
8
P .ﺖﺳﺍ ﻩﺩﻮﺑ
P
) 4 (
ﺖﻗﺭ ﺎﻫ ﻱ ﻣ ﻩﺎﺠﻨﭘ ﻴ ﻟﻭﺮﻜ ﻴ ﺮﺘ ﻱ ﺴﻧﺎﭙﺳﻮﺳ ﺯﺍ ﻴ
ﻥﻮ ﺮﺘﻛﺎﺑ ﻱ ﺭﺩ
ﺩﻳ ﻚﺴ ﺎﻫ ﻱ ﺘﺳﺍ ﺮﻳ ﻞ ﻘﻠﺗ ﻴ ﺢ ﻭﺭ ﻭ ﻩﺪﺷ ﻱ ﻧﻮﺧ ﺭﺎﮔﺁ ﺢﻄﺳ ﻲ
ﺭﺍﺮﻗ
ﻪﻧﻮﻤﻧ .ﺪﻨﺘﻓﺮﮔ ﺕﺪﻣ ﻪﺑ ﺎﻫ
48 ﻭﺭ ﺖﻋﺎﺳ ﻱ ﺎﻣﺩ ﺭﺩ ﺭﺎﮔﺁ ﻱ
37
ﻲﺘﻧﺎﺳ ﻪﺟﺭﺩ ﺩﺍﺮﮔ
ﺤﻣ ﺭﺩ ﻴ ﻂ ﺑ ﻲ ﺯﺍﻮﻫ ﻱ ﺯﺍ ﺪﻌﺑ .ﺪﻧﺪﺷ ﻪﺑﻮﻜﻧﺍ 48
ﺩ ؛ﺖﻋﺎﺳ ﻳ ﻚﺴ ﺎﻫ ﺍﺮﺷ ﺭﺩ ﻳ ﻂ ﺮﺘﺳﺍ ﻳ ﻞ ﻠﭘ ﺯﺍ ﻴ ﺖ ﻪﺘﺷﺍﺩﺮﺑ ﺭﺎﮔﺁ
ﻗﺩ ﻪﺑ ﻭ ﻩﺪﺷ ﺖ
ﺤﻣ ﻪﺑ ﻴ ﻂ ﻭﺎﺣ ﻱ ﺎﺗ ﺪﻧﺪﺷ ﻞﻘﺘﻨﻣ ﺕﺎﻔﺴﻓ ﺮﻓﺎﺑ
ﺮﺘﻛﺎﺑ ﻱ ﺎﻫ ﻲﻳ ﻝﺎﺼﺗﺍ ﻞﺷ ﺕﺭﻮﺻ ﻪﺑ ﻪﻛ ﻳ
ﻪﺘﻓﺎ ﺪﻧﺩﻮﺑ
، .ﺪﻧﻮﺷ ﺍﺪﺟ
ﺩ ؛ﻪﻣﺍﺩﺍ ﺭﺩ ﻳ
ﻚﺴ ﺎﻫ ﺕﺪﻣ ﻪﺑ ﻳ ﻚ ﺤﻣ ﺭﺩ ﺖﻋﺎﺳ ﻴ
ﻂ 37 ﻪﺟﺭﺩ
ﻲﺘﻧﺎﺳ ﺩﺍﺮﮔ ﺑ ﺕﺭﻮﺻ ﻪﺑ ﻭ ﻲ
ﺯﺍﻮﻫ ﻱ ﺛﺄﺗ ﺖﺤﺗ ﻴﺮ ﻩﻭﺮﮔ ﺎﻫ ﻱ
ﻭﺭﺍﺩ ﻒﻠﺘﺨﻣ ﻲﻳ
ﺮﻳﺯ ﺡﺮﺷ ﻪﺑ .ﺪﻨﺘﻓﺮﮔ ﺭﺍﺮﻗ
) 10
، 4 (
ﺴﻠﻛ- ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺭﺁ) ﻳ ﺖﻧﺩﺎ ﺍ ، ﻥﺍﺮﻬﺗ ، ﻳ
ﻥﺍﺮ (
ﺩﻳ- ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ 100 ﻣ ﻴﻠ ﻲ ﻡﺮﮔ (Shasun Ltd,
India) ﻛﺮﺗ- ﻴ ﺐ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ ﻦ ﺩ ﻭ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ
ﺮﺘﻛﺩ ﻱﺮﻫﺍ ﻲﻠﺳﺮﻣ ﻲﻠﻋ ﻥﺍﺭﺎﻜﻤﻫ ﻭ
9
ﻩﺭﻭﺩ /ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻡﻮﻠﻋ ﺭﺩ ﻖﻴﻘﺤﺗ ﻪﻠﺠﻣ
ﻢﻫﺩﺯﺎﻳ ﻩﺭﺎﻤﺷ / ﻝﻭﺍ / ﺭﺎﻬﺑ 1393 ﻲﭘﺎﻴﭘ / 39
ﻛﺮﺗ- ﻴ ﺐ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺳ،
ﻴ ﺳﺎﺴﻛﻮﻠﻓﻭﺮﭙ ﻴ
ﻦ 250 ﻣ ﻴﻠ ﻲ ﻡﺮﮔ
(Bayer plc, UK) ﻧﻭﺮﺘﻣ ،
ﻴ ﻝﻭﺯﺍﺪ 250 ﻣ ﻴﻠ ﻲ ﻡﺮﮔ
(Flagyl, Winthrop Pharmaceuticals, UK) ﻭ
ﺎﻣ ﻳ ﻮﻨ ﻳ ﻠﻜﺴ ﻴ ﻦ 100 ﻣ ﻴﻠ ﻲ ﻡﺮﮔ (Expanscience
(Laboratories, Paris, France) ﻤﺠﺣ ﺖﺒﺴﻧ ﻪﺑ
ﻲ
ﺮﺑﺍﺮﺑ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ- ﻳ
ﺴ ﻴ ﻦ 1 ﻡﺮﮔ (X-GEN Pharmaceuticals,
Inc,Horseheads, US) - ﻛﺮﺗ ﻴ ﺐ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻐﺗ ﻴﻴ ﺮ ﻳ ﻪﺘﻓﺎ ﺩ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ) ﻳ
ﻙﺎﻨﻓﻮﻠﻜ
ﺪﺳ ﻳﻢ ﺎﺟ ﻪﺑ ﻱ ﺎﻣ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ (
- ﻟﺎﺳ ﻝﺎﻣﺮﻧ ﻝﺮﺘﻨﻛ ﻩﻭﺮﮔ ﻴ
ﻦ ﺯﺍﺭ) ﻱ
،ﺝﺮﻛ،
ﺍﻳ ﻥﺍﺮ (
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﻱ ﺳﺍ ﺩﺭﻮﻣ ﻘﺤﺗ ﺭﺩ ﻩﺩﺎﻔﺘ ﻴ
ﻖ ﺭﺎﺠﺗ ﺕﺭﻮﺻ ﻪﺑ ﻱ
ﻭ
ﺭﺰﺗ ﻳﻘ ﻲ ﺖﻛﺮﺷ ﻞﻤﻌﻟﺍﺭﻮﺘﺳﺩ ﻖﺒﻃ ﻭ ﻩﺩﻮﺑ ﺩﻮﺟﻮﻣ ﺭﺍﺯﺎﺑ ﺭﺩ
ﺪﻧﺪﺷ ﻪﺘﻓﺮﮔ ﺭﺎﻛ ﻪﺑ ﻩﺪﻧﺯﺎﺳ .
ﻪﺘﻳﺪﻴﺳﺍ ﻪﻧﻮﻤﻧ
ﻂﺳﻮﺗ ﻢﻫ ﺎﻫ
ﻩﺯﺍﺪﻧﺍ ﺮﺘﻣpH ﮔ ﻴﺮ ﻱ ﺩ ﺶﺷ .ﺪﺷ ﻳ
ﻚﺴ ﺛﺄﺗ ﺖﺤﺗ ﻴﺮ ﺮﻫ ﻳ ﻚ ﺯﺍ
ﻩﻭﺮﮔ ؛ﻉﻮﻤﺠﻣ ﺭﺩ) ﺪﻧﺪﺷ ﻩﺩﺍﺩ ﺭﺍﺮﻗ ﺎﻫ 36
.(ﻪﻧﻮﻤﻧ ﻳ ﻚ ﺩ ﻳ ﻚﺴ
ﺑ ﻢﻫ ﺍﺮ ﻱ ﻤﻃﺍ ﻴ ﻥﺎﻨ ﻮﺟﻭ ﺯﺍ ﺮﺘﻛﺎﺑ ﺩ ﻱ ﺛﺎﺗ ﺯﺍ ﻞﺒﻗ ﻴﺮ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺭﺩ
ﺍ .ﺪﺷ ﻩﺩﺍﺩ ﺭﺍﺮﻗ ﺮﻓﺎﺑ ﺕﺎﻔﺴﻓ ﻝﻮﻠﺤﻣ ﻳ
ﻦ ﻳ ﻚ ﻏ ﻪﻧﻮﻤﻧ ﻴﺮ ﺞﻨﭘ ﺯﺍ
ﻪﻧﻮﻤﻧ ﺍ ﻱ ﺎﺳ ﺪﻨﻧﺎﻤﻫ ﻭ ﻪﺘﻓﺮﮔ ﺭﺍﺮﻗ ﺕﺎﻔﺴﻓ ﺮﻓﺎﺑ ﻩﻭﺮﮔ ﺭﺩ ﻪﻛ ﺩﻮﺑ ﻳﺮ
ﻩﻭﺮﮔ ﺭﺍﺪﻬﮕﻧ ﺭﻮﺗﺎﺑﻮﻜﻧﺍ ﺭﺩ ﺎﻫ ﻱ
ﺯﺍ ﺪﻌﺑ .ﺪﺷ ﻳ
ﻚ ﺱﺎﻤﺗ ﺖﻋﺎﺳ
ﻭﺭ ﻝﺎﻌﻓ ﻩﺩﺎﻣ ﻱ
ﺩ ﻳ ﻚﺴ
،ﺎﻫ ﻪﻧﻮﻤﻧ ﭘ ﺎﻫ ﺞﻨ ﻣ ﻩﺩ ﺎﺑ ﺭﺎﺑ ﻴﻠ
ﻲ ﻟﻴ ﺮﺘ
ﻟﺎﺳ ﻝﻮﻠﺤﻣ ﻴ
ﻦ ﻗﺎﺑ ؛ﺲﭙﺳ .ﺪﺷ ﻩﺩﺍﺩ ﻮﺸﺘﺴﺷ ﺮﻓﺎﺑ ﺕﺎﻔﺴﻓ ﻲ
ﻩﺪﻧﺎﻣ
ﺮﺘﻛﺎﺑ ﻳﺎ ﻲﻳ ﻭﺭ ﻱ ﺩ ﻳ ﻚﺴ ﻧﻮﺳﺍﺮﺘﻟﻭﺍ ﻩﺎﮕﺘﺳﺩ ﺭﺩ ﻴ
ﻚ ﺕﺪﻣ ﻪﺑ ﻭ 10
ﻗﺩ ﻴ ﻪﻘ ﺴﻧﺎﭙﺳﻮﺳ ﻭ ﻩﺪﺷ ﺍﺪﺟ ﻴ
ﻥﻮ ﺮﺘﻛﺎﺑ ﻱ ﻲﺒﺳﺎﻨﻣ ﺖﺳﺩ ﻪﺑ ﺁﻳ ﺪ .
