:ﻪﺒﺗﺎﮑﻣ سردآ*
زاﺮﯿﺷ .ﯽﻨﯿﻟﺎﺑ ﯽﻤﯿﺷﻮﯿﺑ هوﺮﮔ ،ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،زاﺮﯿﺷ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،
ﺖﺴﭘ :ﮏﯿﻧوﺮﺘﮑﻟا [email protected]
) ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ زا هدﺎﻔﺘﺳا ﺪﯿﻟﻮﺗ رد (
VLPsﻦﺴﮐاو
ﯽﺘﻤﻫ دﺎﺷﺮﻓ ﺪﻧورﺎﻨﯾد
،
1ﯽﻫﺎﺸﮑﻠﻣ اﺮﺳا
، 2
يرﺎﺸﻓا ﺎﺿﺮﯿﻠﻋ ﺮﻓ
،
3ﺪﻧورﺎﻨﯾد ﯽﺘﻤﻫ ﻦﺴﺤﻣ
4
*
1 - ﺮﺘﮐد يﻮﺠﺸﻧاد ا
ي ﯽﻫﺎﯿﮔ ﯽﺳﺎﻨﺷ سوﺮﯾو ،
يزروﺎﺸﮐ هﺪﮑﺸﻧاد ،ﯽﻫﺎﯿﮔ ﯽﺳﺎﻨﺷ سوﺮﯾو تﺎﻘﯿﻘﺤﺗ ﺰﮐﺮﻣ
،
،زاﺮﯿﺷ ،زاﺮﯿﺷ هﺎﮕﺸﻧاد .ناﺮﯾا
2 - ﺪﺷرا ﯽﺳﺎﻨﺷرﺎﮐ ﯽﮑﺷﺰﭘ ﯽﺳﺎﻨﺷ سوﺮﯾو
ﺸﻧاد ،ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ﯽﮑﺷﺰﭘ ﯽﺳﺎﻨﺷ سوﺮﯾو هوﺮﮔ ، ﺮﯾا ،دﺎﺑآ مﺮﺧ ،نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕ
.نا
3 - دﺎﺘﺳا و ﯽﻫﺎﯿﮔ ﯽﺳﺎﻨﺷ سوﺮﯾ ،
ﻘﺤﺗ ﺰﮐﺮﻣ ﯿ تﺎﻘ و ﯾ سوﺮ ﺳﺎﻨﺷ ﯽ ﮔ ﯿ ﻫﺎ ﯽ
، زروﺎﺸﮐ هﺪﮑﺸﻧاد ي
، ﺷ هﺎﮕﺸﻧاد ﯿ
،زاﺮ ﺷ ﯿ
،زاﺮ اﯾ ناﺮ .
4 - ﺮﺘﮐد يﻮﺠﺸﻧاد ا
ي ﯽﻨﯿﻟﺎﺑ ﯽﻤﯿﺷﻮﯿﺑ ،
.ناﺮﯾا ،زاﺮﯿﺷ ،زاﺮﯿﺷ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ،ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ﯽﻨﯿﻟﺎﺑ ﯽﻤﯿﺷﻮﯿﺑ هوﺮﮔ
هرود / ﻪﺘﻓﺎﯾ 23
هرﺎﻤﺷ / 5
ز / نﺎﺘﺴﻣ 1400
/ ﺴﻠﺴﻣ ﻞ
90
:ﻪﻟﺎﻘﻣ ﺖﻓﺎﯾرد 13
/ 6 / 1400 :ﻪﻟﺎﻘﻣ شﺮﯾﺬﭘ 3
/ 9 / 1400
ﻪﻣﺪﻘﻣ :
) ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ Virus-Like Particles; VLPs
ﯾر ( ﯽﮔﮋﯾو ﺮﯾﺎﺳ و هزاﺪﻧا ،ﻞﮑﺷ ﺮﻈﻧ زا ﻪﮐ ﺪﻨﺘﺴﻫ ﯽﯾﺎﻫرﺎﺘﺧﺎﺳﺰ يﺎﻫ
ﺖﺨﯾر سوﺮﯾو ﻪﺑ ﯽﺳﺎﻨﺷ ﺪﻗﺎﻓ ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ ﻪﮐ توﺎﻔﺗ ﻦﯾا ﺎﺑ ،ﺪﻧراد ﺖﻫﺎﺒﺷ ﯽﻌﯿﺒﻃ يﺎﻫ
ژ مﻮﻧ ﺪﻨﺘﺴﻫ دﻮﺟو ﻞﯿﻟد ﻪﺑ. رﺎﺘﺧﺎﺳ
يﺎﻫ
هﺮﮑﯿﭘ رد يراﺮﮑﺗ ﯾا ﺶﯾاﺰﻓا ﺚﻋﺎﺑ تارذ ﻦﯾا زا هدﺎﻔﺘﺳا ،ﻦﯾاﺮﺑﺎﻨﺑ .دراد دﻮﺟو ﯽﻨﻤﯾا ﻢﺘﺴﯿﺳ يﻮﻗ ﮏﯾﺮﺤﺗ نﺎﮑﻣا ﺎﻫVLP
رد نﺪﺑ ﯽﻨﻤ
ﺎﮕﻨﻫ م .ﺪﻨﺘﺴﻫ ﯽﯾاز يرﺎﻤﯿﺑ ناﻮﺗ ﺪﻗﺎﻓ مﻮﻧژ دﻮﺟو مﺪﻋ ﻞﯿﻟد ﻪﺑ و دﻮﺷ ﯽﻣ تارذ ﻦﯾا ﺖﻓﺎﯾرد ﺲﭘ و ﺖﻓﺎﯾرد ﯿﻟﻮﺗ ياﺮﺑ
ﺪ VLP ﻦﮑﻤﻣ
ﻪﺑ زﺎﯿﻧ و ﻪﻨﯾﺰﻫ ﻪﻠﻤﺟ زا ،دراد يدﺪﻌﺘﻣ ﻞﻣاﻮﻋ ﻪﺑ ﯽﮕﺘﺴﺑ ﺪﯿﻟﻮﺗ ﻢﺘﺴﯿﺳ عﻮﻧ بﺎﺨﺘﻧا .دﻮﺷ هدﺎﻔﺘﺳا ﻢﺘﺴﯿﺳ ﻦﯾﺪﻨﭼ زا ﺖﺳا اﺮﯿﯿﻐﺗ
ﺲﭘ ت
ﯽﻣ ﻪﮐ ﻪﻤﺟﺮﺗ زا ﺪﺷﺎﺑ يروﺮﺿ ﻪﻨﯿﻬﺑ ﻦﻤﯾا ﺦﺳﺎﭘ ﺪﯿﻟﻮﺗ رد ﺪﻧاﻮﺗ
ﺮﺑ هوﻼﻋ. سوﺮﯾو ،ﻦﯾا ﯽﺑﻮﺧ ﻪﺑ ﺪﻧراد ﻪﮐ يرﺎﺘﺧﺎﺳ ﻞﯿﻟد ﻪﺑ ﯽﻫﺎﯿﮔ يﺎﻫ
ﺑ ردﺎﻗ فﺮﻃ زا .ﺪﻨﺘﺴﻫ ناراﺪﻧﺎﺘﺴﭘ ﯽﻨﻤﯾا ﻢﺘﺴﯿﺳ ﮏﯾﺮﺤﺗ ﻪ ناراﺪﻧﺎﺘﺴﭘ ياﺮﺑ ،ﺮﮕﯾد
يرﺎﻤﯿﺑ ناﻮﺗ ﯽﻣ ﺮﻃﺎﺧ ﻦﯿﻤﻫ ﻪﺑ .ﺪﻧراﺪﻧ ﯽﯾاز
ناﻮﺗ
نآ زا ﻪﻋﻮﻤﺠﻣ ﺮﯾز ﮏﯾ ناﻮﻨﻋ ﻪﺑ ار ﺎﻫ ﻦﺴﮐاو زا ﯽﺧﺮﺑ .دروآ بﺎﺴﺣ ﻪﺑ ﺎﻫVLP
ﺮﺑ ﯽﻨﺘﺒﻣ يﺎﻫ VLP
سوﺮﯾو و ﺎﻫ ﯽﻫﺎﯿﮔ يﺎﻫ
ياﺮﺑ
ﻃ ﯽﻧﻮﻔﻋ يرﺎﻤﯿﺑ ﻦﯾﺪﻨﭼ زا يﺮﯿﮔﻮﻠﺟ هﺪﺷ ﯽﺣاﺮ
ﺪﻧا درﻮﻣ و ﺗﺄ ﺪﯿﯾ ﻪﺘﻓﺮﮔ راﺮﻗ د يرﺎﯿﺴﺑ و ﺪﻧا
رد ﺮﮕﯾ ﻪﻠﺣﺮﻣ ﻟﺎﺑ ﯿﻨ .ﺪﻨﺘﺴﻫ ﻖﯿﻘﺤﺗ ﺎﯾ ﯽ
زا هدﺎﻔﺘﺳا ﻪﺑ ﻪﻗﻼﻋ
ًاﺮﯿﺧا ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ياﺮﺑ ﺎﻫVLP ﻦﺴﮐاو ﺮﺑاﺮﺑ رد نآ يﺎﯾاﺰﻣ ﻞﯿﻟد ﻪﺑ
ﯽﻤﯾﺪﻗ ﺎﯾ ﯽﺘﻨﺳ يﺎﻫ رد .ﺖﺳا ﻪﺘﻓﺎﯾ ﺶﯾاﺰﻓا ﺮﺗ
ﻢﺘﺴﯿﺳ ﺎﺗ ﺖﺳا هﺪﺷ ﯽﻌﺳ يروﺮﻣ ﻪﻟﺎﻘﻣ ﻦﯾا ﻟﻮﺗ يﺎﻫ
ﺪﯿ .ﺪﻧﻮﺷ ﻪﺴﯾﺎﻘﻣ ﻢﻫ ﺎﺑ ﺎﯾاﺰﻣ و ﺐﯾﺎﻌﻣ ﺮﻈﻧ زاVLP
هژاو ﺪﯿﻠﮐ يﺎﻫ :ي
ﻦﺴﮐاو ،ﯽﻫﺎﯿﮔ سوﺮﯾو ،نﺎﯿﺑ ﻢﺘﺴﯿﺳ ،ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ .
هﺪﯿﮑﭼ
ﻪﻣﺪﻘﻣ
ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ )
virus-like particles; VLPs
(
ﺖﺨﯾر ﻪﮐ ﺖﺳا سوﺮﯾو هﺮﮑﯿﭘ زا عﻮﻧ ﮏﯾ ﯽﺳﺎﻨﺷ
سوﺮﯾو
ﯽﻌﯿﺒﻃ ﯽﻣ ﺪﯿﻠﻘﺗ ار ﺑ ﯽﻣﻮﻧژ داﻮﻣ ﺪﻗﺎﻓ ﺎﻣا ﺪﻨﮐ
يرﺎﻤﯿ ﺖﺳا از
) 1،2 ( لﺎﺣ ﻦﯾا ﺎﺑ . ﺐﯿﮐﺮﺗ ﺎﻫVLP
ﯽﺘﻧآ ﻧژ زا ﯽﻌﯿﺒﻃ ﯽﮑﯿﺘ
ﻦﯿﺌﺗوﺮﭘ ﯽﻨﻤﯾا يﺎﻫ ﯽﻠﺻا هﺮﮑﯿﭘ يراﺮﮑﺗ رﺎﺘﺧﺎﺳ و از
ﯽﻣ ﻆﻔﺣ ار سوﺮﯾو ﺪﻨﻨﮐ
) 3 ( . تارذ ﻦﯾا ،هزاﺪﻧا ﺮﻃﺎﺧ ﻪﺑ
ﻞﮑﺷ ﺢﻄﺳ و ﯽﭘا ﻪﮐ نﺎﺷ پﻮﺗ
يراﺮﮑﺗ ﻪﯾارآ ﮏﯾ رد ار ﺎﻫ
ﯽﻣ ﺶﯾﺎﻤﻧ ﻪﺑ ﻢﮐاﺮﺘﻣ يﻮﻗ ﺦﺳﺎﭘ ﺎﻘﻟا ﻞﯿﺴﻧﺎﺘﭘ ،ﺪﻧراﺬﮔ
ﺪﻧراد ار ﯽﻨﻤﯾا )
4-7 ( . ﻦﯿﺌﺗوﺮﭘ نﺎﯿﺑ لﺎﺒﻧد ﻪﺑ ﺎﻫVLP
ﯽﯾﺎﻫ
نآ يﺪﻨﺑ ﻢﻫ ﺮﺳ ﺲﭙﺳ و صﺎﺧ ﺑ ﺎﻫ
ﻪ ترﻮﺻ يدﻮﺧ ﻪﺑ دﻮﺧ
ﺑ ﻪ ﯽﻣ دﻮﺟو .ﺪﻨﯾآ
ﻦﺴﮐاو ﺮﺿﺎﺣ لﺎﺣ رد ﺎﻫ
ي ﻏ ﯿﺮ ﮐﺮﺗﻮﻧ ﯿ ﺐ
ﻠﻋ ﯿ ﻪ ﺑﯿ رﺎﻤ ي ﺎﻫ ي و ﯾ ﺳوﺮ ﯽ زا يرﺎﻤﯿﺑ ﻞﻣاﻮﻋ ياز
هﺪﺷ ﺖﺸﮐ
ﺎﻣزآ ﯾ ﻫﺎﮕﺸ ،ﯽ ﺎﺑ ﻪﮐ ﯾﺪ ﻌﺿ ﯿ ﻒ ﯾﺎ ﻏ ﯿ لﺎﻌﻓﺮ ﻪﺘﺧﺎﺳ ﺪﻧﻮﺷ
ﻣ ﯽ ﻮﺷ ﻧﺪ لﺎﻤﻋا ﻦﯾا ﯽﻟﺎﻤﺘﺣا نﺪﺷ مﺎﺠﻧا ﺺﻗﺎﻧ ﻞﯿﻟد ﻪﺑ ﻪﮐ
ﯽﺘﺴﯾز رﺎﻬﻣ ﺎﺑ و هﺪﺷ ﻆﻔﺣ نآ ﯽﯾاز يرﺎﻤﯿﺑ )
- o bi
containmen
( ﺖﺳا هاﺮﻤﻫ )
8 ( ﯾ . ﮏ ور ﯾ دﺮﮑ ا هﻮﻘﻟﺎﺑ ﯾ ﻦﻤ ﺮﺗ
ﻦﺴﮐاو ﺰﺘﻨﺳ ﺑ سﺎﺳا ﺮﺑ ﺎﻫ
ﯿ نﺎ اﺰﺟا ي ﯽﺻﺎﺼﺘﺧا ﻞﻣاﻮﻋ
يرﺎﻤﯿﺑ از ﻣ ﻪﮐ ﺖﺳا ﯽ
صاﻮﺧ زا ﺪﻧاﻮﺗ ﻢﺘﺴﯿﺳ ﮏﯾﺮﺤﺗ
اﯾ ﻨﻤ ﯽ ﻪﻄﺳاﻮﺑ نﺪﺑ وﯾ
سوﺮ ﻠﺻا ﯽ ﻠﻘﺗ ﯿ ﺪ ﺪﻨﮐ ﻪﮑﻨﯾا نوﺪﺑ
،ﻦﯾا ﺮﺑﺎﻨﺑ .دﻮﺷ يرﺎﻤﯿﺑ ﺚﻋﺎﺑ ﺎﻫ VLP
ﻧ هﺪﻨﯾﺎﻤ يا ﻟﺎﻋ ﯽ
اﺮﺑ ي ﻨﭼ ﯿ ﻦ ﻦﺴﮐاو ﺎﻫ ي ﻋﻮﻨﺼﻣ ﯽ ﺪﻨﺘﺴﻫ ) 9 (.
زا فﺪﻫ
ﻪﻟﺎﻘﻣ ﻦﯾا شرﺎﮕﻧ ﻞﯿﺴﻧﺎﺘﭘ و دﺮﺑرﺎﮐ ﯽﺳرﺮﺑ يروﺮﻣ ي
ﻮﺗ ياﺮﺑ ﺎﻫVLP
ﻦﺴﮐاو ﺪﯿﻟ ﮏﻤﮐ ﻪﺑ
ﻢﺘﺴﯿﺳ ﯽﻧﺎﯿﺑ يﺎﻫ
ﯽﻣ .ﺪﺷﺎﺑ ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ يﺪﻨﺑ ﻢﯿﺴﻘﺗ رﺎﺘﺧﺎﺳ سﺎﺳاﺮﺑ
و ﻪﺒﺷ تارذ ﯾ
ﺳوﺮ ﯽ زا ﯾ ﮏ ﯾﺎ ﺌﺗوﺮﭘ ﺪﻨﭼ ﯿ
ﻦ رﺎﺘﺧﺎﺳ ي
ﮑﺸﺗ ﯿ ﻞ هﺪﺷ ﺪﻧا . ﻣﺎﮕﻨﻫ تارذ ﻦﯾا ﻪﮐ ﯽ ﮐﺮﺗﻮﻧ ترﻮﺻ ﻪﺑ
ﯿ ﺐ
ﺑﯿ نﺎ ﻣ ﯽ ﺎﻧاﻮﺗ ﺪﻧﻮﺷ ﯽﯾ
دﻮﺧ يﺪﻨﺑ ﻢﻫﺮﺳ .ﺪﻧراد
ﻦﯾا
ﺌﺗوﺮﭘ ﯿ ﻦ ﻣ ﺎﻫ ﯽ ﻧاﻮﺗ ﺪﻨ ﻻ رد ﯾﻪ ﺎﻫ ي ﮏﯾ ود ، ﯾﺎ ﺎﺗ ﻪﺳ ﯽﯾ ﺐﺗﺮﻣ
ﺪﻧﻮﺷ ) 10 (.
