Effect of Eight-Weeks Chitosan Supplementation and Combined Exercise on the Blood Pressure and Lipid Profile of Women With Hypertension
Elahe Rasouli Jokar1 , Saeid Shamlou Kazemi2
1. Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Danesh Alborz, Univesity of Qazvin,
Qazvin, Iran. E-mail:[email protected]
2. Corresponding Author, Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University of Hamedan, Hamedan, Iran. E-mail:[email protected]
Article Info ABSTRACT
Article type:
Research
Article history:
Received:
22 December 2022 Received in revised form:
16 March 2023 Accepted:
23 April 2023 Published online:
25 April 2023
Keywords:
Blood pressure, Chitosan,
Combined exercise, Lipid profile.
Introduction: Hypertension and dyslipidemia are risk factors for cardiovascular diseases and are the leading causes of death. However, taking herbal supplements and physical activity engagement can help prevent this disease. Therefore, the present study investigated the effect of chitosan supplementation and combined exercise on blood pressure and lipid profile in women with hypertension.
Methods: The study was conducted as a clinical trial on 40 women with high blood pressure. The participants were randomly divided into four Chitosan Supplement (N=10), Combined Exercise (N=10), Chitosan Supplements + Combined Exercise (N=10), and Control (N=10) groups. For combined exercise, participants performed aerobic exercise for eight weeks (three days a week) followed by resistance training, while for the supplement, participants consumed four grams of Chitosan daily (eight capsules of 500 mg each). Blood sampling and blood pressure measurements were conducted before eight weeks and again 48 hours after the last exercise and supplementation session and all the measurements were recorded.
Results: Statistical analysis of data was done via SPSS version 23 using Analysis of Variance (ANOVA) and Covariance at a significant level of P≤0.05. The highest mean value of post-test systolic blood pressure (141.9±9.8), and post-test total cholesterol (213.28±3.9) was observed in the participants of the Combined Exercise group. The results of the between-group comparison indicated a significant improvement in systolic blood pressure, total cholesterol, triglyceride, VLDL, and LDL indices. In diastolic blood pressure and HDL indices, the results were close to the significant level.
Conclusion: Overall, the results showed that the consumption of Chitosan supplements and combined exercise have beneficial effects on the blood pressure and lipid profile of women with high blood pressure.
Cite this article: Rasouli Jokar E., & Shamlou Kazemi S. The Effect of Eight-Weeks Chitosan Supplementation and Combined Exercise on Blood Pressure and Lipid Profile of Women With Hypertension. Journal of Sport Biosciences. 2023; 15 (1): 55-70.
DOI: http//doi.org/10.22059/JSB.2023.354853.1574
Journal of Sport Biosciences by University of Tehran Press is licensed under CC BY-NC 4.0.
Web site: https://jsb.ut.ac.ir/ | Email: [email protected].
© The Author(s). Publisher: University of TehranPress.
Introduction
High blood pressure and dyslipidemia (abnormal increase or decrease in the serum levels of blood lipids) are the main risk factors for cardiovascular diseases and there is a 90% risk of developing high blood pressure in middle-aged and elderly people. Also, in most cases, cardiovascular diseases are associated with dyslipidemia. All over the world, there are vast changes in the levels of serum lipid profiles among different population groups. To promote cardiovascular health, lifestyle changes should be considered as a guide to reduce people's inactivity and modify healthy eating patterns. It is quite evident that inactivity and high-fat diets reduce insulin sensitivity and fat oxidation and dyslipidemia. On the contrary, regular exercise increases maximum oxygen absorption and increases energy from fat stores, and reduces dyslipidemia. Also, regular physical activity and exercise are effective adjunctive treatments for managing and controlling arterial blood pressure. Chitosan is a natural polysaccharide of glucosamine residues derived from chitin, which is the second most abundant biopolymer on earth. Chitosan is obtained from the exoskeleton of crustaceans or the cell wall of fungi in the first stage and is recommended as a supplement for weight loss and is an adjunctive treatment for blood fat, blood sugar, and blood pressure. Based on the studies conducted on combined exercise to improve body composition, increase muscle strength, and favorably change blood lipid and apolipoprotein profiles, the combination of aerobic training and strength training causes a significant improvement in maintaining and reducing blood pressure levels too. so, this study aimed to investigate the effect of Chitosan supplementation and eight weeks of combined exercise on the blood pressure and lipid profile of women with hypertension.
Methods
The study was conducted as a clinical trial on 40 women with high blood pressure. The participants were randomly divided into four Chitosan Supplement (N=10), Combined Exercise (N=10), Chitosan Supplements + Combined Exercise (N=10), and Control (N=10) groups. For combined exercise (in Combined Exercise and Supplement + Combined Exercise groups) participants performed aerobic exercise for eight weeks (three days a week) followed by resistance training, while for the supplement consumption (in Supplement
participants consumed four grams of Chitosan daily (eight capsules of 500 mg each). Blood sampling and blood pressure measurements were conducted before eight weeks and again 48 hours after the last exercise and supplementation session and all the measurements were recorded.
Result
Statistical analysis of data was done via spss version 23 using Analysis of Variance (ANOVA) and Covariance at a significant level of P≤0.05. The highest mean value of post-test systolic blood pressure (141.9±9.8), and post-test total cholesterol (213.28±3.9) was observed in the participants of the Combined Exercise group. The results of the between-group comparison indicated a significant improvement in systolic blood pressure, total cholesterol, triglyceride, VLDL, and LDL indices. In diastolic blood pressure and HDL indices, the results were close to the significant level.
Conclusion
Overall, the results showed that the consumption of Chitosan supplements and combined exercise have beneficial effects on the blood pressure and lipid profile of women with high blood pressure.
Ethical Considerations
Compliance with ethical guidelines:This research was approved by the ethics committee with the ethical code of
IR.SSRI.REC.2021.11013.1224
Funding: The research was done without using financial resources.
Authors’ contribution: All authors have contributed to the research equally.
Conflict of interest: No conflict of interest is declared.
Acknowledgments: Thanks to all people who helped us to conduct the research.
ﺗﺄ ﺮﯿﺛ ﺖﺸﻫ ﻼﺘﺒﻣ نﺎﻧز رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و نﻮﺧ رﺎﺸﻓ ﺮﺑ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ و نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﻪﺘﻔﻫ ﺎﺸﻓ ﻪﺑ
ر
ﻻﺎﺑ نﻮﺧ
رﺎﮐﻮﺟ ﯽﻟﻮﺳر ﻪﻬﻟا ، ۱
ﯽﻤﻇﺎﮐ ﻮﻠﻣﺎﺷ ﺪﯿﻌﺳ
۲
۱ هوﺮﮔ. ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ ﺪﮑﺸﻧاد
ة د ،ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ ناﺮﯾا ،ﻦﯾوﺰﻗ ،زﺮﺒﻟا ﺶﻧاد هﺎﮕﺸﻧا
:ﻪﻣﺎﻧﺎﯾار.
@gmail.com 13660
elaherasuli
2 . لوﺆﺴﻣ ةﺪﻨﺴﯾﻮﻧ
، ،ﯽﺷزرو يژﻮﻟﻮﯾﺰﯿﻓ هوﺮﮔ ﺪﮑﺸﻧاد
ة ﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ و ﯽﻧﺪﺑ ﺖﯿﺑﺮﺗ ناﺮﯾا ،ناﺪﻤﻫ ،ﺎﻨﯿﺳ ﯽﻠﻋﻮﺑ هﺎﮕ
:ﻪﻣﺎﻧﺎﯾار .
@gmail.com 9092
saeidshamlou
ﻪﻟﺎﻘﻣ تﺎﻋﻼﻃا هﺪﯿﮑﭼ
:ﻪﻟﺎﻘﻣ عﻮﻧ ﯽﺸﻫوﮋﭘ
:ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ 01
/ 10 / 1401
:يﺮﮕﻧزﺎﺑ ﺦﯾرﺎﺗ 25
/ 12 / 1401
:شﺮﯾﺬﭘ ﺦﯾرﺎﺗ 03
/ 02 / 1402
:رﺎﺸﺘﻧا ﺦﯾرﺎﺗ 05
/ 02 / 1402
ﺪﯿﻠﮐ هژاو :ﺎﻫ
،يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ
،ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ
،نازﻮﺘﯿﭼ نﻮﺧ رﺎﺸﻓ . :ﻪﻣﺪﻘﻣ
رﺎﺸﻓ نﻮﺧ ﻻﺎﺑ و ﺲﯾد ﯽﻣﺪﯿﭙﯿﻟ زا ﻞﻣاﻮﻋ ﺮﻄﺧ يرﺎﻤﯿﺑ يﺎﻫ ﯽﺒﻠﻗ - ﯽﻗوﺮﻋ زا ﻞﻠﻋ ﻠﺻا ﯽ گﺮﻣ ﺪﻧﺮﯿﻣو . ﺎﺑ ﻦﯾا
،لﺎﺣ فﺮﺼﻣ ﻞﻤﮑﻣ يﺎﻫ ﯽﻫﺎﯿﮔ و مﺎﺠﻧا ﺖﯿﻟﺎﻌﻓ يﺎﻫ ﯽﻧﺪﺑ ﯽﻣ ﺪﻧاﻮﺗ ﻪﺑ يﺮﯿﮕﺸﯿﭘ زا ﻦﯾا ﯿﺑ يرﺎﻤ ﮐ ﮏﻤ ﺪﻨﮐ . ﻦﯾاﺮﺑﺎﻨﺑ
ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ ﻪﺑ ﯽﺳرﺮﺑ ﺮﯿﺛﺄﺗ ﻞﻤﮑﻣ نازﻮﺘﯿﭼ و شزرو ﯽﺒﯿﮐﺮﺗ ﺮﺑ رﺎﺸﻓ نﻮﺧ و ﻞﯾﺎﻓوﺮﭘ يﺪﯿﭙﯿﻟ نﺎﻧز ﻼﺘﺒﻣ ﻪﺑ رﺎﺸﻓ نﻮﺧ
ﻻﺎﺑ ﺖﺧادﺮﭘ .
:ﺶﻫوﮋﭘ شور ﻖﯿﻘﺤﺗ
ﻪﺑ ترﻮﺻ ﯽﻨﯿﻟﺎﺑ ﯽﯾﺎﻣزآرﺎﮐ يور
40 نز ﻼﺘﺒﻣ ﻪﺑ رﺎﺸﻓ نﻮﺧ ﻻﺎﺑ ﻧا ﺖﮐﺮﺷ .ﺖﻓﺮﮔ مﺎﺠ نﺎﮔﺪﻨﻨﮐ
ﻪﺑ رﻮﻃ ﯽﻓدﺎﺼﺗ د ر رﺎﻬﭼ ) هوﺮﮔ 10 نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﺮﻔﻧ -
10 ﻦﯾﺮﻤﺗ ﺮﻔﻧ ﯽﺒﯿﮐﺮﺗ - 10 نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﺮﻔﻧ ﻪﺑ
ﻦﯾﺮﻤﺗ هاﺮﻤﻫ
و ﯽﺒﯿﮐﺮﺗ 10 ﺪﻨﺘﻓﺮﮔ راﺮﻗ (لﺮﺘﻨﮐ ﺮﻔﻧ .