ﺴﻧﺎﭙﺳﻮﺳ ﻴ ﻥﻮ ﻗﺭ ﺮﺑﺍﺮﺑ ﻩﺩ ﻞﺻﺎﺣ ﻴ
ﻖ ﻠﭘ ﺭﺩ ﻭ ﻩﺪﺷ ﻴ
ﺖ ﺎﻫ ﻱ ﺭﺎﮔﺁ
ﻧﻮﺧ ﻲ Columbia horse ﺖﺧﺎﺳ
ﺖﻛﺮﺷ
Thermo Scientific ﺎﻜﻳﺮﻣﺁ ﺭﻮﺸﻛ
.ﺪﻧﺪﺷ ﻩﺩﺍﺩ ﺭﺍﺮﻗ
ﻪﻧﻮﻤﻧ ﺕﺪﻣ ﻪﺑ ﺎﻫ 24
ﺤﻣ ﺭﺩ ﺖﻋﺎﺳ ﻴ
ﻂ ﺑ ﺖﺸﻛ ﻲ ﺯﺍﻮﻫ ﻱ ﺎﻣﺩ ﺎﺑ ﻱ
37 ﺩﺍﺮﮔ ﻲﺘﻧﺎﺳ ﻪﺟﺭﺩ ﺭﺍﺮﻗ
ﺪﻨﺘﻓﺮﮔ
).
11
ﺵﺭﺎﻤﺷ (
ﺎﻫﺪﺣﺍﻭ ﻱ
ﻜﺸﺗ ﻴ ﻞ ﻧﻮﻠﻛ ﺓﺪﻫﺩ ﻲ
(CFU) ﺍﺮﺑ
ﻱ ﺩ ﺮﻫ ﻳ ﻚﺴ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ
ﻣﻴ پﻮﻜﺳﻭﺮﻜ ﺭﻮﻧ
ﻱ ﻲﻳﺎﻤﻨﮔﺭﺰﺑ ﺭﺩ
× 40 ﺪﺷ ﻡﺎﺠﻧﺍ .
ﺺﺧﺎﺷ ﺎﻫ ﻱ ﮔﺪﻨﻛﺍﺮﭘ ﻲ ﺰﻛﺮﻣ ﻱ ﻣ) ﻴ ﮕﻧﺎ ﻴ
،ﻦ ﻌﻣ ﻑﺍﺮﺤﻧﺍ ﻴ
،ﺭﺎ
ﺎﻄﺧ ﻱ ﻌﻣ ﻴ
،ﺭﺎ ﺰﮔﺎﻣ ﻳ
،ﻢﻤ ﻣ ﻲ ﻧﻴ ﻢﻤ ﻭ 95 ﺪﺻﺭﺩ ﻤﻃﺍ ﺔﻠﺻﺎﻓ ﻴ
ﻥﺎﻨ ﻣﻴ
ﮕﻧﺎ ﻴ ﻦ ﻧﻮﻠﻛ ( ﻲ ﺎﻫ ﻱ ﻜﺸﺗ ﻴ ﻞ ﺮﺘﻛﺎﺑ ﺓﺪﻨﻫﺩ ﻱ
ﻙﻮﻛﻭﺮﺘﻧﺍ
ﻟﺎﻜﻓ ﻴ ﺲ ﺩ ﺭﺩ ﻳ ﻚﺴ ﺎﻫ ﺮﺑﺍﺮﺑ ﺭﺩ ﻥﺪﺷ ﺯﻮﭙﺴﻛﺍ ﻝﺎﺒﻧﺩ ﻪﺑ ﻭ
ﺎﻫﻭﺭﺍﺩ ﻱ ﺩﺮﮔ ﺵﺭﺍﺰﮔ ﻭ ﻪﺒﺳﺎﺤﻣ ﻒﻠﺘﺨﻣ ﻳﺪ
ﻟﺩ ﻪﺑ . ﻴ ﻞ ﻦﮕﻤﻫ
ﻩﻭﺮﮔ ﻥﺩﻮﺒﻧ ﺎﻫ
ﺯﺍ ﺩﺎﻘﻣ ﺮﻈﻧ ﻳﺮ ﺭﺍﻭ ﻳ
؛ﺲﻧﺎ ﻌﺒﺗ ﻡﺪﻋ ﻴ ﺖ ﺯﻮﺗ ﺯﺍ ﻳ ﻊ
ﺧﺮﺑ ﺭﺩ ﻝﺎﻣﺮﻧ ﻲ
ﻩﻭﺮﮔ ﻧ ﻭ ﺎﻫ ﻴﺰ ﻪﻧﻮﻤﻧ ﺩﺍﺪﻌﺗ ﻥﺩﻮﺑ ﻙﺪﻧﺍ ﺭﺩ ﺎﻫ
ﻩﻭﺮﮔ ﺎﻫ ﻱ ﺯﺍ ؛ﻒﻠﺘﺨﻣ ﻥﻮﻣﺯﺁ
Kruskal-wallis ﺍﺮﺑ
ﻱ
ﺎﻘﻣ ﻳ ﺔﺴ ﺩﺎﻘﻣ ﻳﺮ ژﺭ ﺭﺩ CFU
ﻳﻢ ﺎﻫ ﻱ ﻧﺎﻣﺭﺩ ﻲ ﻩﺩﺎﻔﺘﺳﺍ ﻒﻠﺘﺨﻣ
ﺎﻬﻧ ﺭﺩ .ﺪﺷ ﻳ
،ﺖ ﻟﺩ ﻪﺑ ﻴ ﻞ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﺎﺘﻧ ﻥﺩﻮﺑ ﻳ ﺞ ﻝﺎﻜﺳﻭﺮﻛ ﻥﻮﻣﺯﺁ
ﻟﺍﻭ ﻴ ﺲ ﻠﻛ ﺖﻟﺎﺣ ﺭﺩ ﻲ
؛ ﻣ ﺎﻘ ﻳ ﻪﺴ ﺎﻫ ﻱ ﻭﺩ ﻪﺑ ﻭﺩ ﻱ ﻩﻭﺮﮔ ﺎﺑ ﻢﻫ ﺎﻫ
ﻥﻮﻣﺯﺁ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ Mann-U- whitney
.ﺪﺷ ﻡﺎﺠﻧﺍ
:ﺎﻫ ﻪﺘﻓﺎﻳ ﻥﺍﺰﻴﻣ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺭﺩ 56 ﺩ ﻳ ﻚﺴ
ﺎﺗ ﺖﺸﻫ ﻩﺮﮔ ﺖﻔﻫ) ﻲﻳ
ﺎﺑ ﻪﻬﺟﺍﻮﻣ ﻝﺎﺒﻧﺩ ﻪﺑ ( ﻱﺎﻫﻭﺭﺍﺩ
ﻒﻠﺘﺨﻣ
ﺯ ﻝﻭﺪﺟ ﺭﺩ ﻳﺮ
ﺩﺮﮔ ﻪﺻﻼﺧ ﻳﺪ
) . ﻝﻭﺪﺟ 1 (
ﻝﻭﺪﺟ 1 - ﻲﻧﻮﻠﻛ ﺩﺍﺪﻌﺗ ﻱﺎﻫ
ﻧﺍ ﺭﺩ ﺲﻴﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﺮﺘ ﺪﺣﺍﻭ
(CFU)
ﻚﻴﻜﻔﺗ ﻪﺑ 8
/ 52 5± / 794 ﻲﻳﻭﺭﺍﺩ ﻒﻠﺘﺨﻣ ﻱﺎﻫ ﻩﻭﺮﮔ
ﺎﻫ ﻩﻭﺮﮔ ﻦﻴﮕﻧﺎﻴﻣ±
ﺭﺎﻴﻌﻣ ﻑﺍﺮﺤﻧﺍ ﻩﺯﺎﺑ
ﻦﻴﺋﺎﭘ ﻩﺯﺎﺑ
ﻻﺎﺑ
ﺪﻳﺎﺴﻛﻭﺭﺪﻴﻫ ﻢﻴﺴﻠﻛ 8/
52 5/± 794 99 / 738 0/
850
ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ 7/
23 207± 12
/ 182 88
/ 231
ﻱﺮﺗ ﻲﺘﻧﺁ ﻚﻴﺗﻮﻴﺑ 0
0 0
ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ﺘﺳﺍ + ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮ 3/
21 67± / 160 21 / 138 12
/ 183
ﻝﺮﺘﻨﻛ (ﻦﻴﻟﺎﺳ ﻝﺎﻣﺮﻧ) 3/
124 7/± 1556 2/
1426 18
/ 1687
ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮﺘﺳﺍ 0
0 0
ﻱﺮﺗ ﻲﺘﻧﺁ ﻚﻴﺗﻮﻴﺑ
ﻪﺘﻓﺎﻳ ﺮﻴﻴﻐﺗ 3/
12 8/± 135 91 / 122 76
/ 148
ﻥﻮﻣﺯﺁ Kruskal-wallis ﻨﻌﻣ ﺕﻭﺎﻔﺗ ﺩﺍﺩ ﻥﺎﺸﻧ
ﻲ ﺭﺍﺩ ﻱ ﺑﻴ ﻦ
ﻩﻭﺮﮔ ﺎﻫ ﻱ ﺩﺎﻘﻣ ﺮﻈﻧ ﺯﺍ ﻒﻠﺘﺨﻣ ﻳﺮ
ﻣ ﻴ ﮕﻧﺎ ﻴ ﻦ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ
ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺖﺳﺍ ﻪﺘﺷﺍﺩ ﺩﻮﺟﻭ )
004 /0 p<
( ﻪﺟﻮﺗ ﺎﺑ .
