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6 ; _75 ;
BDNF
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CM sig
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17 ±137 /66 00
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BMI (kg/m2) [ ,
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P 8 [ ,
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IL-6 (pg/mL) [ ,
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BDNF (pg/mL) [ ,
3 ` 37
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F Sig
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145 ±2483/75 17
/
118 ±2541/83 162
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/
16 ±145 /66 00
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BMI (kg/m2) 85
/ 2 ±28/84 68
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P 8 52
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IL-6 (pg/mL) 75
/ 0 92± / 2 28
/ 1 00± / 5 00
/ 0
BDNF (pg/mL) 02
/ 1 72± / 17 12
/ 1 99± / 5 00
/ 0
?q) F O % 4 3 60
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5
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M ) 68
/ 0 - 00
/ 0
7O 73
/ 0 - 00
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(O 47
/ 0 - 01
/ 0
% T 58
/ 0 - 00
/ 0
HDL 58
/ 0 00
/ 0
BMI 90
/ 0 - 00
/ 0
89 / 0 - 00
/ 0
P 8 87
/ 0 - 00
/ 0
IL-6 78
/ 0 - 00
/ 0
?q) F O % 4 3 92
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A3
% V1!
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/
9796 References
1. Cavalieri M, Ropele S, Petrovic K, Pluta- Fuerst A, Homayoon N, Enzinger C, et al.
Metabolic syndrome, brain magnetic resonance imaging, and cognition. Diabetes Care. 2010; 33(12): 2489-2495.
2. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al.
Diagnosis and management of the metabolic syndrome: an American heart association/
national heart, lung, and blood institute scientific statement. Circulation. 2005; 112:
2735-2752.
3. Bullo M, Peeraully MR, Trayhurn P, Folch J, Salas-Salvado J .Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur J Endocrinol. 2007; 157(3):303-310.
4. Devaraj S, Torok N, Dasu MR, Samols D, Jialal I. Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. Arterioscler Thromb Vasc Biol. 2008; 28: 1368-1374.
5. Rader DJ. Inflammatory markers of coronary risk. N Engl J Med. 2000; 343: 1179-1182.
6. Phillips C, Baktir MA, Srivatsan M, Salehi A. Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling. Cell Neurosci. 2014; 8: 12- 17.
7. Patanella AK, Zinno M, Quaranta D, Nociti V, Frisullo G, Gainotti G, et al. Correlations Between Peripheral Blood Mononuclear Cell Production of BDNF, TNF-alpha, IL-6, IL- 10 and Cognitive Performances in Multiple
Sclerosis Patients. J Neurosci Res. 2010; 88:
1106-1112.
8. Tanaka S, Ide M, Shibutani T, Ohtaki H, Numazawa S, Shioda S, et al.
Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death. J Neurosci Res. 2006; 83: 557-566.
9. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology 2003; 61: 76-80.
10.Kasapis C, Thompson PD. The Effects of Physical Activity on Serum C-Reactive Protein and Inflammatory Markers. J Am Coll Cardiol. 2005; 45(10): 1563-1569.
11.Meek TH, Wisse BE, Thaler JP, Guyenet SJ, Matsen ME, Fischer JD, et al. BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production.
Diabetes. 2013; 62(5): 1512-1518.
12.Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia.
2007; 50(2): 431-438.
13.Brown JP, Sollers JJ, Thayer JF, Zonderman AB, Waldstein SR. Blood pressure reactivity and cognitive function in the Baltimore Longitudinal Study of Aging. Health Psychol. 2009; 28(5): 641-646.
14.Thomas SR, Keaney JF. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and
/
9896
dephosphorylation via a phosphoinositide 3- kinase -dependent signaling pathway. J Biol Chem. 2002; 277: 6017–6024.
15.Lee SS, Yoo JH, Kang S, Woo JH, Shin KO, Kim KB, et al. The effects of 12 weeks regular aerobic exercise on brain-derived neurotrophic factor and inflammatory factors in juvenile obesity and type 2 diabetes mellitus. J Physical Ther Sci. 2014; 26(8):
1199-1204.
16.Babaei P, Damirchi A, Azali- Alamdari K.
Effects of Endurance Training and Detraining on Serum BDNF and Memory Performance in Middle Aged Males with Metabolic Syndrome. IJEM. 2013; 15(2):
132-142.
17.Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial.
Arch Neurol. 2010; 67(1): 71-79.
18.Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci.
2011; 108(7): 3017-3022.
19.Qi Z, He J, Zhang Y, Shao Y, Ding S.
Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. Free Radic Biol Med. 2011; 50(7): 794- 800.
20.Miller AH, Maletic V, Raison CL.
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression. Biol Psychiatry. 2009;
65(9): 732-741.
21.Schottelius AJ, Mayo MW, Sartor RB, Baldwin AS. Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J Biol Chem. 1999; 274(45): 3168-3174.
22.Glaser R, Robles TF, Sheridan J, Malarkey WB, Kiecolt-Glaser JK. Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults.
Arch Gen Psychiatry. 2003; 60: 1009-1014.
23.Ziegenhorn AA, Schulte-Herbra ggen O, Danker-Hopfe H, Malbranc M, Hartung HD, Anders D. Serum neurotrophins-A study on the time course and influencing factors in a large old age sample. Neurobiol Aging.
2007; 28: 1436-1445.
24.Lommatzsch M, Schloetcke K, Klotz J, Schuhbaeck K, Zingler D, Zingler C. Brain- derived neurotrophic factor in platelets and airflow limitation in asthma. Am J Respir Crit Care Med. 2005; 171: 1105-1120.