ﺖﮐﺮﺷ نﺎﮔﺪﻨﻨﮐ ﻪﺑ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ هوﺮﮔ رد ﻣ
تﺪ ﺖﺸﻫ ﻪﺘﻔﻫ ) ﻪﺳ ور (ﻪﺘﻔﻫ رد ز
و يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺲﭘ
ﺮﻤﺗ ﺎﺑ ﻞﻤﮑﻣ و ﻞﻤﮑﻣ هوﺮﮔ و ﯽﺘﻣوﺎﻘﻣ تﺎﻨﯾﺮﻤﺗ نآ زا ﻪﻧازور ﻦﯾ
4 مﺮﮔ ) نازﻮﺘﯿﭼ 8 لﻮﺴﭙﮐ 500
ﻣﯿ ﻠ ﯽ ﻣﺮﮔ ﯽ ( .ﺪﻧدﺮﮐ فﺮﺼﻣ ﻪﻧﻮﻤﻧ
ﮔﯿ ﺮ ي و ﯽﻧﻮﺧ هزاﺪﻧا ﮔﯿ ﺮ ي نﻮﺧ رﺎﺸﻓ ﺶﯿﭘ
زا ﺖﺸﻫ و ﻪﺘﻔﻫ هرﺎﺑود 48 ﺖﻋﺎﺳ ﭘ ﺲ زا
ﻦﯾﺮﺧآ ﺴﻠﺟ ﮥ و ﻦﯾﺮﻤﺗ ﻞﻤﮑﻣ مﺎﺠﻧا ﯽﻫد ﺖﻓﺮﮔ
. هزاﺪﻧا ﮔﯿ ﺮ ي ﺎﻫ .ﺪﺷ ﺖﺒﺛ
ﯾ ﻪﺘﻓﺎ ﺎﻫ : ﺰﺠﺗ ﯾﻪ ﻠﺤﺗو ﯿ ﻞ يرﺎﻣآ هداد ﺎﻫ ﺎﺑ ﺨﺴﻧspss ﮥ 23 ﺎﺑ نﻮﻣزآ زا هدﺎﻔﺘﺳا و اﻮﻧآ ﺲﻧﺎﯾراو ﻞﯿﻠﺤﺗ
ﺲﻧﺎﯾراوﻮﮐ رد
ﺢﻄﺳ يرادﺎﻨﻌﻣ ) 05 /0 P≤ ( مﺎﺠﻧا .ﺖﻓﺮﮔ ﻦﯿﮕﻧﺎﯿﻣ راﺪﻘﻣ ﻦﯾﺮﺘﺸﯿﺑ نﻮﺧ رﺎﺸﻓ
) نﻮﻣزآ زا ﺲﭘ ﮏﯿﻟﻮﺘﺴﯿﺳ 8/
9±9 / 141 ،(
) نﻮﻣزآ زا ﺲﭘ ﻞﮐ لوﺮﺘﺴﻠﮐ 9/
3±28 / 213 ﺖﮐﺮﺷ داﺮﻓا رد ( ﺎﻨﯾﺮﻤﺗ هوﺮﮔ رد هﺪﻨﻨﮐ
ﯽﺒﯿﮐﺮﺗ ت ﺪﺷ هﺪﻫﺎﺸﻣ ﺎﺘﻧ و
ﯾ ﺞ ﺴﯾﺎﻘﻣ ﮥ
ﯽﻫوﺮﮔ ﻦﯿﺑ ﮐﺎﺣ
ﯽ دﻮﺒﻬﺑ زا ﺎﻨﻌﻣ راد ﺺﺧﺎﺷ ﺎﻫ ي نﻮﺧ رﺎﺸﻓ ﮏﯿﻟﻮﺘﯿﺳ
و ،ﻞﮐ لوﺮﺘﺴﻠﮐ يﺮﺗ
،ﺪﯾﺮﯿﺴﯿﻠﮔ
VLDL,LDL رد و دﻮﺑ
ﺺﺧﺎﺷ ﺎﻫ ي نﻮﺧ رﺎﺸﻓ و ﮏﯿﻟﻮﺘﺳﺎﯾد ﺪﺷ هﺪﻫﺎﺸﻣ يرادﺎﻨﻌﻣ ﺢﻄﺳ ﻪﺑ ﮏﯾدﺰﻧ ﺞﯾﺎﺘﻧHDL
.
ﺘﻧ ﯿ ﻪﺠ ﮔﯿ ﺮ ي : ﺎﺘﻧ عﻮﻤﺠﻣ رد ﯾ
ﺞ نﺎﺸﻧ داد ﻞﻤﮑﻣ فﺮﺼﻣ ﻪﮐ ﯿﭼ
نازﻮﺘ و ﻦﯾﺮﻤﺗ ﮐﺮﺗ ﯿﺒ ﯽ ﯿﺛﺄﺗ تاﺮ ﻣ ﻔﯿ ﺪ ي ﺎﺸﻓ ﺮﺑ و نﻮﺧ ر
يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ .دراد ﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد
:دﺎﻨﺘﺳا ﻪﻬﻟا ،رﺎﮐﻮﺟ ﯽﻟﻮﺳر و ؛
،ﯽﻤﻇﺎﮐ ﻮﻠﻣﺎﺷ ﯿﻌﺳ
.ﺪ ﺛﺄﺗ ﯿﺮ ﺖﺸﻫ ﺮﺑ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ و نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﻪﺘﻔﻫ نﻮﺧ رﺎﺸﻓ
ﺎﻓوﺮﭘ و رد يﺪﯿﭙﯿﻟ ﻞﯾ ﻼﺘﺒﻣ نﺎﻧز
ﺑ ﻪ نﻮﺧ رﺎﺸﻓ ﻻﺎﺑ .
ﮥﯾﺮﺸﻧ ﯽﺷزرو ﯽﺘﺴﯾز مﻮﻠﻋ .
1402
؛ ) 1 ( 15 : 55-70 .
2023.354853.1574
JSB.
/ 10.22059 DOI: http//doi.org/
ﻪﺑ ﯽﺳﺮﺘﺳد اﯾ ﻦ ﺮﺸﻧ ﯾﻪ ﻤﻠﻋ
،ﯽ ار ﯾ نﺎﮕ ﮑﻟﺎﻣ ﻖﺣ و ﺖﺳا ﯿ
ﺖ ﺮﮑﻓ ي ﻻ سﺎﺳا ﺮﺑ ار دﻮﺧ ﯾ
ﺲﻨﺴ ﺮﮐ ﯾﺘ ﯿﻮ ﺰﻨﻣﺎﮐ ) CC BY-NC 4.0 (
ﻮﻧ ﻪﺑ ﯾ نﺎﮔﺪﻨﺴ
ﺖﺳا هدﺮﮐ راﺬﮔاو .
:ﻪﯾﺮﺸﻧ سردآ| /
https://jsb.ut.ac.ir :ﻞﯿﻤﯾا|
:ﺮﺷﺎﻧ تارﺎﺸﺘﻧا ناﺮﻬﺗ هﺎﮕﺸﻧاد .نﺎﮔﺪﻨﺴﯾﻮﻧ©
ﻪﻣﺪﻘﻣ ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ - ﻗوﺮﻋ ﯽ ﺸﺨﺑ1
ﯽ زا ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﻦﻣﺰﻣ ﻞﺑﺎﻗ ﭘﯿ ﮕﺸ ﯿﺮ ي ﺪﻨﺘﺴﻫ ﻪﮐ ﺑﺎ ﻐﺗ ﯿﯿ ﺮ رد ةﻮﯿﺷ ﮔﺪﻧز ﯽ ﻂﺒﺗﺮﻣ ا ﺪﻧ ) 1 (.
ﺷ ﯿ عﻮ
ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ - ﻗوﺮﻋ ﯽ رد ﺢﻄﺳ ﻧﺎﻬﺟ ﯽ رد لﺎﺣ اﺰﻓا ﯾ ﺶ ﺖﺳا . ﺮﺑ سﺎﺳا شراﺰﮔ نﺎﻣزﺎﺳ ﺖﺷاﺪﻬﺑ ﻧﺎﻬﺟ ﯽ ﻪﻧﻻﺎﺳ ﺑﯿ ﺶ زا 5 / 17 ﻣ ﯿﻠﯿ نﻮ
ﺮﻔﻧ ﺮﺑ ﺮﺛا ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ ﻗوﺮﻋ-
ﯽ نﺎﺟ دﻮﺧ ار زا ﺖﺳد ﻣ ﯽ ﺪﻨﻫد ) 2 ( و ﭘﯿ ﺶ ﺑﯿﻨ ﯽ ﻣ ﯽ دﻮﺷ ﺷﺎﻧ گﺮﻣ داﺪﻌﺗ ﻪﮐ ﯽ
زا ﺎﺗCVD
لﺎﺳ 2030
ﻪﺑ 4 / 23 ﻣﯿ ﻠﯿ نﻮ ﺮﻔﻧ ﺪﺳﺮﺑ ) 3 ((
نﻮﺧ رﺎﺸﻓ.
ﻻﺎﺑ و د ﯾ ﺲ ﻟﯿﭙ ﯿ ﻣﺪ ﯽ اﺰﻓا)2
ﯾ ﺶ ﯾﺎ ﺶﻫﺎﮐ ﻏ ﯿ ﺒﻃﺮ ﯿﻌ ﯽ رد ﺢﻄﺳ ﻣﺮﺳ ﯽ ﺑﺮﭼ ﯽ ﺎﻫ ي نﻮﺧ ( زا ﻞﻣاﻮﻋ
زﺎﺳﺮﻄﺧ ﻠﺻا ﯽ اﺮﺑ ي ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ - ﻗوﺮﻋ ﯽ ا ﺪﻧ و ﺑﯿ ﺶ زا 80 ﺪﺻرد گﺮﻣ ﻣو ﯿ ﺎﻫﺮ و ﺎﻧاﻮﺗﺎﻧ ﯽﯾ ﺎﻫ ار رد ﺎﻫرﻮﺸﮐ ي ﺎﺑ ﺪﻣآرد ﻢﮐ و ﻂﺳﻮﺘﻣ
اﯾ دﺎﺠ ﻣ ﯽ ﺪﻨﻨﮐ ) 4 ( نﻮﺧ رﺎﺸﻓ.
ﺑ زا ﻻﺎﺑ ﯿ رﺎﻤ ي ﺎﻫ ي ار ﯾ ﺞ ﺖﺳا نﺎﻬﺟ رد
، رد اﯾ تﻻﺎ ﺪﺤﺘﻣ ة ﺮﻣآ ﯾ ﺎﮑ لﺎﺴﮔرﺰﺑ ﻪﺳ ﺮﻫ زا ﯾ
ﮏ ﻼﺘﺒﻣ ﺮﻔﻧ ﻪﺑ
رﺎﺸﻓ
نﻮﺧ ﺨﺸﺗ ﻻﺎﺑ ﯿ ﺺ هداد ﻣ ﯽ دﻮﺷ و 90 ﭘ ﺮﻄﺧ ﺪﺻرد ﯿ
ﺖﻓﺮﺸ نﻮﺧ رﺎﺸﻓ ﻻﺎﺑ
رد داﺮﻓا ﻣ ﯿ لﺎﺴﻧﺎ ﻦﺴﻣ و دراد دﻮﺟو )
5 ( .