ﻨﻌﻣ ﻪﺑ ﻲ ﺭﺍﺩ ﺎﺘﻧ ﻥﺩﻮﺑ ﻳ ﺞ ﻠﻛ ﻥﻮﻣﺯﺁ ﻲ Kruskal-wallis ﺯﺍ ؛
ﻥﻮﻣﺯﺁ Mann-U-whitney ﺍﺮﺑ
ﻱ ﺎﻘﻣ ﻳ ﺔﺴ ﻭﺩ ﻪﺑ ﻭﺩ ﻱ
10
ﺘﻧﺁ ﺮﺛﺍ ﻪﺴﻳﺎﻘﻣ ﻲ
ﻝﺎﻳﺮﺘﻛﺎﺑ ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ﺐﻴﻛﺮﺗ ،ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ...
ﻩﻭﺮﮔ ﺎﻫ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺘﻧ .ﺪﺷ ﻳ ﺞ ﻥﻮﻣﺯﺁ Mann-U-whitney ﻢﻫ
ﺑ ﺕﻭﺎﻔﺗ ،ﺩﺍﺩ ﻥﺎﺸﻧ ﻴ
ﻦ ﻩﻭﺮﮔ ﺎﻫ ﻱ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻭ
ﺳﺍ ﺎﻣﻮﺘﭘﺮﺘ ﻳ ﺴ ﻴ ﻦ ) 1/
0
= ﻛﺮﺗ ﻭ (p ﻴ ﺐ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﻭ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ ﻦ ﺮﺗ ﺎﺑ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻐﺗ ﻴﻴ ﺮ ﻳ ﻪﺘﻓﺎ ) 07 /0
= ﺯﺍ (p
ﺭﺎﻣﺁ ﺮﻈﻧ ﻱ ﻨﻌﻣ ﻲ ﺭﺍﺩ ﻋ ﺭﺩ .ﺖﺳﺍ ﻩﺩﻮﺒﻧ ﻴ
ﻦ ﺕﻭﺎﻔﺗ،ﻝﺎﺣ ﺎﻫ
ﻱ
ﻨﻌﻣ ﻲ ﺭﺍﺩ ﻱ ﺩﺎﻘﻣ ﺮﻈﻧ ﺯﺍ ﻳﺮ
ﻣ ﻴ ﮕﻧﺎ ﻴ ﻦ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ
ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺑﻴ ﻦ ﺎﺳ ﻳﺮ ﻩﻭﺮﮔ .ﺖﺷﺍﺩ ﺩﻮﺟﻭ ﺎﻫ
ﺚﺤﺑ :
ﺎﺳﺍﺮﺑ ﺎﺘﻧ ﺱ ﻳ ﺞ ﻘﺤﺗ ﻴ ﻖ ﻭﺭﺍﺩ ﻞﻣﺍﻮﻋ ؛ﺮﺿﺎﺣ ﻲﻳ
ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻳ
ﺴ ﻴ
،ﻦ ﺑﻴ ﺮﺘﺸ ﻳ ﻦ ﺮﺘﻛﺎﺑ ﺕﺍﺮﺛﺍ ﻱ
ﺸﻛ ﻲ ﻠﻋﺮﺑ ﻴ ﺔ
ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻪﺘﺷﺍﺩ ﺍﺭ ؛ﺎﻬﻧﺁ ﺯﺍ ﺪﻌﺑ ﻭ
ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻐﺗ ﻴﻴ ﺮ ﻳ ﻪﺘﻓﺎ ﺎﺟ) ﻳ ﺰﮕ ﻳﻨ ﻲ ﺎﻣ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﺎﺑ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺩ ؛(
ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ
؛ﻦ
ﺩﻳ ﻓﻮﻠﻜ ﻙﺎﻨ ﺪﺳ ﻳﻢ ﺎﻬﻨﺗ ﻪﺑ ﻲﻳ ﺴﻠﻛ ﻭ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺭﺍﺮﻗ
ﺘﺷﺍﺩ ﺪﻨ ﺑ . ﻴ ﺮﺘﺸ ﻳ ﻦ ﺩﺎﻘﻣ ﻳﺮ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻩﻭﺮﮔ ﺭﺩ ﻢﻫ
ﺳﺭ ﺖﺒﺛ ﻪﺑ ﻝﺮﺘﻨﻛ ﻴ
ﺪ .
ﺍﺮﺑ ﻳ ﻦ ﻣ ؛ﺱﺎﺳﺍ ﻴ ﻥﺍﺰ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻪﺑ
ﺮﺗ ﺎﺑ ﻪﻬﺟﺍﻮﻣ ﻝﺎﺒﻧﺩ ﻱ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻭﺎﺣ) ﻱ ﺳ ﻴ ﺳﺎﺴﻛﻮﻠﻓﻭﺮﭙ ﻴ
ﻦ
،
ﻧﻭﺮﺘﻣ ﻴ ﻝﻭﺯﺍﺪ
،ﻣ ﻴ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﻮﺑ ﺮﻔﺻ ﺮﺑﺍﺮﺑ ( ﺍ ﻭ ﻩﺩ
ﻳ ﻦ ﻭﺭﺍﺩ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﺪﻨﻧﺎﻤﻫ ﺩﻮﺑ ﻪﺘﺴﻧﺍﻮﺗ ﻳ
ﺴ ﻴ ﻦ ﻣﺎﻤﺗ ﻲ ﻣ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ
ﺑ ﺯﺍ ﺍﺭ ﻴ ﻦ ﺩ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﻪﺘﺒﻟﺍ .ﺩﺮﺒﺑ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺎﺟ ﻪﺑ ﻱ
ﺎﻣ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﻛﺮﺗ ﺭﺩ ﻴ ﺐ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺶﻫﺎﻛ ﺐﺟﻮﻣ
ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺘﻧﺁ ﻲ ﺮﺘﻛﺎﺑ ﻱ ﻛﺮﺗ ﻴ ﺐ ﺩﺮﮔ ﻳ ﻩﺪ ﺩﻮﺑ
، ﺿﺮﻓ ﺍﺬﻟ ﻴﺔ
ﻮﻘﺗ ﻳ ﺖ ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺮﻃ ﺯﺍ ﻳ ﻖ ﺎﺟ ﻳ ﺰﮕ ﻳﻨ ﻲ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺎﻣ ﺎﺑ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﺍ ﺭﺩ ﻳ ﻦ ﻘﺤﺗ ﻴ ﻖ ﺪﺷ ﺩﺭ .
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻛﺮﺗ ﻴﺒ ﻲ ﺖﺒﺴﻧ ﻞﻣﺎﺷ ﻪﻛ ﺎﻫ
ﻱ ﻭﺎﺴﻣ ﻱ ﻪﺳ ﺯﺍ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻧﻭﺮﺘﻣ ﻴ
،ﻝﻭﺯﺍﺪ ﺎﻣ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﺳ ﻭ ﻴ ﺳﺎﺴﻛﻮﻠﻓﻭﺮﭙ ﻴ
ﻦ
ﻟﺎﺳ ﻝﺎﻣﺮﻧ ﻩﺍﺮﻤﻫ ﻪﺑ ﻴ
ﻦ ﻣ ﻲ
،ﺪﺷﺎﺑ ﺎﻫﺩﺮﺑﺭﺎﻛ ﻱ ﻧﺍﻭﺍﺮﻓ ﻲ ﺭﺩ
ﻧﻮﻔﻋﺪﺿ ﻲ ﻥﺎﻣﺭﺩ ﺭﺩ ﺹﻮﺼﺨﺑ ،ﻝﺎﻧﺎﻛ ﻥﺩﺮﻛ ﺎﻫ
ﻱ
regeneration ﺧﺮﺑ ﻭ ﻪﺘﺷﺍﺩ
ﻲ ﻘﺤﺗ ﻴ ﺕﺎﻘ ﺑ ﻢﻫ ﻴ ﺮﮕﻧﺎ ﺕﺍﺮﺛﺍ
ﻣ ﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﻮﻗ ﻱ ﻠﻋﺮﺑ ﻥﺁ ﻴ ﺔ ﻣ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﻱ ﺭﺩ ﺩﻮﺟﻮﻣ
ﻝﺎﻧﺎﻛ ﺎﻫ ﻱ ﻧﻮﻔﻋ ﻲ ﻣ ﻲ ﺪﺷﺎﺑ
).
13
، 12
ﺍ ﺏﺎﺨﺘﻧﺍ ﺖﻠﻋ (
ﻳ ﻦ ﺘﻧﺁ
ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺍﺮﺑ ﻱ ﻘﺤﺗ ﻴ ﻖ ﻧﻴ
؛ﺰ ﻟﺩ ﻪﺑ ﻥﺁ ﺯﺍ ﺭﺮﻜﻣ ﺓﺩﺎﻔﺘﺳﺍ ﻴ
ﻞ
ﺻﺎﺧ ﻴ ﺖ revasculation ﺩ ﻑﺮﻃ ﺯﺍ .ﺖﺳﺍ ﻩﺩﻮﺑ ﻥﺁ
ﻳ
،ﺮﮕ ﻪﺑ
ﺮﻈﻧ ﻣ ﻲ ﺪﺳﺭ ﻟﺩ ﻪﺑ ﻴ ﻞ ﺘﻧﺁ ﻞﻣﺍﻮﻋ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﻲ
ﺑﻴ ﺗﻮ ﻴ ﻚ ﻪﺳ ﻪﻧﺎﮔ
ﻥﺁ ﺭﺩ
، ﺭﺎﻛ ﺁ ﻲﻳ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺑﻴ ﺮﺘﺸ ﻱ ﻪﺑ ﻥﺁ ﻝﺎﻤﻌﺘﺳﺍ ﺩﺭﺍﻮﻣ ﺭﺩ
ﺁ ﺖﺳﺩ ﻳﺪ .
