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31 4 :
1- Michael F. Holick. Vitamin D Deficiency. N Engl J Med. 2007;357:266-281.
2- Bringhurst F.R, Demay M.B, Kronenberg H.m.Willims. 11.ed . Saunders. Chapter 27, 2008;1217-1224.
3- Morad Zadeh K, Larijani B, Keshtkar AA, Hossein Nezhad A, Rajabian R, Nabi Poor I, et al. Normal values of vitamin D and prevalence of vitamin D deficiency among Iranian population. Sci J Kurdistan U Med Sci.2006;10:33- 43[persian].
4- Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18-28.
5- Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81:353-73.
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Abstract Original Article
Vitamin D Deficiency and Its Cut-off Point among Young Teenagers
A. Talaei1, N. Yadegari2, M. Rafee3, M.R Rezvanfar4
Background and Aim: Vitamin D has a basic role in bone development and metabolism. Regarding high prevalence of vitamin D deficiency in Iran, we aimed to investigate its point prevalence in Arak, Iran and determine a cut-off point for vitamin D deficiency in the region.
Materials and Methods: In a cross-sectional study,420 adolescents (220 girls, 200 boys) aged 10-16 years old were selected using a multistage sampling. Plasma level of vitamin D and PTH were evaluated using radio immune assay and immune radio metric assay, respectively. The relation between vitamin D and PTH was assessed through scatter diagram and the cut-off points for vitamin D deficiency were detected accordingly. The prevalence of vitamin D deficiency in different cut-off points, as well as, the associated factors were analyzed using SPSS 15.00. Student t-test was used to compare the girls and the boys.
Results: Considering 25(OH) vit-D level <20 ng/ml as vitamin D deficiency, 84% of the students were vitamin D deficient (99.1% of girls, 66.5% of boys) (P=0.001). Scatter diagram showed three cut-off points for vitamin D deficiency as 25(OH) vit-D level < 13, 21, 33 ng/ml.
Conclusion: Vitamin D deficiency is more prevalent among girls than boys and increases with increased weight (P=0.05). A cut-off point of 25(OH) vit-D <13 ng/ml is recommended for detecting vitamin D deficiency in Arak, Iran.
Key Words: Parathormone, adolescents, vitamin D deficiency, cut-off point.
Journal of Birjand University of Medical Sciences. 2011; 17(3): 210- 216 Received: February 26, 2011 Accepted: November 08, 2011
1Corresponding Author; Assistant professor, endocrinologist, Arak University of Medical Sciences [email protected]
2 Nutritionist, Arak University of Medical Sciences
3 Epidemiologist, Assistant professor, Arak University of Medical Sciences