ﻨﭽﻤﻫ
ﯿ ﻦ رد ﺘﺸﯿﺑ ﺮ دراﻮﻣ ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ - ﻗوﺮﻋ ﯽ ﺎﺑ د ﯾ ﺲ ﻟﯿﭙ ﯿ ﻣﺪ ﯽ هاﺮﻤﻫ ﺖﺳا . رد ﺮﺳاﺮﺳ نﺎﻬﺟ ﻐﺗ ﯿﯿ تاﺮ هدﺮﺘﺴﮔ ا ي رد ﺢﻄﺳ ﭘ ﺎﻓوﺮ ﯾ ﻞ
ﻟﯿﭙ ﯿﺪ مﺮﺳ رد ﺑﯿ ﻦ هوﺮﮔ ﺎﻫ ي ﻌﻤﺟ ﻒﻠﺘﺨﻣ ﯿ
ﺖ دراد دﻮﺟو ﺎﺑ ﻪﮐ
اﺰﻓا ﯾ ﺶ ﻣﺮﺳ حﻮﻄﺳ ﯽ
لوﺮﺘﺴﻠﮐ مﺎﺗ
3، ﺮﺗ ي ﻠﮔ ﯿ ﺴ ﯿﺮ ﯾﺪ و 4
ﻟﯿ ﻮﭙ ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﺑ ﻟﺎﮕﭼ ﯽ
ﺎﭘ ﯿﯾ ﻦ
5 و ﺶﻫﺎﮐ ﻟﯿ ﺌﺗوﺮﭘﻮﭙ ﯿ ﻦ ﺎﺑ ﻟﺎﮕﭼ ﯽ ﻻﺎﺑ ﻪﺘﺧﺎﻨﺷ 6
هﺪﺷ ﺖﺳا ﻞﻣاﻮﻋ ﺎﺑ و ﺮﻄﺧ
ﻠﺻا ﯽ ﺖﺳا ﻂﺒﺗﺮﻣCVD
) 4 (.
اﺮﺑ ي ﺎﻘﺗرا ي و ﺐﻠﻗ ﺖﻣﻼﺳ
ﻐﺗ ،قوﺮﻋ ﯿﯿ ﺮ ﮔﺪﻧز ﮏﺒﺳ ﯽ
ﺎﺑ ﯾﺪ ﻪﺑ ﺎﻤﻨﻫار ناﻮﻨﻋ ي
ﺑ ﺶﻫﺎﮐ ﯽ ﮐﺮﺤﺗ ﯽ ﻮﮕﻟا حﻼﺻا و داﺮﻓا ي
ﺬﻐﺗ ﯾﮥ دﻮﻬﺸﻣ ًﻼﻣﺎﮐ ،دﻮﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ رد ﻢﻟﺎﺳ
ﻢﮐ ﻪﮐ ﺖﺳا ﮐﺮﺤﺗ
ﯽ ژر و ﯾ ﻢ ﺎﻫ ي اﺬﻏ ﯽﯾ بﺮﭼﺮﭘ ﺐﺟﻮﻣ ﺳﺎﺴﺣ ﺶﻫﺎﮐ ﯿ
ﺖ ﻟﻮﺴﻧا ﻪﺑ ﯿ ﻦ ﺴﮐا و ﯿ ﺳاﺪ ﯿ نﻮ ﺑﺮﭼ ﯽ د و ﯾ ﺲ ﻟﯿﭙ ﯿ ﻣﺪ ﯽ ﻣ ﯽ دﻮﺷ .
ﺴﮐا بﺬﺟ ﺮﺜﮐاﺪﺣ ﻢﻈﻨﻣ شزرو ﺲﮑﻋﺮﺑ ﯿ
نﮋ ار اﺰﻓا ﯾ ﺶ ﻣ ﯽ ﺪﻫد و ﺐﺟﻮﻣ اﺰﻓا ﯾ ﺶ ژﺮﻧا ي ﺎﺧذ زا ﯾﺮ ﺑﺮﭼ ﯽ ﻣ ﯽ دﻮﺷ د و ﯾ ﺲ ﻟﯿﭙ ﯿ ﻣﺪ ﯽ ﺶﻫﺎﮐ ار
ﻣ ﯽ ﺪﻫد ) 1 ( . ﻬﺑ ﯿ ﻪﻨ زﺎﺳ ي ةﻮﯿﺷ ﯽﮔﺪﻧز قﺎﭼ ﺎﯾ نزو ﻪﻓﺎﺿا ياراد نارﺎﻤﯿﺑ ﺮﺜﮐا نﺎﻣرد ﻂﺧ ﻦﯿﻟوا .ﺖﺳا
سﺎﺳا ﺮﺑ ﺪﻫاﻮﺷ
دﻮﺟﻮﻣ ﯽﺧﺮﺑ ﺎﻫاﺬﻏ
نﺎﻣرد و لﺮﺘﻨﮐ رد ﺖﺳا ﻦﮑﻤﻣ ﻪﻔﻟﺆﻣ
ﺎﻫ ي ،ﯽﻗﺎﭼ ﺪﻨﻧﺎﻣ ﮏﯿﻟﻮﺑﺎﺘﻣ مورﺪﻨﺳ نﻮﺧ رﺎﺸﻓ
ﺎﺑ ﻻ ﻻﻼﺘﺧا ﺎﯾ ت
ﺪﺷﺎﺑ ﺪﯿﻔﻣ ﯽﺑﺮﭼ )
6 (.
ﻨﭽﻤﻫ ﯿ ﻦ
ﻌﻓ ﻟﺎﯿ ﺖ ﻧﺪﺑ ﯽ و ﻢﻈﻨﻣ نﺎﻣرد ﮑﻤﮐ ﯽ ﺮﺛﺆﻣ ي اﺮﺑ ي ﺪﻣ ﯾﺮ ﯾ ﺖ لﺮﺘﻨﮐ و نﻮﺧ رﺎﺸﻓ ﺮﺷ
ﯾﻧﺎ ﯽ زاﻮﻫ ﻢﻈﻨﻣ شزرو .ﺖﺳا ي
ﺘﻣوﺎﻘﻣ و ﯽ ﺎﻨﺑ ﮓﻨﺳ ي
لﺮﺘﻨﮐ نﻮﺧ رﺎﺸﻓ ﺖﺳا
) 7 (.
ﺮﺑ سﺎﺳا ﺎﻘﯿﻘﺤﺗ ت مﺎﺠﻧا ﺘﻓﺮﮔ ﻪ ﺮﻤﺗ ﯾ تﺎﻨ ﮐﺮﺗ ﯿﺒ ﯽ ﺐﺟﻮﻣ دﻮﺒﻬﺑ ﮐﺮﺗ ﯿ ﺐ
،نﺪﺑ اﺰﻓا ﯾ ﺶ ترﺪﻗ ﻧﻼﻀﻋ ﯽ و ﻐﺗ ﯿﯿ ﺮ
بﻮﻠﻄﻣ ﺎﻓوﺮﭘ ﯾ ﻞ ﻟﯿ ﭙﯿ ﺪ ي و ﻟﻮﭘآ ﯿ ﺌﺗوﺮﭘﻮﭙ ﯿ ﻦ نﻮﺧ ﻣ ﯽ دﻮﺷ . ﻖﯿﻘﺤﺗ ﺘﺳا ﯿ نﻮ و نارﺎﮑﻤﻫ ) 2013 ( تاﺮﯿﺛﺄﺗ ﻔﻣ ﯿﺪ ﻟﺎﻌﻓ ﯿ ﺖ ﻢﻈﻨﻣ ﺮﺑ ﺢﻄﺳ لوﺮﺘﺴﻠﮐ
ار ﺄﺗ ﯿﯾ ﺪ ﻣ ﯽ ﺪﻨﮐ ) 8 (.
تﺎﻨﯾﺮﻤﺗ ﯽﺒﯿﮐﺮﺗ ﻣﺎﮕﻨﻫ ﯽ ﻪﮐ لﺎﻤﻋا ﺮﻧوﺮﮐ قوﺮﻋ يرﺎﻤﯿﺑ ﺎﺑ ﻦﺴﻣ نارﺎﻤﯿﺑ رد ﻣ
ﯽ دﻮﺷ
، ﻦﯾﺮﺘﺸﯿﺑ ﺛﺄﺗ ﯿﺮ ﺮﺑ ار بﻮﻠﻄﻣ
يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ .دراد نﻮﺧ
ﻐﺗ ﯿﯿ تاﺮ رد بﻮﻠﻄﻣ ار بﻮﻠﻄﻣ تاﺮﯿﯿﻐﺗ .ﺖﺳا هاﺮﻤﻫ نﺪﺑ ﯽﺑﺮﭼ و نﺪﺑ نزو ﺶﻫﺎﮐ ﺎﺑ نﻮﺧ ﯽﺑﺮﭼ تﺎﺼﺨﺸﻣ
ﻣ ﯽ ناﻮﺗ ﻪﻠﻀﻋ ﻢﺴﯿﻟﻮﺑﺎﺘﻣ ﺮﯿﯿﻐﺗ ﻪﺑ ﻪﺑ
ﺎﺟ ي ﺘﺳا داد ﺖﺒﺴﻧ ﺪﯿﭙﯿﻟ زا هدﺎﻔﺘﺳا ﻪﺑ نژﻮﮑﯿﻠﮔ زا هدﺎﻔ )
9 ((.
ﭼﯿ نازﻮﺘ ﯾ7
ﮏ ﻠﭘ ﯽ رﺎﮐﺎﺳ ﯾﺪ ﺒﻃ ﯿﻌ ﯽ زا ﺎﻘﺑ ﯾﺎ ي ﻣاﺰﮐﻮﻠﮔ ﯿ ﻦ ﻖﺘﺸﻣ زا ﻦﯿﺘﯿﭼ ، ﻣود ﯿ ﻦ ﺑﯿ ﻠﭘﻮ ﯿ ﺮﻤ ناواﺮﻓ ور ي ﻣز ﯿ ﻦ ﻪﮐ ﺖﺳا ﻠﺣﺮﻣ رد ﮥ زا لوا
ﺖﻠﮑﺳا ﺟرﺎﺧ ﯽ ﺖﺨﺳ نﺎﺘﺳﻮﭘ ﯾﺎ زا ةراﻮﯾد ﻮﻠﺳ ﻟ ﯽ چرﺎﻗ ﺎﻫ ﻪﺑ ﻣ ﺖﺳد ﯽ آﯾ
،ﺪ ﭼ ﯿ نازﻮﺘ زا د ي ﺘﺳا ﯿ ﺳﻼ ﯿ نﻮ ﭼ ﯿﺘ ﯿ ﻦ ﺷﺎﻧ ﯽ ﻣ ﯽ دﻮﺷ و ﻪﺑ ناﻮﻨﻋ
و نزو ﺶﻫﺎﮐ ﻞﻤﮑﻣ نﺎﻣرد
ﮑﻤﮐ ﯽ اﺮﺑ ي ﺑﺮﭼ ﯽ و نﻮﺧ ﺪﻨﻗ ،نﻮﺧ نﻮﺧ رﺎﺸﻓ
ﺻﻮﺗ ﯿﻪ ﻣ ﯽ دﻮﺷ ) 2
، 6 (
.