Sato ﺩﺎﻘﻣ ﺎﻬﻨﺗ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ،ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﻳﺮ
ﻛﺪﻧﺍ ﻲ ﺍ ﺯﺍ ﻳ ﻦ
ﺮﺘﺳﺍ ﺖﻬﺟ ﻁﻮﻠﺨﻣ ﻳﻠ
ﻴ ﻩﺰ ﻧﻮﻔﻋ ﺝﺎﻋ ﻥﺩﺮﻛ ﻲ
ﻧ ﺩﺭﻮﻣ ﻴ ﺯﺎ ﻭ ﻩﺩﻮﺑ
ﺍﻳ ﻦ ﻫ ﺭﺍﺪﻘﻣ ﻴ ﭻ ﻐﺗ ﻴﻴ ﺕﺍﺮ ژﻮﻟﻮﺗﺎﭘ ﻳﻜ ﻲ ﺻﺎﺧ ﻲ ﻭﺭ ﻱ ﭗﻟﺎﭘ ﺖﻓﺎﺑ
ﺍ ﻥﺎﺴﻧﺍ ﻳ ﺩﺎﺠ ﻤﻧ ﻲ ﺪﻨﻛ
) .
12 (
Hoshino ﻣﺪﺿ ﺕﺍﺮﺛﺍ ،ﻥﺍﺭﺎﻜﻤﻫ ﻭ
ﻴ ﺑﻭﺮﻜ ﻲ ﻁﻮﻠﺨﻣ
ﺳ ﻴ ﺳﺎﺴﻛﻮﻠﻓﻭﺮﭙ ﻴ
،ﻦ ﻧﻭﺮﺘﻣ ﻴ ﻝﻭﺯﺍﺪ ﺎﻣ ﻭ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﻥﻭﺪﺑ ﻭ ﺎﺑ
ﻥﺩﻭﺰﻓﺍ Rifampicin ﻭﺭ ﺍﺭ
ﻱ ﺮﺘﻛﺎﺑ ﻱ ﺎﻫ ﻱ ﻬﺗ ﻴ ﻪ ﺯﺍ ﻩﺪﺷ
ﺩﻳ ﻩﺭﺍﻮ ﺎﻫ ﻱ ﻝﺎﻧﺎﻛ ﺎﻫ ﻱ ﺭ ﻳ ﻪﺸ ﻧﻮﻔﻋ ﻲ ﺯﺭﺍ ﻳﺑﺎ ﻲ ﺪﻧﺩﺮﻛ ﺵﺭﺍﺰﮔ ﻭ ،
ﺸﻧ ﻖﻴﻘﺤﺗ ﻦﻳﺍ ﺞﻳﺎﺘﻧ ﺩﺍﺩ ﻥﺎ
ﺁﺭﺎﻛ ﻲﻳ ﺮﺘﻛﺎﺑ ﻱ ﺸﻛ ﻲ ﻣﺎﻤﺗ ﻲ
ﻛﺮﺗ ﻴ ﺕﺎﺒ ﻭﺭﺍﺩ ﻲﻳ ﺪﺣ ﻪﺑ ﻱ ﺑ ﻪﻛ ﺖﺳﺍ ﻩﺩﻮﺑ ﺪﻨﻧﺍﻮﺘ
ﺮﺘﻛﺎﺑ ﻱ ﺎﻫ ﺍﺭ
ﻝﺎﻧﺎﻛ ﺭﺩ ﺎﻫ ﻱ ﺭ ﻳ ﺔﺸ ﻧﻮﻔﻋ ﻲ ﺑ ﺯﺍ ﻴ ﻦ ﺩﺮﺒﺑ
) .
13 (
Kritbikadatta ﻭ
ﻥﺍﺭﺎﻜﻤﻫ ﻧﻴ ﺰ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺭﺎﻬﭼ
ﺴﻠﻛ) ﻒﻠﺘﺨﻣ ﺓﺩﺎﻣ ﻴ
ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳ
،ﺪ ﺰﮕﻫﺮﻠﻛ ﻝژ ﻳﺪ
ﻳ ﻦ 2 ﺪﺻﺭﺩ ،
ﻧﻭﺮﺘﻣ ﻴ ﻝﻭﺯﺍﺪ 2 ﺪﺻﺭﺩ ﺑ ﻭ ﻴﻮ ﺘﻛﺍ ﻴ ﺱﻼﮔﻮ ﻧﺎﻣﺯ ﺓﺯﺎﺑ ﻪﺳ ﺭﺩ ﺍﺭ ( ﻲ
1 ، 3 ﻭ 5 ﻠﻋﺮﺑ ﺯﻭﺭ ﻴ ﺔ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺖﺸﻛ ﻳ ﻪﺘﻓﺎ ﻝﺎﻧﺎﻛ ﺭﺩ
ﺭﻳ ﻪﺸ ﻝﻮﺑﻮﺗ ﻭ ﺎﻫ ﻱ ﺟﺎﻋ ﻲ ﺳﺭﺮﺑ ﻲ ﺸﺨﺑﺮﺛﺍ ﻭ ﻲ ﻝژ ﻧﻭﺮﺘﻣ ﻴ ﻝﻭﺯﺍﺪ
2 ﺪﺻﺭﺩ ﻥﺍﻮﻨﻋ ﻪﺑ) ﻳﻜ
ﻲ ﻛﺮﺗ ﺯﺍ ﻴ ﺕﺎﺒ ﺮﺗ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺍﺭ (
ﻮﻗ ﻱ ﺮﺗ ﺴﻠﻛ ﺯﺍ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻌﺿ ﻭ ﻴ ﻒ ﺮﺗ ﺰﮕﻫﺮﻠﻛ ﺯﺍ ﻳﺪ
ﻳ ﻦ
2 ﺪﺻﺭﺩ ﺮﻛ ﺩﺭﻭﺁﺮﺑ ﺪﻧﺩ .
P
) 14 (
ﻥﺍﺭﺎﻜﻤﻫ ﻭAdl
، ﻟﺎﻌﻓ ﻴ ﺖ ﻣﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﻫ ﻴ ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ ﻭ
ﻤﺧ ﻴﺮ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻜ ﻲ ﻪﺳ ﻠﻋﺮﺑ ﺍﺭ ﻪﻧﺎﮔ ﻴ
ﻪ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻙﻮﻛﻭﺮﺘﻧﺍ
ﻟﺎﻜﻓ ﻴ ﺲ ﺯﺭﺍ ﻳﺑﺎ ﻲ ﺑ ﻭ ﻴ ﺮﺘﺸ ﻳ ﻦ ﺩﺎﻘﻣ ﻳﺮ ﺣﺍﻮﻧ ﻲ ﭘ ﻴ ﮕﺸ ﻴﺮ ﻱ ﺪﺷﺭ ﺯﺍ
ﺘﻧﺁ ﻁﻮﻠﺨﻣ ﺭﺩ ﺍﺭ ﻲ
ﺑﻴ ﺗﻮ ﻴ ﻚ ﻪﺳ ﻟﺎﺳ ﻭ ﻪﻧﺎﮔ ﻴ
،ﻦ ﻁﻮﻠﺨﻣ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﻪﺳ ﺰﮕﻫﺮﻠﻛ ﻭ ﻪﻧﺎﮔ ﻳﺪ
ﻳ ﻦ 2 ﺪﺻﺭﺩ ﻭ ﺭﺩ ﻥﺁ ﺯﺍ ﺪﻌﺑ
ﻁﻮﻠﺨﻣ ﺎﻣ ﻳ ﺎﺳﻮﻨ ﻳ ﻠﻜ ﻴ ﻦ ﻟﺎﺳ/
ﻴ ﻦ ﺪﻧﺩﺮﻛ ﻩﺪﻫﺎﺸﻣ
) .
15 (
ﺑﻴ ﻓﻮ ﻴ ﻢﻠ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻟﺩ ﺖﺳﺍ ﻦﻜﻤﻣ ﻴ
ﻞ ﻠﺻﺍ ﻲ
ﺘﻧﺁ ﺮﺑﺍﺮﺑ ﺭﺩ ﻥﺁ ﺖﻣﻭﺎﻘﻣ ﻲ
ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﺪﺷﺎﺑ ﻭ ﺮﺗﺎﻣ ﻳ ﺲﻜ ﺩﻮﺟﻮﻣ
ﺑ ﺭﺩ ﻴ ﻓﻮ ﻴ ﻢﻠ ﻧﻴ ﺰ ﻠﻣﺎﻋ ﻥﺍﻮﻨﻋ ﻪﺑ ﻲ
ﺘﻧﺁ ﺭﺎﺸﺘﻧﺍ ﺯﺍ ﻪﻛ ﻲ
ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ
ﺮﺘﻛﺩ ﻱﺮﻫﺍ ﻲﻠﺳﺮﻣ ﻲﻠﻋ ﻥﺍﺭﺎﻜﻤﻫ ﻭ
11
ﻩﺭﻭﺩ /ﻲﻜﺷﺰﭙﻧﺍﺪﻧﺩ ﻡﻮﻠﻋ ﺭﺩ ﻖﻴﻘﺤﺗ ﻪﻠﺠﻣ
ﻢﻫﺩﺯﺎﻳ ﻩﺭﺎﻤﺷ / ﻝﻭﺍ / ﺭﺎﻬﺑ 1393 ﻲﭘﺎﻴﭘ / 39
ﭘﻴ ﮕﺸ ﻴﺮ ﻱ ﻣ ﻲ ﺎﻤﻧ ﻳ
؛ﺪ ﺘﻧ ﺭﺩ ﻭ ﻩﺩﺮﻛ ﻞﻤﻋ ﻴ
،ﻪﺠ ﻝﺎﻘﺘﻧﺍ
ﻝﻮﻜﻟﻮﻣ ﺎﻫ ﻱ ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺑ ﻥﻭﺭﺩ ﻪﺑ ﻴ
ﻓﻮ ﻴ ﻢﻠ ﻳﺎ ﺶﻨﻛﺍﻭ ﺩﺍﻮﻣ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺮﺗﺎﻣ ﻥﻭﺭﺩ ﺭﺩ ﻳ
ﺲﻜ ﻮﻌﺗ ﻪﺑ ﻳ ﻖ ﺪﺘﻓﺍ
).
