Effects of a moderate intensity aerobic exercise on serum levels of BDNF, DCX, and DBHB in triathlon male adolescents

/

86

هرود ،ﻪﺘﻓﺎﯾ 23

، ﺰﯿﯾﺎﭘ 1400

:ﻪﺒﺗﺎﮑﻣ سردآ*

مﺮﺧ دﺎﺑآ

، نﺎﺘﺳﺮﻟ هﺎﮕﺸﻧاد

، ﯽﻧﺎﺴﻧا مﻮﻠﻋ و تﺎﯿﺑدا هﺪﮑﺸﻧاد

، ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ

.

ﺖﺴﭘ :ﮏﯿﻧوﺮﺘﮑﻟا :

valipour.v@lu.ac.ir

ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻪﺴﻠﺟ ﮏﯾ ﺮﺛا ﯽﺳرﺮﺑ ،

BDNF

و

DCX

رد

DBHB

ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ ﻪﻧﺎﮔ

رﺎﮐ

ﯽﮕﯿﺑﺪﻤﺤﻣ دﺎﺠﺳ ،

1

ﯽﻟو ﺪﯿﺣو رﻮﭘ

هد ﻧﻮ

2

*

1 - ،ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ مﺮﺧ ،نﺎﺘﺳﺮﻟ هﺎﮕﺸﻧاد ،ﯽﻧﺎﺴﻧا مﻮﻠﻋ و تﺎﯿﺑدا هﺪﮑﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ

ناﺮﯾا ،دﺎﺑآ

2 - ،رﺎﯿﺸﻧاد مﺮﺧ ،نﺎﺘﺳﺮﻟ هﺎﮕﺸﻧاد ،ﯽﻧﺎﺴﻧا مﻮﻠﻋ و تﺎﯿﺑدا هﺪﮑﺸﻧاد ،ﯽﺷزرو مﻮﻠﻋ هوﺮﮔ ناﺮﯾا ،دﺎﺑآ

هرود / ﻪﺘﻓﺎﯾ 23

هرﺎﻤﺷ / 4

/ ﺰﯿﯾﺎﭘ 1400 / ﻞﺴﻠﺴﻣ 89

:ﻪﻟﺎﻘﻣ ﺖﻓﺎﯾرد 13

/ 4 / 1400 ﻟﺎﻘﻣ شﺮﯾﺬﭘ :ﻪ

28 / 6 / 1400

ﻪﻣﺪﻘﻣ :

ﯽﻣ دﻮﺒﻬﺑ ار ﻢﻟﺎﺳ داﺮﻓا ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ يزاﻮﻫ شزرو ﻪﺑ ﺦﺳﺎﭘ رد ﯽﻔﻠﺘﺨﻣ ﯽﻣﺮﺳ ﻞﻣاﻮﻋ رو ﺮﯿﺛﺄـﺗ ناﺰـﯿﻣ ﺎـﻣا ،ﺪـﻨﻫد

شز

تﺪﺷ ﺎﺑ يزاﻮﻫ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻪﺴﻠﺟ ﮏﯾ ﺮﺛا ﯽﺳرﺮﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ فﺪﻫ ،ﻦﯾاﺮﺑﺎﻨﺑ .ﺖﺳا هﺪﺸﻧ ﯽﺳرﺮﺑ ﺎﻬﻧآ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ

ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ ،BDNF

وDCX ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ ردDBHB

ﻪﻧﺎﮔ .دﻮﺑ نﺎﮐﺮﺴﯾﻮﺗ رد رﺎﮐ

شور و داﻮﻣ :ﺎﻫ

ﻪﻤﯿﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد ،ﯽﺑﺮﺠﺗ

22 ﻪﺳ دﺮﻣ ﻪﻧﺎﮔ :ﻦﺳ) رﺎﮐ 52

/0 60± / 17 :نزو ،لﺎﺳ 96

/ 4 74± / 60 ﺮﮔﻮﻠﯿﮐ :ﺪﻗ ،م

52 / 5 60± / 175 ﯽﺘﻧﺎﺳ ﻪﺑ (ﺮﺘﻣ ﯽﻧدﻮﻣزآ .ﺪﻧدﺮﮐ ﺖﮐﺮﺷ ﻪﻧﺎﺒﻠﻃواد رﻮﻃ ﻪﺴﻠﺟ ﮏﯾ رد ﺎﻫ

60 تﺪﺷ ﺎﺑ نﺪﯾود ﻪﻘﯿﻗد 13

- 12 سﺎﯿﻘﻣ رد

ﯽﻧدﻮﻣزآ زا ﯽﻧﻮﺧ ﻪﻧﻮﻤﻧ ﻦﯾﺮﻤﺗ زا ﺲﭘ و ﺶﯿﭘ ﻪﻘﯿﻗد ﺞﻨﭘ .ﺪﻧداد مﺎﺠﻧا ار گرﻮﺑ ﯽﻣﺮﺳ حﻮﻄﺳ .ﺪﺷ ﻪﺘﻓﺮﮔ ﺎﻫ

،BDNF وDCX

ﻪﺑDBHB هزاﺪﻧا اﺰﯾﻻا شور .ﺪﺷ يﺮﯿﮔ

ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ ياﺮﺑ هداد

ﺎﻫ نﻮﻣزآ زا ﯽﺟوزt

هدﺎﻔﺘﺳا ﺪﺷ ﯽﻨﻌﻣ ﺢﻄﺳ و يراد

05 /0 p<

رد

.ﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ ﺶﯿﭘ ﻪﺑ ﺖﺒﺴﻧ تاﺮﯿﯿﻐﺗ ﺪﺻرد ،ﻦﯿﻨﭽﻤﻫ

.ﺪﺷ ﻪﺒﺳﺎﺤﻣ نﻮﻣزآ

ﻪﺘﻓﺎﯾ :ﺎﻫ

ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ )DCX

0005 /0

= ،(p )BDNF 0005 /0

= و (p )DBHB 001 /0

= ﺶﯿﭘ ﻪﺑ ﺖﺒﺴﻧ (p ﻣزآ

ﻪﺑ نﻮ -

.ﺖﻓﺎﯾ ﺶﯾاﺰﻓا يرادﺎﻨﻌﻣ رﻮﻃ ﻦﯿﻨﭽﻤﻫ

ﻪﺑ ، ﯽﻣﺮﺳ حﻮﻄﺳ ﺐﯿﺗﺮﺗ )BDNF

30 / 21 ،(ﺪﺻرد )DBHB 95 / 12 و (ﺪﺻرد )DCX

01 / 12

ﺶﯿﭘ ﻪﺑ ﺖﺒﺴﻧ ار ﺶﯾاﺰﻓا ﻦﯾﺮﺘﺸﯿﺑ (ﺪﺻرد .ﺪﻨﺘﺷاد نﻮﻣزآ

ﻪﺠﯿﺘﻧ و ﺚﺤﺑ :يﺮﯿﮔ

ﯽﻣﺮﺳ ﻞﻣﺎﻋ ﻪﺳ ﺮﻫ ،BDNF

وDCX ﻪﺑ يرادﺎﻨﻌﻣ ﺖﺒﺜﻣ ﺦﺳﺎﭘDBHB

رد ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو

ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ ﻪﻧﺎﮔ

ﯽﻣ رﺎﮐ ﺪﺷر ﻞﻣﺎﻋ/ﻦﯿﻓوﺮﺗوﺮﻧ ﺎﻣا ،ﺪﻨﻫد ﯽﻣ نﺎﺸﻧ يﺮﺘﺸﯿﺑ تاﺮﯿﯿﻐﺗBDNF

ﻪﺑ و ﺪﻫد ﯽﻣ ﺮﻈﻧ ﺪﺳر ﻧ يﺮﺘﺸﯿﺑ ﺶﻘ

.دراد ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ و يﺮﯿﮔدﺎﯾ ،ﻪﻈﻓﺎﺣ دﻮﺒﻬﺑ ،ﯽﺒﺼﻋ ﺖﻈﻓﺎﺤﻣ رد

هژاو ﺪﯿﻠﮐ يﺎﻫ :ي

،ﻦﯿﻓوﺮﺗوﺮﻧ ،يزاﻮﻫ شزرو ﺎﮑﺷزرو ،DBHB

ﻪﺳ ر ﻪﻧﺎﮔ .رﺎﮐ

هﺪﯿﮑﭼ

ﻪﻣﺪﻘﻣ

ﺖﯾﺰﻣ ﯽﺒﻠﻗ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ياﺮﺑ يزاﻮﻫ شزرو يﺎﻫ -

ﻪﺑ ﯽﻗوﺮﻋ ﻞﻣﺎﮐ رﻮﻃ

ﺖﺑﺎﺛ هﮋﯾﻮﺑ ،شزرو ﺎﻣا .ﺖﺳا هﺪﺷ

شزرو يزاﻮﻫ يﺎﻫ نﺎﻨﭽﻤﻫ

ﻪﺑ ﻪﻨﯾﺰﻫ ﻢﮐ ﻢﯾژر ﮏﯾ ناﻮﻨﻋ

دﻮﺒﻬﺑ ياﺮﺑ ﺮﻓ

آ يﺎﻫﺪﻨﯾ و ﻪﻈﻓﺎﺣ ﺪﻨﻧﺎﻣ ﯽﺘﺧﺎﻨﺷ

) ﺖﺳا هﺪﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ رد ﯽﯾاﺮﺟا يﺎﻫدﺮﮑﻠﻤﻋ 1