ﺒﻃ تﻻﻮﺼﺤﻣ
ﯿﻌ ﯽ ﯾﺎ اﺬﻏ ﯽﯾ دﺮﺑرﺎﮐ ي ﺘﻈﻓﺎﺤﻣ صاﻮﺧ ﺎﺑ ﯽ
ﺑ ﻪﺑ ﺖﺳا ﻦﮑﻤﻣ قوﺮﻋ و ﺐﻠﻗ ﯿ
رﺎﻤ ﺘﺳد رد ﯿﺑﺎ ﯽ قوﺮﻋ و ﺐﻠﻗ ﺖﻣﻼﺳ ﻆﻔﺣ و
ﺑﺮﭼ تﻻﻼﺘﺧا دﻮﺒﻬﺑ و ﯽ
ﺮﻃ زا ﯾ ﻖ ﺎﮐوزﺎﺳ ر ﺎﻫ ي ﺪﺟ ﯾﺪ ﺪﻨﮐ ﮏﻤﮐ )
10 .(
ﭼﯿ ﺘ نازﻮ ﻪﺑ رﻮﻃ ﻢﻀﻫ ﺎﻣ شراﻮﮔ هﺎﮕﺘﺳد رد صﺎﺧ ﻤﻧ
ﯽ دﻮﺷ
، ﭼﯿ نازﻮﺘ مرﻮﺘﻣ ﻣ ﯽ دﻮﺷ ﻓ ندﺮﮐ ﺮﭘ ﺎﺑ و ﯿﺰ
ﯾﮑ ﯽ هﺪﻌﻣ اﯾ دﺎﺠ ﺳ سﺎﺴﺣا ﯿﺮ
ي
ﻣ ﯽ ﺪﻨﮐ
، ﭼﯿ نازﻮﺘ ﺎﺑ رﺎﻬﻣ ﻟﺎﻌﻓ ﯿ ﺖ ﻟﯿ زﺎﭙ ﮑﻧﺎﭘ ساﺮ ﻣ ﯽ ﺪﻧاﻮﺗ ﺑﺮﭼ بﺬﺟ ﯽ
اﺬﻏ ار .ﺪﻫد ﺶﻫﺎﮐ هدور رد هوﻼﻋ
ا ﺮﺑ ﯾ
،ﻦ ﻣ ﯽ ﺪﻧاﻮﺗ ﻪﺑ ﺑﺮﭼ ﯽ و ﺪﺒﺴﭽﺑ
رد هدور ﺎﻫ ا ﺎﺗ ﺪﻨﮐ بﻮﺳر ﯾ
ﻪﮑﻨ .دﻮﺸﻧ بﺬﺟ ﭼﯿ
نازﻮﺘ ﺗﺎﮐ ﯿ ﻧﻮ ﯽ ﻪﺑ هوﺮﮔ ﺎﻫ ي ﺴﮐﻮﺑﺮﮐ ﯿ ﻞ ﻧآ ﯿ ﻧﻮ ﯽ ﺳا ﯿ ﺎﻫﺪ ي بﺮﭼ و ﺳا ﯿ ﺎﻫﺪ ي واﺮﻔﺻ ي ﻞﺼﺘﻣ
(CVD) Cardio Vascular Deseases
1.
Dyslipidemia
2.
(TC) Total Cholestrol
3.
(TG) Trigliceride
4.
(LDL) Low Density Lipoprotein
5.
(HDL) High Density Lipoprotein
6.
Chitosan
7.
ﺗ ﺛﺄ ﯿ ﺮ 8 ﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و نﻮﺧ رﺎﺸﻓ ﺮﺑ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ و نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﻪﺘﻔﻫ
59
ﻣ ﯽ
،دﻮﺷ ﻨﭽﻤﻫ ﯿ ﻦ رد ﺴﻟﻮﻣا ﯿ نﻮ ندﺮﮐ ﻟﯿ ﭙﯿ ﺎﻫﺪ ي ﺜﻨﺧ ﯽ ﺪﻨﻧﺎﻣ لوﺮﺘﺴﻠﮐ و ﺎﺳ ﯾﺮ لوﺮﺘﺳا ﺎﻫ ﺎﺑ ﺗا لﺎﺼ ﺎﻬﻧآ ﺎﺑ ﻞﻌﻓ و لﺎﻌﻔﻧا ﺮﮕﺑآ ﯾ
،ﺰ ﻞﺧاﺪﺗ اﯾ دﺎﺠ
ﻣ ﯽ
،ﺪﻨﮐ اﺮﺑﺎﻨﺑ ﯾ ﻦ بﺬﺟ ﺑﺮﭼ ﯽ و لوﺮﺘﺴﻠﮐ زا هﺎﮕﺘﺳد شراﻮﮔ ﺶﻫﺎﮐ ﻣ ﯽ ﯾ ﺪﺑﺎ ) 11 ( زا ﯽﮑﯾ .
ﺮﯿﺛﺄﺗ تا ﺶﻫﺎﮐ ،نازﻮﺘﯿﭼ ﯽﯾﺎﯿﻤﯿﺷﻮﯿﺑ بﻮﻠﻄﻣﺎﻧ
و ﯽﻧﺪﻌﻣ داﻮﻣ بﺬﺟ وﯾ
ﻣﺎﺘ ﯿ ﻦ ﺎﻫ ي ﯽﺑﺮﭼ رد لﻮﻠﺤﻣ ﺪﻨﻧﺎﻣ
وﯾ ﻣﺎﺘ ﯿ ﻦ ﺎﻫ ي
E,D,A,K)
،ﺖﺳا ( هوﻼﻋ ندﺎﺘﻓا ماد ﻪﺑ ﺮﺑ ﻟﯿﭙ
ﯿ ﺎﻫﺪ ،لوﺮﺘﺴﻠﮐ و
لژ ﺎﻫ ي نازﻮﺘﯿﭼ ﮑﺸﺗ ﯿ ﻞ هﺪﺷ رد هدور ﺎﻫ و ﯽﻧﺪﻌﻣ داﻮﻣ ﻪﺑ وﯾ
ﻣﺎﺘ ﯿ ﻦ ﺎﻫ ﻞﺼﺘﻣ ﻣ ﯽ دﻮﺷ ﻪﺑ ﻢﯾﺪﺳ تﺎﺑرﻮﮑﺳآ ﺎﺑ هاﺮﻤﻫ نازﻮﺘﯿﭼ . شﻮﻣ
ﺎﻫ ي
ﺬﻐﺗ ﯾﻪ هﺪﺷ تﺪﻣ ﻪﺑ بﺮﭼﺮﭘ ﯽﯾاﺬﻏ ﻢﯾژر ﺎﺑ ود
ﺶﻫﺎﮐ ﻪﺑ ﻪﮐ ﺪﺷ هداد ﻪﺘﻔﻫ يدﺎﯾز
ﺎﺑ ﻂﺒﺗﺮﻣ ﯽﻧﺪﻌﻣ داﻮﻣ بﺬﺟ رد رد ﺶﻫﺎﮐ
ياﻮﺘﺤﻣ داﻮﻣ
ناﻮﺨﺘﺳا ﯽﻧﺪﻌﻣ ﺮﺠﻨﻣ
ﺪﺷ ) 12 .(
رد
لﺎﺣ ﺮﺿﺎﺣ هﺪﻨﻨﮐرﺎﻬﻣ ﺎﻫ
ي
ACE1
، هﺪﻨﻨﮐرﺎﻬﻣ ﺎﻫ
ي ﻧر ﯿ
،ﻦ هﺪﻨﻨﮐرﺎﻬﻣ ﺎﻫ
ي
،نوﺮﺘﺳﺪﻟآ هﺪﻨﻨﮐدوﺪﺴﻣ
ﺎﻫ ي ﺎﺘﺑ و هﺪﻨﻨﮐدوﺪﺴﻣ ﺎﻫ
ي ﮔ ﯿ ﺪﻧﺮ ة
ﮋﻧآ ﯾ ﺴﻧﺎﺗﻮ ﯿ
،ﻦ ﺞﻨﭘ ﺘﺳد ﮥ ﻠﺻا ﯽ ﺎﻫوراد ي ﺪﺿ نﻮﺧ رﺎﺸﻓ ﺎﺑ
ﺮﺛا رﺎﻬﻣ ي
،صﺎﺧ فﺪﻫ رد ﺳ ﯿ ﻢﺘﺴ ﻧر ﯿ ﻦ - ﮋﻧآ ﯾ ﺴﻧﺎﺗﻮ ﯿ ﻦ - نوﺮﺘﺳﺪﻟآ ﺪﻨﺘﺴﻫ 2
. ﺎﺑ اﯾ ﻦ
لﺎﺣ ﺴﻧﺎﺘﭘ ﯿ ﻞ ﻧﺎﻣرد ﯽ اﯾ ﻦ ﺎﻫوراد ﺎﺑ ﺰﻫ ﯾﻨ ﮥ ﺎﻬﻧآ و تاﺮﯿﺛﺄﺗ ﻮﺳ ء طﻮﺑﺮﻣ ﻪﺑ
،ﺎﻬﻧآ زا ﻪﻠﻤﺟ ﺖﻣوﺎﻘﻣ ﻪﺑ ﻟﻮﺴﻧا ﯿ ﻦ و د ﯾ
،ﺖﺑﺎ ﮐآ ﻪﻨ ﺎﻫ ي ﺘﺳﻮﭘ ﯽ و
تﻻﻼﺘﺧا ﺎﺸﭼ
ﯽﯾ و ﻏ ﯿ هﺮ هاﺮﻤﻫ ﺖﺳا
، ﻪﺑ رﻮﻃ بوﺎﻨﺘﻣ ﺑ ﻪﮐ ﺖﺳا هﺪﺷ شراﺰﮔ ﯿ
ﺘﭙﭘﻮ ﯿﺪ ﺎﻫ ي ﺪﻨﻨﮐرﺎﻬﻣ ة ﺮﻃ زا ﻪﮐ ACE
ﯾ ﻖ ﻫ ﯿ ﻟورﺪ ﯿﺰ ﺰﻧآ ﯾﻤ ﯽ
ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي اﺬﻏ ﯽﯾ ﻟﻮﺗ ﯿﺪ ﻣ ﯽ
،دﻮﺷ ﻓﺮﻇ ﯿ ﺖ ﺎﻫ ي ﺎﭘ ﯿﯾ ﻦ ﺪﻧروآ ة نﻮﺧ رﺎﺸﻓ رد ار
ﺣﯿ تﺎﻧاﻮ ﻼﺘﺒﻣ ﻪﺑ نﻮﺧ رﺎﺸﻓ ﻣ نﺎﺸﻧ ﻻﺎﺑ
ﯽ ﺪﻨﻫد ضراﻮﻋ ﻪﮐ
ﺒﻧﺎﺟ ﯽ ﺖﺳا كﺪﻧا نآ ﯾﺎ
ﺘﺣ ﯽ ﻫ ﯿ ﭻ ﻪﻧﻮﮔ ﺒﻧﺎﺟ ضراﻮﻋ ﯽ
دراﺪﻧ
، رد ﯽﻘﯿﻘﺤﺗ ﺪﻧرادزﺎﺑ يﺎﻫﺪﯿﺘﭙﭘﻮﯿﺑ ة
ﯽﮕﻨﺳ ﯽﻫﺎﻣ ﻦﯿﺌﺗوﺮﭘ زاACE
هﺪﺷ ﺪﯿﻟﻮﺗ3
دﻮﺑ ﺎﻬﻧآ ندﺮﮐ ﻪﻟﻮﺴﭙﮐ ﺎﺑ و ﺪﻧﺪﺷ ﺖﯿﺒﺜﺗ نازﻮﺘﯿﭼ تارذﻮﻧﺎﻧ رد
) 13 (.