16
ﻧﺎﻜﻣ (
ﻴ ﻢﺴ
ﻟﺎﻤﺘﺣﺍ ﻲ ﺩ ﻳ ﺮﮕ ﺍ ﺭﺩ ﻳ ﻦ ﻣﺯ ﻴ
؛ﻪﻨ ﻐﺗ ﻴﻴ ﺮ ﺪﺷﺭ ﺖﻋﺮﺳ
ﻣﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺑ ﻥﻭﺭﺩ ﺭﺩ ﻴ
ﻓﻮ ﻴ ﻢﻠ ﻣ ﻲ ﺪﺷﺎﺑ
، ﺭﻮﻃ ﻪﺑ ﻱ ﻪﻛ
ﺤﻣ ﻴ ﻂ ﺬﻐﻣ ﻱ ﻐﺗ ﻴﻴ ﺮ ﻳ ﻪﺘﻓﺎ ﺑ ﻥﻭﺭﺩ ﺭﺩ ﻴ
ﻓﻮ ﻴ ﻢﻠ
، ﻣﻴ ﻥﺍﺰ ﺖﻋﺮﺳ
ﻣ ﺪﺷﺭ ﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﻱ ﻧ ﺍﺭ ﺩﻮﺟﻮﻣ ﻴﺰ
ﻐﺗ ﻴﻴ ﺮ ﻣ ﻲ ﺪﻫﺩ
).
15،16 (
ﺳﺎﺴﺣ ﻴ ﺖ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺘﻧﺁ ﻪﺑ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻚ ﺎﻫ ﺧﺮﺑ ﺭﺩ ﻲ
ﺯﺭﺍ ﺩﺭﺍﻮﻣ ﻳﺑﺎ ﻲ ﻩﺪﺷ ﺎﺘﻧ ﻭ ﻳ ﺞ ﺗﻭﺎﻔﺘﻣ ﻲ ﻧﻴ ﺰ ﺖﻈﻠﻏ ﻞﻗﺍﺪﺣ ﺮﻈﻧ ﺯﺍ
ﺧﺮﺑ .ﺖﺳﺍ ﻩﺪﺷ ﺵﺭﺍﺰﮔ ﻩﺪﻨﻨﻛ ﺭﺎﻬﻣ ﻲ
؛ ﺳﺎﺴﺣ ﻴ ﺖ ﺑﻴ ﺮﺘﺸ ﺍﻳ ﻦ
ﺮﺘﻛﺎﺑ ﻱ ﺴﻛﻮﻣﺁ ﺮﺑﺍﺮﺑ ﺭﺩ ﻲ
ﺳ ﻴﻠ ﻴ
،ﻦ ﺰﻨﺑ ﻳ ﻞ ﻨﭘ ﻲ ﺳ ﻴﻠ ﻴ
،ﻦ
ﺎﻣﻮﻜﻧﻭ ﻳ ﺴ ﻴ ﻦ ﺴﻛﺍﺩ ﻭ ﻲ ﺎﺳ ﻳ ﻠﻜ ﻴ ﻦ ﺳﺎﺴﺣ ،ﻞﺑﺎﻘﻣ ﺭﺩ ﻭ ﻴ
ﺖ ﺮﺘﻤﻛ
ﻥﺁ ﺭﺍ ﺮﺑﺍﺮﺑ ﺭﺩ ﻳ
ﺎﻣﻭﺮﺘ ﻳ ﺴ ﻴ ﻦ ﺯﺁ ﻭ ﻳ ﺎﻣﻭﺮﺘ ﻳ ﺴ ﻴ ﻦ ﺵﺭﺍﺰﮔ ﺍﺭ
ﻩﺩﺮﻛ ﺪﻧﺍ
).
5
ﻨﭽﻤﻫ (
ﻴ
؛ﻦ Danlen ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﻥﺍﺭﺎﻜﻤﻫ ﻭ
ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺰﻨﺑ ﺮﺑﺍﺮﺑ ﺭﺩ ﻳ
ﻞ ﻨﭘ ﻲ ﺳ ﻴﻠ ﻴ
،ﻦ ﭙﻣﺁ ﻲ ﺳ ﻴﻠ ﻴ
،ﻦ
ﻠﻛ ﻴ ﺎﻣﺍﺪﻨ ﻳ ﺴ ﻴ
،ﻦ ﻧﻭﺮﺘﻣ ﻴ ﻝﻭﺯﺍﺪ ﺎﺳﺍﺮﺘﺗ ﻭ ﻳ ﻠﻜ ﻴ ﻦ ﺎﻘﻣ ﻟﻭ ﻩﺩﻮﺑ ﻡﻭ ﻲ
ﺭﺍ ﻪﺑ ﺖﺒﺴﻧ ﻳ
ﺎﻣﻭﺮﺘ ﻳ ﺴ ﻴ ﻦ ﺎﻣﻮﻜﻧﻭ ﻭ ﻳ ﺴ ﻴ ﻦ ﻣ ﺱﺎﺴﺣ ﻲ
ﺪﺷﺎﺑ
).
16 (
ﺍﻳ ﻦ ﺕﻭﺎﻔﺗ ﻣ ﺎﻫ ﻲ ﺪﻧﺍﻮﺗ ﺮﺘﻛﺎﺑ ﺔﻧﻮﮔ ﺯﺍ ﻱ
ﺖﻗﺩ ،ﺕﻭﺎﻔﺘﻣ
ﻨﻜﺗ ﻴ ﻚ ﺎﻫ ﻱ ﺳﺭﺮﺑ ﻒﻠﺘﺨﻣ ﻲ
ﺳﺎﺴﺣ ﻴ ﺖ ﻣ ﻴ ﺑﻭﺮﻜ ﻲ ﻳﺎ ﺛﺄﺗ ﻴﺮ
ﺍﺮﺷ ﻳ ﻂ ﺮﺘﻛﺎﺑ ﺖﺸﻛ ﻉﻮﻨﺘﻣ ﻱ
ﺻﻮﺼﺧ ﺮﺑ ﻴ
ﺕﺎ ﺷﺎﻧ ﻥﺁ ﻲ ﻩﺪﺷ
ﺪﺷﺎﺑ
) .
5 (
ﺱﺎﺳﺍﺮﺑ ﺎﺘﻧ
ﻳ ﺞ ﻘﺤﺗ ﻴ ﻖ ﺻﻮﺼﺧ ،ﺮﺿﺎﺣ ﻴ
ﺕﺎ ﺮﺘﻛﺎﺑﺪﺿ ﻱ
ﻫﻴ ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ ﺭﺎﻜﺷﺁ ﺕﺭﻮﺻ ﻪﺑ ﻱ
ﻞﺧﺍﺩ ﺩﺍﻮﻣ ﺯﺍ ﺮﺘﻤﻛ
ﺩ ﻝﺎﻧﺎﻛ ﻳ ﺮﮕ ﺮﺧﺁ ﺭﺩ ﻭ ﻩﺩﻮﺑ ﻳ
ﻦ ﻩﺩﺭ ﻲﻳﻭﺭﺍﺩ ﺻﻮﺼﺧ ﺮﻈﻧ ﺯﺍ ﻴ
ﺕﺎ
ﺮﺘﻛﺎﺑ ﻱ ﺸﻛ ﻲ ﺭﺍﺮﻗ .ﺖﺷﺍﺩ
Salem-Milani ﻥﺍﺭﺎﻜﻤﻫ ﻭ
، ﺮﺘﻛﺎﺑﺪﺿ ﺕﺍﺮﺛﺍ ﻳﺎ
ﻲﻳ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﻠﻋﺮﺑ ﻴ ﺔ ﻥﺍﻮﻨﻋ ﻪﺑ ﺲﻧﺎﺗﻮﻣ ﻙﻮﻛﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﻚ
ﺮﺘﻛﺎﺑ ﻱ ﺘﻧﺩﻭﺪﻧﺍ ﻡﻭﺎﻘﻣ ﻴ
ﻚ ﻫﻭﺭﺍﺩ ﺎﺑ ﺍﺭ ﺎ
ﻱ ﺮﺘﻛﺎﺑﺪﺿ ﻲﻳ ﻝﻮﻤﻌﻣ
ﻝﺎﻧﺎﻛ ﻞﺧﺍﺩ ﻳﺎ
ﺎﻫﻭﺭﺍﺩ ﻱ ﺳ ﻴ ﻤﺘﺴ ﻴ ﻚ ﺎﻘﻣ ﻳ ﻪﺴ ﻘﺤﺗ ﻪﺑﺎﺸﻣ ﻭ ﻴ
ﻖ
ﺴﻠﻛ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﺮﺿﺎﺣ ﻴ
ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ
، ﺮﺘﻤﻛ ﻳ ﻦ ﺕﺍﺮﺛﺍ
ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺭﺍ ﺖﺳﺍ ﻪﺘﺷﺍﺩ
) .
10
ﻤﻫ(
ﻴ ﻦ ﺭﻮﻃ
، Kritbikadatta
ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﺳﺭﺮﺑ ﺭﺩ
ﻲ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻲ
ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺴﻠﻛ ﻴ ﻢ
ﻫﻴ ﺎﺴﻛﻭﺭﺪ ﻳ
،ﺪ ﺰﮕﻫﺮﻠﻛ ﻝژ ﻳﺪ
ﻳ ﻦ 2 ﺪﺻﺭﺩ ﻧﻭﺮﺘﻣ ، ﻴ ﺯﺍﺪ ﻝﻭ 2
ﺪﺻﺭﺩ ﺑ ﻭ ﻴ ﺘﻛﺍﻮ ﻴﻮ ﻠﻋﺮﺑ ﺱﻼﮔ ﻴ
ﺔ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺖﺸﻛ
ﻳ ﻪﺘﻓﺎ ﺭ ﻝﺎﻧﺎﻛ ﺭﺩ ﻳ
ﻪﺸ ﻝﻮﺑﻮﺗ ﻭ ﺎﻫ ﻱ ﺟﺎﻋ ﻲ
، ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ
ﻌﺿ ﺍﺭ ﻴ ﻒ ﺮﺗ ﻳ ﻦ ﺮﺘﻛﺎﺑ ﻞﻣﺎﻋ ﻱ
ﺸﻛ ﻲ ﻓﺮﻌﻣ ﻲ ﺪﻧﺩﺮﻛ
).