ﻪﺑ .(

ﺮﻫ

ﺣ ﯽﻣ نﺎﺸﻧ ﯽﻧاﻮﯿﺣ و ﯽﻧﺎﺴﻧا تﺎﻌﻟﺎﻄﻣ ،لﺎ شزرو ﻪﮐ ﺪﻫد

ﻪﺒﻨﺟ زا يرﺎﯿﺴﺑ يزاﻮﻫ ﺮﯿﺛﺄﺗ ﺖﺤﺗ ار ﺰﻐﻣ دﺮﮑﻠﻤﻋ يﺎﻫ

راﺮﻗ

ﯽﻣ هدﺮﺘﺴﮔ تاﺮﯿﺛﺄﺗ و ﺪﻫد ﺑ .دراد ﺰﻐﻣ ﺖﻣﻼﺳ ﺮﺑ يا

ﻪ -

ﺎﺑ شزرو ،لﺎﺜﻣ ناﻮﻨﻋ ﺮﺛا

ﻪﺑ ﻢﯿﻘﺘﺴﻣ ﺑ ﺶﯾاﺰﻓا ﻪﻠﯿﺳو

نﺎﯿ

ﻦﯿﻓوﺮﺗوﺮﻧ و ﯽﺴﭘﺎﻨﯿﺳ رﺎﺘﺧﺎﺳ ﺮﺑ ،يﺪﺷر ﻞﻣاﻮﻋ و ﺎﻫ

ﺖﯾﻮﻘﺗ ﻢﺘﺴﯿﺳ ﺖﯾﻮﻘﺗ ،ﯽﺴﭘﺎﻨﯿﺳ ترﺪﻗ ﯽﺳﺎﺳا يﺎﻫ

ﯽﻧﺎﺒﯿﺘﺸﭘ نوﺮﻧ ﻪﻠﻤﺟ زا هﺪﻨﻨﮐ

و ﻢﺴﯿﻟﻮﺑﺎﺘﻣ ،ﯽﯾاز ﻋ

دﺮﮑﻠﻤ

ﻞﮑﺷ ﺖﯿﻠﺑﺎﻗ ،ﯽﻗوﺮﻋ ﯽﺴﭘﺎﻨﯿﺳ يﺮﯾﺬﭘ

ﯽﻣ ﺶﯾاﺰﻓا ار ﺪﻫد

) 2 ﻪﺑ .(

شزرو ﻦﯿﺑ ﯽﺒﺳﺎﻨﺗ ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ،ﯽﮔزﺎﺗ نﻮﺧ نﺎﯾﺮﺟ دﻮﺒﻬﺑ و ﭗﻤﮐﻮﭙﯾﺎﻫ ﻢﺠﺣ ﺶﯾاﺰﻓا و يزاﻮﻫ

ﻦﯾا ﻪﮐ دراد دﻮﺟو ﺰﻐﻣ ﺎﻨﺷ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ﺎﺑ تاﺮﯿﯿﻐﺗ

،ﯽﺘﺧ

) دراد طﺎﺒﺗرا يﺮﯿﮔدﺎﯾ و ﻪﻈﻓﺎﺣ 3

.(

لﺎﺳ رد ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ ﯽﺳرﺮﺑ ﻪﺑ ناﺮﮕﺸﻫوﮋﭘ ﺮﯿﺧا يﺎﻫ

ﻦﯿﻓوﺮﺗوﺮﻧ ﺦﺳﺎﭘ ﺮﺑ ﯽﻧﺪﺑ ﻪﺘﺧادﺮﭘ ﯽﺒﺼﻋ ﺪﺷر ﻞﻣاﻮﻋ و ﺎﻫ

-

ﯽﻣ ﻞﻣاﻮﻋ ﻦﯾا ﻪﮐ هﺪﺷ شراﺰﮔ تﺎﻌﻟﺎﻄﻣ ﺮﺘﺸﯿﺑ رد و ﺪﻧا -

ﺖﯿﻟﺎﻌﻓ ﺮﯿﺛﺄﺗ ﺖﺤﺗ ﺪﻨﻧاﻮﺗ ﻪﺑ ﯽﻧﺪﺑ يﺎﻫ

ﻨﻌﻣ رﻮﻃ يرادﺎ

ﻦﯿﻓوﺮﺗوﺮﻧ .ﺪﻨﺑﺎﯾ ﺶﯾاﺰﻓا ﻦﯿﺌﺗوﺮﭘ زا يﺎﻫداﻮﻧﺎﺧ ﺎﻫ

ﺎﻫ

نوﺮﻧ ﺖﯿﻟﺎﻌﻓ و ﺪﺷر ﺐﺟﻮﻣ ﻪﮐﺪﻨﺘﺴﻫ ﯽﻣ ﺎﻫ

) ﺪﻧﻮﺷ 4 .(

) ﺰﻐﻣ زا ﻖﺘﺸﻣ ﯽﺒﺼﻋ يﺬﻐﻣ ﻞﻣﺎﻋ Brain-derived

neurotrophic factor, (

زا يﻮــﻀﻋ ﻪﮐ BDNF

ﻦﯿﻓوﺮﺗوﺮﻧ ةداﻮــﻧﺎﺧ ﻪـﺑ ار دﻮــﺧ ﺮــﺛا ﺖﺳﺎــﻫ

ود ﻪﻠﯿﺳو

ﻨﯿﺌﺗوﺮﭘ ةﺪـﻧﺮﯿﮔ ﻪﺑ ﯽـ

مﺎﻧ زﺎـﻨﯿﮐ ﻦـﯾزوﺮﯿﺗ يﺎﻫ هﺪﻧﺮﯿﮔ و

ﻢﮐ ﯽﺒﯿﮐﺮﺗ ﻞﯿﻣ ﺎﺑ ﯽﺒﺼﻋ ﺪﺷر ﻞﻣﺎﻋ LNGFR

) Low-

affinity nerve growth factor receptor, رد (

ﯽﻣ لﺎــﻤﻋا ﯽﻟﻮﻠــﺳ ﺢﻄــﺳ ) ﺪــﻨﮐ

5 .(

BDNF ﻪﮐ

) ﺪﺷ ﯽﯾﺎﺳﺎﻨﺷ كﻮﺧ ﺰﻐﻣ زا اﺪﺘﺑا 6

ﻢﯿﻈﻨﺗ رد ﯽﻤﻬﻣ ﺶﻘﻧ ( لﻮﻠﺳ ﺖﯿﻌﻤﺟ ﺰﯾﺎﻤﺗ و ءﺎﻘﺑ

راد ﯽﺒﺼﻋ يﺎﻫ ﻪﺑ و د

هﺪﻤﻋ رﻮﻃ

ﻪﺑ لﻮﻠﺳ ﻪﻠﯿﺳو ﯽﻣ ﺰﺘﻨﺳ ﯽﺒﺼﻋ يﺎﻫ

ﭗﻤﮐﻮﭙﯾﺎﻫ رد ﺎﻣا ،دﻮﺷ

ﻪﺑ ﯽﻣ نﺎﯿﺑ يدﺎﯾز راﺪﻘﻣ ) دﻮﺷ

7 .(

BDNF نوﺮﻧ

ار ﯽﯾاز

ﯽﻣ ﺖﯾﻮﻘﺗ ﺪﻨﮐ

) 8 ﺶﻘﻧ ﯽﺴﭘﺎﻨﯿﺳ و ﯽﺒﺼﻋ ﺪﺷر رد و (

ﻪﺑ و دراد هﺎﺗﻮﮐ رد ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ ياﺮﺑ هﮋﯾو رﻮﻃ و تﺪﻣ

ﺖﺨﯾر رد يرﺎﮔزﺎﺳ ﺮﺿ تﺪﻣزارد رد ﺰﻐﻣ ﯽﺳﺎﻨﺷ

ﺖﺳا يرو

) 9 ﯽﻣ شزرو ﻪﮐ ﺖﺳا هﺪﺷ ﺺﺨﺸﻣ .(

ﺢﻄﺳ ﺪﻧاﻮﺗ

ﻦﯾا زا و ﺪﻫد ﺶﯾاﺰﻓا ار ﺪﺷر ﻞﻣاﻮﻋ زا ﯽﺧﺮﺑ و BDNF

نوﺮﻧ ﮏﯾﺮﺤﺗ ﺐﺟﻮﻣ ﻖﯾﺮﻃ ) دﻮﺷ ﯽﯾاز

12-10 ،ﻦﯿﻨﭽﻤﻫ .(

هداد نﺎﺸﻧ تﺎﻌﻟﺎﻄﻣ ﯽﻣﺮﺳ ﺢﻄﺳ ﻪﮐ ﺪﻧا

زا ﺲﭘ BDNF

هدﺮﮐ اﺪﯿﭘ ﺶﯾاﺰﻓا ﻢﻟﺎﺳ نادﺮﻣ رد يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ ) ﺖﺳا 13-10 .(