ﻦﯿﻨﭽﻤﻫ ﺞﯾﺎﺘﻧ ﺎﻣزآ ﯾ ﺶ ﺎﻫ ي ﺖﺳا هداد نﺎﺸﻧ نﻮﺴﮑﯾد تﺎﻘﺘﺸﻣ زا ﻪﮐ
ﻪﺑ ﺖﺳد ،ﻦﯿﺘﯿﭼ زا هﺪﻣآ ﺎﺑ ﻦﯿﺘﯿﭼ ﻞﯿﺗاﻮﻨﯿﻣآ
90
% نﻮﯿﺴﻟﺎﯿﺘﺳا ﻪﺟرد
(AEC90)
ﮏﯾ ﺪﻨﻨﮐرﺎﻬﻣ ة ﯽﺘﺑﺎﻗر و ﺖﺳاACE
ﻋ ﻼ هو ﺮﺑ ﺪﺿ ﺮﺛا رﺎﺸﻓ
نﻮﺧ
، ﺮﺑ شﻮﻣ ﺎﻫ ي ﻪﺑﻼﺘﺒﻣ نﻮﺧ رﺎﺸﻓ ﯽﺗاذ
)
(SHR
نﺎﺸﻧ ﻪﺠﯿﺘﻧ و ﺪﺷ ﯽﺑﺎﯾزرا داد
رﺎﺸﻓ نﻮﺧ ﮏﯿﻟﻮﺘﺴﯿﺳ )
ار(SBP
ﻪﺑ رﻮﻃ ﻪﺑ ﻪﺘﺴﺑاو
ﺶﻫﺎﮐ زود ﻣ
ﯽ ﺪﻫد ) 14 .(
ﺎﻘﯿﻘﺤﺗ
ت ز ﯾ دﺎ ي ﺳرﺮﺑ صﻮﺼﺧ رد ﯽ
ﺛﺄﺗ ﯿﺮ ﺮﻤﺗ ﯾ تﺎﻨ ﯽﺷزرو ﺑ ﻪﺑ ﻼﺘﺒﻣ داﺮﻓا رد ﯿ
رﺎﻤ ي ﺒﻠﻗ ﯽ مﺎﺠﻧا ﻪﺘﻓﺮﮔ
، ﺎﻣا ﻘﯿﻘﺤﺗ تﺎ صﻮﺼﺧ رد دوﺪﺤﻣ
مﺎﺠﻧا نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز ﺘﻓﺮﮔ
ﻪ ﺖﺳا
، بﺎﺨﺘﻧا ﺖﻠﻋ ﻣﺎﻧﺮﺑ
ﮥ ﻖﯿﻘﺤﺗ ياﺮﺑ ﯽﺒﯿﮐﺮﺗ ﯽﻨﯾﺮﻤﺗ ﺮﻈﻧدرﻮﻣ
ﻪﮐ دﻮﺑ ﻦﯾا تﺎﻨﯾﺮﻤﺗ
ﻪﮐ ﯽﺒﯿﮐﺮﺗ
ﺳا ﯽﺘﻣوﺎﻘﻣ و يزاﻮﻫ تﺎﻨﯾﺮﻤﺗ زا ﯽﺒﯿﮐﺮﺗ ﺖ
، ﻣ ﯽ ﺪﻧاﻮﺗ و ﺪﺷﺎﺑ ﻪﺘﺷاد ﯽﻧدوﺰﻓا ﺮﺛا ﻞﻣﺎﻋ
ﺎﻫ ي ﺮﻄﺧ ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﯽﺒﻠﻗ - ﺪﻫد ﺶﻫﺎﮐ ار ﯽﻗوﺮﻋ
) 15 (.
ﺎﺑ ﯽﺒﯿﮐﺮﺗ تﺎﻨﯾﺮﻤﺗ ﯽﺘﻗﻮﻣ ﺶﻫﺎﮐ دﺎﺠﯾا
رد نﻮﺧ رﺎﺸﻓ ﻞﯿﻟد ﻪﺑ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ زا ﺪﻌﺑ ﯽﺘﺣ
ﺪﭘ ﯾ هﺪ ا ي ﺖﻓا مﺎﻧ ﻪﺑ نﻮﺧ رﺎﺸﻓ
ﺲﭘ زا
شزرو
(PEH)
ﺛﺄﺗ ﯿ تاﺮ دﻮﺧ نﺎﺸﻧ ار ﻣ ﯽ ﺪﻫد . ﯽﻠﻣاﻮﻋ ﻪﻠﻤﺟ زا تﺪﻣ ،تﺪﺷ ﻦﯾﺮﻤﺗ عﻮﻧ و نﺎﻣز
مﺎﺠﻧا هﺪﺷ حﻮﻄﺳ ﺎﺑ هاﺮﻤﻫ نﻮﺧ رﺎﺸﻓ
تﺪﻣ و ﻪﻨﻣاد ﺖﺳا ﻦﮑﻤﻣ ﯽﺘﺣاﺮﺘﺳا نﺎﻣز
PEH
ﺖﺤﺗ ار ﺛﺄﺗ ﯿﺮ هداد راﺮﻗ ﺪﻫد هزﺎﺟا و ﺦﺳﺎﭘ
ﺎﻫ ي ﯽﺒﻠﻗ ﻢﺘﺴﯿﺳ رد ﯽﻔﻠﺘﺨﻣ -
ﯽﻗوﺮﻋ ﻪﺑ دﻮﺟو
ﻪﮐ ﺪﯾﺎﯿﺑ ﻪﺑ رﻮﻃ يﺮﯿﮕﻤﺸﭼ نﻮﺧ رﺎﺸﻓ
رد ار تاﺮﯿﺛﺄﺗ و دﺎﺣ ﻪﻤﯿﻧ ﺮﯿﯿﻐﺗ شزرو زا ﺪﻌﺑ ﻦﻣﺰﻣ و دﺎﺣ ﻣ
ﯽ ﺪﻫد ) 16 (.
ﻪﮑﻨﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﻦﯿﻨﭽﻤﻫ
ﺎﻣزآ ﯾ ﺶ ﺎﻫ ي ﻞﻤﮑﻣ ﺮﺛا ﻪﺘﺷﺬﮔ ﯽﻨﯿﻟﺎﺑ ار نازﻮﺘﯿﭼ
ﻪﺑ ترﻮﺻ ﺮﺑ دوﺪﻌﻣ نﻮﺧ رﺎﺸﻓ
يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و ﺳرﺮﺑ
ﯽ هدﺮﮐ ا ﺪﻧ ﺎﯾ ﻪﺑ ﺎﻬﻨﺗ ﯽﯾ ﺎﯾ ﻪﺑ ﻫ هاﺮﻤ
ﮏﯾ ﻣﺎﻧﺮﺑ ﮥ ﯽﻨﯾﺮﻤﺗ هدﺎﺳ ور ي نﻮﺧ رﺎﺸﻓ هدﺮﮐ ﯽﺳرﺮﺑ داﺮﻓا يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ ﺎﯾ
دﻮﺑ
، ﻦﯾا رد ﻖﯿﻘﺤﺗ ﯽﻌﺳ ﺪﺷ ﺎﺑ ﯽﺳرﺮﺑ ﺛﺄﺗ ﯿﺮ ﻞﻤﮑﻣ ﯽﻧدوﺰﻓا
ﯽﺘﻣوﺎﻘﻣ و يزاﻮﻫ ﯽﺒﯿﮐﺮﺗ تﺎﻨﯾﺮﻤﺗ و نازﻮﺘﯿﭼ ﺺﺨﺸﻣ
دﻮﺷ ﺮﺑ ﯽﺒﯿﮐﺮﺗ تﺎﻨﯾﺮﻤﺗ و ﻞﻤﮑﻣ ﺮﺛا ﻦﯿﯿﻌﺗ ﻪﮐ نﻮﺧ رﺎﺸﻓ
ﻟ ﺺﺧﺎﺷ و يﺪﯿﭙﯿ
رﺪﻘﭼ
ﺖﺳا شور ﻦﯾا . يروآﻮﻧ
هﺪﺷ ﻣ ﯽ ﺪﻧاﻮﺗ ﻪﺑ ناﻮﻨﻋ ﯽﮑﻤﮐ نﺎﻣرد ياﺮﺑ
ﺶﻫﺎﮐ و لﺮﺘﻨﮐ ﺿرﺎﻋ
ﮥ نﻮﺧ رﺎﺸﻓ يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و
ﻪﺑ ناﻮﻨﻋ ﮏﺒﺳ
ﺬﻐﺗ ﯾﻪ ا ي ﯽﻨﯾﺮﻤﺗ و و ﻢﻟﺎﺳ
ﺮﺛﺆﻣ ﺐﺳﺎﻨﻣ داﺮﻓا ياﺮﺑ .ﺪﺷﺎﺑ
ﻦﯾازا ور اﯾ ﻦ ﻖﯿﻘﺤﺗ ﺳرﺮﺑ فﺪﻫ ﺎﺑ ﯽ
ﺛﺄﺗ ﯿﺮ ﭼ ﻞﻤﮑﻣ فﺮﺼﻣ ﯿ
نازﻮﺘ و ﺖﺸﻫ ﺮﻤﺗ ﻪﺘﻔﻫ ﯾ تﺎﻨ ﮐﺮﺗ ﯿﺒ ﯽ ﺮﺑ ﻮﺧ رﺎﺸﻓ ن ﺎﻓوﺮﭘ و ﯾ ﻞ ﻟﯿ ﭙﯿ ﺪ ي ﺧ نﻮ رد
نﺎﻧز ﺎﻫ ﻪﺑ ﻼﺘﺒﻣ ﯾ
ﻦﺸﻨﺗﺮﭙ مﺎﺠﻧا ﺖﻓﺮﮔ .
Angiotensin Converter Enzyme
1.
(RAAS) enin Angiotensin Aldosterone R
2.
3. Actinopyga lecanora
شور ﻖﯿﻘﺤﺗ
ﻖﯿﻘﺤﺗ ﺮﺿﺎﺣ ﻪﺑ ترﻮﺻ ﯽﻨﯿﻟﺎﺑ ﯽﯾﺎﻣزآرﺎﮐ )
IRCTID: IRCT20221120056548N2
( رد رﺎﻬﭼ اراد نﺎﻧز زا هوﺮﮔ ي
نﻮﺧ رﺎﺸﻓ ﻻﺎﺑ
ﺎﺑ هاﺮﻤﻫ ﺑﺮﭼ ﯽ ﻪﺑ ﻻﺎﺑ نﻮﺧ ﭘ ترﻮﺻ
ﯿ ﺶ نﻮﻣزآ ﺲﭘ و ﻧا نﻮﻣزآ مﺎﺠ ﯽﻣﺎﻤﺗ .ﺖﻓﺮﮔ ﻞﺣاﺮﻣ
ﺶﻫوﮋﭘ اﺪﺘﺑا رد ياﺮﺑ داﺮﻓا ﺢﯿﺿﻮﺗ هداد ﺪﺷ . ﺲﭘ
زا ﻤﮑﺗ ﯿ ﻞ و ﺎﻀﻣا ي ﺖﯾﺎﺿر ﻪﻣﺎﻧ و ﮥﮔﺮﺑ تﺎﻋﻼﻃا
،يدﺮﻓ ﯽﮕﻨﻫﺎﻤﻫ يﺎﻫ
مزﻻ ﺎﺑ داﺮﻓا ﺖﻬﺟ ﺖﮐﺮﺷ رد ﻖﯿﻘﺤﺗ ياﺮﺑ مﺎﺠﻧا ﻞﺣاﺮﻣ ﺪﻌﺑ ي
ﺶﻫوﮋﭘ ﻪﺑ ﻞﻤﻋ ﺪﻣآ . اﯾ ﻦ ﻪﺑ قﻼﺧا ﺪﮐ ﻪﻌﻟﺎﻄﻣ رﺎﻤﺷ
ة
IR.SSRI.REC.2021.11013.1224
رد ﯾ ﺖﻓﺎ دﺮﮐ ﮏﯾ ﻦﯿﻨﭽﻤﻫ و ﻌﻟﺎﻄﻣ
ﮥ
ﺖﺳﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز ﻦﯿﺑ رد ﻞﯾاﺮﺗ لﺎﮑﯿﻨﯿﻠﮐ .