ﭘﺎﭘ درﻮﻣ رد ﯿ
ﺎﻣﻮﻠ سوﺮﯾو ﻧﺎﺴﻧا ﯽ )
Human
( ) 11 (
، ﺎﻫ زا ﯾ ﮏ ﺌﺗوﺮﭘ ﯿ ﻦ رﺎﺘﺧﺎﺳ
ﺪﺣاو ي ﮑﺸﺗ ﯿ ﻞ ﻣ ﯽ ﻮﺷ ﻧﺪ ﻦﯾا زا يداﺪﻌﺗ ﻪﮐ ﯽﻧﺎﻣز ،
ﻦﯿﺌﺗوﺮﭘ ﯽﻣ راﺮﻗ ﻢﻫ رﺎﻨﮐ رد يراﺮﮑﺗ ترﻮﺻ ﻪﺑ ﺎﻫ ،ﺪﻧﺮﯿﮔ
هﺮﮑﯿﭘ ي ﻠﺻا ﯽ ار هرذ ﯽﻣ دزﺎﺳ . ﺎﻫVLP
ي ﭘ ﯿ ﭽ ﯿ هﺪ ﻞﻣﺎﺷ ﺮﺗ
ﺪﻨﭼ ﯾ ﻦ ﺌﺗوﺮﭘ ﯿ ﻦ رﺎﺘﺧﺎﺳ ي لﺎﺜﻣ ناﻮﻨﻋ ﻪﺑ ،ﺪﻨﺘﺴﻫ
ﺎﻫVLP
ي هداﻮﻧﺎﺧ
Reoviridae
زا 2 ﺎﺗ 4 ﺌﺗوﺮﭘ ﯿ ﻦ ﻒﻠﺘﺨﻣ
ﺪﻨﭼ رد ﻪﮐ ﯾ
ﻦ ﻻ ﯾﻪ ﮑﺸﺗ ﺪﻧا ﻪﺘﻓﺮﮔ راﺮﻗ ﯿ
ﻞ ﻣ ﯽ ﺪﻧﻮﺷ ) 10 (.
ﻨﭽﻤﻫ ﺎﻫVLP
ﯿ ﻦ ﻣ ﯽ ﺪﻨﻧاﻮﺗ ﯾ ﮏ ﺶﺷﻮﭘ يﺪﯿﭙﯿﻟ ﺟرﺎﺧ ﯽ
.ﺪﻨﺷﺎﺑ ﻪﺘﺷاد ا رد
ﯾ ﻦ
،ﺖﻟﺎﺣ ﺌﺗوﺮﭘ ﯿ ﻦ رﺎﺘﺧﺎﺳ ﯽﻠﺻا ي
)
Structural protein core
( ﺮﻃ زا ﯾ ﻖ آﺮﻓ ﯾ ﺪﻨ ﻪﻧاﻮﺟ ﻧز ﯽ زا
ﻣ جرﺎﺧ لﻮﻠﺳ ﯽ
ﺴﭙﮐ و دﻮﺷ ﯿ
ﺪ ﺘﻤﺴﻗ رد ار ﯽ
ﺎﺸﻏ زا ي
ﻟﻮﻠﺳ ﯽ ﻣ ﯽ .ﺪﻧﺎﺷﻮﭘ درﻮﻣ ﻦﯾا رد
ﺎﻫ VLP
ي
HIV-1
ﻪﮐ ، زا
ﻠﭘ ﯽ ﺌﺗوﺮﭘ ﯿ ﻦ ﮑﺸﺗGag
ﯿ ﻞ ﺸﺨﺑ و ﺪﻧا هﺪﺷ ﯽ
ﺎﺸﻏ زا ي لﻮﻠﺳ
ﻣﯿ نﺎﺑﺰ ناﻮﻨﻋ ﻪﺑ ار ﺶﺷﻮﭘ
ﻣ ﯽ ﮔﯿ ﺪﻧﺮ ﯽﻣ قﺪﺻ ﺪﻨﮐ
) 12 (.
ﺎﻫVLP
ي اﺰﻧﻻﻮﻔﻧآ ﻢﻫ ﺌﺗوﺮﭘ ﻂﺳﻮﺗ ﯿ
ﻦ ﯽﻠﺻا يرﺎﺘﺧﺎﺳ
)
Protein core
( ﻪﻠﺒﻨﺳ و ﺎﻫ ي ﺗﻮﻠﮔﺎﻤﻫ ﯿﻨ ﯽﻨﯿ ﺢﻄﺳ رد ﻪﮐ
نآ ﯽﻣ راﺮﻗ ﺪﻧﺮﯿﮔ ﻣ ﻞﮑﺷ ، ﯽ ﮔﯿ دﺮ ) 13 (.
اﺮﺑﺎﻨﺑ ﯾ ﻦ بﺎﺨﺘﻧا ،
هدر ﻟﻮﻠﺳ ﯽ ﻟﻮﺗ ﯿ ﺪ ﺴﺑ هﺪﻨﻨﮐ ﯿ رﺎ ز ﺖﺳا ﻢﻬﻣ ﯾ
اﺮ ﺎﻫ VLP
ي
ﺶﺷﻮﭘ راد وﺎﺣ ي ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي ﺑﯿ نﺎ ﺎﺸﻏ رد هﺪﺷ ي
نآ
.دﻮﺑ ﺪﻨﻫاﻮﺧ ﮔزﺎﺗ ﻪﺑ
ﯽ ﺪﺟ عﻮﻧ ، ﯾﺪ
ي زا مﺎﻧ ﺎﺑ VLP
"
ﺎﻫVLP
ي ﺐﯿﮐﺮﺗﻮﻧ
"
ﻪﻌﺳﻮﺗ ﯾ ﻪﺘﻓﺎ ﺖﺳا ﻪﮐ نآ رﺎﺘﺧﺎﺳ ﺎﻫ
زا ﯾ ﮏ ﺌﺗوﺮﭘ ﯿ ﻦ و ﯾ ﺳوﺮ ﯽ ﮑﺸﺗ ﯿ ﻞ ﻟﺎﺣ رد هﺪﺷ ﯽ
ﻪﮐ
ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي ﯽﺸﺷﻮﭘ زا ﯾ ﮏ و ﯾ سوﺮ هﺪﺷ ﻖﺘﺸﻣ مود ﺪﻧا
) 14 ( . اﯾ ﻦ زا عﻮﻧ ﺎﻫVLP
ﻧﺎﮑﻣا ﯽﻣ ﻢﻫآﺮﻓ ار ﯽ ﺪﻨﻨﮐ
ناﻮﺘﺑ ﺎﺗ
نآ زا ﺎﻫ ﺳ ناﻮﻨﻋ ﻪﺑ ﯿ
ﻢﺘﺴ ﻮﺤﺗ ﯾ ﻞ ﻪﺑ .دﺮﮐ هدﺎﻔﺘﺳا وراد
ﯽﻣ ار ﺮﻈﻧ درﻮﻣ ﺪﯿﺘﭙﭘ ﻪﮐ يرﻮﻃ راﻮﺳ هﺮﮑﯿﭘ يور ناﻮﺗ
دﺮﮐ . ﺌﺗوﺮﭘ ﯿ ﻦ ﺎﻫ ي ﯽﺸﺷﻮﭘ ﻣ ﯽ ناﻮﻨﻋ ﻪﺑ ﺪﻨﻧاﻮﺗ ﺖﻣﻼﻋ ﮏﯾ
اﺮﺑ ي ﮔ ﯿ هﺪﻧﺮ ﺎﻫ ي ﺘﻓﺎﺑ ﯽ .ﺪﻨﻨﮐ ﻞﻤﻋ صﺎﺧ اﺮﺑﺎﻨﺑ
ﯾ ﻦ ، ﺎﻫVLP
رﺎﮐ ﺎﻫدﺮﺑ ي ﺪﺟ ﯾﺪ ي ﻧﺎﻣرد نژ ،وراد لﺎﻘﺘﻧا رد ﯽ
نﺎﻣرد و
ﺪﻧراد نﺎﻃﺮﺳ )
15-17 (.
ﻢﺘﺴﯿﺳ ﺪﯿﻟﻮﺗ يﺎﻫ VLP
ﺪﯿﻟﻮﺗ ياﺮﺑ شور ﺪﻨﭼ ﯽﻠﮐ رﻮﻃ ﻪﺑ ﻪﮐ دراد دﻮﺟو ﺎﻫVLP
شور ﻞﻣﺎﺷ ﯽﯾﺎﯿﻤﯿﺷ ،ﯽﮑﯿﺘﻧژ يﺎﻫ
، ﯽﻤﯾﺰﻧآ
، ﯽﮑﯾﺰﯿﻓ و
ﯽﻧﺎﯿﺑ يﺎﻫ ﻢﺘﺴﯿﺳ زا هدﺎﻔﺘﺳا ﯽﻣ
ﺷﺎﺑ ﻨ .ﺪ هزوﺮﻣا ﻢﺘﺴﯿﺳ شور
ﯽﻧﺎﯿﺑ راﺮﻗ ﻪﺟﻮﺗ درﻮﻣ ﺖﺳا ﻪﺘﻓﺮﮔ
) 18 ( رد ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ .
ﺪﯿﻟﻮﺗ
VLP
و ﻦﯿﺌﺗوﺮﭘ نﺪﺷ ﺎﺗ تاﺮﯿﯿﻐﺗ ياﺮﺑ مزﻻ ﻂﯾاﺮﺷ ﺪﯾﺎﺑ ﻦﯾﺪﻨﭼ هزوﺮﻣا .ﺪﻫد راﺮﻗ ﻪﺟﻮﺗ درﻮﻣ ار ﻪﻤﺟﺮﺗ زا ﺲﭘ تاﺮﯿﯿﻐﺗ
اﺮﺑ ﯽﻠﺻا ﻢﺘﺴﯿﺳ ﺪﯿﻟﻮﺗ و نﺎﯿﺑ ي
ﺎﻫVLP
درﻮﻣ راﺮﻗ هدﺎﻔﺘﺳا
ﯽﻣ لوﺪﺟ) ﺪﻨﺘﺴﻫ ﯽﺒﯾﺎﻌﻣ و ﺎﯾاﺰﻣ ياراد ماﺪﮐ ﺮﻫ ﻪﮐ دﺮﯿﮔ 1
.(
لوﺪﺟ 1 . ﻢﺘﺴﯿﺳ ﺐﯾﺎﻌﻣ و ﺎﯾاﺰﻣ ﺪﯿﻟﻮﺗ ﻒﻠﺘﺨﻣ يﺎﻫ
VLP
ﻢﺘﺴﯿﺳ عﻮﻧ ﺪﯿﻟﻮﺗ ﺎﯾاﺰﻣ
ﺐﯾﺎﻌﻣ
E.coli -
نﺎﯿﺑ ﺖﻟﻮﻬﺳ - يﺮﯾﺬﭘ سﺎﯿﻘﻣ ﺖﯿﻠﺑﺎﻗ
- ﻦﯿﯾﺎﭘ ﺪﯿﻟﻮﺗ ﻪﻨﯾﺰﻫ -
ﯽﻤﻧ ﻦﺸﯿﻠﯾزﻮﮑﯿﻠﮔ هزﺎﺟا ﻫد
ﺪ
- ﺎﻫ ﻦﯿﺴﮐﻮﺗوﺪﻧا
ﺮﻤﺨﻣ -
نﺎﯿﺑ ﺖﻟﻮﻬﺳ - يﺮﯾﺬﭘ سﺎﯿﻘﻣ ﺖﯿﻠﺑﺎﻗ
- ﻦﯿﯾﺎﭘ ﺪﯿﻟﻮﺗ ﻪﻨﯾﺰﻫ -ﻏ
ﺮﯿﯿﻐﺗ ﺪﻨﻧﺎﻣ) ﻦﯿﺌﺗوﺮﭘ ﻦﺸﯿﻠﯾزﻮﮑﯿﻠﮔ ﺐﺳﺎﻨﻣ ﺎﻧ ﺖﻈﻠ (زﻮﻧﺎﻣ ﻦﯿﺌﺗوﺮﭘ يﻻﺎﺑ
- ﯽﮔدرﻮﺧ ﭻﯿﭘ ﺮﻄﺧ و
هﺎﺒﺘﺷا ژﺎﺘﻧﻮﻣ
هﺮﺸﺣ يﺎﻫ لﻮﻠﺳ -
ﯽﻣ ﺮﯾدﺎﻘﻣ ﺪﻧاﻮﺗ زا يدﺎﯾز VLP ﺗ ﻻﺎﺑ ﻢﮐاﺮﺗ ﺎﺑ ﯽﻟﻮﻠﺳ ﺖﺸﮐ ﻂﯾاﺮﺷ رد ﻮ
ﺪﻨﮐ ﺪﯿﻟ
- يﺮﯾﺬﭘ سﺎﯿﻘﻣ ﺖﯿﻠﺑﺎﻗ
- ﺧ يرﺎﻤﯿﺑ ﻞﻣاﻮﻋ ﺖﺸﮐ ﺮﻄ ﯽﻟﻮﻠﺳ ﺖﺸﮐ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﺐﻠﻃ ﺖﺻﺮﻓ ياز
ﺪﺑﺎﯾ ﯽﻣ ﺶﻫﺎﮐ ناراﺪﻧﺎﺘﺴﭘ -ﺗ ﯽﻣ سوﺮﯾوﻮﻟﻮﮐﺎﺑ/هﺮﺸﺣ يﺎﻫ لﻮﻠﺳ ﺐﯿﮐﺮ ﻞﻤﻋ ﺖﻧاﻮﺟدا ﮏﯾ ناﻮﻨﻋ ﻪﺑ ﺪﻧاﻮﺗ
دﻮﺷ ﺮﺘﺸﯿﺑ ﯽﻨﻤﯾا ﺦﺳﺎﭘ ﺎﺗ ﺪﻨﮐ -
ﯿﻐﺗ ﻪﺑ دوﺪﺤﻣ زﻮﻧﺎﻣ ﻦﯿﺌﺗوﺮﭘ يﻻﺎﺑ ﺮﯿ
- ﺎﺑ ﯽﮔدﻮﻟآ فﺬﺣ ا ﻦﮑﻤﻣ سوﺮﯾوﻮﻟﻮﮐ
ﺪﺷﺎﺑ راﻮﺷد ﺖﺳ
- ا ﺦﺳﺎﭘ ﺖﺳا ﻦﮑﻤﻣ سوﺮﯾوﻮﻟﻮﮐﺎﺑ / هﺮﺸﺣ لﻮﻠﺳ ياﺰﺟ ﺎﻬﻨﭘ ار هﺪﺷ ﻪﺘﺳاﻮﺧ يﺎﻫ پﻮﺘﯿﭘا ﺮﺑاﺮﺑ رد ار ﯽﻨﻤﯾا ﮐ ن
ﺪﻨ
لﻮﻠﺳ يﺎﻫ ناراﺪﻧﺎﺘﺴﭘ -
ﺳ د ﯽﮑﯾدﺰﻧ طﺎﺒﺗرا ﯽﻌﯿﺒﻃ نﺎﺑﺰﯿﻣ يﺎﻫ لﻮﻠﺳ ﻪﺑ هﺪﻨﻨﮐ ﺪﯿﻟﻮﺗ يﺎﻫ لﻮﻠ ﺪﻧرا
- ﺢﯿﺤﺻ ژﺎﺘﻧﻮﻣ و ﺐﺳﺎﻨﻣ PTM VLPs
- ﻪﻨﯾﺰﻫ ﻻﺎﺑ ﺪﯿﻟﻮﺗ ي
- ﻦﯿﯾﺎﭘ يرو هﺮﻬﺑ
نﺎﻫﺎﯿﮔ -
نﺎﯿﺑ ﺖﻟﻮﻬﺳ - يﺮﯾﺬﭘ سﺎﯿﻘﻣ ﺖﯿﻠﺑﺎﻗ
- ﻧﺎﺴﻧا ﯽﺳوﺮﯾو ﯽﮔدﻮﻟآ ﭻﯿﻫ ﺖﺴﯿﻧ نآ رد ﯽ
- ﯽﺘﻧآ ﻪﯾﺰﺠﺗ :يراﺪﯾﺎﭘ نژ
- نﺎﯿﺑ ﻦﯿﯾﺎﭘ حﻮﻄﺳ
- ﯽﻤﻧ ﺪﻧاﻮﺗ و ﺎﻫPTM ژﺎﺘﻧﻮﻣ ﺪﻨﮐ ﻞﻤﺤﺗ ارVLP
يﺮﺘﮐﺎﺑ نﺎﯿﺑ ﻢﺘﺴﯿﺳ ﺎﻫﺮﻤﺨﻣ و ﺎﻫ
يﺮﺘﮐﺎﺑ ﻪﺑ ﺎﻫﺮﻤﺨﻣ و ﺎﻫ ﯿﺳ ﯽﺘﺣار
ﻢﺘﺴ نوﺮﻘﻣ ﺪﯿﻟﻮﺗ يﺎﻫ
ﯽﻣ دﺎﺠﯾا ار ﻪﻓﺮﺻ ﻪﺑ ﺪﻨﻨﮐ
يﺮﺘﮐﺎﺑ .