ﮑﻠﺑاد ) ﻦﯿﺗرﻮ Doublecortin, DCX

ﯽﻨﯿﺌﺗوﺮﭘ (

ﻪﺑ ﻪﮐ ﺖﺳا لﻮﺑﻮﺗوﺮﮑﯿﻣ ﺎﺑ ﻂﺒﺗﺮﻣ هدﺮﺘﺴﮔ رﻮﻃ

رد يا

.دﻮﺷ ﯽﻣ نﺎﯿﺑ ﺪﺷر لﺎﺣ رد ناراﺪﻧﺎﺘﺴﭘ ﯽﺒﺼﻋ ﻢﺘﺴﯿﺳ

،ﻦﯿﻨﭽﻤﻫ ﻞﮑﺷ رد DCX

و نﻮﺴﮐآ ﺪﺷر ،ﯽﺒﺼﻋ يﺮﯾﺬﭘ

ﺲﭘﺎﻨﯿﺳ ) دراد ﺶﻘﻧ ﯽﯾاز 13

،ﻦﯾا ﺮﺑ هوﻼﻋ .(

ﻪﺑ DCX -

د هﺪﺷ ﺪﻟﻮﺘﻣ هزﺎﺗ نوﺮﻧ ﺮﮕﻧﺎﺸﻧ ﮏﯾ ناﻮﻨﻋ ﯽﻣ ﻪﺘﻓﺮﮔ ﺮﻈﻧ ر

-

نوﺮﻧ ﺢﻄﺳ ﻦﯿﯿﻌﺗ ياﺮﺑ و دﻮﺷ ﻪﻧاﺪﻧد ﺞﻨﮑﺷ رد ﯽﯾاز

راد

) Dentate gyrus, DG ياﺮﺑ ﺮﺒﺘﻌﻣ ﻞﻣﺎﻋ ﮏﯾ ،ﻎﻟﺎﺑ (

لﻮﻠﺳ ﺪﯿﻟﻮﺗ رد تاﺮﯿﯿﻐﺗ ﻦﯿﯿﻌﺗ ﻪﺑ و ﺪﯾﺪﺟ ﯽﺒﺼﻋ يﺎﻫ

-

يرﺎﻤﯿﺑ ﺎﯾ يﺮﯿﭘ زا يﺮﮕﻧﺎﺸﻧ ناﻮﻨﻋ رد ﻒﻠﺘﺨﻣ ﯽﺒﺼﻋ يﺎﻫ

ﯽﻣ هدﺎﻔﺘﺳا نﺎﺴﻧا ﭗﻤﮐﻮﭙﯾﺎﻫ ) دﻮﺷ

14 ﻪﺑ .(

ﺮﻫ ،لﺎﺣ ﺮﻫ

يود وBDNF نوﺮﻧ ﺐﺟﻮﻣDCX

و ﭗﻤﮐﻮﭙﯾﺎﻫ رد ﯽﯾاز

ﯽﻣ ﻪﯿﺣور و ﻪﻈﻓﺎﺣ ،يﺮﯿﮔدﺎﯾ دﻮﺒﻬﺑ ﻪﺠﯿﺘﻧ رد ﺪﻧﻮﺷ

) 15،16 ﻪﺑ ،هوﻼﻌﺑ .(

شزرو ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ﯽﮔزﺎﺗ

ﯽﻣﺮﺳ حﻮﻄﺳ ﯽﺘﻣوﺎﻘﻣ و يزاﻮﻫ ﯽﻣ ﺶﯾاﺰﻓا ارDCX

ﺪﻫد

) 16،17 .(

و ﺪﺒﮐ تارﺪﯿﻫﻮﺑﺮﮐ ﺶﻫﺎﮐ ﻂﯾاﺮﺷ رد ﯽﻧﻮﺘﮐ مﺎﺴﺟا ژﺮﻧا ﻊﺒﻨﻣ ﮏﯾ ﻪﻠﻀﻋ ﺖﻓﺎﺑ ياﺮﺑ ﺐﺳﺎﻨﻣ ي

ﺪﻨﻧﺎﻣ ﯽﯾﺎﻫ

ﻪﯿﻠﮐ ،ﺐﻠﻗ ﻪﻠﻀﻋ ،ﯽﺘﻠﮑﺳا تﻼﻀﻋ نوﺮﻧ و ﺎﻫ

ﯽﻣ ﺎﻫ ﺪﺷﺎﺑ

) 18 تاﺮﯿﺗﻮﺑ ﯽﺴﮐورﺪﯿﻫ ﺎﺘﺑ ﯽﻧﻮﺘﮐ مﺎﺴﺟا ﻦﯾا زا ﯽﮑﯾ .(

/

88

هرود ،ﻪﺘﻓﺎﯾ 23

، ﺰﯿﯾﺎﭘ 1400

) beta-hydroxybutyrate, DBHB ﯽﻣ (

ﻪﮐ ﺪﺷﺎﺑ

ﯽﺑﺮﭼ ﺺﻗﺎﻧ ﺶﯾﺎﺴﮐا زا ﯽﺷﺎﻧ ﻪﺑ نﺪﺑ رد ﺎﻫ

ﺪﯿﻟﻮﺗ لﺎﺒﻧد

ﻢﯾﺰﻧآﻮﮐ ﻞﯿﺘﺳا ﺎﻫﺪﯿﺳا ﺶﯾﺎﺴﮐا زا ﻞﺻﺎﺣ A

و بﺮﭼ ي

) ﺖﺳا تﺎﺘﺳاﻮﺘﺳا ﻪﺑ نآ ﻞﯾﺪﺒﺗ 19

.(

ﮏﯾ DBHB

نورد لﻮﮑﻟﻮﻣ ﺪﺒﮐ رد شزرو زا ﺲﭘ و ﻦﯿﺣ رد ﻪﮐ ﺖﺳاز

ﯽﻣ ﺪﯿﻟﻮﺗ ﯽﻧﻮﺧ ﺪﺳ زا رﻮﺒﻋ زا ﺲﭘ و دﻮﺷ

- ﺐﺟﻮﻣ يﺰﻐﻣ

نﺎﯿﺑ ﺶﯾاﺰﻓا ﯽﻣ BDNF

.دﻮﺷ ،ﻦﯿﻨﭽﻤﻫ ﺚﻋﺎﺑ DBHB

ﯽﻣ ﯽﺒﺼﻋ هﺪﻨﻫد لﺎﻘﺘﻧا رﺎﺸﺘﻧا ﺶﯾاﺰﻓا ﻪﺑ .دﻮﺷ

،لﺎﺣ ﺮﻫ

زرو ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ﺢﻄﺳ يزاﻮﻫ ش

ار DBHB

ﯽﻣ ﺶﯾاﺰﻓا ) ﺪﻫد

20 .(

ﻪﺑ ﯽﻣﺮﺳ ﻞﻣاﻮﻋ ﺖﯿﻤﻫا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ،لﺎﺣ ﺮﻫ ،BDNF

و DCX ،نﺎﺴﻧا رد ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ رد DBHB

ﻪﺑ ﺦﺳﺎﭘ رد ﻞﻣاﻮﻋ ﻦﯾا تاﺮﯿﯿﻐﺗ ناﺰﯿﻣ ندﺮﮐ ﺺﺨﺸﻣ ﻪﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻮﯿﺷ ﻦﯾا ندﻮﺑ ﺞﯾار ﺖﻠﻋ

ه

ﻢﻬﻣ رﺎﯿﺴﺑ ،ﯽﻨﯾﺮﻤﺗ ﺖﺳا

ﺗ ﺎﺑ اﺮﯾز ، ﺮﯿﯿﻐﺗ ﻦﯾا ﻪﺑ ﻪﺟﻮ

تا

ﯽﻣ تﺪﺷ ﻪﻠﻤﺟ زا ﯽﻨﯾﺮﻤﺗ يﺎﻫﺮﯿﻐﺘﻣ ﯽﺧﺮﺑ ناﻮﺗ ،

و تﺪﻣ

هﺮﻬﺑ ياﺮﺑ ار ﻦﯾﺮﻤﺗ عﻮﻧ ﯽﺘﺣ ﺮﮐ يرﺎﮑﺘﺳد ﺮﺘﺸﯿﺑ يﺮﯿﮔ

.د

ﻪﺑ ﻪﻌﻟﺎﻄﻣ نﻮﻨﮐﺎﺗ لﺎﺣﺮﻫ رد عﻮﺿﻮﻣ ﻦﯾا ﯽﺳرﺮﺑ ﻪﺑ يا

ﻪﺳ دﺮﻣ ناﻮﺟﻮﻧ نارﺎﮑﺷزرو ﻪﻧﺎﮔ

.ﺖﺳا ﻪﺘﺧادﺮﭙﻧ رﺎﮐ

ﻪﺑ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ،ﻦﯾاﺮﺑﺎﻨﺑ زرو ﺮﺛا ﯽﺳرﺮﺑ رﻮﻈﻨﻣ

زاﻮﻫ ش ي

ﻪﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ ﻦﯾا ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ نﺎﻣﺰﻤﻫ رﻮﻃ

ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ رد ﻞﻣاﻮﻋ ﻪﻧﺎﮔ

،ﺖﺳا هﺪﺷ مﺎﺠﻧا رﺎﮐ ﻦﯾا ﺎﺑ

رد يﺮﺘﺸﯿﺑ تاﺮﯿﯿﻐﺗ ﻞﻣاﻮﻋ ﻦﯾا زا ﮏﯾ ماﺪﮐ ﻪﮐ فﺪﻫ ﻪﯿﺿﺮﻓ ،ﻦﯾاﺮﺑﺎﻨﺑ .ﺪﻧراد نﺎﺴﻧا رد يزاﻮﻫ شزرو ﻪﺠﯿﺘﻧ ﺎﻣ

ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻪﺴﻠﺟ ﮏﯾ ﻪﮐ ﺖﺳا ﻦﯾا ﯾا حﻮﻄﺳ ﯽﻣ ﺶﯾاﺰﻓا ار ﻞﻣاﻮﻋ ﻦ ﺖﯿﺳﺎﺴﺣ ناﺰﯿﻣ ﺎﻣا ﺪﻫد

و

.ﺖﺴﯿﻧ ﺺﺨﺸﻣ ﺎﻬﻧآ ﺦﺳﺎﭘ

شور و داﻮﻣ ﺎﻫ

ﻪﻤﯿﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾا ﺲﭘ و نﻮﻣزآ ﺶﯿﭘ حﺮﻃ ﺎﺑ ﯽﺑﺮﺠﺗ