مﺪﻋ ﻼﺘﺑا ﻪﺑ ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﻣز ﯿ ﻪﻨ ا ي و ادﻮﺧ ﯾ ﻨﻤ ﯽ و ﻧﻮﻣرﻮﻫ ﯽ و ﺑﯿ رﺎﻤ ي ﺎﻫ ي ﺒﻠﻗ ﯽ -
ﻗوﺮﻋ ﯽ و سﺮﻘﻧ و نﺎﻃﺮﺳ ) 17 ( ، مﺪﻋ ﺳﺎﺴﺣ ﯿ ﺖ ﻪﺑ اﺬﻏ ﺎﻫ ي رد ﯾﺎ ﯽﯾ ، مﺪﻋ فﺮﺼﻣ ﺎﻫوراد ي ﮔ ﯿ ﻫﺎ ﯽ ﻪﺑ ناﻮﻨﻋ
،ﻪﻠﺧاﺪﻣ مﺪﻋ فﺮﺼﻣ ﺎﻫوراد ي
لﺮﺘﻨﮐ نﻮﺧ رﺎﺸﻓ و
ﺑﺮﭼ ﯽ نﻮﺧ و ﻞﻤﮑﻣ ﺬﻐﺗ ﯾﻪ ا ي
،ﻂﺒﺗﺮﻣ نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺑا زا ﺮﺘﺸﯿﺑ ﮏﯿﻟﻮﺘﺴﯿﺳ نﻮﺧ رﺎﺸﻓ)
120 ﻣ ﯿﻠ ﯽ ﺮﺘﻣ رﺎﺸﻓ و هﻮﯿﺟ
زا ﺮﺘﺸﯿﺑ ﮏﯿﻟﻮﺘﺳﺎﯾد نﻮﺧ 100
ﻣ ﯿﻠ ﯽ ﺮﺘﻣ (هﻮﯿﺟ ﻪﺑ ناﻮﻨﻋ ﻌﻣ ﯿ رﺎ و دورو ﺸﻓ نﻮﺧ رﺎ ﻮﻧﺎﺛ ﯾ
،ﻪ دﺮﮑﻠﻤﻋ ﻏ ﯿ ﺒﻃﺮ ﯿﻌ ﯽ ﺪﺒﮐ ﯾﺎ ﻠﮐ ﯿﻪ ﯾﺎ اﺮﺷ ﯾ ﻂ د ﯾ ﺮﮕ ي
ﻪﺑ ﻪﮐ ﺘﻔﮔ ﮥ اﺮﺑ ﻪﻌﻟﺎﻄﻣ رد نﺎﻘﻘﺤﻣ ي
ﺑﯿ رﺎﻤ ﻧ ﺐﺳﺎﻨﻣ ﯿ ﺖﺴ ﯾﺎ ﻣ ﯽ ﺪﻧاﻮﺗ
،ﻊﻧﺎﻣ دوﺪﺤﻣ ﯾﺎ ﻞﺘﺨﻣ ﺪﻨﻨﮐ ة زرا ﯾﺑﺎ ﯽ ﺎﻫ ي ﺸﺨﺑﺮﺛا ﯽ دﻮﺷ ﻞﮑﺗوﺮﭘ )
18 (
ﺮﻤﺗ نداﺪﻧ مﺎﺠﻧا و ﯾ
تﺎﻨ ﺑﯿ ﺮﺘﺸ زا ود ﻪﺘﻔﻫ رد ﻪﺴﻠﺟ
، فﺮﺼﻣ ندﺮﮑﻧ ﻞﻤﮑﻣ ﺎﻫ ﻪﺑ ترﻮﺻ ﻪﻧازور ، ﺳآ ﯿ ﺐ دﯾ ﮔﺪ ﯽ و مﺪﻋ رﻮﻀﺣ رد ﺮﻤﺗ ﯾ تﺎﻨ ) 17 (
ﻌﻣ ﯿ رﺎ ﺧ جوﺮ .دﻮﺑ ﻨﭽﻤﻫ ﯿ ﻦ زا داﺮﻓا درﻮﻣ ﯽﺳرﺮﺑ ﺖﺳاﻮﺧرد ﺪﺷ
ﺎﺗ ﺶﯿﭘ زا ياﺮﺟا
،نﻮﻣزآ يﺎﻫﻮﮕﻟا باﻮﺧ ﺒﻃ ﯿﻌ ﯽ ) ﻞﻗاﺪﺣ 8 ﺖﻋﺎﺳ باﻮﺧ (،
يﺎﻫﻮﮕﻟا ﻟﺎﻌﻓ ﯿ ﺖ يﺎﻫ ﻪﻧازور و ژر ﯾ ﻢ اﺬﻏ ﯽﯾ ) 12 ﺖﻋﺎﺳ ﺖﻟﺎﺣ ﺎﺘﺷﺎﻧ ﺶﯿﭘ زا نﻮﻣزآ ( رد لﻮﻃ ﺶﻫوﮋﭘ ار ﺎﻋر ﯾ ﺖ ﺪﻨﻨﮐ و زا ﻪﻧﻮﮔﺮﻫ ﻟﺎﻌﻓ ﯿ ﺖ
ﻧﺪﺑ ﯽ ﺪﺷ ﯾ
،ﺪ فﺮﺼﻣ ﻞﻤﮑﻣ اﺬﻏ ﯽﯾ
، فﺮﺼﻣ
،وراد فﺮﺼﻣ
،هﻮﻬﻗ ﻧﺎﺧد ﯿ تﺎ و ﻮﺋﺎﮐﺎﮐ ﺎﺗ 48 ﺖﻋﺎﺳ ﺶﯿﭘ زا مﺎﺠﻧا نﻮﻣزآ و ﺎﺗ نﺎﻣز ﻊﻤﺟ يروآ
ﻧﻮﻤﻧ ﮥ ﻧﻮﺧ ﯽ ﻪﮐ ﺮﺑ يور ﺳ ﯿ ﻢﺘﺴ و دﺮﮑﻠﻤﻋ اﯾ ﻨﻤ ﯽ ﺛﺄﺗ ﯿﺮ
،دراد يراددﻮﺧ ﺪﻨﻨﮐ
) 19 ( ( مﺎﻤﺗ .
اﯾ ﻦ تﺎﻋﻼﻃا ﺎﺑ
ﻣﺎﻨﺸﺳﺮﭘ ﮥ ﮔدﺎﻣآ ﯽ اﺮﺑ ي ﻟﺎﻌﻓ ﯿ ﺖ
ﻧﺪﺑ ﯽ و ﻘﺑﺎﺳ ﮥ ﮑﺷﺰﭘ ﯽ
(PAR-Q)
ﺑ رد ﯿ ﻦ ﻧدﻮﻣزآ ﯽ ﺎﻫ ﻪﺑ .ﺪﻣآ ﺖﺳد
ﻌﻣﺎﺟ
ﮥ رﺎﻣآ ي ﺶﻫوﮋﭘ ﯽﻣﺎﻤﺗ نﺎﻧز هﺎﮕﺷﺎﺑ ﺎﻫ ي ﻪﺘﺴﺑاو ﻪﺑ نﺎﻣزﺎﺳ رادﺮﻬﺷ ي ﻘﻄﻨﻣ ﮥ 5 ﺮﻬﺷ ناﺮﻬﺗ ﻦﯿﯿﻌﺗ .دﻮﺑ سﺎﺳا ﺮﺑ ﻪﻧﻮﻤﻧ ﻢﺠﺣ
تﺎﻘﯿﻘﺤﺗ ﻠﺒﻗ
ﯽ ا رد ﻦﯾ ﻪﻨﯿﻣز و ﺲﭙﺳ ﺮﺑ سﺎﺳا دروآﺮﺑ مﺮﻧ راﺰﻓا ﯽﺟ روﺎﭘ
(G-power3.1.9.2)
ﺬﭘ مﺎﺠﻧا ﺖﻓﺮﯾ و ﻪﺑ ناﺰﯿﻣ 40 ﻪﺒﺳﺎﺤﻣ ﺮﻔﻧ
ﺪﺷ ) 20 (
، رد ﻪﮐ رﺎﻬﭼ هوﺮﮔ ﯽﺑﺮﺠﺗ 10 يﺮﻔﻧ ) ﻞﻤﮑﻣ تﺎﻨﯾﺮﻤﺗ ،نازﻮﺘﯿﭼ
،ﯽﺒﯿﮐﺮﺗ نازﻮﺘﯿﭼ ﺮﻤﺗ+
تﺎﻨﯾ ﯽﺒﯿﮐﺮﺗ و ﮏﯾ هوﺮﮔ لﺮﺘﻨﮐ ( ﻢﯿﺴﻘﺗ
.ﺪﻧﺪﺷ ﺮﻃ زا ﻖﯾ ﮑﺸﺗ ﻞﯿ ﮏﯾ ﺴﻠﺟ ﮥ ﺟﻮﺗ
،ﯽﻬﯿ عﻼﻃا ﻧﺎﺳر ﯽ و نﺎﻣز صﻮﺼﺧ رد مزﻻ ةﻮﯿﺷ
اﺮﺟا ي ﺮﻤﺗ تﺎﻨﯾ ﻮﺤﻧ و ة ﻞﻤﮑﻣ فﺮﺼﻣ ﻂﺳﻮﺗ ﺎﻫ
مﺎﺠﻧا ﻖﻘﺤﻣ ﺖﻓﺮﮔ
. ياﺮﺑ ﻦﯾا مﺎﺠﻧا ﻖﯿﻘﺤﺗ
ﻦﯿﻟوا ﻠﺣﺮﻣ ﮥ نﻮﺧ ﮔﯿ ﺮ ي ﺎﻣزآ رد هﺎﮕﺸﯾ ﺶﯿﭘ ﻪﻠﺣﺮﻣ رد نﻮﻣزآ زا ﭘﯿ
ﺶ نﻮﻣزآ ﺖﯿﻌﺿو رد 12
-
14 ﺎﻧ ﺖﻋﺎﺳ و ندﻮﺑ ﺎﺘﺷ
ًادﺪﺠﻣ 48 ﺖﻋﺎﺳ ﺲﭘ ﺮﺧآ زا ﻦﯾ ﺴﻠﺟ ﮥ ﺮﻤﺗ ﻦﯾ ﻞﻤﮑﻣ و ﻫد ﯽ رد ) ﺲﭘ نﻮﻣزآ ( ﻪﺑ رﻮﻈﻨﻣ ﭘ يﺮﯿﮕﺸﯿ زا ﺛﺄﺗ ﯿﺮ ﺷﺎﻧ دﺎﺣ ﯽ
زا ﺮﻤﺗ ﻦﯾ ﻟ ﺮﺑ يﺎﻫﺪﯿﭙﯿ .ﺪﺷ اﺮﺟا نﻮﺧ
ﺶﯿﭘ زا ﺮﻫ ﺖﺑﻮﻧ نﻮﺧ ﮔﯿ ﺮ ي ﯽﻧدﻮﻣزآ ﺎﻫ ﺪﻨﭼ ﻪﻘﯿﻗد رد ﺖﻟﺎﺣ ﻪﺘﺴﺸﻧ ﻪﺑ ﺖﺣاﺮﺘﺳا ﺘﺧادﺮﭘ
ﺪﻨ و ﺲﭙﺳ
ﻪﺑ ﺐﯿﺗﺮﺗ رد ﻦﯾﺮﺘﻤﮐ نﺎﻣز زا ﺪﯾرو ﯽﯾوزﺎﺑ رد ﯿﺣﺎﻧ ﮥ ﺞﻧرآ ﺎﻬﻧآ 10 ﯽﺳ ﯽﺳ نﻮﺧ ﺖﻓﺎﯾرد ﺪﺷ ﻪﻧﻮﻤﻧ ﻦﯾا . ﺎﻫ
ﻪﺑ تاﺮﯿﯿﻐﺗ نﺪﻧﺎﺳر ﻞﻗاﺪﺣ ﻪﺑ ﻞﯿﻟد
ﺖﻋﺎﺳ ﻦﯿﺑ ﻪﻧازور ﯽﻟﺎﻤﺘﺣا 00
:9 ﺎﺗ 00 : 11 رد و ﻪﺘﻓﺮﮔ ﻟﻮﻟ
ﮥ يوﺎﺣ
EDTA 1
يﺮﺗ ،مﺎﺗ لوﺮﺘﺴﻠﮐ ﺲﭙﺳ .ﺪﺷ ﻪﺘﺨﯾر لوﺮﺘﺴﻠﮐ ،ﺪﯾﺮﯿﺴﯿﻠﮔ
، HDL
لوﺮﺘﺴﻠﮐ
LDL
و
VLDL
هزاﺪﻧا ﺪﺷ يﺮﯿﮔ ﻣ .