نﺎﯿﺑ ﻢﺘﺴﯿﺳ ﮏﯾ ﺎﻫ
ياﺮﺑ ﺐﺳﺎﻨﻣ ود ﺎﯾ ﮏﯾ زا ﺎﻬﻨﺗ ﻪﮐ ﺪﻨﺘﺴﻫ ﯽﯾﺎﻫ VLP
هﺪﺷ ﻞﯿﮑﺸﺗ يرﺎﺘﺧﺎﺳ ﻦﯿﺌﺗوﺮﭘ ﯽﻨﯿﺌﺗوﺮﭘ ﺶﺷﻮﭘ ﺪﻗﺎﻓ و ﺪﻧا
ﻪﮐ ﺖﺳا ﻦﯾا دراد ﻢﺘﺴﯿﺳ ﻦﯾا ﻪﮐ ﯽﻠﺻا ﺖﯾﺰﻣ .ﺪﻨﺘﺴﻫ ﻦﯿﺌﺗوﺮﭘ ﺪﯿﻟﻮﺗ ياﺮﺑ ﯽﯾﻻﺎﺑ دﺮﮑﻠﻤﻋ ﻈﻧ درﻮﻣ يﺎﻫ
،دراد ار ﺮ
يﺮﺘﮐﺎﺑ ﻪﮐ ﺖﺳا ﯽﻟﺎﺣ رد ﻦﯾا ﺲﭘ تاﺮﯿﯿﻐﺗ مﺎﺠﻧا ﻪﺑ ردﺎﻗ ﺎﻫ
ﯽﻣ ﻪﮐ ﻪﻤﺟﺮﺗ زا ﯽﻨﻤﯾا ياﺮﺑ ﺪﻧاﻮﺗ
ﯽﯾاز
VLP
ﺪﺷﺎﺑ ﻢﻬﻣ رﺎﯿﺴﺑ
ﺪﻨﺘﺴﯿﻧ ) 9 ( . دﻮﺟو ﻦﯾا ﺎﺑ
، يﺮﺘﮐﺎﺑ ﻪﺒﺷ تارذ ﺪﯿﻟﻮﺗ ياﺮﺑ ﺎﻫ
ﺶﺷﻮﭘ ﺮﯿﻏ ﯽﺳوﺮﯾو ﺎﺑ نژﻮﺗﺎﭘ ﮏﯾ زا ﯽﺋاﺰﺟا ﺮﺑ ﯽﻨﺘﺒﻣ راد
ناﻮﻨﻋ ﻪﺑ ﺎﯾ ﯽﯾﺎﯾﺮﺘﮐﺎﺑ نﺎﺑﺰﯿﻣ رد يﺪﻨﺑ ﻢﻫﺮﺳ دﻮﺧ ﺖﯿﻠﺑﺎﻗ ﺎﺼﺗا ﺗﻻ ﯽﺘﻧآ زا ﯽ نژ
ﻦﯿﺌﺗوﺮﭘ ﻪﺑ ﻦﺴﮐاو فﺪﻫ يﺎﻫ يﺎﻫ
هﺪﺷ هدﺎﻔﺘﺳا ژﺎﻓﻮﯾﺮﺘﮐﺎﺑ ﯽﺤﻄﺳ ﺪﻧا
) 19 (.
نﺎﺑﺰﯿﻣ ﮏﯾ ﺮﻤﺨﻣ ﯽﻣ ﺐﯿﮐﺮﺗﻮﻧ ﻦﯿﺌﺗوﺮﭘ نﺎﯿﺑ ياﺮﺑ بﻮﺧ هﺪﺷ ﺖﯿﺒﺜﺗ
و ﺪﺷﺎﺑ
ﺪﯿﻟﻮﺗ ياﺮﺑ ﻦﯿﻨﭽﻤﻫ
VLP
ﯽﻣ هدﺎﻔﺘﺳا دﻮﺷ
. ﻮﺗ ﺎﺑ ﻪﺑ ﻪﺟ
نﺎﺸﻧ ﻦﯾا ،ﻪﻤﺟﺮﺗ زا ﺲﭘ تﺎﺣﻼﺻا مﺎﺠﻧا ياﺮﺑ ﺮﻤﺨﻣ ﯽﯾﺎﻧاﻮﺗ ﺪﯿﻟﻮﺗ رد ﻮﻠﺟ ﻪﺑ ور مﺎﮔ ﮏﯾ هﺪﻨﻫد
VLP
،ﯽﮔزﺎﺗ ﻪﺑ .ﺖﺳا
VLP Chikungunya
زا هدﺎﻔﺘﺳا ﺎﺑ
P. pastoris
و هﺪﺷ ﺪﯿﻟﻮﺗ
هﺪﻨﻨﮐ راوﺪﯿﻣا ﺞﯾﺎﺘﻧ ﻦﻤﯾا ظﺎﺤﻟ زا يا
هﺪﻣآ ﺖﺳد ﻪﺑ يزﺎﺳ
ﻪﻤﺟﺮﺗ زا ﺲﭘ تﺎﺣﻼﺻا ،دﻮﺟو ﻦﯾا ﺎﺑ .ﺖﺳا ﺎﻫﺮﻤﺨﻣ رد
ﺑ ﻪ
ﯾزﻮﮑﯿﻠﮔ رد هﮋﯾو ﻼ
نﻮﯿﺳ ﻦﯿﺌﺗوﺮﭘ ﺖﺴﯿﻧ نﺎﺴﻧا ﺪﻨﻧﺎﻤﻫ ﺎﻘﯿﻗد
) 18 (.
ﻦﯾا ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ ﺖﯾدوﺪﺤﻣ
ﺎﻫ ﻢﺘﺴﯿﺳ ﻦﯾا ﯽﻧﺎﯿﺑ
ًﺎﻣﻮﻤﻋ
ﺪﯿﻟﻮﺗ ياﺮﺑ
VLP
ﺎﺑ .ﺖﺳا هﺪﺷ هدﺎﻔﺘﺳا راد ﺶﺷﻮﭘﺮﯿﻏ يﺎﻫ
ﺪﯿﻟﻮﺗ دﻮﺟو ﻦﯾا
VLP
اد ﺶﺷﻮﭘ يﺎﻫ ر
Pr55Gag 1-HIV
رد
ﺎﻫ ﺖﺴﻟﺎﭘوﺮﻔﺳا ﻪﯾﺰﯾوﺮﺳ ﺲﺴﯾﺎﻣوﺮﮐﺎﺳ زا هدﺎﻔﺘﺳا ﺎﺑ ﺮﻤﺨﻣ ﺖﺳا هﺪﻣآ ﺖﺳﺪﺑ ،لﺪﻣ ﻦﯾا رد .
ﺪﯿﻟﻮﺗ يوﺮﮐ يﺎﻫVLP
ﭘ ءﺎﺸﻏ ﺎﺑ هﺪﺷ ﻼ
ظﺎﺤﻟ زا و هدﻮﺑ رﻮﺼﺤﻣ ﺮﻤﺨﻣ لﻮﻠﺳ ﯽﯾﺎﻤﺳ
ﯽﺳﺎﻨﺷ ﺖﺨﯾر تارذ ﻪﯿﺒﺷ
HIV
ﻎﻟﺎﺑﺎﻧ ﺪﻨﺘﺴﻫ ) 20،21 (.
هﺮﺸﺣ نﺎﯿﺑ ﻢﺘﺴﯿﺳ ﻢﺘﺴﯿﺳ زا ﺮﮕﯾد ﯽﮑﯾ ﺑ ﻪﮐ ﯽﯾﺎﻫ
ﻪ ﻟﻮﺗ ياﺮﺑ هدﺮﺘﺴﮔ رﻮﻃ ﺪﯿ
ﺎﻫVLP
هﺪﺷ هدﺎﻔﺘﺳا ﺖﺳا
، ﻢﺘﺴﯿﺳ سوﺮﯾوﻮﻠﮐﺎﺑ لﻮﻠﺳ_
ﺮﺸﺣ ه )
Baculovirus/Insect cell; B/IC
( ﺪﺷﺎﺑ ﯽﻣ .
زا
لﻮﻠﺳ ﻦﺴﮐاو زا يداﺪﻌﺗ ﺪﯿﻟﻮﺗ ياﺮﺑ تاﺮﺸﺣ يﺎﻫ ﯽﻨﺘﺒﻣ يﺎﻫ
ﺮﺑ
VLP
ًﺎﺻﻮﺼﺧ ﺞﯾار يﺎﻫ ﻦﺴﮐاو زا ﯽﮑﯾ لواﺪﺘﻣ و
، HPV
هﺪﺷ هدﺎﻔﺘﺳا ا
ﺖﺳ ) 22 ( زا ناﻮﺗ ﯽﻣ.
لﻮﻠﺳ تاﺮﺸﺣ يﺎﻫ ياﺮﺑ
ﺮﻫ ﺪﯿﻟﻮﺗ ﻮﻧ ود ع ﺶﺷﻮﭘ يﺎﻫ VLP
ﺶﺷﻮﭘ ﺮﯿﻏ و راد هﺮﻬﺑ راد
ﺪﯿﻟﻮﺗ .ﺖﺴﺟ ﻦﺴﮐاو
يﺎﻫ
VLP
ﺶﺷﻮﭘ راد لﻮﻠﺳ رد يﺎﻫ
ﻪﺘﻓﺮﺸﯿﭘ ءﺰﺟ تاﺮﺸﺣ ﻦﯾﺮﺗ
ﺎﻫVLP
ﻢﺘﺴﯿﺳ .ﺪﻨﺘﺴﻫ ﯽﻧﺎﯿﺑ
لﻮﻠﺳ يﺎﻫ عﻮﻧ زا ﻪﻤﺟﺮﺗ زا ﺲﭘ تاﺮﯿﯿﻐﺗ ياراد تاﺮﺸﺣ
ﯽﺗﻮﯾرﺎﮐﻮﯾ ناﻮﻨﻋ ﻪﺑ ،ﺪﻨﺷﺎﺑ ﯽﻣ
لﺎﺜﻣ ﯾزﻮﮑﯿﻠﮔ ﻼ نﻮﯿﺳ وﺮﭘ ﻦﯿﺌﺗ
ﺎﻫ ) 23 ( ﻢﺘﺴﯿﺳ مﺎﻤﺗ ﻦﯿﺑ رد ،ﯽﻧﺎﯿﺑ يﺎﻫ
لﻮﻠﺳ يﺎﻫ تاﺮﺸﺣ
ﺘﺴﯿﺳ ﺎﺑ هاﺮﻤﻫ سوﺮﯾوﻮﻠﮐﺎﺑ ﯽﻧﺎﯿﺑ ﻢ
- ﺮﺸﺣ لﻮﻠﺳ ) ه
(B/IC
ﯽﮑﯾ
ﯾﻮﻧ زا ﺪ ﺶﺨﺑ ﻢﺘﺴﯿﺳ ﻦﯾﺮﺗ يروﺎﻨﻓ ياﺮﺑ ﺎﻫ
VLP
رﻮﻈﻨﻣ ﻪﺑ
ﺪﯿﻟﻮﺗ ﻦﺴﮐاو ﺷﺎﺑ ﯽﻣ ﯽﺳوﺮﯾو يﺎﻫ ﻨ
ﺪ ) 24،25 (.