لﺎﺳ رد و نﻮﻣزآ 1399

.ﺪﺷ مﺎﺠﻧا نﺎﮐﺮﺴﯾﻮﺗ نﺎﺘﺳﺮﻬﺷ رد

ﺶﻫوﮋﭘ يرﺎﻣآ ﻪﻧﻮﻤﻧ 22

ﻪﺳ دﺮﻣ ﻪﻧﺎﮔ

:ﻦﺳ) رﺎﮐ

52 /0 60± / 17 :نزو ،لﺎﺳ 96

/4 74± / 60 ،مﺮﮔﻮﻠﯿﮐ :ﺪﻗ

52 /5 60± / 175 ﯽﺘﻧﺎﺳ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ياراد ﻪﮐ ﺪﻧدﻮﺑ (ﺮﺘﻣ

.ﺪﻧدﻮﺑ ﻢﻈﻨﻣ ﯽﻧدﻮﻣزآ

ﻪﻌﻟﺎﻄﻣ رد ﺖﮐﺮﺷ زا ﺶﯿﭘ ﺎﻫ

ﺖﯾﺎﺿر .ﺪﻧدﺮﮐ ءﺎﻀﻣا ﯽﺒﺘﮐ ﻪﻣﺎﻧ ﻪﻌﻟﺎﻄﻣ ﻪﺑ دورو يﺎﻫرﺎﯿﻌﻣ

ﺖﮐﺮﺷ ﻪﺑ ﻞﯾﺎﻤﺗ ،ﯽﻤﺴﺟ ﻞﻣﺎﮐ ﯽﺘﻣﻼﺳ ﻦﺘﺷاد :زا ترﺎﺒﻋ جوﺮﺧ يﺎﻫرﺎﯿﻌﻣ .هﮋﯾو يرﺎﻤﯿﺑ ﻪﻘﺑﺎﺳ ﻦﺘﺷاﺪﻧ ،ﺶﻫوﮋﭘ رد ﻋ ﺰﯿﻧ ﯽﺒﻠﻗ تﻼﮑﺸﻣ زوﺮﺑ :زا ﺪﻧدﻮﺑ ترﺎﺒ -

ﯽﻤﺴﺟ ﺎﯾ ﯽﻗوﺮﻋ

شزرو ﻪﻣادا ﻪﺑ ﻦﺘﺷاﺪﻧ ﻞﯾﺎﻤﺗ و شزرو ﻦﯿﺣ رد ﺪﻧدﻮﺑ

.

ﯽﻧدﻮﻣزآ ﻪﺑ اﺪﺘﺑا ،ﯽﻨﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ رد ﺎﻫ تﺪﻣ

10

هدﺎﯿﭘ رود ود ﻞﻣﺎﺷ ندﺮﮐ مﺮﮔ ﻪﻘﯿﻗد مارآ نﺪﯾود /يور

رد

ﯽﺸﺸﮐ تﺎﮐﺮﺣ ﺲﭙﺳ و ﯽﻧاﺪﯿﻣ و ود دراﺪﻧﺎﺘﺳا ﺖﺴﯿﭘ .ﺪﻧداد مﺎﺠﻧا ار لﺎﻌﻓ ،ﻦﯾﺮﻤﺗ ﯽﻠﺻا ﻪﻧﺪﺑ ﺶﺨﺑ رد

60 د ﻪﻘﯿﻗ

ﺮﺑاﺮﺑ تﺪﺷ ﺎﺑ نﺪﯾود 13

- 12 سﺎﯿﻘﻣ رد ﺑ

تﺪﺷ) گرﻮ

د ود ﺮﻫ زا ﺲﭘ ،شور ﻦﯾا رد .ﺪﻧداد مﺎﺠﻧا ار (ﻂﺳﻮﺘﻣ رو

ﯽﻧدﻮﻣزآ زا نﺪﯿﺳﺮﭘ ﺎﺑ ﺮﮕﺸﻫوﮋﭘ ،نﺪﯾود رد ار تﺪﺷ ﺎﻫ

ﯽﻣ ﻢﯿﻈﻨﺗ ﺮﻈﻧ درﻮﻣ ﻪﻨﻣاد ﯽﻧدﻮﻣزآ .دﺮﮐ

ﻃ مﺎﻤﺗ رد ﺎﻫ لﻮ

ﻧﺎﺘﺳا ﺖﺴﯿﭘ لوا ﻂﺧ رد ﻦﯾﺮﻤﺗ ) دراﺪ

400 و ود (ﺮﺘﻣ

ﯽﻣ ﯽﻧاﺪﯿﻣ ﯽﻧدﻮﻣزآ ،ندﺮﮐ دﺮﺳ ﺶﺨﺑ رد .ﺪﻧﺪﯾود

ﻪﺑ ﺎﻫ -

تﺪﻣ 5 .ﺪﻧداد مﺎﺠﻧا ار لﺎﻌﻓ ﺮﯿﻏ ﯽﺸﺸﮐ تﺎﮐﺮﺣ ﻪﻘﯿﻗد

ﺖﻋﺎﺳ سأر شزرو ﻪﺴﻠﺟ 19

.ﺪﺷ مﺎﺠﻧا

ﯽﻧﻮﺧ ﻪﻧﻮﻤﻧ زا ﯽﻧﻮﺧ ﻪﻧﻮﻤﻧ شزرو ﻪﺴﻠﺟ زا ﺲﭘ و ﺶﯿﭘ ﻪﻘﯿﻗد ﺞﻨﭘ

ﯽﻧدﻮﻣزآ ﺎﺑ ﯽﻧﻮﺧ ﻪﻧﻮﻤﻧ .ﺪﺷ ﻪﺘﻓﺮﮔ ﺎﻫ 3500

د رد رود ﯿﻗ ﻪﻘ

ياﺮﺑ 5 ﻪﺑ مﺮﺳ و ﺪﺷ ژﻮﯿﻔﯾﺮﺘﻧﺎﺳ ﻪﻘﯿﻗد رد هﺪﻣآ ﺖﺳد

ﻞﺧاد وﺮﮑﯿﻣ بﻮﯿﺗ ﺶﯾﺎﻣزآ ياﺮﺑ و ﺪﺷ ﻪﺘﺨﯾر هﮋﯾو يﺎﻫ ﺎﻫ

ي

يﺎﻣد رد يﺪﻌﺑ 20

- ﯽﺘﻧﺎﺳ ﻪﺟرد ﺪﻬﮕﻧ داﺮﮔ

ﺪﺷ يرا ﺪﻧ .

شور هزاﺪﻧا يﺎﻫ ﯽﻣﺮﺳ حﻮﻄﺳ يﺮﯿﮔ

،BDNF DCX

و DBHB

ﺖﻈﻠﻏ ﯽﻣﺮﺳ يﺎﻫ ،BDNF

وDCX ﻪﺑDBHB

ﻪﻠﯿﺳو

ﺖﯿﮐ ) اﺰﯾﻻا يﺎﻫ :ﺖﯿﺳﺎﺴﺣ :BDNF

063 /0 ﯽﻠﯿﻣ /مﺮﮔﻮﻧﺎﻧ ،ﺮﺘﯿﻟ

:ﺺﯿﺨﺸﺗ ﻪﻨﻣاد 20

- 312 /0 ﯽﻠﯿﻣ/مﺮﮔﻮﻧﺎﻧ ،ﺮﺘﯿﻟ

CUSABIO

؛ﻦﭘاژ :ﺖﯿﺳﺎﺴﺣ :DCX

13 /2 ﯽﻠﯿﻣ/مﺮﮔﻮﮑﯿﭘ ﻪﻨﻣاد ،ﺮﺘﯿﻟ

:ﺺﯿﺨﺸﺗ 1000 - 63 / 15 ﯽﻠﯿﻣ/مﺮﮔﻮﮑﯿﭘ ،ﺮﺘﯿﻟ

AbCam و ﻦﭘاژ

ﺖﯿﺳﺎﺴﺣ :DBHB 01

/0 ﯽﻠﯿﻣ/مﺮﮔوﺮﮑﯿﻣ >

ﻪﻨﻣاد ،ﺮﺘﯿﻟ

:ﺺﯿﺨﺸﺗ 2/

0 - 01 /0 ﻣ/مﺮﮔوﺮﮑﯿﻣ ﯽﻠﯿ

،ﺮﺘﯿﻟ AbCam ﺮﺑ (ﻦﭘاژ

هزاﺪﻧا ﻪﻃﻮﺑﺮﻣ ﺖﮐﺮﺷ ﻞﻤﻌﻟارﻮﺘﺳد سﺎﺳا .ﺪﻧﺪﺷ يﺮﯿﮔ

يرﺎﻣآ ﺰﯿﻟﺎﻧآ فوﺮﮔﻮﻤﻠﮐ نﻮﻣزآ ﺞﯾﺎﺘﻧ -ا

هداد ﻪﮐ داد نﺎﺸﻧ ﻒﻧﺮﯿﻤﺳ ﺎﻫ

ﯽﺳرﺮﺑ ياﺮﺑ ،ﻦﯾاﺮﺑﺎﻨﺑ .ﺪﻧرادرﻮﺧﺮﺑ ﯽﻌﯿﺒﻃ ﻊﯾزﻮﺗ زا نﻮﻣزآ زا نﻮﻣزآ ﺶﯿﭘ ﻪﺑ ﺖﺒﺴﻧ نﻮﻣزآ ﺲﭘ تاﺮﯿﯿﻐﺗ t

ﯽﻨﻌﻣ ﺢﻄﺳ و ﺪﺷ هدﺎﻔﺘﺳا ﯽﺟوز اد

ير 05 /0

<

ﺮﻈﻧ رد p

ﺮﻓ زا تاﺮﯿﯿﻐﺗ ناﺰﯿﻣ ﯽﺳرﺮﺑ ياﺮﺑ ،ﻦﯿﻨﭽﻤﻫ .ﺪﺷ ﻪﺘﻓﺮﮔ لﻮﻣ

posttest-pretest/pretest×100 .ﺪﺷ هدﺎﻔﺘﺳا

ﻪﺘﻓﺎﯾ ﺎﻫ

ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد 22

ﻪﺳ دﺮﻣ ﻪﻧﺎﮔ نﺎﺘﺳﺮﻬﺷ رﺎﮐ

و ﯽﻔﯿﺻﻮﺗ ﺞﯾﺎﺘﻧ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﯽﺳرﺮﺑ درﻮﻣ نﺎﮐﺮﺴﯾﻮﺗ ﻧ

ﺞﯾﺎﺘ

نﻮﻣزآ هرﺎﻤﺷ لوﺪﺟ رد ﯽﺟوزt 1

ﺖﺳا هﺪﺷ هدروآ ﺞﯾﺎﺘﻧ .

