% &
' $(
" ) * 1
,-. * 14
- 8 ) 3 1384 (
6 ( 78 9 '3: ;
3 <)< < = (
3 3 ,. > ?
@3 =
1*
*
A = B9 ),
" = -@ D <)A *2
" E 3 D D < ! *1
? ? 3 4
F3 $G ! " H ) ! IJ<( K!1
*
? L B ! " #$
J<( K!2
=: M 3 < " H ) ! I
*
? 9 ! " #$
& I N 93
*
? L B ! " #$
& < " H ) ! IJ<( K!4
*
? L B ! " #$
" < O
< E :
# Q R <8 O = ( <& "S3 ; 3
# 6
< = ( 9 =
U, ? 3 <)<
. 73
( 78 W ; D A @M X
)
# E 8
3 ( 6 78 )
# E 8
6 (
= ( 9 =
Y ) E ? 3 <)< <
*
G % B 9
* 3 B< H = G
*
% B 9
*HDL
% B 9
'3 9 & 7 I 3 LG % LDL .
( >
:
= LG @M X 73 4
L ZM 3 ,. > " H .
= 3E [3 G #3 " H & 'M & " H \3
mg/kg 50 3 7<& G E &
. I,G I 3 _ `M E @ -( O #3 " H H a % 9 ? ! " H \3
'3: ?
I 3 -( I$( ? 73 H Y 6 3 ( 78 9
. G % B 9
* 3 B< H = G
*
% B 9
% B 9 LDL
= <H "E A & )&b HDL .
( 3 :
<G G )&b 9 H c( 9 6 3 ( 78 -( O W 7
/ 40 8 / 46
` .
3 ? <A B3 .
% B 9 )&b 3 B< H = G G % B 9 Ia 8 '3: ( f& G ' $( -( ? 3 3 c3 I 3 ; 9LDL
% B 9 ? < 7< g)( 9 < c( 9 = @ H B3 ` ' $( -( ? 3 78 ( f& G < HDL
I 3 c( 9 % 9 "
.
= <H L<
: hi ) A 6 ( 78 <) G '3:
3 ? <A ? Y % 9 )9 ' c` \3
*
= $< = ( c( S
9 jk$ > ( )! l< = ( 'B< G I& Ei .
:
= < 9 ? H :
( 78
* 6 78
* 3
*I
&
<
(
= O
M ` I 3 : 1 / 12 / –83
<Ab. I 3 :
1 / 6 / –84 M ` > 3m :
15 / 6 / 84
? L B * - b` ? <
" $ – 7- G F3 $G ! " H–
: 5234003
\< M IB shariatik @ Yahoo.com:
`
! "# $ %
" "&
"' (
)* +
" % %
) 1 2 ( .
" % "1* ' 2 3
"1* 1 ! 2 3 * % # 4 5 #
678 9 3 %: ;
<
= >3 %: ; )
? *
(
<
% ? @ A B
<
C D ; @4E%C
<
6C
? %
6C A FG # C F
"
) 5 - 3 .(
17 ?
K A: $ $ )% L 3 F+#
C +C M 71 N $
.
O* " P+%( Q# 6 N + *
"*
.
1 R* C $ $
"11 6 S1
O T
$ + "1 :
"1 ) 6 .(
"* 6 OV % F # = 8 "
.
W = 8 "
( 6) 6 W = 8 "
3
.( 3) W = 8 " F1 6
; #
" F1 W %: # @ X # "1*
W = 8
3
<
* T
<
<
Q *
%
<
; )
7 (.
8 P+%( *
K A: $ + * = 8 " Z Q#
"1%O N $ )
6 (.
[V* = 8 "
"1 C \ N $ ? \ N $ ! :
) 8 (.
* D !; P+%( VV^ W
"*
+ = 8 "
_ * Q# 6 N
< $ +
" % : $ A: [ !:
<
$ + !
<
= %$ " 5 $ ` [ a G = %$ [
<
b [ !:
<TSH
% 4 ? ADH
"1%O ) 13 - 9 (.
= 8 " " ) ( 3)
'
" ! * % @ * .
@ A$ `
7* W7 @ * ' " d R*
"1T ' # C e >
6C F "& O f '
) 8 9 ( .
8 + 3 $ %' VV^
8 "1T ! g
"1* C
<
1
"* a V^ B )+%( W7 Z?
<
"* " * "' R %* 1 .