ﻢﺘﺴﯿﺳ ﺪﻨﯾآﺮﻓ ﯽﻣ ﻢﯿﺴﻘﺗ ﻪﻠﺣﺮﻣ ود ﻪﺑB/IC
ﻪﻠﺣﺮﻣ :دﻮﺷ
ﺪﯿﻟﻮﺗ ﻪﻠﺣﺮﻣ و ﺖﻧﻮﻔﻋ و ﻊﯾﺮﺳ شور ﮏﯾ سوﺮﯾوﻮﻟﻮﮐﺎﺑ ﯽﺣاﺮﻃ.
ﻪﯿﻠﻋﺮﺑ ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ياﺮﺑ ،ﻞﯿﻟد ﻦﯿﻤﻫ ﻪﺑ .ﺖﺳا نﺎﺳآ سوﺮﯾو نآ ﯽﺤﻄﺳ ﻦﯿﺌﺗوﺮﭘ ﻪﮐ ﯽﯾﺎﻫ ﻨﻫ رد ﺎﻫ
دﺪﺠﻣ عﻮﯿﺷ مﺎﮕ
ﯽﻣ اﺪﯿﭘ ﺮﯿﯿﻐﺗ .ﺖﺳا ﺐﺳﺎﻨﻣ ﺪﻨﮐ
ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ رد ﻦﯿﺌﺗوﺮﭘ ﺪﯿﻟﻮﺗ
ﯽﻣB/IC
ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ رد ﺪﯿﻟﻮﺗ ﻪﺑ ﺖﺒﺴﻧ يﺮﺑاﺮﺑ ﺮﯾدﺎﻘﻣ ﺪﻧاﻮﺗ مﺎﺠﻧا ياﺮﺑ نآ ﺖﯿﻓﺮﻇ ﺎﻣا ،ﺪﺷﺎﺑ ﺮﻤﺨﻣ ﺎﯾ يﺮﺘﮐﺎﺑ زا ﺲﭘ تاﺮﯿﯿﻐﺗ
ﻪﻤﺟﺮﺗ ﻪﮐ يا هﺪﯿﭽﯿﭘ ﺖﺳا ﺮﺘﺸﯿﺑ ﺪﻨﺘﺴﻫ ﺮﺗ ود ،لﻮﻤﻌﻣ رﻮﻄﺑ .
هدر
هﺮﺸﺣ لﻮﻠﺳ ﮏﻤﮐ ﻪﺑ ﺐﯿﮐﺮﺗﻮﻧ ﻦﯿﺌﺗوﺮﭘ ﺪﯿﻟﻮﺗ ياﺮﺑ ﯽﻠﺻا يا
نﺎﯿﺑ ﻢﺘﺴﯿﺳ هدﺎﻔﺘﺳا B/IC
ﯽﻣ دﻮﺷ ، )Sf9 Spodoptera
frugiperda
و (
High Five cells
)
Trichoplusia ni
زا يرﺎﯿﺴﺑ .(
عاﻮﻧا
VLP
ﻢﺘﺴﯿﺳ زا هدﺎﻔﺘﺳا ﺎﺑ
B/IC
هﺪﺷ ﺪﯿﻟﻮﺗ ﻪﻠﻤﺟ زا ،ﺪﻧا
Chikungunya
و ﯽﮑﯾ .HIV
ﻢﺘﺴﯿﺳ ﻦﯾا ﯽﻠﺻا ﺐﯾﺎﻌﻣ زا ﻦﯾا
ﺖﺳا سوﺮﯾﻮﻟﻮﮐﺎﺑ ﻪﮐ ﺎﺑ نﺎﻣﺰﻤﻫ هﺪﺷ هداد ﺶﺷﻮﭘ يﺎﻫ
VLP
ﯽﻣ ﺪﯿﻟﻮﺗ ﺺﻟﺎﺧ و ﺪﻧﻮﺷ و هدﺮﮐ ﺮﺗراﻮﺷد ﻪﻠﺣﺮﻣ ﮏﯾ ار نآ يزﺎﺳ
ﺖﺳا ﺮﺑ ﻪﻨﯾﺰﻫ ﻪﻠﺣﺮﻣ ﻦﯾا )
26-28 ( ﻢﺘﺴﯿﺳ ﺮﺿﺎﺣ لﺎﺣ رد . يﺎﻫ
ﺪﯿﻟﻮﺗ ياﺮﺑ يﺮﮕﯾد ﺎﻫVLP
ﻢﺘﺴﯿﺳ فﻼﺧﺮﺑ ﻪﮐ دراد دﻮﺟو
ﺑ نآ رد ﻦﯿﺌﺗوﺮﭘ يزﺎﺳ ﺺﻟﺎﺧ ،سوﺮﯾوﻮﻟﻮﮐﺎ .ﺖﺳا ﺖﺣار ﺎﻫ
هدر
ﯽﻣ راﺪﯾﺎﭘ ﯽﻟﻮﻠﺳ ﺮﻈﻧ درﻮﻣ ﻦﯿﺌﺗوﺮﭘ نآ رد ﻪﮐ ﺪﻧﻮﺷ ﺪﯿﻟﻮﺗ ﺪﻨﻧاﻮﺗ
ﯽﻣ نﺎﯿﺑ مواﺪﻣ رﻮﻃ ﻪﺑ دﻮﺷ
. HIV-1 VLP
لﻮﻠﺳ ﻂﺳﻮﺗ ﺎﻫ يﺎﻫ
Drosophila S2
ﯽﻣ ﺪﯿﻟﻮﺗ راﺪﯾﺎﭘ رﻮﻃ ﻪﺑ ﺪﻧﻮﺷ
)7 (.
لﻮﻠﺳ نﺎﯿﺑ ﻢﺘﺴﯿﺳ ناراﺪﻧﺎﺘﺴﭘ يﺎﻫ
ﺗ هﺪﯿﭽﯿﭘ ﻪﻤﺟﺮﺗ زا ﺲﭘ تاﺮﯿﯿﻐﺗ مﺎﺠﻧا ﯽﯾﺎﻧاﻮ يور ﺮﺑ
ﻦﯿﺌﺗوﺮﭘ ﻢﺘﺴﯿﺳ ﯽﻠﺻا ﺖﯾﺰﻣ ﺐﯿﮐﺮﺗﻮﻧ يﺎﻫ لﻮﻠﺳ ﯽﻧﺎﯿﺑ يﺎﻫ
ﺖﺳا نﺎﮔﺪﻧﺮﭘ و ناراﺪﻧﺎﺘﺴﭘ .
،لﺎﺣ ﻦﯾا ﺎﺑ ﻪﻨﯾﺰﻫ
ﺑ ﺪﯿﻟﻮﺗ يﺎﻫ ﺎﻻ
و
ﯽﻧاﺮﮕﻧ ﺶﻟﺎﭼ ﮏﯾ ناﻮﻨﻋ ﻪﺑ هﻮﻘﻟﺎﺑ ﯽﻨﻤﯾا يﺎﻫ دﻮﺟو نﺎﻨﭽﻤﻫ
د درا . ﺪﻨﻧﺎﻤﻫ ﻢﺘﺴﯿﺳ ﺮﮕﯾد لﻮﻠﺳ ،ﺐﯿﮐﺮﺗﻮﻧ ﯽﻧﺎﯿﺑ يﺎﻫ
يﺎﻫ
هﺪﻨﯾاﺰﻓ رﻮﻃ ﻪﺑ ناراﺪﻧﺎﺘﺴﭘ ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ياﺮﺑ يا
ﺐﻠﻃواد يﺎﻫ
ﺮﺑ ﯽﻨﺘﺒﻣ
VLP
ﻪﻋﻮﻤﺠﻣ ﺮﺑاﺮﺑ رد يرﺎﻤﯿﺑ ﻞﻣاﻮﻋ زا يا
هدﺎﻔﺘﺳا از
ﯽﻣ ﺪﻧﻮﺷ ) 29،30 ( لﻮﻠﺳ ﻪﭼ ﺮﮔا . يﺮﺘﻤﮐ ناﺰﯿﻣ ناراﺪﻧﺎﺘﺴﭘ يﺎﻫ
ﺮﯾﺎﺳ ﻪﺑ ﺖﺒﺴﻧ ﺮﻈﻧ درﻮﻣ ﻦﯿﺌﺗوﺮﭘ زا ﻢﺘﺴﯿﺳ
ﯽﻣ ﺪﯿﻟﻮﺗ ﺎﻫ ،ﺪﻨﻨﮐ
نآ ﺎﻣا ﻪﻤﺟﺮﺗ زا ﺲﭘ تاﺮﯿﯿﻐﺗ دﺎﺠﯾا ﯽﯾﺎﻧاﻮﺗ ﺎﻫ هﺪﯿﭽﯿﭘ
و ﺮﺗ
ﻖﯿﻗد ) ﺪﻧراد ار يﺮﺗ 13
لﻮﻠﺳ ،ﺖﻠﻋ ﻦﯿﻤﻫ ﻪﺑ .(
ناراﺪﻧﺎﺘﺴﭘ يﺎﻫ
ًﻻﻮﻤﻌﻣ ﺪﯿﻟﻮﺗ ياﺮﺑ ﻦﯾﺪﻨﭼ ﺎﺑ هﺪﺷ هداد ﺶﺷﻮﭘ يﺎﻫVLP
ﯽﻣ هدﺎﻔﺘﺳا ﻒﻠﺘﺨﻣ يرﺎﺘﺧﺎﺳ ﻦﯿﺌﺗوﺮﭘ ﺪﻧﻮﺷ
ﻦﯾﺪﻨﭼ .