نﻮﻣزآ ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ ﻪﮐ داد نﺎﺸﻧ ﯽﺟوز t

DCX

) 0005 /0

= ،(p ) BDNF 0005

/0

= و (p DBHB

) 001 /0

= زا ﺲﭘ (p 60

تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻪﻘﯿﻗد 13

-

12 ﻪﺑ (ﻂﺳﻮﺘﻣ تﺪﺷ) گرﻮﺑ سﺎﯿﻘﻣ رد يرادﺎﻨﻌﻣ رﻮﻃ

تاﺮﯿﯿﻐﺗ ﺪﺻرد ﻪﺒﺳﺎﺤﻣ ﺎﺑ ،ﻦﯿﻨﭽﻤﻫ .ﺖﻓﺎﯾ ﺶﯾاﺰﻓا ﻪﺑ ﻪﮐ ﺪﺷ ﺺﺨﺸﻣ ﯽﻣﺮﺳ حﻮﻄﺳ ﺐﯿﺗﺮﺗ

)BDNF 30

/ 21

،(ﺪﺻرد )DBHB

95 / 12 و (ﺪﺻرد ) DCX

01 / 12

لوﺪﺟ) ﺪﻨﺘﺷاد ار ﺶﯾاﺰﻓا ﻦﯾﺮﺘﺸﯿﺑ (ﺪﺻرد 2

.(

لوﺪﺟ 1 ﺖﻈﻠﻏ . نﻮﻣزآ ﺞﯾﺎﺘﻧ و ﺎﻫﺮﯿﻐﺘﻣ ﯽﻣﺮﺳ يﺎﻫ ﯽﺟوزt

ﺎﻫﺮﯿﻐﺘﻣ ﺶﯿﭘ

نﻮﻣزآ ﻦﯿﮕﻧﺎﯿﻣ) فاﺮﺤﻧا±

(رﺎﯿﻌﻣ ﺲﭘ

نﻮﻣزآ ﻦﯿﮕﻧﺎﯿﻣ)

±

(رﺎﯿﻌﻣ فاﺮﺤﻧا

BDNF (ng/ml) 72

/0 84± /7 92*

/0 51± /9

DBHB (μg/ml) 84

/0 24± /2 74*

/0 53± /2

DCX (pg/ml) 97

/6 69± / 121 95*

/ 10

± 31 / 136

ﺢﻄﺳ رد رادﺎﻨﻌﻣ فﻼﺘﺧا*

001 /0

لوﺪﺟ 2 ﺎﻫﺮﯿﻐﺘﻣ تاﺮﯿﯿﻐﺗ ﺪﺻرد .

ﺎﻫﺮﯿﻐﺘﻣ تاﺮﯿﯿﻐﺗ ﺪﺻرد

30 BDNF / 21

95 DBHB / 12

01 DCX / 12

ﻪﺠﯿﺘﻧ و ﺚﺤﺑ يﺮﯿﮔ

شزرو ﻪﺴﻠﺟ ﮏﯾ ﺮﺛا ﯽﺳرﺮﺑ فﺪﻫ ﺎﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ زاﻮﻫ ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ ي ،BDNF

DCX

و ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ رد DBHB

ﻪﻧﺎﮔ ﺞﯾﺎﺘﻧ .ﺪﺷ مﺎﺠﻧا رﺎﮐ

ﻪﺑ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ ﻪﮐ داد نﺎﺸﻧ -

ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ يرادﺎﻨﻌﻣ رﻮﻃ ،DCX

وBDNF DBHB

ﯽﻣ ﺶﯾاﺰﻓا ار ﻦﯿﺑ رد ﻪﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ ﻦﯿﻨﭽﻤﻫ .ﺪﻫد

ﺖﻈﻓﺎﺤﻣ ﺶﻘﻧ ﻪﮐ ﺮﯿﻐﺘﻣ ﻪﺳ ﻦﯾا ﻪﺑ ﺪﻧراد ﯽﺒﺼﻋ هﺪﻨﻨﮐ

-

ﻪﺑ طﻮﺑﺮﻣ يﺮﯾﺬﭘﺮﯿﯿﻐﺗ ناﺰﯿﻣ ﻦﯾﺮﺘﺸﯿﺑ ﺐﯿﺗﺮﺗ ،BDNF

وDBHB .ﺖﺳا هدﻮﺑDCX

ﯽﺷزرو ﻦﯾﺮﻤﺗ و ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﻪﮐ ﺖﺳا هﺪﺷ ﺺﺨﺸﻣ رد يﺮﺛﺆﻣ رﺎﮑﻫار و ﺖﻣﻼﺳ ﻆﻔﺣ ياﺮﺑ ﯽﺒﺳﺎﻨﻣ ﻞﺣ هار

ﺖﻓﺎﺑ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ) ﺖﺳا نﺪﺑ ﻒﻠﺘﺨﻣ يﺎﻫ

21 ﺎﻌﻟﺎﻄﻣ .(

ت

ﯽﻣ نﺎﺸﻧ يزاﻮﻫ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ﺪﻫد

ﯽﻣ ،رﺎﺘﺧﺎﺳ ﺪﻧاﻮﺗ

ﻼﺳ ﻪﺠﯿﺘﻧ رد و ﺪﻫد ﺮﯿﯿﻐﺗ ار ﺰﻐﻣ دﺮﮑﻠﻤﻋ و يژﻮﻟﻮﯿﺑ ﺖﻣ

) ﺪﻫد ءﺎﻘﺗرا ار نآ 12،22

ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ،ﻦﯿﻨﭽﻤﻫ .(

ﯽﻣ ﺶﻫﺎﮐ ار ﺮﻤﯾاﺰﻟآ و ﻞﻘﻋ لاوز زوﺮﺑ ﺮﻄﺧ يزاﻮﻫ

،ﺪﻫد

ﯽﻣ ﻆﻔﺣ ار ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ يزﺎﺳ و ﺖﺧﻮﺳ لﺮﺘﻨﮐ و ﺪﻨﮐ

ﯽﻣ دﻮﺒﻬﺑ ار ﺰﻐﻣ رد ) ﺪﻫد

23 د تاﺮﯿﯿﻐﺗ ﻦﯾا .(

ﺎﺘﺧﺎﺳ ر و ر

ﻦﯿﻓوﺮﺗوﺮﻧ نﺎﯿﺑ ﺶﯾاﺰﻓا ﻪﺑ ﻪﺘﺴﺑاو ﺰﻐﻣ دﺮﮑﻠﻤﻋ اﻮﻋ/ﺎﻫ

ﻞﻣ

ﻪﺑ) يﺪﺷر لﺎﺜﻣ ناﻮﻨﻋ

،BDNF وDCX

ﺖﺳا (DBHB

ﯽﻣ راﺮﻗ شزرو ﺮﯿﺛﺄﺗ ﺖﺤﺗ ﻪﮐ ) ﺪﻧﺮﯿﮔ

12 .(

نوﺮﻧ ﺪﺷر رد ﯽﻤﻬﻣ ﺶﻘﻧ BDNF زا يرﺎﯿﺴﺑ رد ﺎﻫ

) ﺰﻐﻣ ﻖﻃﺎﻨﻣ 24

نوﺮﻧ ﮥﻌﺳﻮﺗ و ( ﯽﻣ ﺎﻔﯾا ﯽﯾاز

) ﺪﻨﮐ 25 ﻪﮐ (

ﺴﻣ ﮥﻄﺑار عﻮﺿﻮﻣ ﻦﯾا يرﺎﻤﯿﺑ زا يرﺎﯿﺴﺑ ﺎﺑ ﯽﻤﯿﻘﺘ

زا ﺎﻫ

) دراد ﯽﮔدﺮﺴﻓا و ﺮﻤﯾاﺰﻟآ ،عﺮﺻ ﻪﻠﻤﺟ 26

.(

BDNF رد

ﻪﺑ و دراد ﺶﻘﻧ ﯽﺴﭘﺎﻨﯿﺳ و ﯽﺒﺼﻋ ﺪﺷر ياﺮﺑ هﮋﯾو رﻮﻃ

هﺎﺗﻮﮐ رد ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ ﺖﺨﯾر رد يرﺎﮔزﺎﺳ و تﺪﻣ

-

) ﺖﺳا يروﺮﺿ تﺪﻣزارد رد ﺰﻐﻣ ﯽﺳﺎﻨﺷ 9

ﻊـﯾزﻮﺗ .(

رد هﮋﯾﻮﺑ و يﺰــﻐﻣ ﻒـﻠﺘﺨﻣ ﻖـﻃﺎﻨﻣ رد BDNF

ﻫ يﺮــﯿﮔدﺎﯾ و ﻪــﻈﻓﺎﺣ لﻮﺌــﺴﻣ ﻪــﮐ ﭗــﻤﮐﻮﭙﯾﺎ

/

90

هرود ،ﻪﺘﻓﺎﯾ 23

، ﺰﯿﯾﺎﭘ 1400

ﻆــﻔﺣ رد ار ﯽــﻠﺻا ﺶــﻘﻧ و هﺪــﺷ شراﺰــﮔ ،ﺖــﺳا لﻮﻠــﺳ ﺖﻣﻼﺳ ﯽﻣ ءﺎــﻔﯾا ﯽــﺒﺼﻋ يﺎﻫ