يﺮﺗ ناﺰﯿ ﻞﯾﺪﺒﺗ ياﺮﺑ زﺎﭙﯿﻟ) ﮏﯿﺗﺎﻤﯾﺰﻧآ شور ﻪﺑ ﺪﯾﺮﯿﺴﯿﻠﮔ
يﺮﺗ ﻪﺑ ﺪﯾﺮﯿﺴﯿﻠﮔ
ﻞﯾﺪﺒﺗ ياﺮﺑ زﺎﭙﯿﻟ) زاﺮﺘﺳا لوﺮﺘﺴﻠﮐ ﮏﯿﺗﺎﻤﯾﺰﻧآ شور ﻪﺑ لوﺮﺘﺴﻠﮐ و (لوﺮﺴﯿﻠﮔ يﺮﺗ
لوﺮﺘﺴﻠﮐ (لوﺮﺴﯿﻠﮔ ﻪﺑ ﺪﯾﺮﯿﺴﯿﻠﮔ
HDL
شور ﻂﺳﻮﺗ
ﯽﻤﯾﺰﻧآ ﯽﺑﻮﺳر ﯽﮕﻤﻫ)
ﺖﺴﺗ ﺎﻫ ﺎﺑ ﻪﺑ ﮔرﺎﮐ ﯿﺮ ي درﻮﻣ ﻪﮐ ﮏﯿﻧﻮﯿﺑ ﺖﮐﺮﺷ يرﺎﺠﺗ ﺖﯿﮐ ﺄﺗ
ﯿﯾ ﺪ هﺎﮕﺘﺳد ﺎﺑ و دﻮﺑ ناﺮﯾا ﺖﻣﻼﺳ ﻊﺟﺮﻣ هﺎﮕﺸﯾﺎﻣزآ
رﺰﯾﻻﺎﻧآﻮﺗا
Hitachi ,
Japan
مﺎﺠﻧا(
ﺖﻓﺮﮔ لوﺮﺘﺴﻠﮐ و ﻪﺒﺳﺎﺤﻣ ﺪﻟاوﺪﯾﺮﻓ لﻮﻣﺮﻓ ﻂﺳﻮﺗLDL
ﺷ ﺪ ) 17 (.
يﺎﻫراﺰﺑا هزاﺪﻧا ﮔﯿ ﺮ ي ﺎﻫ ي ﻟوا ﯿﮥ وﺮﺘﻧآ ﺮﺘﻣﻮﭘ ﮏﯾ نزو) - :(ﺪﻗ وزاﺮﺗ ي د لﺎﺘﯿﺠﯾ اﺮﺑ ي هزاﺪﻧا ﮔﯿ ﺮ ي نزو
(OMRON)
) 17 (،
ﺮﺘﻣ يراﻮﻧ ياﺮﺑ
هزاﺪﻧا ﮔﯿ ﺮ ي ﺪﻗ
(SECA)
ﺎﻣزآ راﺰﺑا و ﯽﻫﺎﮕﺸﯾ
ﻟﺎﻧآ ﺖﻬﺟ ﺰﯿ ﻪﻧﻮﻤﻧ ﺎﻫ ي ﻧﻮﺧ ﯽ ﻣ دروآﺮﺑ و ناﺰﯿ
ﻐﺗ تاﺮﯿﯿ ﺎﻓوﺮﭘ ﻞﯾ ﻟ يﺪﯿﭙﯿ ﻟﻮﻟ) ﮥ وﺎﺣ ي ( EDTA
و راﺰﺑا هزاﺪﻧا ﮔﯿ ﺮ ي ﻐﺗ تاﺮﯿﯿ نﻮﺧ رﺎﺸﻓ
، ﺟ ﺞﻨﺳرﺎﺸﻓ هﻮﯿ
يا
) OMRON
)(
18 (،
و ﻞﯾﺎﺳو يزﺎﺴﻧﺪﺑ ﺶﮐ)
يﺎﻫ ﯽﺘﻣوﺎﻘﻣ ﺪﻧﺮﺑ
RACINESS
ﺘﺨﺳ ﺎﺑ ﯽ ﺎﻫ ي توﺎﻔﺘﻣ ) ﮓﻧر ﺎﻫ ي (ﻒﻠﺘﺨﻣ
،
،ﻞﺒﻣد ﺖﮑﻤﯿﻧ ﺎﯾ ﯽﻟﺪﻨﺻ ( ياﺮﺑ مﺎﺠﻧا ﻞﮑﺗوﺮﭘ ﯽﻨﯾﺮﻤﺗ رد ﺮﻈﻧ ﻪﺘﻓﺮﮔ ﺪﺷ . هزاﺪﻧا يﺮﯿﮔ ﺪﻗ و نزو
thylene diamine tetra acetic acid . E
1
ﺗ ﺛﺄ ﯿ ﺮ 8 ﻻﺎﺑ نﻮﺧ رﺎﺸﻓ ﻪﺑ ﻼﺘﺒﻣ نﺎﻧز رد يﺪﯿﭙﯿﻟ ﻞﯾﺎﻓوﺮﭘ و نﻮﺧ رﺎﺸﻓ ﺮﺑ ﯽﺒﯿﮐﺮﺗ ﻦﯾﺮﻤﺗ و نازﻮﺘﯿﭼ ﻞﻤﮑﻣ ﻪﺘﻔﻫ
61
ود ﺖﺒﺛ ﺎﻬﻧآ ﻦﯿﮕﻧﺎﯿﻣ و مﺎﺠﻧا يراﻮﻧ ﺮﺘﻣ و لﺎﺘﯿﺠﯾد يوزاﺮﺗ زا هدﺎﻔﺘﺳا ﺎﺑ ﺮﮕﺸﻫوﮋﭘ و ﯽﺑﺮﻣ ﺮﻈﻧ ﺮﯾز ﺎﻄﺧ ناﺰﯿﻣ نﺪﯿﺳر ﻞﻗاﺪﺣ ﻪﺑ ياﺮﺑ رﺎﺑ
.ﺪﺷ ﻪﺑ
رﻮﻈﻨﻣ هزاﺪﻧا يﺮﯿﮔ نﻮﺧ رﺎﺸﻓ ﺳ
ﯽﻟﻮﺘﺴﯿ د و ﯽﻟﻮﺘﺳﺎﯾ ﻧدﻮﻣزآ ﯽ زا ﺲﭘ داﺮﻓا ،ﺎﻫ 15
ﯿﻗد ﯽﻟﺪﻨﺻ يور ﻦﺘﺴﺸﻧ ﻪﻘ ﻟﺎﺣرد
ﯽ ﻪﮐ وزﺎﺑ ي
ﺘﺳار نﺎﺸ ﺎﺑ ﯾواز ﮥ 45 ﻪﺑ ﺖﺒﺴﻧ ﻪﺟرد ﺴﻔﻗ
ﮥ هﺪﻧد ﻦﯿﺑ يﺎﻀﻓ رد ﺞﻧرآ و ﻪﻨﯿﺳ )
3-5 ( ﺶﺷﻮﭘ نوﺪﺑ ﺢﻄﺳ ﺎﯾ ﯽﻟﺪﻨﺻ يور
راﺮﻗ يﺮﮕﯾد فﺎﺻ
،دﻮﺑ هﺪﺷ هداد ﻪﺑ
رﻮﻃ ي ﻪﮐ وزﺎﺑ رود ﺮﻄﻗ ﺎﺑ ﺐﺳﺎﻨﺘﻣ ﺞﻨﺳرﺎﺸﻓ هﺎﮕﺘﺳد ﻟﺎﺣرد
ﯽ ﻪﮐ ﺴﯿﮐ ﮥ ﻪﺑ ﺞﻨﺳرﺎﺸﻓ ﻠﺻﺎﻓ
ﮥ 2 /5 ﺘﻧﺎﺳ ﯽ ﺮﺘﻣ ﺞﻧرآ زا ﺮﺗﻻﺎﺑ
دﻮﺑ هﺪﺷ ﻪﺘﺴﺑ
، ﻪﺒﺗﺮﻣود زا ﺖﺳار يوزﺎﺑ ﻪﺑ
رﻮﻈﻨﻣ ﺎﻄﺧ نﺪﻧﺎﺳر ﻞﻗاﺪﺣ ﻪﺑ ﺎﺑ و
ﺞﻨﺳرﺎﺸﻓ هﺎﮕﺘﺳد زا هدﺎﻔﺘﺳا هزاﺪﻧا
ﮔﯿ ﺮ ي .ﺪﺷ نﻮﺧ رﺎﺸﻓ
ﺳ ﯽﻟﻮﺘﺴﯿ سﺎﺳا ﺮﺑ ﻟوا ﻦﯿ اﺪﺻ ي د نﻮﺧ رﺎﺸﻓ و فﻮﮑﺗرﻮﮐ ﯽﻟﻮﺘﺳﺎﯾ
ﻤﺠﻨﭘ سﺎﺳا ﺮﺑ ﻦﯿ
اﺪﺻ ي هزاﺪﻧا فﻮﮑﺗرﻮﮐ ﮔ
يﺮﯿ ﺪﺷ ) 17 ((،
ﻞﻤﮑﻣ يرﺎﯾ
ﻞﻤﮑﻣ نازﻮﺘﯿﭼ ﻧدﻮﻣزآ ﻪﺑ ﯽ ﺎﻫ ي ﺑﺮﺠﺗ هوﺮﮔ ﯽ
ﻞﻤﮑﻣ) نازﻮﺘﯿﭼ ﺮﻤﺗ و تﺎﻨﯾ ﮐﺮﺗ ﯽﺒﯿ + نازﻮﺘﯿﭼ ( ﻪﻧازور فﺮﺼﻣ ناﺰﯿﻣ ﻪﺑ 4
نازﻮﺘﯿﭼ ﻞﻤﮑﻣ مﺮﮔ
) 21 (،
ﻪﺑ ترﻮﺻ 8 دﺪﻋ لﻮﺴﭙﮐ 500 ﻣ ﯿﻠ ﯽ ﻣﺮﮔ ﯽ ﺖﮐﺮﺷ يزﺎﺳوراد نرﺎﮐ
، ﺶﯿﭘ زا ﺪﻋو ة و ﻪﻧﺎﺤﺒﺻ رﺎﻫﺎﻧ