14
Adl (
ﻭ
ﻟﺎﻌﻓ ؛ ﻥﺍﺭﺎﻜﻤﻫ ﻴ
ﺖ ﻣﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﻫ ﻴ ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ ﻤﺧ ﻭ ﻴﺮ
ﺘﻧﺁ ﻲ ﺑﻴ ﺗﻮ ﻴ ﻜ ﻲ ﻪﺳ ﻠﻋﺮﺑ ﺍﺭ ﻪﻧﺎﮔ ﻴ
ﻪ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻛﻭﺮﺘﻧﺍ ﻟﺎﻜﻓ ﻙﻮ ﻴ ﺲ
ﺯﺭﺍ ﻳﺑﺎ ﻲ ﺮﺘﻤﻛ ﻭ ﻳ ﻦ ﺣﺎﻧ ﻴ ﺔ ﭘ ﻴ ﮕﺸ ﻴﺮ ﻱ ﻁﻮﻠﺨﻣ ﺭﺩ ﺍﺭ ﺪﺷﺭ ﺯﺍ
ﻫﻴ ﺴﻛﻭﺭﺪ ﻴ ــــ ﺪ ﺴﻠﻛ ﻴ ــــ ﻢ - ﺳ ــــ ﻟﺎﻴ ﻦ ﻫ ﻭ ﻴ ـــــ ﺴﻛﻭﺭﺪ ﻴ ﺪ
ﺴﻠﻛ ﻴ ﻢ ﺰﮕﻫﺮﻠﻛ+
ﻳﺪ ﻳ ﻦ 2 ﺪﺻﺭﺩ ﺪﻧﺩﺮﻛ ﺵﺭﺍﺰﮔ
) .
15 (
ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺪﻳﺎﺴﻛﻭﺭﺪﻴﻫ ﻢﻴﺴﻠﻛ ﺻﻮﺼﺧ ﻪﺑ
ﻴ ﺕﺎ
ﻠﻗ ﻴﺎ ﻲﻳ ﺎﻧﺍﻮﺗ ﻭ ﻲﻳ ﺍﺮﺑ ﻥﺁ ﻱ ﺑ ﺯﺍ ﻴ ﻦ ﺳ ءﺎﺸﻏ ﻥﺩﺮﺑ ﻴ
ﻤﺳﻼﭘﻮﺘ ﻲ
،
ﻮﺗﺎﻧﺩ ﺌﺗﻭﺮﭘ ﻥﺩﺮﻛ ﻩﺭ ﻴ
ﻦ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻧ ﻭ ﻴﺰ ﺳﺁ ﻴ ﺐ ﻪﺑ DNA
ﺮﺘﻛﺎﺑ ﻱ ﮕﺘﺴﺑ ﻲ ﺩﺭﺍﺩ
) .
17
ﻠﻋ (
ﻴ ﻢﻏﺮ ﺧﺮﺑ ﻲ ﺎﻌﻣ ﻳ ﺐ ﺴﻠﻛ ﻴ ﻢ
ﻫﻴ ﺎﺴﻛﻭﺭﺪ ﻳ
؛ﺪ ﺍﻳ ﻦ ﻣﺪﺿ ﻞﻣﺎﻋ ﻴ
ﺑﻭﺮﻜ ﻲ ﺑ ﺕﺍﺮﺛﺍ ﻴ ژﻮﻟﻮ ﻳ ﻚ ﺑﻮﻠﻄﻣ ﻲ
ﺍ ﻪﻠﻤﺟ ﺯﺍ ،ﺩﺭﺍﺩ ﻢﻫ ﻳ
ﻪﻜﻨ ﺜﻨﺧ ﺭﺩ ﻲ ﺯﺎﺳ ﻱ ﻟﻴ ﻠﭘﻮﭙ ﻲ ﺭﺎﻛﺎﺳ ﻳ ﺎﻫﺪ ﻱ
ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﻟﺎﻌﻓ ﻭ ﻴ ﺖ ﻠﺤﺗﺪﺿ ﻴ ﻞ ﻜﺸﺗ ﻪﺑ ﻭ ﻪﺘﺷﺍﺩ ﺶﻘﻧ ﻴ
ﻞ ﺖﻓﺎﺑ
ﺖﺨﺳ ﻧﻴ ﺰ ﻣ ﻚﻤﻛ ﻲ ﺎﻤﻧ ﻳﺪ
).
18
ﻭﻼﻋ (
ﻩ ﺧﺮﺑ ﺖﻣﻭﺎﻘﻣ ﺮﺑ ﻲ
ﺯ ﻳﺮ
ﺎﻫ ﻪﻧﻮﮔ ﻱ ﻟﺎﻜﻓ ﺱﻮﻛﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻞﺑﺎﻘﻣ ﺭﺩ ﺴﻠﻛ
ﻴ ﻢ
ﻫﻴ ﺎﺴﻛﻭﺭﺪ ﻳ ﻟﻼﺣ،ﺪ ﻴ ﺖ ﻠﺑﺎﻗ ﻭ ﻴ ﺖ ﻫ ﺩﻭﺪﺤﻣ ﺭﺎﺸﺘﻧﺍ ﻴ
ﺴﻛﻭﺭﺪ ﻴ ﺪ
ﺴﻠﻛ ﻴ ﻢ ﻧ ﻭ ﻴﺰ ﺎﻧﺍﻮﺗ ﻲﻳ ﺮﻓﺎﺑ ﻱ ﺟﺎﻋ ﻲ ﺍﺮﺷ ﺖﺳﺍ ﻦﻜﻤﻣ ﻥﺁ ﻳ
ﻂ
ﺍﺮﺑ ﻩﺩﺎﻣ ﻱ ﺳﺭ ﻴ ﻥﺪ ﻪﺑ pH ﻧ ﺩﺭﻮﻣ ﻴ ﺯﺎ ﺍﺮﺑ ﻱ ﺯﺎﺳﺩﻮﺑﺎﻧ ﻱ
ﻣﻴ ﻧﺎﮔﺭﺍﻭﺮﻜ ﻴ ﻢﺴ ﺎﻫ ﺍﺭ ﻝﻮﺑﻮﺗ ﺭﺩ ﺎﻫ ﻱ ﺟﺎﻋ ﻲ ﻳﺎ ﺣﺍﻮﻧ ﻲ ﻣﻮﺗﺎﻧﺁ ﻴ ﻜ ﻲ
ﭘﻴ ﭽ ﻴ ﻩﺪ ﺖﺨﺳ ﺎﻤﻧ ﺮﺗ ﻳﺪ
) .
19
ﻣﺎﮕﻨﻫ(
ﻲ ﻫ ﻪﻛ ﻴ ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ
ﺣﺍﻮﻧ ﻪﺑ ﻲ ﺤﻣ ﺝﺎﻋ ﻴ ﻄ ﻲ ﻣ ﻲ
،ﺪﺳﺭ ﺓﺩﻭﺪﺤﻣ ﻪﺑ ﻥﺁ pH
6 ﺎﺗ 4/
7
ﺳﺭ ﻴ ﻩﺪ ﺍﺮﺑ ﺖﺳﺍ ﻦﻜﻤﻣ ﻭ ﻱ
ﻝﻮﻠﺳ ﺎﻫ ﻱ ﻮﻴﺗﺍﺮﻨﺟﺭ ﺮﭘ
ﻳ ﻝﺎﺘﻧﺩﻮ
ﺁ ﺳ ﻴ ﺐ ﺪﺷﺎﺑ ﺍﺯ
).
3 (
ﻘﺤﺗ ﻴ ﺗﺎﻘ ﻲ ﻥﺍﺪﻧﺩ ﻝﺪﻣ ﺯﺍ ﻪﻛ ﺎﻫ
ﻱ ﻩﺪﺷ ﻩﺩﻮﻟﺁ ﺑﺍﺮ
ﻱ ﺯﺭﺍ ﻳﺑﺎ ﻲ
ﺁﺭﺎﻛ ﻲﻳ ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻠﻋﺮﺑ ﻴ ﻪ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻙﻮﻛﻭﺮﺘﻧﺍ
ﻟﺎﻜﻓ ﻴ ﺲ ﻩﺩﺮﻛ ﻩﺩﺎﻔﺘﺳﺍ ﮕﻤﻫ ؛ﺪﻧﺍ
ﻲ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﺍ ﺪﻧﺍ
ﻳ ﻦ ﻩﺩﺎﻣ
ﻣﺎﮕﻨﻫ ًﺎﺻﻮﺼﺨﻣ ﻲ
ﺎﻬﻨﺗ ﻪﺑ ﻪﻛ ﻲﻳ
ﻠﻋ ﻴ ﻪ ﺍﻳ ﻦ ﻪﻧﻮﮔ ﺭﺎﻛ ﻪﺑ ﺎﻫ
ﻣ ﻲ
؛ﺩﻭﺭ ﺁﺭﺎﻛ ﻲﻳ ﺻﺎﺧ ﻲ ﻠﻋ ﻴ ﺔ ﺍﻳ ﻦ ﺘﻛﺎﺑ ﺮ ﻱ ﺩﺭﺍﺪﻧ
) .
20
، 19 (
؛ﺲﻜﻋﺮﺑ Chai ﺭﺍ ﺪﻧﺩﺮﻛ ﺵﺭﺍﺰﮔ ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﻳ
ﺎﻣﻭﺮﺘ ﻳ ﺴ ﻴ
،ﻦ
ﺴﻛﺍ ﻲ ﺎﺳﺍﺮﺘﺗ ﻳ ﻠﻜ ﻴ ﻦ ﺴﻠﻛ ﻭ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺭﺩ ﻞﻣﺎﻛ ﺕﺭﻮﺻ ﻪﺑ
ﺑ ﺖﺷﺍﺩﺮﺑ ﻴ ﻓﻮ ﻴ ﻢﻠ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﻩﺩﻮﺑ ﺮﺛﺆﻣ ﺪﻧﺍ
).