) ﺪــﻨﮐ 5 .(

ﺶﻫوﮋﭘ رد ﻪﺘﻓﺎﯾ ﻒﻠﺘﺨﻣ يﺎﻫ

ﻪﻨﯿﻣز رد ﯽﻀﻗﺎﻨﺘﻣ يﺎﻫ

ﺮﯾدﺎﻘﻣ ﺮﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﺮﯿﺛﺄﺗ BDNF

ﺖﺳا هﺪﺷ شراﺰﮔ

ﻪﺑ ﻫوﮋﭘ زا ﯽﺧﺮﺑ رد ﻪﮐ يرﻮﻃ ﺶ

يزاﻮﻫ ﯽﺷزرو ﺖﯿﻟﺎﻌﻓ ،ﺎﻫ

ﯽﻨﻌﻣ ﺶﯾاﺰﻓا ﺐﺟﻮﻣ ﺮﯾدﺎﻘﻣ راد

BDNF ﺖﺳا هﺪﺷ

) 13 ﻞﺿﺎﻓ ﻂﺳﻮﺗ هﺪﺷ مﺎﺠﻧا ﺶﻫوﮋﭘ رد .(

نارﺎﮑﻤﻫ و هداز

) 2017 ﻪﺑ يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ( -

ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ يرادﺎﻨﻌﻣ رﻮﻃ BDNF

لﺎﻌﻓ نادﺮﻣ رد ار

ﯽﻣ ﺶﯾاﺰﻓا ) ﺪﻫد

27 ﻣ ﻮﺴﻤﻫ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ ﺎﺑ ﻪﮐ ( ﯽ

.ﺪﺷﺎﺑ

ﺶﻫوﮋﭘ رد ،ﻦﯿﻨﭽﻤﻫ Plümpe

) نارﺎﮑﻤﻫ و 2006

ﺰﯿﻧ (

ﯽﻨﻌﻣ توﺎﻔﺗ مﺪﻋ ) ﺖﺳا هﺪﺷ هﺪﻫﺎﺸﻣ ﺮﯿﻐﺘﻣ ﻦﯾا راد

28 .(

هداد نﺎﺸﻧ تﺎﻌﻟﺎﻄﻣ حﻮﻄﺳ ﺮﺗﻻﺎﺑ تﺪﺷ ﺎﺑ ﻦﯾﺮﻤﺗ ﻪﮐ ﺪﻧا

ﯽﻣﺮﺳ ﯽﻣ ﺶﯾاﺰﻓا ﺮﺘﺸﯿﺑ ار BDNF

) ﺪﻫ 29 رد ﺎﻣا ،(

ﺮﺘﺸﯿﺑ تﺪﻣ ﺎﻣا ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ شزرو زا ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ) 60 (ﻪﻘﯿﻗد ًﺎﺒﯾﺮﻘﺗ ياﺮﺑ شزرو تﺪﺷ ﻦﯾا اﺮﯾز ،ﺪﺷ هدﺎﻔﺘﺳا

عﻮﻧ ﻦﯾا داد نﺎﺸﻧ ﺖﯾﺎﻬﻧ رد ﻪﮐ ﺖﺳاﺮﺟا ﻞﺑﺎﻗ داﺮﻓا ﻪﻤﻫ ﯽﻣﺮﺳ حﻮﻄﺳ ﺰﯿﻧ ﻦﯾﺮﻤﺗ ﻪﺑ ار BDNF

يرادﺎﻨﻌﻣ رﻮﻃ

ﯽﻣ ﺶﯾاﺰﻓا ﻪﺑ ،ﻦﯾاﺮﺑﺎﻨﺑ .ﺪﻫد

ﯽﻣ ﺮﻈﻧ هﻮﯿﺷ ﻦﯾا ﻪﮐ ﺪﺳر

ﯽﻣ ﯽﻨﯾﺮﻤﺗ ﻪﺑ ﺪﻧاﻮﺗ

ﺶﯾاﺰﻓا ياﺮﺑ ﺐﺳﺎﻨﻣ ﯽﻨﯾﺮﻤﺗ ناﻮﻨﻋ

ﯽﻣﺮﺳ حﻮﻄﺳ دBDNF

.دﻮﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ ر

ﺖﺳا ﻂﺒﺗﺮﻣ ﯽﺒﺼﻋ ﺰﯾﺎﻤﺗ ﺎﺑ ﻪﮐ ﺖﺳا ﯽﻨﯿﺌﺗوﺮﭘDCX

ﻪﺒﻨﺟ و ﯽﻟﻮﻠﺳ تﺮﺟﺎﻬﻣ ﺎﺑ يدﺮﮑﻠﻤﻋ ﺮﻈﻧ زا و ﺮﮕﯾد يﺎﻫ

ﺲﭘﺎﻨﯿﺳ ﻪﻠﻤﺟ زا غﻮﻠﺑ ) ﺖﺳا ﻂﺒﺗﺮﻣ ﯽﯾاز

30 رد و (

) ﺲﮑﺗرﻮﮐﻮﺌﻧ زا ﯽﻘﻃﺎﻨﻣ neocortex

نوﺮﻧ ﻪﮐ ﻪﭽﺨﻣ و ( -

) ﺖﺳا هﺪﺷ نﺎﯿﺑ ًﻼﻣﺎﮐ ،ﺖﺳا لﺎﻌﻓ ﯽﯾاز 31

ﯽﺧﺮﺑ .(

تﺎﻌﻟﺎﻄﻣ هداد نﺎﺸﻧ

ﺶﯾاﺰﻓا ﺚﻋﺎﺑ ﯽﻧﺪﺑ ﺖﯿﻟﺎﻌﻓ ﻪﮐ ﺪﻧا

ﯽﻣ DCX ) دﻮﺷ 16،32 ﻪﻌﻟﺎﻄﻣ رد ﺎﻣا ( شزرو ﺮﮕﯾد يا

شﻮﻣ رد ﺪﯾﺪﺷ ﺢﻄﺳ ﺎﻫ

هداﺪﻧ ﺮﯿﯿﻐﺗ ار ﯽﭙﻤﮐﻮﭙﯾﺎﻫ DCX

) ﺖﺳا 33 يزاﻮﻫ ﻦﯾﺮﻤﺗ ﻪﺴﻠﺟ ﮏﯾ ،ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد .(

ﯽﻣﺮﺳ حﻮﻄﺳ ﺮﺑ يرادﺎﻨﻌﻣ ﺮﯿﺛﺄﺗ ﺞﯾﺎﺘﻧ .ﺖﺷاد DCX

ﺶﻫوﮋﭘ ﺎﺑ ﺮﺿﺎﺣ ﺶﻫوﮋﭘ Moon

ﺎﮑﻤﻫ و ) نار 2016 ﻢﻫ ( ﺶﯾاﺰﻓا ﻪﮐ ﺪﺷ هداد نﺎﺸﻧ ﺎﻬﻧآ ﺶﻫوﮋﭘ رد .ﺖﺳا ﻮﺳ

ﻦﯿﺴﭙﺗﺎﮐ ﯽﻤﺘﺴﯿﺳ حﻮﻄﺳ دﺎﺣ يزاﻮﻫ شزرو ﻪﺠﯿﺘﻧ ردB

ﯽﻣ حﻮﻄﺳ ﺪﻧاﻮﺗ و BDNF

ﭗﻤﮐﻮﭙﯾﺎﻫ رد ار DCX

نوﺮﻧ ﻖﯾﺮﻃ ﻦﯾا زا و ﺪﻫد ﺶﯾاﺰﻓا ار ﭗﻤﮐﻮﭙﯾﺎﻫ رد ﯽﯾاز

) ﺪﻨﮐ ﮏﯾﺮﺤﺗ 34

يدﺎﯾز تﺎﻌﻟﺎﻄﻣ ﻪﭼ ﺮﮔا .(

درﻮﻣ رد ﺮﺛا

ﺑ يزاﻮﻫ شزرو ﯽﻣﺮﺳ حﻮﻄﺳ يور ﺮ

هﺪﺸﻧ مﺎﺠﻧا DCX

ﻪﺑ ﺎﻣا ،ﺖﺳا ﯽﻣ ﺮﻈﻧ

ﺮﯿﻐﺘﻣ ﻦﯾا يﺮﯾﺬﭘﺮﯿﺛﺄﺗ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﺪﺳر

ﻦﯿﺴﭙﺗﺎﮐ زا ﻪﺑ B

شزرو ،ﻦﯾﺎﮐﻮﯾﺎﻣ ﮏﯾ ناﻮﻨﻋ ﻪﮐ ﯽﯾﺎﻫ

ﻦﯿﺴﭙﺗﺎﮐ حﻮﻄﺳ ﯽﻣ ﺶﯾاﺰﻓا ار B

ﯽﻣ ﺪﻨﻫد حﻮﻄﺳ ﺪﻨﻧاﻮﺗ

ﯽﻣﺮﺳ ﻪﺑ .ﺪﻨﻫد ﺶﯾاﺰﻓا ﺰﯿﻧ ارDCX

ﯽﺸﯾورد ،لﺎﺜﻣ ناﻮﻨﻋ

) نارﺎﮑﻤﻫ و 1399

ﺎﻄﻣ رد ( ﻪﻌﻟ

ﮏﯾ ﻪﮐ ﺪﻧداد نﺎﺸﻧ يا

ناﻮﺟ نادﺮﻣ رد ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﺖﻋﺎﺳ ﻦﯿﺴﭙﺗﺎﮐ ﯽﻣﺮﺳ حﻮﻄﺳ ﯽﻣ ﺶﯾاﺰﻓا ارB