هدر
لﻮﻠﺳ زا ﯽﻟﻮﻠﺳ ﺘﺴﭘ يﺎﻫ
وﺮﭘ ﺪﯿﻟﻮﺗ ياﺮﺑ ناراﺪﻧﺎ ﺐﯿﮐﺮﺗﻮﻧ ﻦﯿﺌﺗ
نوﺪﺑ ﯽﯾﺎﯿﻤﯿﺷ لﻮﻠﺤﻣ رد ﺪﺷر ياﺮﺑ و ﺪﻨﺘﺴﻫ سﺮﺘﺳد رد هﺪﺷ رﺎﮔزﺎﺳ مﺮﺳ ﺪﻧا
) 31-33 (
.
نﺎﻫﺎﯿﮔ نﺎﯿﺑ ﻢﺘﺴﯿﺳ ﺪﯿﻟﻮﺗ ياﺮﺑ يدﺎﯾز ﻞﯿﺴﻧﺎﺘﭘ نﺎﻫﺎﯿﮔ ﻪﺘﺷﺬﮔ ﻪﻫد ود لﻮﻃ رد
ﻌﻨﺻ فاﺪﻫا ﺖﻬﺟ ﺐﯿﮐﺮﺗﻮﻧ يﺎﻫ ﻦﯿﺌﺗوﺮﭘ ﻪﻠﻤﺟ زا ﯽﯾوراد ﺎﯾ ﯽﺘ
ﺪﯿﻟﻮﺗ هداد نﺎﺸﻧ ﻦﺴﮐاو ﺪﻧا
) 34 , 35 ( ﻢﺘﺴﯿﺳ ناﻮﻨﻋ ﻪﺑ .
ﻞﻣﺎﻋ ﻢﺘﺴﯿﺳ ،ﺪﯿﻟﻮﺗ يﺎﻫ سﺎﯿﻘﻣ رﺎﯿﺴﺑ ،ﻊﯾﺮﺳ ﯽﻫﺎﯿﮔ نﺎﯿﺑ يﺎﻫ
يرﺎﻤﯿﺑ ﻞﻣاﻮﻋ زا يرﺎﻋ و ﻪﻓﺮﺻ ﻪﺑ نوﺮﻘﻣ ،ﺮﯾﺬﭘ ناراﺪﻧﺎﺘﺴﭘ ياز
ﯽﻣ ﺪﻨﺷﺎﺑ ) 36-39 ( ﻋ . ﻼ ﻢﻫﺮﺳ ،ﻦﯿﺌﺗوﺮﭘ رﺎﺘﺧﺎﺳ ،ﻦﯾا ﺮﺑ هو
ﮔ رد ﻪﻤﺟﺮﺗ زا ﺲﭘ تاﺮﯿﯿﻐﺗ و يﺪﻨﺑ نآ ﻪﺑ ﻪﯿﺒﺷ نﺎﻫﺎﯿ
ﯽﯾﺎﻫ
لﻮﻠﺳ رد ﻪﮐ ﺖﺳا ﯽﻣ ناراﺪﻧﺎﺘﺴﭘ يﺎﻫ
ﺪﺷﺎﺑ ) 40-42 ( . ﺎﺑ ﻪﺑﺎﺸﻣ
لﻮﻠﺳ ﯽﻣ نﺎﻫﺎﯿﮔ ،ﺮﻤﺨﻣ و تاﺮﺸﺣ ،ناراﺪﻧﺎﺘﺴﭘ يﺎﻫ ياﺮﺑ ﺪﻨﻧاﻮﺗ
عﻮﻧ ود ﺮﻫ ﺪﯿﻟﻮﺗ ﺶﺷﻮﭘ يﺎﻫVLP
ﺶﺷﻮﭘ ﺮﯿﻏ و راد راد
هدﺎﻔﺘﺳا
.ﺪﻧﻮﺷ ﻦﺴﮐاو عﻮﻧ ود ﺮﻫ ﺎﻫ
ي ﺐﻠﻃواد ﺶﺷﻮﭘ VLP
ﺮﯿﻏ و راد
ﺶﺷﻮﭘ ﻂﯾاﺮﺷ ﺖﺤﺗ ﻊﯿﺳو سﺎﯿﻘﻣ رد هﺎﯿﮔ رد راد ﺐﺳﺎﻨﻣ
ﺪﯿﻟﻮﺗ
هﺪﺷ ﻪﻠﺣﺮﻣ ﻪﺑ و ﺪﻧا تﺎﺸﯾﺎﻣزآ
ﯽﻨﯿﻟﺎﺑ ﻪﻌﺳﻮﺗ ﻪﺘﻓﺎﯾ ﺪﻧا ) 43-45 ( .
ًﻻﻮﻤﻌﻣ هﺎﯿﮔ رد صﺎﺧ ﻦﯿﺌﺗوﺮﭘ ﮏﯾ ﺪﯿﻟﻮﺗ و نﺎﯿﺑ ياﺮﺑ يﺮﺘﮐﺎﺑ زا
ﯽﻫﺎﯿﮔ
Agrobacterium tumefaciens
ا ﯽﻣ هدﺎﻔﺘﺳ ﻦﯾا .دﻮﺷ
يﺮﺘﮐﺎﺑ ﯽﻣ لﻮﻠﺳ ﺪﻧاﻮﺗ ﻪﺑ ار ﯽﺻﺎﺧ نژ و هدﻮﻟآ ار ﯽﻫﺎﯿﮔ يﺎﻫ
ﺪﻨﮐ دراو ﯽﻫﺎﯿﮔ نﺎﺑﺰﯿﻣ )
46 ( ﻪﻧﻮﻤﻧ نﻮﻨﮐ ﺎﺗ . زا يدﺪﻌﺘﻣ يﺎﻫ
ﺪﻨﻧﺎﻣ) ﻒﻠﺘﺨﻣ يﺎﻫVLP
،اﺰﻧﻻﻮﻔﻧآ ،HPV
،HBV SARS-
CoV-2
( رد ﻢﺘﺴﯿﺳ ﻦﯾا ﮏﻤﮐ ﻪﺑ ﺖﺳا هﺪﺷ ﺪﯿﻟﻮﺗ نﺎﻫﺎﯿﮔ
) 5 (.
سوﺮﯾو زا هدﺎﻔﺘﺳا ﯽﻫﺎﯿﮔ يﺎﻫ
سوﺮﯾو تارذ ) ﺐﯿﮐﺮﺗﻮﻧ ﯽﻫﺎﯿﮔ يﺎﻫ
Recombinant plant
virus particles; rPVPs
راﺮﻗ ﻪﻌﻟﺎﻄﻣ درﻮﻣ ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ياﺮﺑ ( ﻪﺘﻓﺮﮔ
نآ .ﺪﻧا ﯽﻣ ﺎﻫ ا ﻪﻋﻮﻤﺠﻣﺮﯾز ﮏﯾ ناﻮﻨﻋ ﻪﺑ ﺪﻨﻧاﻮﺗ ز
VLP
ﻪﻘﺒﻃ رد ﻪﮐ ﺪﻨﺘﺴﻫ ﯽﺳوﺮﯾو تارذ ﺎﻬﻧآ اﺮﯾز ،ﺪﻧﻮﺷ يﺪﻨﺑ
ﯽﻤﻧ يرﺎﻤﯿﺑ دﺎﺠﯾا ناراﺪﻧﺎﺘﺴﭘ ﺪﻨﻨﮐ
ﺐﻠﻏا ،لﺎﺣ ﻦﯾا ﺎﺑ. rPVP
ﺎﻫ
ﯽﻣ ﻆﻔﺣ ار نﺎﻫﺎﯿﮔ رد ﺮﯿﺜﮑﺗ هﻮﻘﻟﺎﺑ ناﻮﺗ زا ﻪﻠﺌﺴﻣ ﻦﯾا و ﺪﻨﻨﮐ
ﺶﻟﺎﭼ دﺎﺠﯾا ﺚﻋﺎﺑ ﯽﻓﺮﻃ ﯽﻣ ﯽﻄﯿﺤﻣ ﺖﺴﯾز و ﯽﺘﯿﻨﻣا يﺎﻫ
دﻮﺷ
ﻮﺴﺤﻣ ﺖﯿﯾﺰﻣ ﮏﯾ ﻦﯾا ﺮﮕﯾد فﺮﻃ زا و ﻦﯾا اﺮﯾز ﺪﺷ ﺪﻫاﻮﺧ ب
زا عﻮﻧ ﻦﯾا نﺎﺳآ و ﻊﯾﺮﺳ ﺪﯿﻟﻮﺗ ياﺮﺑ ار نﺎﮑﻣا ﻢﺠﺣ رد ار ﺎﻫVLP
ﯽﻣ ﻻﺎﺑ ﺪﻫد ،دﻮﺟو ﻦﯾا ﺎﺑ.