11 (
12
ﺘﻧﺁ ﺮﺛﺍ ﻪﺴﻳﺎﻘﻣ ﻲ
ﻝﺎﻳﺮﺘﻛﺎﺑ ﻦﻴﺴﻳﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻭ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ﺐﻴﻛﺮﺗ ،ﻢﻳﺪﺳ ﻙﺎﻨﻓﻮﻠﻜﻳﺩ ...
ﻘﺤﺗ ﺭﺩ ﻴ ﻖ ﺧﺍ ﻴ
؛ﺮ ﺯﺍ ﻝﺪﻣ ءﺎﺸﻏ ﺮﺘﻠﻴﻓ ﻠﻋﺮﺑ
ﻴ ﻪ ﺑﻴ ﻓﻮ ﻴ ﻢﻠ
ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺪﺷ ﻩﺩﺎﻔﺘﺳﺍ
، ﺭﺩ ﻝﺪﻣ ﻥﺍﺪﻧﺩ ﺎﻫ ﻱ
؛ﻩﺩﻮﻟﺁ
ﺴﻠﻛpH ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻟﺩ ﻪﺑ ﻴ ﻞ ﺻﺎﺧ ﻴ ﺖ ﺮﻓﺎﺑ ﻱ ﺭ ﺝﺎﻋ ﻳ ﻪﺸ
ﺻﺎﺧ ﻭ ﻩﺩﻮﺑ ﻙﺪﻧﺍ ﻴ
ﺖ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﻤﻧ ﻝﺎﻤﻋﺍ ﻥﺁ ﻲ
ﺩﻮﺷ
).
21 (
ﻘﺤﺗ ﺪﻨﻧﺎﻤﻫ ﻴ
ﻖ ﺎﺘﻧ ؛ﺮﺿﺎﺣ ﻳ
ﺞ ﻪﻌﻟﺎﻄﻣ ﺍ ﻱ ﻝﺪﻣ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﺎﺑ ﻪﻛ
ﻓﻴ ﺮﺘﻠ ﺩﺮﮔ ﻡﺎﺠﻧﺍ ءﺎﺸﻏ ﻳ
؛ﺪ ﺯﺍ ﺪﻌﺑ ﺩﺍﺩ ﻥﺎﺸﻧ ﻳ
ﻚ ﺯﻮﭙﺴﻛﺍ ﺖﻋﺎﺳ
ﺩﻳ ﻚﺴ ﺎﻫ ﺴﻠﻛ ﺮﺑﺍﺮﺑ ﺭﺩ ﻴ
ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳ
؛ﺪ ﺧﺮﺑ ﺯﻮﻨﻫ ﻲ ﻪﻧﻮﮔ ﺎﻫ ﻱ
ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺷﺍﺩ ﺭﻮﻀﺣ ﺖﺸﻛ ﺭﺩ ﻪﺘ
ﺪﻧﺍ
) .
22 (
ﻞﻗﺍﺪﺣ ﻧﺎﻣﺯ ﻲ ﻫ ﺖﺳﺍ ﻡﺯﻻ ﻪﻛ ﻴ
ﺴﻛﻭﺭﺪ ﻴ ﺪ ﺴﻠﻛ ﻴ ﻢ ﺕﺍﺮﺛﺍ
ﺘﻧﺁ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺎﻤﻧ ﻝﺎﻤﻋﺍ ﺍﺭ ﺩﻮﺧ ﻳ
؛ﺪ ﻩﺪﺸﻧ ﺺﺨﺸﻣ ﺯﻮﻨﻫ
ﺖﺳﺍ
).
3
Siqueira (
ﺴﻠﻛ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﻴ
ﻢ
ﻫﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺎﺑ ﻳﺪ ﻗﺎﺑ ﻝﺎﻧﺎﻛ ﻞﺧﺍﺩ ﺭﺩ ﺯﻭﺭ ﺖﻔﻫ ﻞﻗﺍﺪﺣ ﻲ
ﺪﻧﺎﻤﺑ
ﻥﺍﻮﻨﻋ ﻪﺑ ﺎﺗ ﻳ
ﻚ ﻣﺪﺿ ﻞﻣﺎﻋ ﻴ
ﺑﻭﺮﻜ ﻲ .ﺩﻮﺷ ﺏﻮﺴﺤﻣ
) 17
ﺑ(
ﺎ
ﻪﺑ ﻪﺟﻮﺗ ﺯﻮﭙﺴﻛﺍ ﻳ ﻚ ﺘﻋﺎﺳ ﻲ ﺩ ﻳ ﻚﺴ ﺎﻫ ﻘﺤﺗ ﺭﺩ ﻴ ﻖ ﺭﺩ ﺮﺿﺎﺣ
ﺍ ﺮﺑﺍﺮﺑ ﻳ ﻦ ﺩﺮﺗ ؛ﻭﺭﺍﺩ ﻳﺪ ﻱ ﻧﻴ ﺖﺴ ﺘﻧﺁ ﺕﺍﺮﺛﺍ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩﻭﺪﺤﻣ ﻥﺁ
ﺭﻮﻃ ﻪﺑ ؛ﺪﺷ ﺪﻫﺍﻮﺧ ﻱ
ﻪﻛ Kritbikadatta ﻭ
ﻥﺍﺭﺎﻜﻤﻫ ﻥﺎﺸﻧ
ﻟﺎﻌﻓ ﺪﻧﺩﺍﺩ ﻴ
ﺖ ﻣﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻡﻮﺳ ﺯﻭﺭ ﺭﺩ
ﺍﺰﻓﺍ ﻳ ﺶ ﻲﻣ ﺪﺑﺎﻳ
) .
14
ﺍﺮﺑ (
ﻳ ﻦ ﻟﺎﻌﻓ ؛ﺱﺎﺳﺍ ﻴ
ﺖ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺩﻭﺪﺤﻣ
ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻣ ﻲ ﺪﻧﺍﻮﺗ ﺎﻣﺯﺁ ﺵﻭﺭ ﺎﺑ ﻳ
ﻫﺎﮕﺸ ﻲ ﺭﺎﻛ ﻪﺑ
(ﺭﺎﮔﺁ ﺭﺎﺸﺘﻧﺍ) ﻪﺘﻓﺭ ﻳﺎ
ﺩ ﺯﻮﭙﺴﻛﺍ ﻙﺪﻧﺍ ﻥﺎﻣﺯ ﻳ
ﻚﺴ ﺎﻫ ﻥﺁ ﻪﺑ
ﺪﺷﺎﺑ ﻂﺒﺗﺮﻣ
، ﺎﺘﻧ ﻪﻛ ﻳ ﺞ ﻘﺤﺗ ﺎﺑ ﻴ ﻖ ﺩﺭﺍﺩ ﺖﻘﺑﺎﻄﻣ ﺮﺿﺎﺣ .
ﺱﺎﺳﺍﺮﺑ ﺎﺘﻧ ﻳ ﺞ ﻘﺤﺗ ﻴ ﻖ ﺻﺎﺧ ؛ﺮﺿﺎﺣ ﻴ
ﺖ ﻣﺪﺿ ﻴ ﺑﻭﺮﻜ ﻲ ﻭﺭﺍﺩ ﻱ
ﺑﺎﻬﺘﻟﺍﺪﺿ ﻲ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺭﺎﻜﺷﺁ ﺕﺭﻮﺻ ﻪﺑ ﻱ
ﺑﻴ ﺮﺘﺸ ﺯﺍ
ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ .(ﺮﺑﺍﺮﺑ ﻪﺳ ﺩﻭﺪﺣ) ﺖﺳﺍ ﻩﺩﻮﺑ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ ﻦ ﻛﺮﺗ ﺭﺩ ﻴ ﺐ ﺩ ﺎﺑ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺕﺭﻮﺻ ﻪﺑ ﻢﻫ
ﻨﻌﻣ ﻲ ﺭﺍﺩ ﻱ ﻮﻘﺗ ﺚﻋﺎﺑ ﻳ ﺐ ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ
ﺪﺳ ﻳ ﻢ ﺷ ﻩﺪ ﺍ ﻪﻛ ﺩﻮﺑ ﻳ
ﻦ ﻣ ﻉﻮﺿﻮﻣ ﻲ
ﺪﻧﺍﻮﺗ ﺎﻧﺍﻮﺗ ﺎﺑ ﻲﻳ
ﺮﺘﻛﺎﺑ ﻱ ﺸﻛ ﻲ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ
ﺴ ﻴ ﻦ ﺯ ؛ﺪﺷﺎﺑ ﻂﺒﺗﺮﻣ ﻳ
ﺍﺮ ﺔﻬﺟﺍﻮﻣ
ﺩﻳ ﻚﺴ ﺎﻫ ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﺎﺑ ﻳ
ﺴ ﻴ ﻦ ﻞﻣﺎﻛ ﺕﺭﻮﺻ ﻪﺑ ﺩﻮﺑ ﻪﺘﺴﻧﺍﻮﺗ
ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺑ ﺯﺍ ﺍﺭ ﻴ ﻦ ﺩﺮﺒﺑ .