3 لﻮﺴﭙﮐ و ﺶﯿﭘ زا مﺎﺷ 2 لﻮﺴﭙﮐ
.ﺪﺷ هداد زا ﻖﯿﻘﺤﺗ ﻦﯾا رد ﻦﯿﻨﭽﻤﻫ ﺎﻤﻧوراد
.ﺖﺳا هﺪﺸﻧ هدﺎﻔﺘﺳا
ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﻞﮑﺗوﺮﭘ مﺎﺠﻧا ﻞﮑﺗوﺮﭘ ﺎﻫ ي ﺮﻤﺗ ﯽﻨﯾ ا ﻦﯾ ﺶﻫوﮋﭘ ﻪﺑ ترﻮﺻ ﻪﺳ ﻪﺘﻔﻫ رد رﺎﺑ تﺪﻣ ﻪﺑ
ﻫ ﺖﺸ ﻪﺘﻔﻫ دﻮﺑ فﺮﺼﻣ . ﮑﻣ
ﻞﻤ ﺎﻫ ز ﯾﺮ ﺮﻈﻧ ﻖﻘﺤﻣ و ﮏﺷﺰﭘ
مﺎﺠﻧا طﻮﺑﺮﻣ ﺖﻓﺮﮔ
. ﻠﺧاﺪﻣ ﮥ ﯽﻨﯾﺮﻤﺗ مﺎﺠﻧا ﺖﺸﻫ ﻪﺘﻔﻫ تﺎﻨﯾﺮﻤﺗ ﯽﺒﯿﮐﺮﺗ يزاﻮﻫ و ﯽﺘﻣوﺎﻘﻣ ﯽﺑﺮﻣ ﺮﻈﻧ ﺮﯾز ﻦﯿﯿﻌﺗ
،هﺪﺷ 3 زور رد ﻪﺘﻔﻫ
ﻪﺒﻨﺷ) - ﻪﺒﻨﺷود - (ﻪﺒﻨﺷرﺎﻬﭼ ﺖﻋﺎﺳ
5 ﺎﺗ 6 ﺮﺼﻋ ﻂﺳﻮﺗ ﯽﻧدﻮﻣزآ مﺎﺠﻧا ﺖﻓﺮﮔ .
ﻦﯾﺮﻤﺗ
يزاﻮﻫ ﻞﻣﺎﺷ 30 ﻪﻘﯿﻗد ﭘﯿ هدﺎ ور ي ﺑ ﯽ ﻪﻔﻗو ) 16 (
، ﺘﻔﻫ ﮥ لوا ﺎﺗ مرﺎﻬﭼ ﺎﺑ تﺪﺷ 40 ﺪﺻرد نﺎﺑﺮﺿ ﺐﻠﻗ ﻪﻨﯿﺸﯿﺑ و 1
ﺘﻔﻫ ﮥ ﺎﺗ مرﺎﻬﭼ
تﺪﺷ ﺎﺑ ﺶﻫوﮋﭘ ﻢﺘﺸﻫ 60
ﺑ ﺐﻠﻗ نﺎﺑﺮﺿ ﺪﺻرد ﻪﻨﯿﺸﯿ
مﺎﺠﻧا ﺖﻓﺮﮔ ) نﺎﯾﺎﺷ ﺖﺳا ﺮﮐذ ﻖﯾﺮﻃ زا ﻦﯾﺮﻤﺗ تﺪﺷ
ﺒﺳﺎﺤﻣ ﮥ و ﻪﻨﯿﺸﯿﺑ ﺐﻠﻗ نﺎﺑﺮﺿ
ﻪﺑ ﺳو ﯿﻠ ﮥ نﺎﺑﺮﺿ ﭘ ﺞﻨﺳ رﻻﻮ اﯾ ﻦ ﻪﻧﻮﮔ لﻮﻣﺮﻓ زا ﻪﮐ دﻮﺑ )
ﻦﺳ - 220 لﻮﻣﺮﻓ زا ﻪﺴﻠﺟ ﺮﻫ رد فﺪﻫ ﺐﻠﻗ نﺎﺑﺮﺿ ﺪﺻرد و ﻪﻨﯿﺸﯿﺑ ﺐﻠﻗ نﺎﺑﺮﺿ (
ﻦﻧورﺎﮐ ﻪﺑ ﯽﻣ ﺖﺳد ﺪﻣآ
) 22 (.
ﺑ ندﺮﮐ مﺮﮔ ﻦﯿ
ﺮﻤﺗ ود ﻦﯾ ﺎﺑ 10 راﺮﮑﺗ رﺎﺑ ﮏﯾ
و ﺖﮐﺮﺣ ﺲﭘ
زا 5 ﻗد ﻪﻘﯿ ﺖﺴﺗ
RM2
مﺎﺠﻧا 1
ﺖﻓﺮﮔ ﺖﺴﺗ)
رﺎﺑ ﻦﯾﺮﺘﺸﯿﺑ ﻦﺘﻓﺮﮔ ﺮﻈﻧ رد ﺎﺑ 1RM
هدﺎﻔﺘﺳا راﺮﮑﺗ ياﺮﺑ هﺪﺷ ﯽﻧدﻮﻣزآ ﻂﺳﻮﺗ ﻞﻣﺎﮐ
ﺎﻫ ( و ﺲﭘ ﺮﻤﺗ نآ زا تﺎﻨﯾ
ﺘﻣوﺎﻘﻣ ﯽ مﺎﺠﻧا ﺖﻓﺮﮔ .
ﺮﻤﺗ تﺎﻨﯾ ﺘﻣوﺎﻘﻣ ﯽ ﻢﻫ 30 ﻗد ﻪﻘﯿ رد رﺎﻬﭼ ﺘﻔﻫ ﮥ تﺪﺷ ﺎﺑ لوا 40
ﺪﺻرد ﮏﯾ ﺑ راﺮﮑﺗ ﻪﻨﯿﺸﯿ هدﺎﻔﺘﺳا) زا ﻞﺒﻣد 2 ﺎﯾ 3 ﯽﯾﻮﻠﯿﮐ و ﺶﮐ يﺎﻫ
ﯽﺘﻣوﺎﻘﻣ ﺎﺑ ﮓﻧر درز تﺪﺷ) ﻢﮐ ( ﺪﻧﺮﺑ )
RACINESS
( و رد رﺎﻬﭼ ﺘﻔﻫ ﮥ مود ﺎﺑ تﺪﺷ 60 ﺪﺻرد ﮏﯾ راﺮﮑﺗ ﻪﻨﯿﺸﯿﺑ هدﺎﻔﺘﺳا) زا ﻞﺒﻣد 4 ﺎﯾ 5
ﯽﯾﻮﻠﯿﮐ و ﺶﮐ يﺎﻫ ﯽﺘﻣوﺎﻘﻣ ﺎﺑ ﮓﻧر ﯽﺑآ تﺪﺷ) ﻂﺳﻮﺘﻣ مﺎﺠﻧا ( ﺖﻓﺮﮔ ﻣﺎﻤﺗ . ﯽ رد تﺎﮐﺮﺣ ﺳ
ﻪ راﺮﮑﺗ ﺎﺑ ﺖﺳ 12
ﺎﺗ ﯽﯾ ﺑ ﺖﺣاﺮﺘﺳا و ﻦﯿ
ﺮﻫ
ﺖﺳ 90 ﻧﺎﺛ ﻪﯿ ﺑ و ﻦﯿ ﺮﻤﺗ ﺮﻫ ﻦﯾ 120 ﻧﺎﺛ ﻪﯿ ﺮﻤﺗ .دﻮﺑ تﺎﻨﯾ ﺘﻣوﺎﻘﻣ ﯽ ﻖﺒﻃ لوﺪﺟ 1 ﺎﭘ سﺮﭘ ﻞﻣﺎﺷ ي
ﻘﻓا ﯽ
، 3
ﯽﯾورﺎﭘ زا ﻦﯿﯾﺎﭘ
، 4
ﺮﻤﺗ تﺎﻨﯾ ﻪﺘﺴﺸﻧ
ﺎﺑ ﻟﺪﻨﺻ ﯽ ،5
تﺎﻨﯾﺮﻤﺗ سﺮﭘ ﻪﺘﺴﺸﻧ يور ﺖﮑﻤﯿﻧ ﺳ) ﻪﻨﯿ (ﻪﻧﺎﺷﺮﺳ و دﻮﺑ6
) 16 (
.
لوﺪﺟ 1 . ﻞﮑﺗوﺮﭘ ﺮﻤﺗ ﯾ تﺎﻨ ﺘﻣوﺎﻘﻣ ﯽ و ﻐﺘﻣ ﯿ ﺎﻫﺮ ي نآ ﻪﺘﻓﺮﮔﺮﺑ زا ﻌﻟﺎﻄﻣ ﮥ ﻮﮕﻧﺎﻣ ﻧوﺮﺘﭘ ﯿﻮ و نارﺎﮑﻤﻫ ) 2019 (
ﺘﻔﻫ ﮥ لوا - مرﺎﻬﭼ ﺘﻔﻫ
ﮥ مرﺎﻬﭼ - ﻢﺘﺸﻫ
تﺪﺷ تﺎﮐﺮﺣ ﮏﺒﺳ
ﻂﺳﻮﺘﻣ
تﺎﮐﺮﺣ ﺖﺳ
راﺮﮑﺗ ﺖﻣوﺎﻘﻣ
) ﺪﺻرد ( ﺖﺳ راﺮﮑﺗ ﺖﻣوﺎﻘﻣ
) ﺪﺻرد (
سﺮﭘ ﺎﭘ ﻘﻓا ﯽ 3
12 40
3 12 60
ورﺎﭘ ﯽﯾ زا ﺎﭘ ﯿﯾ ﻦ 3
12 40
3 12 60
(MHR) Maximum Heart Rate
1.
One Repetition Maximum
2.
Horizontal leg press
3.
Low Row
4.
Extensor chair
5.
seat bench press
. 6