25.Zoladz JA, Pilc A. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol. 2010; 61(5): 533-541.
26.Castellano V, White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. J Neurol Sci.
2008; 269(1-2): 85-91.
27.Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci.
2011; 108: 3017-3122.
28.Schiffer T, Schulte S, Hollmann W, Bloch W, Strader HK. Effects of strength and
/
9996
endurance training on brain-derived neurotrophic factor and insulin-like growth factor 1 in humans. Horm Metab Res. 2009;
41: 250-254.
29.Goekint M, Roelands B, De Pauw K, Knaepen K, Bos I, Meeusen R. Does a period of detraining cause a decrease in serum brain-derived neurotrophic factor?
Neurosci Lett. 2010; 486: 146-149.
30.Griffin ÉW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly ÁM.
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav. 2011;
104: 934-941.
31.Zoladz JA, Pilc A, Majerczak J, Grandys M, Zapart-Bukowska J, Duda K. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol. 2008; 59:
119-132.
32.Berchtold NC, Chinn G, Chou M, Kesslak JP, Cotman CW. Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus. Neuroscience. 2005; 133:
853-861.
33.Shayan A, Bagherzadeh F, Shahbazi M, Choobineh S. The Effect of Two Types of Exercise (Endurance and Resistance) on Attention and Brain Derived Neurotropic Factor Levels in Sedentary Students. JDML.
2015; 6(4): 433-452.
34.Suwa M, Kishimoto H, Nofuji Y, Nakano H, Sasaki H, Radak Z. Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed
female patients with type 2 diabetes mellitus.
Diabetes Nutr Metabol Clin Exp. 2006; 55:
852-857.
35.Gomes da Silva S, Simões PSR, Mortara RA, Scorza FA, Cavalheiro EA, da Graça Naffah-Mazzacoratti M, et al. Exercise- induced hippocampal anti-inflammatory response in aged rats. Neuroinflammation.
2013; 10: 61.
36.Itamar L. The effects of resistance training on individuals with clusters of metabolic risk factors: focus on functional capacities, clinical outcomes and quality of life PhD thesis, Victoria University. 2008.
37.Sohrabji F, Miranda RC, Toran-Allerand CD. Identification of a putative estrogen response element in the gene encoding brain- derived neurotrophic factor. Proc Natl Acad Sci. 1995; 92(24): 110–114.
38.Ramsbottom R, Currie J, Gilder M.
Relationships between components of physical activity, cardiorespiratory fitness, cardiac autonomic health, and brain-derived neurotrophic factor. J Sports Sci. 2010; 28:
843-849.
39.Dahl A, Hassing LB, Fransson E, Berg S, Gatz M, Reynolds CA, et al. Being Overweight in Midlife Is Associated With Lower Cognitive Ability and Steeper Cognitive Decline in Late Life. J Gerontol Biol Med Sci. 2010; 65: 57-62.
40.Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science. 2001; 294(5548):
1945-1948.
41.Pencea V, Bingaman KD, Wiegand SJ, Luskin MB. Infusion of brain-derived
/
10096
neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci.
2001; 21: 6706-6717.
42.Streltsov VA, Varghese JN, Masters CL, Nuttall SD. Crystal structure of the amyloid- β p3 fragment provides a model for oligomer
formation in Alzheimer's disease. J Neurosci.
2011; 31(4): 1419-1426.
43.Ratey JJ, Loehr JE. The positive impact of physical activity on cognition during adulthood: a review of underlying
mechanisms, evidence and
recommendations. Rev Neurosci. 2011;
22(2): 171-185.
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The effect of six months aerobic exercise with moderate intensity on BDNF, IL-6, and short-term memory in 50-65 years old women with syndrome
metabolic
Osali A*1, Mostafavi H2
1. Assistant Professor, Department of Physical Education and Sport Sciences, University of Bonab, Bonab, Iran.
2. Assistant Professor, Department of Neurophysiology, Zanjan University of Medical Sciences, Zanjan, Iran.
Received:25 Sep 2017 Accepted:20 Nov 2017
Abstract
Background : The aim of this research was to investigate the effect of six months aerobic exercise with moderate intensity on BDNF, IL-6, and short-term memory in 50-65 years old women with syndrome metabolic.
Materials and Methods: 24 women with metabolic syndrome (MetS) took part voluntarily and divided in tow groups MetS exercise (ME), MetS control (MC). ME group participated in an aerobic exercise training (AT) program (six months), tree session per week, each session containing tree performing part and tow rest part (five minutes). Initially, the duration of aerobic exercise in each session was eight minutes. One minute added each week to the duration of aerobic exercise till twelve weeks. Also, blood samples were conducted before and after six months training for evaluating levels of BDNF and IL-6. Short-term memory measured by Digit span memory test, BDNF, and IL-6 measured by Radioimmunoassay before and after six months aerobic training. Data were analyzed using Pearson coefficient, Pried-sample T-Test, and independent samples T-Test.
Results: BDNF and short-term memory after six months aerobic exercise significantly increased (P˃0.05). IL-6 after six months aerobic exercise significantly decreased (P˃0.05).
Conclusion: Findings show that six months aerobic exercises induce to decrease IL-6 and increase BDNF level, so this trend trepan ameliorate short-term memory score.
Keywords:Aerobic exercise, BDNF, IL-6, Short-term memory, Metabolic syndrome
*Citation: Osali A, Mostafavi H. The effect of six months aerobic exercise with moderate intensity on BDNF, IL-6, and short-term memory in 50-65 years old women with syndrome metabolic. Yafte. 2017; 19(4): 88-101.