) ﺪﻫد 11 ﺎﺑ ﻪﮐ (

ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ و نارﺎﮑﻤﻫ و ﯽﺸﯾورد ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ ﻪﺑ ﻪﺟﻮﺗ ﻪﺑ ﯽﻣ ﺮﻈﻧ ﯽﻣ ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﺪﺳر ﺪﻧاﻮﺗ

ﻦﯿﺴﭙﺗﺎﮐ ﯽﻣﺮﺳ حﻮﻄﺳ وB

.ﺪﻫد ﺶﯾاﺰﻓا ارDCX

ﺗ ﺖﺳا يﺰﮐﺮﻣ ﯽﮑﯿﻟﻮﺑﺎﺘﻣ يﺪﻨﯾآﺮﻓ ﯽﻧﻮﺘﮐ مﺎﺴﺟا ﺪﯿﻟﻮ تارﺪﯿﻫﻮﺑﺮﮐ زا ﺖﯿﻣوﺮﺤﻣ و ﺶﻫﺎﮐ ﻪﺑ ﺦﺳﺎﭘ ﯽﻃ رد ﻪﮐ

ﯽﻣ لﺎﻌﻓ ﯽﻧﻮﺘﮐ ﻢﺴﺟ ناراﺪﻧﺎﺘﺴﭘ رد .دﻮﺷ ﻪﺑDBHB

رﻮﻃ

ﻢﯾﺰﻧآﻮﮐ ﻞﯿﺘﺳا زا ﺪﺒﮐ رد هﺪﻤﻋ زا هﺪﺷ ﻖﺘﺸﻣ A

) دﻮﺷ ﯽﻣ ﺪﯿﻟﻮﺗ بﺮﭼ يﺎﻫﺪﯿﺳا نﻮﯿﺳاﺪﯿﺴﮐا 35

اﺮﺑﺎﻨﺑ .(

ﻦﯾ

ا ﺐﺳﺎﻨﻣ ﻞﻣﺎﺣ ﮏﯾ DBHB لﻮﻠﺳ زا يژﺮﻧ

ﻪﺑ ﯽﺑﺮﭼ يﺎﻫ

ﺖﻓﺎﺑ ) ﺖﺳا ﯽﻄﯿﺤﻣ يﺎﻫ 36

ﺖﯾدوﺪﺤﻣ ،ﯽﮕﻨﺳﺮﮔ ﺎﺑ ﻪﮐ (

ﻢﮐ ﮏﯿﻧژﻮﺘﮐ ﻢﯾژر ﺎﯾ دﺎﯾز تﺪﺷ ﺎﺑ شزرو ،يﺮﻟﺎﮐ هزور ﻦﯿﻨﭽﻤﻫ تارﺪﯿﻫﻮﺑﺮﮐ ) ﺪﺑﺎﯾ ﯽﻣ ﺶﯾاﺰﻓا يراد

37،38 .(

ﯽﻣDBHB زا ،ﺪﻫد ﺶﻫﺎﮐ ار ﯽﺒﺼﻋ بﺎﻬﺘﻟا ﺪﻧاﻮﺗ ﺮﻓ

آ ﺪﻨﯾ

دﺮﺴﻓا ﻪﺑﺎﺸﻣ يﺎﻫرﺎﺘﻓر و لﺎﯿﻠﮔوﺮﮑﯿﻣ نﺪﺷ ﻊﻤﺟ ﯽﮔ

) ﺪﻨﮐ يﺮﯿﮔﻮﻠﺟ 38

دﻮﺒﻤﮐ يور ﺮﺑ ﯽﺘﻈﻓﺎﺤﻣ تاﺮﺛا و (

) ﺪﺷﺎﺑ ﻪﺘﺷاد يﺰﻐﻣ نﮋﯿﺴﮐا 39

.(

ﻪﺑ ﯽﻧﻮﺘﮐ ﻢﺴﺟ ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ﯽﮔزﺎﺗ ﻪﮐDBHB

ﯽﻣ ﺪﯿﻟﻮﺗ ﺪﺒﮐ رد ﯽﻧﻮﺧ ﺪﺳ زا و دﻮﺷ

- ﯽﻣ رﻮﺒﻋ يﺰﻐﻣ ﺪﻨﮐ

ﯽﻣ اﺪﯿﭘ ﻊﻤﺠﺗ شزرو زا ﺲﭘ و ﻦﯿﺣ رد ﺪﯿﻟﻮﺗ و ﺪﻨﮐ

ﯽﻣ ﮏﯾﺮﺤﺗ ار ﭗﻤﮐﻮﭙﯾﺎﻫ رد BDNF ) ﺪﻨﮐ

38 .(

رد

ﯽﻣﺮﺳ حﻮﻄﺳ ﺰﯿﻧ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ وBDNF

ﻪﺑ DBHB -

رﺎﮐوزﺎﺳ ﻦﯾا هﺪﻨﻨﮐ ﺪﯿﯾﺄﺗ ﻪﮐ ﺖﻓﺎﯾ ﺶﯾاﺰﻓا يرادﺎﻨﻌﻣ رﻮﻃ ﻠﻋ ﻤ ﯽﻣ ﯽ ﻪﻌﻟﺎﻄﻣ رد ،ﺎﺘﺳار ﻦﯿﻤﻫ رد .ﺪﺷﺎﺑ هداد نﺎﺸﻧ يا

شﻮﻣ ﻪﮐ هﺪﺷ تﺪﻣ ياﺮﺑ ﻪﮐ ﯽﯾﺎﻫ

30 قﺎﺗا ﮏﯾ رد زور

هﺪﺷ هداد راﺮﻗ ﻞﯿﻣدﺮﺗ ياراد نژ نﺎﯿﺑ ﺶﯾاﺰﻓا ﺪﻧا

BDNF

ﺘﻧ رد ﺎﻬﻧآ هﺪﻧﺮﯿﮔ ﮏﯾﺮﺤﺗ ﻪﺑ ﻪﺘﺴﺑاو ﯽﻧﺎﻤﺴﺟ ﺖﯿﻟﺎﻌﻓ ﻪﺠﯿ

ﻪﺠﯿﺘﻧ رد BDNF ) ﺖﺳا هدﻮﺑ DBHB

40 ،ﻦﯿﻨﭽﻤﻫ .(

سﻼﮐ يﺎﻫزﻼﯿﺘﺳاد نﻮﺘﺴﯿﻫ 1

ﻞﺤﻣ ﻪﮐ هﺪﻧﺮﺒﺸﯿﭘ يﺎﻫ

ﯽﻣ لﺎﻐﺷا ارBDNF ﻪﺑ ﺪﻨﻨﮐ

ﮥﻠﯿﺳو هﺪﺷ رﺎﻬﻣDBHB

-

نﺎﯿﺑ ﻪﺠﯿﺘﻧ رد و ﺪﻧا ) ﺖﺳا ﻪﺘﻓﺎﯾ ﺶﯾاﺰﻓاBDNF

40،41 .(

،ﻦﯾاﺮﺑﺎﻨﺑ ﯽﻣ DBHB

ﯿﺑ رد ﺪﻧاﻮﺗ ﻦﯿﻓوﺮﺗوﺮﻧ نژ نﺎ

ﻪﮐ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ اﺮﯾز .ﺪﺷﺎﺑ ﻪﺘﺷاد ﺶﻘﻧ BDNF

ﺪﯿﻟﻮﺗ ﻪﺑ BDNF ﯽﻣ ﻢﯿﻈﻨﺗ ﯽﻧﻮﺧ شدﺮﮔ ﻞﻣاﻮﻋ ﮥﻠﯿﺳو -

) دﻮﺷ 41 ﻪﺑ .(

داد نﺎﺸﻧ ﺰﯿﻧ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ ،لﺎﺣ ﺮﻫ

ﺮﯿﻐﺘﻣ ود ﺮﻫ حﻮﻄﺳ ﻪﮐ و BDNF

ﻪﺑ DBHB رﻮﻃ

ﯽﻣ ﻪﮐ ﺖﺳا ﻪﺘﻓﺎﯾ ﺶﯾاﺰﻓا يرادﺎﻨﻌﻣ ﻦﯾا هﺪﻨﻨﮐ ﺪﯿﯾﺄﺗ ﺪﻧاﻮﺗ

ﺿﻮﻣ ﯽﻧﻮﺘﮐ ﻢﺴﺟ ﺖﯿﻫﺎﻣ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .ﺪﺷﺎﺑ عﻮ DBHB

ﻪﺑ ﯽﻣ ﺮﻈﻧ و تﺪﻣ ﯽﻧﻻﻮﻃ ﯽﮕﻨﺳﺮﮔ ﻂﯾاﺮﺷ رد ﻪﮐ ﺪﺳر

ﯽﻣ ﺶﯾاﺰﻓا نآ ﯽﻣﺮﺳ ﺮﯾدﺎﻘﻣ تﺪﻣ ﺪﻨﻠﺑ شزرو ) ﺪﺑﺎﯾ

42 و (

ﯽﻣ ﯽﻣﺮﺳ حﻮﻄﺳ ﺶﯾاﺰﻓا ﺎﺑ ﺪﻧاﻮﺗ ﺮﺑ ﯽﺘﺒﺜﻣ ﺮﯿﺛﺄﺗ BDNF

ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ اﺮﯾز ،ﺪﺷﺎﺑ ﻪﺘﺷاد ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ ﯽﻣ بوﺎﻨﺘﻣ ﯽﮕﻨﺳﺮﮔ ﻧاﻮﺗ