D !; C
= 8 " "1 [ f ( 3)
" O +;
) 14 (
<
LDL[ ) 15 (
<
K %O+ [
) 16 ( HDL[ !:
) 14 ( '
% @ *
"1 @ !; C i 3
= 8 "
K %O+ g d"3 f ( 3) LDL
)HDL 17 ( C "1T g d"3 )
15 (
" f
<
1 13 W @ !; C $ '
1 e > "
8 [ !: f
) LDL 18 (
"1T [ !:
C
) 19 .(
D !; 1
" j ` @ )%
= 8 " # @ k l F 9 :
6 T B : ( 3)
% : # C 6 N
"1T + C LDL <
HDL <
<
<K %O+
O+ " O +;
" C k % * ' K %
* .
>
9
( ? <A :
R A$ `
120 D
1 F$ Z* * ^&
300 - 250 d ;
: ; d R*
. i)T D 5
'
@ ' R1O: !? " 7* * C 22
- 20
1 L ; %*
12
%3
"*" " W*
.
* %C * Q# =
.
LG I 3 L3 >
: a ! D
"+
50
%? % d ; + d ; +
(STZ)]
[Upjohn Michigan ' *
R %* " R D ;
% ;
18 LFT 3
"7* Q# ' a !
.
"1T '
a ! "A * C [ STZ
mg/dl 300
<
"*" %: ; S* % )
9 .(
( 78 W >
:
# ; '
(Menhaden, Sigma Co Germany) # n
$ $ \ – *
# "A (Fish-Oil)
ml ! 2 / 1
" N ; * "A LC .
6 N
K A "
10
%
* ' C 6 N
"* :
) 8 ( .
"A \ # e >
M V$
'
8
%)
.
@ X #
<
$
# 7 "
" ; e >
.
3 <)< < = ( = <H "E >
:
\ "A
W1 ; f
<
# q 1 ; C
(Cavernous Sinus)
" d R* ' 678 i5
! $ * W% E? ! +;
Kone Specific)
<
"*E1:
(
" ; "*
. K %O+
d
<
" O +;
HDL <
<
<LDL + K %O <
[ "% +' E?
<
4
8
! $ * W% M V$ "A %)
"*" ; "*
.
$3 Eo = ( " H :
: > G D
4
;
; "*" 6 OV 30
'
<
# 6$ ;
%
<
% K %1 % ;
"*"7* "
.
# ^ % ;
@ X 4
M V$ "A %)
<
e > @ X #
"*
.
7 # ^ % ;
# @ X # nV: @ X # ;
"* e >
.
= o >
G
! $ * + " @ 3E
)% K F* : G \ i*
Tukey
Unpaired T-test C
L +^ !R
"*"
.
@ & [ r %*
Mean±SEM
l " D !;
05 / P<0 S1 1A eE%C
" ; .
3 (
@ X # @" @" Qg s$ C k
* C ! +; ! #
1
" 7*
.
* A$ ` 1
D ! +; ! :
6$ ^&
mg/dl )
±5 6 / 120 (
%) 8
R "A mg/dl
) 5 /
± 20 424 (
"
# ^ ; 1A eE%C
# @ X )
001 / P<0 (
<
8 ;
6$ ; 1t W " ^ ;
"1% "* 1A eE%C .
%) 7 ?
; E? "1T ! * #
^ %
% ; %
) 001 / P<0 (
<
K '
# ^ ; E? "1T
6$ ; %7 @"
) 05 / P<0 .(
@ X # @" @" Qg s$ C k
d K %O+ ! #
E? " O +;
<
K %O+
K %O+ LDL HDL
K "
1
" 7*
.
K %O+ ! : K "
6$ ; d 8 %) ? E? d
<
V %
;
) 01 / P<0 (
<
%) 7 "A
#
; E? d K %O+ ! @ X
" ? [ ^
.
nV: G
6$ ;
mg/dl )
±5 1 / 89 (
K %1 ;
mg/dl
) 5 /
±10 1 / 132 (
1A eE%C
) 01 / P<0 .(
? ! * E? " O +; !
%) 8
<
eE%C nV:
; V 6$ ;
) 001 / P<0 (.
% ?
1A eE%C % ; " ;
"*
.
1 8 ; %) 7 ?
; % 6$ ; E? " O +; !
# ; %
1A eE%C <
" O +; ! 1t < "* @ X # ;
@ X # ; E?
mg/dl )
7 /
±2 62 (
0 50 100 150 200 250 300 350 400 450
N D D+F D+C
Groups
Glucose(mg/dl)
***a
***b
***c
) 1 -
? < 7<# <
k = ( " H )&b 9 H
@M X p :N
*'M & " H :D
* 3 " H :D+F
I,G 3 " H
* ( 78 -( O ?