ﺭﺩ ﻝﺎﺳ ﺎﻫ ﻱ ﺧﺍ ﻴﺮ ﺩﺮﮔ ﺺﺨﺸﻣ ﻳ
ﻩﺪ ﻭﺭﺍﺩ ﻱ ﺑﺎﻬﺘﻟﺍﺪﺿ ﻲ ﻭ
ﻏﻴ ﺋﻭﺮﺘﺳﺍﺮ ﻴ ﺪ ﻱ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺮﺘﻛﺎﺑﺪﺿ ﺕﺍﺮﺛﺍ ﻱ
ﺳﻭ ﻴﻌ ﻲ
ﻠﻋﺮﺑ ﻴ ﻪ ﺯ ﻩﻭﺮﮔ ﻳ ﺩﺎ ﻱ ﺮﺘﻛﺎﺑ ﺯﺍ ﻱ ﺎﻫ ﻱ ﻔﻨﻣ ﻡﺮﮔ ﻭ ﺖﺒﺜﻣ ﻡﺮﮔ ﻲ
ﺩﺭﺍﺩ
، ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﻠﻋﺮﺑ ﻢﻫ ﻴ ﺔ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻢﻫ ﻭ ﺖﺒﺜﻣ ﻡﺮﮔ
ﻠﻋ ﺮﺑ ﻴ ﺔ ﻪﻧﻮﮔ ﺎﻫ ﻱ ﻔﻨﻣ ﻡﺮﮔ ﻲ ﺮﺘﻛﺎﺑ ﺕﺍﺮﺛﺍ ﻱ
ﺸﻛ ﻲ ﻭ ﻪﺘﺷﺍﺩ ﺭﺩ
ﺘﻧ ﻴ
؛ﻪﺠ ﻣ ﻲ ﻥﺍﻮﺗ ﺍ ﺯﺍ ﻳ ﻦ ﺍﺮﺑ ﻭﺭﺍﺩ ﻱ ﭘ ﻴ ﮕﺸ ﻴﺮ ﻱ ﺖﻧﻮﻔﻋ ﺯﺍ ﺎﻫ
ﻱ
ﺮﺘﻛﺎﺑ ﻳﺎ ﻲﻳ ﺩﺮﻛ ﻩﺩﺎﻔﺘﺳﺍ .P
) 23 (
Dutta ﺭﺰﺗ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ؛ ﻥﺍﺭﺎﻜﻤﻫ ﻭ ﻳ
ﻖ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺭﺩ
ﺎﻫﺯﻭﺩ ﻱ 5 /1 ﻡﺮﮔ ﺮﺑ ﻡﺮﮔﻭﺮﻜﻴﻣ ﻭ
3 ﻡﺮﮔ ﺮﺑ ﻡﺮﮔﻭﺮﻜﻴﻣ ﻥﺯﻭ
ﺣ ﺩﻮﺑ ﻪﺘﺴﻧﺍﻮﺗ ﺵﻮﻣ ﻥﺪﺑ ﻴ
ﺕﺎﻧﺍﻮ ﺖﻧﻮﻔﻋ ﺮﺑﺍﺮﺑ ﺭﺩ ﺍﺭ
salmonella ﺎﻤﻧ ﺖﻈﻓﺎﺤﻣ ﻩﺪﻨﺸﻛ
) ﻳﺪ
8
ﺍ ﺮﺑ ﻩﻭﻼﻋ .(
ﻳ
؛ﻦ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ ﺖﻧﻮﻔﻋ ﻝﺮﺘﻨﻛ ﺭﺩ ﺖﺳﺍ ﻦﻜﻤﻣ listeria
ﻧﻴ ﺰ ﻔﻣ ﻴ ﺪ ﺪﺷﺎﺑ .
P
) 24 (
P Mazumdar ﺎﺘﻧ، ﻥﺍﺭﺎﻜﻤﻫ ﻭ
ﻳ ﺞ ﻥﺎﻣﺭﺩ
ﺖﻧﻮﻔﻋ ﺎﻫ ﻱ ﺭﺎﺠﻣ ﻱ ﺭﺍﺩﺍ ﻱ ﺷﺎﻧ ﻲ ﺮﺘﻛﺎﺑ ﺯﺍ ﻱ E. coli ﺎﺑ ﺍﺭ
ﺩ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺳﺭﺮﺑ ﻲ ﻡﺎﻤﺗ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﻭ
ﻪﻧﻮﻤﻧ ﺎﻫ ﻱ ﺍﻳ ﻪﻟﻭﺰ ﺮﺘﻛﺎﺑ ﺯﺍ ﻩﺪﺷ ﻱ
ﺩ ﺮﺑﺍﺮﺑ ﺭﺩ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﺱﺎﺴﺣ
ﻩﺩﻮﺑ ﺪﻧﺍ .P
) 7 (
ﻧﺎﻜﻣ ﻴ ﻢﺴ ﻟﺎﻌﻓ ﺎﺑ ﻂﺒﺗﺮﻣ ﻴ
ﺖ ﺮﺘﻛﺎﺑﺪﺿ ﻱ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ
ﻌﻄﻗ ﺕﺭﻮﺻ ﻪﺑ ﺯﻮﻨﻫ ﻲ
ﻌﺗ ﻴﻴ ﻦ ﺧﺮﺑ ؛ﻪﺘﺒﻟﺍ .ﺖﺳﺍ ﻩﺪﺸﻧ ﻲ
ﻘﺤﺗ ﻴ ﺕﺎﻘ ﺍﻳ ﻦ ﭘ ﺎﺑ ﺍﺭ ﻉﻮﺿﻮﻣ ﻴ
ﮕﺸ ﻴﺮ ﻱ ﺯﺍ ﺰﺘﻨﺳ DNA ﺮﺘﻛﺎﺑ ﻱ
ﻳﺎ ﻟﺎﻌﻓ ﺭﺩ ﺺﻘﻧ ﻴ
ﺖ ﻣ ﻂﺒﺗﺮﻣ ءﺎﺸﻏ ﻲ
ﺪﻨﻧﺍﺩ
).
25،9 ، 8
ﺕﺎﻌﻟﺎﻄﻣ (
ﺩﻳ ﺮﮕ ﻱ ﻧﻴ ﺰ ﺩﺮﻛ ﺵﺭﺍﺰﮔ ﻩ
.ﺪﻧﺍ ﺎﻫﻭﺭﺍﺩ ﻱ ﺑﺎﻬﺘﻟﺍﺪﺿ ﻲ ﺪﻨﻧﺎﻣ
ﺗﺭﻮﻛ ﻴ ﺋﻭﺮﺘﺳﺍﻮﻜ ﻴ ﺎﻫﺪ ﻳﺎ ﺩ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺶﺷﻮﭘ ﺭﺩ ﻪﻛ
ﺎﻫ ﻱ ﺑﻴ ﻦ
ﻣ ﻪﺘﻓﺮﮔ ﺭﺎﻛ ﻪﺑ ﻝﺎﻧﺎﻛ ﻲ
؛ﺪﻧﻮﺷ ﻣ ﻲ ﺪﻨﻧﺍﻮﺗ ﺎﻫﺩﺭﺩ ﻱ ﺑﻴ ﻦ ﺕﺎﺴﻠﺟ
ﺪﻨﻫﺩ ﺶﻫﺎﻛ ﺍﺭ ﻭﺪﻧﺍ ﻥﺎﻣﺭﺩ
).
26
ﺍ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ (
ﻳ ﻦ ﺎﺘﻧ ﻳ
؛ﺞ ﺎﺷ ﻳﺪ
ﺩ ﺯﺍ ﻥﺍﻮﺘﺑ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳﻢ ﺎﺟ ﻪﺑ ﻱ ﺴﻠﻛ ﻴ ﻢ ﻫ ﻴ ﺎﺴﻛﻭﺭﺪ ﻳﺪ ﻪﻛ
ﺎﻫﺩﺮﺑﺭﺎﻛ ﻱ ﺳﻭ ﻴﻌ ﻲ ﻥﺎﻣﺭﺩ ﺭﺩ ﺎﻫ ﻱ ﺩﺮﻛ ﻩﺩﺎﻔﺘﺳﺍ ،ﺩﺭﺍﺩ ﻭﺪﻧﺍ .
ﺱﺎﺳﺍﺮﺑ ﺎﺘﻧ
ﻳ ﺞ ﻘﺤﺗ ﻴ ﻖ ﻭﺭﺍﺩ ﺯﺍ ﻩﺩﺎﻔﺘﺳﺍ ؛ﺮﺿﺎﺣ ﻱ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻳ ﺴ ﻴ ﻦ ﻲﻣ ﺪﻧﺍﻮﺗ ﻣ ﻴ ﻥﺍﺰ ﻨﻠﻛ ﻲ ﺎﻫ ﻱ ﻜﺸﺗ ﻴ ﻞ ﺓﺪﻨﻫﺩ
ﺮﺘﻛﺎﺑ ﻱ ﻟﺎﻜﻓ ﻙﻮﻛﻭﺮﺘﻧﺍ ﻴ
ﺲ ﺕﺭﻮﺻ ﻪﺑ ﺍﺭ ﺑ ﺯﺍ ﻞﻣﺎﻛ
ﻴ ﻦ ؛ﺩﺮﺒﺑ
ﻨﭽﻤﻫ ﻴ
،ﻦ ﺍ ﺩﺮﺑﺭﺎﻛ ﻳ ﻦ ﻛﺮﺗ ﺭﺩ ﻭﺭﺍﺩ ﻴ
ﺐ ﺩ ﺎﺑ ﻳ ﻙﺎﻨﻓﻮﻠﻜ ﺪﺳ
ﻳ ﻢ
ﻮﻘﺗ ﺐﺟﻮﻣ ﻳ
ﺖ ﺻﻮﺼﺧ ﻴ ﺕﺎ ﺘﻧﺁ ﻲ ﺮﺘﻛﺎﺑ ﻳ ﻝﺎ ﺩﻮﺑ ﻩﺪﺷ ﻥﺁ .
Dutta ﺭﺎﻜﻤﻫ ﻭ ﻥﺍ ﺍ ﺭﺩ ، ﻳ ﻦ ﻣﺯ ﻴ ﻪﻨ ﺩ ﺪﻧﺩﺍﺩ ﻥﺎﺸﻧ ﻳ
ﻙﺎﻨﻓﻮﻠﻜ ﻪﺑ
ﺎﻣﻮﺘﭘﺮﺘﺳﺍ ﻩﺍﺮﻤﻫ ﻳ
ﺴ ﻴ ﻦ ﺑ ﺕﺍﺮﺛﺍ ﻴ ﺮﺘﺸ ﻱ ﺎﻘﻣ ﺭﺩ ﻳ ﻪﺴ ﺎﺑ
ﺩﻳ ﻙﺎﻨﻓﻮﻠﻜ ﻲﻳﺎﻬﻨﺗ ﻪﺑ
ﺖﻧﻮﻔﻋ ﺮﺑﺍﺮﺑ ﺭﺩ Salmonella
ﻪﺑ
ﺎﻬﻨﺗ ﻲﻳ ﺖﺳﺍ ﻪﺘﺷﺍﺩ
).
8
ﺍ ﺮﺑ ﻩﻭﻼﻋ (
ﻳ
،ﻦ Annadurai ﻭ