ﯽﺘﺧﺎﻨﺷ دﺮﮑﻠﻤﻋ دﻮﺒﻬﺑ ياﺮﺑ ﺪ

) ﺪﺷﺎﺑ ﺪﯿﻔﻣ 42

.(

ﯽﻣﺮﺳ حﻮﻄﺳ توﺎﻔﺘﻣ تاﺮﯿﯿﻐﺗ ،BDNF

و DBHB

رد ﺎﻫﺮﯿﻐﺘﻣ ﻦﯾا ﯽﺒﺴﻧ ﺖﯿﻤﻫا هﺪﻨﻫد نﺎﺸﻧ ﺪﯾﺎﺷ DCX ﻦﯿﺸﯿﭘ تﺎﻌﻟﺎﻄﻣ ﺎﺑ ﻖﻓاﻮﻣ ،اﺮﯾز .ﺪﺷﺎﺑ ﯽﺒﺼﻋ ﺖﻇﺎﻔﺣ )

43،44 حﻮﻄﺳ ﻪﮐ هﺪﺷ هداد نﺎﺸﻧ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد ،(

ﯽﻣﺮﺳ د ﯽﺒﺼﻋ ﺖﻈﻓﺎﺤﻣ رد يﺮﺘﻤﻬﻣ ﺶﻘﻧ BDNF

.درا

ﻒﯿﻌﺿ ﺦﺳﺎﭘ ﺎﺑ ﺪﻨﭼ ﺮﻫ يﺮﮕﯾد يﺎﻫﺮﯿﻐﺘﻣ ،ﺎﻣا شزرو ﻪﺑ ﺮﺗ

ﯽﻣ يزاﻮﻫ ﻪﺘﺷاد ﯽﺒﺼﻋ هﺪﻨﻨﮐ ﺖﻈﻓﺎﺤﻣ تاﺮﺛا ﺪﻨﻧاﻮﺗ

دﻮﺟو لﺎﻤﺘﺣا ﻦﯾا ،ﺎﻣا .ﺪﻨﺷﺎﺑ دراد

ﻦﯾﺮﻤﺗ عﻮﻧ ﺮﯿﯿﻐﺗ ﺎﺑ ﻪﮐ

،تﺪﺷ) ﯽﻨﯾﺮﻤﺗ يﺎﻫﺮﯿﻐﺘﻣ ،(ﯽﺘﻣوﺎﻘﻣ ﺮﺑاﺮﺑ رد يزاﻮﻫ) ﺮﺑاﺮﺑ رد ﯽﻟﻮﻤﻌﻣ ﻂﯿﺤﻣ) ﻦﯾﺮﻤﺗ ﻂﯿﺤﻣ ،(هﺮﯿﻏ و تﺪﻣ ﻂﯿﺤﻣ (ﻦﯾﺮﻤﺗ ﻞﺤﻣ رد ءﺎﯿﺷا و ﻞﯾﺎﺳو زا هدﺎﻔﺘﺳا) ﯽﻨﻏ

) 11 ﺦﺳﺎﭘ ناﻮﺘﺑ شزرو ﻦﯿﺣ رد و ﺶﯿﭘ ﯽﯾاﺬﻏ ﻢﯾژر و ( تاﺮﺛا و داد ﺮﯿﯿﻐﺗ ار يزاﻮﻫ ﯽﺷزرو ﻦﯾﺮﻤﺗ ﻪﺑ ﺎﻫﺮﯿﻐﺘﻣ ﻦﯾا

.داد ﺶﯾاﺰﻓا ار ﺎﻬﻧآ ﯽﺒﺼﻋ هﺪﻨﻨﮐ ﺖﻈﻓﺎﺤﻣ ﯽﻣﺮﺳ ﻞﻣﺎﻋ ﻪﺳ ﺮﻫ ﻪﮐ داد نﺎﺸﻧ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ

،BDNF و DCX

ﺖﺒﺜﻣ ﺦﺳﺎﭘ DBHB ﻪﺑ يرادﺎﻨﻌﻣ

ﻪﺳ دﺮﻣ نﺎﻧاﻮﺟﻮﻧ رد ﻂﺳﻮﺘﻣ تﺪﺷ ﺎﺑ يزاﻮﻫ شزرو ﻪﻧﺎﮔ

ﮐ رﺎ

ﯽﻣ ﺪﺷر ﻞﻣﺎﻋ/ﻦﯿﻓوﺮﺗوﺮﻧ ﺎﻣا ،ﺪﻨﻫد تاﺮﯿﯿﻐﺗ BDNF

ﯽﻣ نﺎﺸﻧ يﺮﺘﺸﯿﺑ ﻪﺑ و ﺪﻫد

ﯽﻣ ﺮﻈﻧ رد يﺮﺘﺸﯿﺑ ﺶﻘﻧ ﺪﺳر

دﺮﮑﻠﻤﻋ و يﺮﯿﮔدﺎﯾ ،ﻪﻈﻓﺎﺣ دﻮﺒﻬﺑ ،ﯽﺒﺼﻋ ﺖﻈﻓﺎﺤﻣ ﻪﮐ دراد دﻮﺟو لﺎﻤﺘﺣا ﻦﯾا ،ﻦﯿﻨﭽﻤﻫ .دراد ﯽﺘﺧﺎﻨﺷ ﺘﻣ يرﺎﮑﺘﺳد تاﺮﯿﯿﻐﺗ ناﺰﯿﻣ يور يزاﻮﻫ ﻦﯾﺮﻤﺗ يﺎﻫﺮﯿﻐ

.ﺪﺷﺎﺑ ﻪﺘﺷاد ﯽﺗوﺎﻔﺘﻣ تاﺮﯿﺛﺄﺗ ﺎﻫﺮﯿﻐﺘﻣ ﻦﯾا

ﯽﻧادرﺪﻗ و ﺮﮑﺸﺗ

نﺎﯾﺎﭘ ﻞﺻﺎﺣ ﻪﻟﺎﻘﻣ ﻦﯾا يژﻮﻟﻮﯾﺰﯿﻓ ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ ﻪﻣﺎﻧ

ﯽﻣ نﺎﺘﺳﺮﻟ هﺎﮕﺸﻧاد ﯽﺷزرو ﺖﻧوﺎﻌﻣ ﺖﯾﺎﻤﺣ ﺎﺑ ﻪﮐ ﺪﺷﺎﺑ

ﺖﺳا هﺪﺷ مﺎﺠﻧا هﺎﮕﺸﻧاد ﯽﺸﻫوﮋﭘ ﻪﺳﺎﻨﺷ ﺎﺑ قﻼﺧا ﺪﮐ ﺎﺑ و

IR.SSRI.REC.1400.1145 ﺪﯿﺳر ﺐﯾﻮﺼﺗ ﻪﺑ

.

ﯽﻧدﻮﻣزآ زا ﻦﯿﻨﭽﻤﻫ ﻪﺑ ﮏﻤﮐ ﺖﻬﺟ ﻪﺑ ﺮﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ يﺎﻫ

سﺎﭙﺳ ﺶﻫوﮋﭘ ﻦﯾا مﺎﺠﻧا يراﺰﮔ

ﯽﻣ ﻢﯿﻨﮐ .

/

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، ﺰﯿﯾﺎﭘ 1400 References

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Effects of a moderate intensity aerobic exercise on serum levels of BDNF, DCX, and DBHB in triathlon male adolescents

Mohammadbeygi S¹, Valipour Dehnou V^2*

1. Master of Exercise Physiology, Department of Sport Sciences, Literature & Human Sciences Faculty, Lorestan University, Khorramabad, Iran

2. Associate Professor, Department of Sport Sciences, Literature & Human Sciences Faculty, Lorestan University, Khorramabad, Iran

Received: 4 July 2021 Accepted: 19 Sep 2021

Abstract

Background:Various serum factors in response to aerobic exercise improve cognitive function in healthy individuals; nonetheless, the effect of moderate intensity aerobic exercise on their levels has not been studied. Therefore, the present study aimed to assess the effect of a moderate intensity aerobic exercise on serum levels of Brain-derived neurotrophic factor (BDNF), Doublecortin (DCX), and D-β-hydroxybutyrate (DBHB) in triathlon male adolescents in Tuyserkan.

Materials and Methods:A total of 22 triathlon male adolescents (age: 17.60±0.52 years, weight:

60.74±4.96 kg, height: 175.60±5.52 cm) voluntarily participated in this quasi-experimental study.

Subjects in one session performed 60 minutes of running with an intensity of 12-13 on the Borg scale. Blood samples were taken from the subjects 5 min before and after training. Serum levels of BDNF, DCX and DBHB were measured by ELISA. To analyze the data, paired samples t-test was used, and a p-value less than 0.05 was considered statistically significant. In addition, the percentage of changes was compared to pre-test.

Results:Based on the results, the serum levels of DCX (P=0.0005), BDNF (P=0.0005), and DBHB (P=0.001) increased significantly, compared to those in the pretest. Furthermore, serum levels of BDNF (21.30%), DBHB (12.95%) and DCX (12.01%) had the highest increase, as compared to the pretest, respectively.

Conclusion: All three serum factors BDNF, DCX, and DBHB have a significant positive response to moderate-intensity aerobic exercise in triathlon male adolescents. Nevertheless, neurotrophin/growth factor BDNF demonstrates more changes and appears to play a greater role in neuroprotection, improving memory, learning, and cognitive function.

Keywords:Aerobic Exercise, Neurotrophin, DBHB, Triathlon.

*Citation: Mohammadbeygi S, Valipour Dehnou V. Effects of a moderate intensity aerobic exercise on serum levels of BDNF, DCX, and DBHB in triathlon male adolescents. Yafte. 2021; 23(4):86-96.