:D+C 6 78 -( O ? I,G 3 " H aq
: 7< @ = o Wb D
qN
:b 7< @ = o Wb D
qD+F :c 7< @ = o Wb D
D+C 001
/ 0
P<
:
***
% 1 ( 3 <)< < = ( = 6 78 ( 78 3 m8 '3: ;
p k = ( -( 3 ,. = ( >
@M X
" H G % B 9
(mg/dl) 3 B< H = G
(mg/dl) LDL-C(mg/dl)
HDL-C(mg/d)
4 -(
8 -(
4 -(
8 -(
4 -(
8 -(
4 -(
8 -(
'M &
3a
6± /
b 92
±5 3 /
c 89
±7 3 / 71 5 /
±6 9 / 65 05 /
±3 4 / 39 1 /
±4 5 / 40 34 /
±1 7 / 36
±2 2 / 38
2 3 /
±8 2 / 129 5 /
±10 1 / 132 3 /
±13 4 / 122 1 /
±12
g 131 5 /
±8 2 / 65 3 /
±7 4 / 66 7 /
±0 8 / 29 2 /
±1 1 / 30
3 + 1 6 78 /
±3 5 / 113 6 /
±7 5 / 115 5 /
±6 7 /
d 115 7 /
±2 62 07 /
±8 8 / 57 9 /
±12 1 / 63 12 /
±2 9 / 31 46 /
±3 40
3 + ( 78 7
/
±12 1 / 131
±8 5 / 107 1 /
±7 7 / 110 7 /
±2 93 07 /
±8 9 / 58 06 /
±3 50 15 /
±2 35 3 /
±2 5 / 39
:a
001 / P<0
:b
"
01 / P<0
:c
#
005 / P<0
:d
% &
"
01 / P<0
:g
005 / P<0
:h
" #
01 / P<0
# % mg/dl
) 7 /
±2 93 ( ) 01 / P<0 .(
K "
1
! @ X # @ k
K %O+
K %O+ LDL
" 7*HDL .
K %O+ ! : K " A$ `
% ; %) 8 i? LDL
mg/dl
) 5 /
±8 2 / 65 (
; V %7 )
05 / P<0 (
!
K %O+
% % ; %) 7 "A HDL
; V )
01 / P<0 .(
U,
7* [ Z? %:
# 6 N
O V E? ! +; ! [ u3 @ X
"* % K %1 ' .
@" 8 ; )
"A
%) 7
(
" ? [ "1T K %1 # @ k
<
C "1T 1A @ ) G
" 6$ ; ;
<
C "1T 1
% ' % ;
.
C ! +; K %1 # k
D !;
vT 1%
<
G
D !; C
C "1T [ )
20 (
W C
[ !:
) 19 ( g d"3 ! * "A )
19 (
* " w
"*
x
@ X # k ;Z
)
= 8 "
– W 6 ( O +; 5 K %1 )
21 .(
d 8 %) ? # e >
<
[ *
1A
% "* E? K %O+
<
'
$
K %O+ [ k 6%7 %) ?
.
K %O+ ! d 8 %) ? @ X #
6%7 %) ? [ E?
"7* f %7 [ .
n d 8 %) ? E? " O +; !
[ # \ y
"7*
<
%) ?
V " O +; @ X # 6%7 zz
O z
;
[ #
.
K %O+ !
[ # * + LDL
"
.
K %O+ 18 6
n ! * HDL
K %1 ; O V 6%7 %) ? #
)
% (
!:
" ? [ .
e A 9 : %:
"1%O
@ X # + 3 eE%C "
K %O+ * @ )% k +3 A$ `
+;
" " O
<
@ X # G
<
[ " O +; { & >C 9 : " 5 $ @ X # { & >C 9 : # g a G {4 %'
D ; $ $ )& " 8 K >
<
D ; KE%C
-
"F
<
"* ; k
6 !* g { % * e" : | ? 5 $
K 3 8 C @ k $ + +C
"*
. LFT @ A$ `
<
+ [ K %O ) 22 (
S+# g d"3 )
23 (
D !; # +
"
x k ! * " O +; [ 18 6
" " w @ A$ ` vA n # ) 21 14 (
<
O * }1 A$ ` r %*
. [
K %O+
K %O+ [ !: LDL + HDL
#
" " w ! * W W7 Z? n
) 21 14 ( x +FT @ A$ ` _
<
= 8 "
W
6 – )
@ X # (
E? " 5 $ @ g
"* k )
21 .(
[ !: D !; \ 8 ;
[ !: " O +;
j ` @ X # k VLDL
"
) 24 .(
1 7* 7 @ A$ ` A$ ` r %* <
W = 8 " @ X # L "
- 6
<
O +; 5 K %1 6 [V* \ {4 %'
" * M ) %
<
" # $ '
W = 8
3 –
<
K %1 F_ [V* {4 %'
O +;
"1 . Q$
<
@ k
[ !: C "1T ;"1 [
` HDL
" " @ X # * ; " e >
* * d~ e > k 17 ? .
[ Z? 1t
d 4 %7
+ 3 L C 6O *
s(7 #
"1 .
= #& s&
Z?
V V^ j G 13 [
<
f > R1O: !? d +3 W7* 7 Z?
C W7* $ '
x
"
" L 3 * "T n X 4 |O +
<
6
"1* d 4 W7 Z? 18 ! d %^
"* L 3 7 * "T !? " 7* 5 .
References:
1 .
! !3 e .
"1T N $ ? < N $ < N $ " ? .
! !? d +3 W7* FC +3 7*
1372 x K 2
<
2 : 46 - 28 .
2 . . t(
.
? +R
!? d +3 W7* < d
" 7 1374 x K 2
<
5 : 29 - 27 .
3. Stepanovic V, Awad O, Jiao C, et al. Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res 2003; 92:1247-53.
4. Anderson WAD, Thomas MS. Text book of pathology. London: Mosby Co, 1984, 532.
5. Jeffcoate WJ, Hading KG. Diabetic foot ulcers.
Lancet 2003;361:1551-4.
6. Ruthing DJ, Meckling – Gill A. Both (n-3) and (n-6) fatty acids stimulates wound healing in the rat intestinal epithelial cell line < IEC-6.J. Nurt 1999;129:1791-8.
7. Luo J. Rizkalla SW, Vidal H, et al. Moderate intake of n-3 fatty acids for months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic man. Diabetes care 1998;21: 717-24.
8 . O C
< d R d .
# ' Q# 6 N k
% ^& D 6C 6
. R N $ ! : +
$ :
N 1378 x K 3
<
2 : 193 - 181 .
9 . O d
<
? "
.
# AB k
W%C L& ' 6C F W7 " ) D
. +R
1 !? d +3 W7*
1381 x K K 1
: 32 - 17 .
10. Sweeney B, Puri P, Reen DJ. Polyunsturated fatty acids infiuence neonatal monocyte survival.Pediart Surg Int 2001;17:228-54.
11. Robertson S, Cameron NE, Cotter MA. The effect of the calcium antagonist nifedipine on peripheral nerve function in streptozotocin diabetic rats. Diabetologica 1992 ;35:1113-17.
12. Lands WEM. Biochemistry and physiology of n-3 fatty acids. FASEB J 1992;6: 2530-6.
13. Thies F, Nebe-Von-Caron G, Powel JR, et al.
Dietary Supplemnatation with eicosapenaenoic acidK but not with other long – chain n-3 or n-6 polyunsturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 years . Am J Clin Nutr 2001;73:534-48.
14. Mori TA, Vandongen R, Masaroi JR, et al.
Comparison of diets supplemented with fish oil or olive oil on plasma lipoproteine in insulin – dependent diabetics. Metabolism 1991;40: 241-6.
15. Farmer A, Montori V. Fish oil in people with type2 diabetes mellitus. Cochrane Database Syst Rev 2001;3: 3205-9.
16. Conner WE. Diabetes fish oil and vascular disease. Ann Inter Med 1996; 123: 450- 952.
17. Petersen M, Pedersen H, Major-Pedersen A, et al. Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. Diabetes care 2002; 25: 1704-8.
18. Morgan WA, Raskin P, Rosentock J. A comparis of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDM. Diabetes care 1995; 18: 83-6.
19. Kasim SE. Dietary marine fish oil and insulin action in zxpe2 diabetes. Ann N Y Acid Sci 1993;14:250-7.
20. Giron MD, Sanchez F, Ortelano P, et al. Effect of dietary fatty acids on lipid metabolism in streptozotocin- induced diabetic rats. Metabolism 1999; 48: 455-60.
21. Jing L. Moderate intake of n-3 fatty acids for 2 months has detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Diabetes Care 1998; 21 : 717- 724.
22. Kusunoki M, Tsutsumi K, Hara T, et al. Ethyl icosapentate (omega-3 fatty acid) causes accumulation lipids in skeletal muscle but suppress
insulin resistance in OLETF rats. Metobolism 2003;
52:30-34.
23. Hankenson KD, Watkins BA, Schoenlein IA, et al. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in
interleukin-6 production. Proc Soc Exp Biol Med 2000; 223:88-95.
24. Ingrid T. Effect of n – 3 polyunsaturated fatty acids on glucose homesostasis and blood pressure in essential hypertension. Ann Intern Med 1995;
123: 911-18.