ﻪﻤﻫ يارادrPVP
يﺎﯾاﺰﻣ ي ﺎﻫVLP
ﻦﺴﮐاو ﺪﯿﻟﻮﺗ نﺎﮑﻣا ﻪﺠﯿﺘﻧ رد و ﺖﺳا ﯽﻣ ﻢﻫاﺮﻓ ار ﺮﺛﺆﻣ يﺎﻫ
دروآ
.
سوﺮﯾو زا يرﺎﯿﺴﺑ ﺪﻨﻧﺎﻣ ﯽﻫﺎﯿﮔ يﺎﻫ
tobacco mosaic virus
،
cowpea mosaic virus
،
potato virus X
،
alfalfa mosaic
virus
،
papaya mosaic virus
ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ياﺮﺑ ﺮﺿﺎﺣ لﺎﺣ رد
ﯽﻣ راﺮﻗ هدﺎﻔﺘﺳا درﻮﻣ لوﺪﺟ) ﺪﻧﺮﯿﮔ
2 ( ) 47،48 ( .
لوﺪﺟ 2 . ﻪﯿﻬﺗ ياﺮﺑ هﺪﺷ هدﺎﻔﺘﺳا يﺎﻫrPVP .ﻦﺴﮐاو ي
وﯾ سوﺮ ﮑﺷ
ﻞ ﺎﻫﺮﺘﻣارﺎﭘ
ي ﺖﺴﺗ هﺪﺷ
Cowpea Mosaic Virus; CPMV ﯽﻬﺟو ﺪﻨﭼ
لارﻮﻣﻮﻫ ﺦﺳﺎﭘ ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ
يزﺎﺳ ﻦﻤﯾا
Potato Virus X; PVX ﻪﻠﯿﻣ
يا لارﻮﻣﻮﻫ ﺦﺳﺎﭘ
ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ يزﺎﺳ ﻦﻤﯾا
Tobacco Mosaic Virus; TMV ﻪﻠﯿﻣ
يا لارﻮﻣﻮﻫ ﺦﺳﺎﭘ
ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ يزﺎﺳ ﻦﻤﯾا
Cucumber Mosaic Virus; CMV ﯽﻬﺟو ﺪﻨﭼ
لارﻮﻣﻮﻫ ﺦﺳﺎﭘ ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ
Alstroemeria Mosaic Virus; ALMV ﯽﻬﺟو ﺪﻨﭼ
لارﻮﻣﻮﻫ ﺦﺳﺎﭘ ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ
Papaya Mosaic Virus; PapMV ﻪﻠﯿﻣ
يا لارﻮﻣﻮﻫ ﺦﺳﺎﭘ
ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ يزﺎﺳ ﻦﻤﯾا ﺖﻧاﻮﺟدا
Bamboo Mosaic Virus; BaMV ﻪﻠﯿﻣ
لارﻮﻣﻮﻫ ﺦﺳﺎﭘ يا ﯽﻟﻮﻠﺳ ﺦﺳﺎﭘ
Tomato Bushy Stunt Virus; TBSV ﯽﻬﺟو ﺪﻨﭼ
لارﻮﻣﻮﻫ ﺦﺳﺎﭘ
Plum Pox Virus; PPV ﻪﻠﯿﻣ
يا لارﻮﻣﻮﻫ ﺦﺳﺎﭘ
ًﻻﻮﻤﻌﻣ سوﺮﯾو ﻪﻠﯿﻣ ﯽﻫﺎﯿﮔ يﺎﻫ نرﺎﻘﺘﻣ ،ﻞﮑﺷ يا
(ﯽﻬﺟو ﺖﺴﯿﺑ) نآ .ﺪﻨﺘﺴﻫ هدﺎﺳ و
ﻦﯿﺌﺗوﺮﭘ ود ﺎﯾ ﮏﯾ ﺎﻫ
ﯽﻨﯿﺌﺗوﺮﭘ ﺶﺷﻮﭘ هﺪﺷ راﺮﮑﺗ )
; CP oat protein
(C
ﮏﯾ و
مﻮﻧژ
RNA
ﺪﻧراد سوﺮﯾو ﻦﯾا .
ًﺎﺘﺒﺴﻧ ﺎﻫ ﯽﺳﺪﻨﻬﻣ نﺎﺳآ
ﯽﻣ ﻪﮐ ،ﺪﻨﺘﺴﻫ راﺪﯾﺎﭘ رﺎﯿﺴﺑ و ﺪﻧراد ﻢﮐ ﺪﯿﻟﻮﺗ ﻪﻨﯾﺰﻫ ،ﺪﻧﻮﺷ
ﻪﮕﻧ نﺎﮑﻣا ﯽﻣ ﻢﻫاﺮﻓ ار قﺎﺗا يﺎﻣد رد يراد
ﻦﯾا ،ﺪﻨﮐ
ﺖﯾﺰﻣ ﺎﻫ ﻪﻌﺳﻮﺗ لﺎﺣ رد يﺎﻫرﻮﺸﮐ رد نﻮﯿﺳﺎﻨﯿﺴﮐاو ياﺮﺑ
ﺖﺳا بﻮﻠﻄﻣ )
49 ( .
ﻞﮑﺷ 1.
ﺮﺑ ﯽﻨﺘﺒﻣ ﻒﻠﺘﺨﻣ يﺎﻫدﺮﺑرﺎﮐ VNPs/VLPs
ﺎﻫ ﻦﺴﮐاو ﻪﯿﻬﺗ و ورادﻮﻧﺎﻧ ،ﻮﻧﺎﻧ يروﺎﻨﻓ رد )
50 (.
ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ ﻪﯾﺎﭘ ﺮﺑ ﻦﺴﮐاو ﺖﺧﺎﺳ ﯾﮑ ﯽ ﺮﺘﻤﻬﻣ زا ﯾ ﻦ ﺻﻮﺼﺧ ﯿ تﺎ ﺗ ،ﺎﻫVLP
ﺎﻧاﻮ ﯽﯾ ﻠﻘﺗ ﯿ ﺪ زا
ﺎﻫرﺎﺘﺧﺎﺳ ي ﯽﻟﻮﮑﻟﻮﻣ ﺖﺷرد و
ﯾ سوﺮ ا ﺦﺳﺎﭘ ءﺎﻘﻟا و ﺎﻫ ﯾ
ﻨﻤ ﯽ
ﻮﻗ ي ﻪﮐ ﺖﺳا ناراﺪﻧﺎﺘﺴﭘ رد ﻨﻤﯾا ﺎﺑ ﻪﺴﯾﺎﻘﻣ ﻞﺑﺎﻗ ﻦﯾا
ﯽ
سوﺮﯾو ﻂﺳﻮﺗ هﺪﺷ ءﺎﻘﻟا ﯽﻣ ﯽﻌﯿﺒﻃ هﺪﻨﻨﮐ هدﻮﻟآ يﺎﻫ
ﺪﺷﺎﺑ
) 18،51 ( . نآ ﺖﻫﺎﺒﺷ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ و ﺎﺑ ﺎﻫ
ﯾ سوﺮ ﺎﻫ ي ﺒﻃ ﯿﻌ ﯽ
هﻮﺤﻧ ،هزاﺪﻧا و ﻞﮑﺷ ﺮﻈﻧ زا ي
ارآ ﯾ ﺶ ز ﯾ ﺎﻫﺪﺣاوﺮ ي ﺌﺗوﺮﭘ ﯿﻨ ﯽ
ﻪﺋارا و ي ﭘا ﯽ پﻮﺗ ﺎﻫ ي اﯾ ﻨﻤ ﯽ ﺢﻄﺳ رد از
، VLP
تارذ ﻦﯾا
ﻧﯿ ﺰ و ﺪﻨﻧﺎﻤﻫ ﯾ
سوﺮ ﺎﻫ ي ﺒﻃ ﯿﻌ ﯽ ءﺎﻘﻟا ﻪﺑ ردﺎﻗ ﺦﺳﺎﭘ
ﺎﻫ ي
اﯾ ﻨﻤ ﯽ ﻟﻮﻠﺳ ﯽ نوﺪﺑ لارﻮﻣﻮﻫ و هدﺎﻔﺘﺳا
زا لﻮﮑﻟﻮﻣ يﺎﻫ
ﻤﮐ ﯽﮑ .ﺪﻨﺘﺴﻫ ﺑﯿ
ﺮﺘﺸ ﺮﺛا ﺸﺨﺑ ﯽ اﯾ ﻨﻤ ﯽ ﺻﻮﺼﺧ ﻪﺑ ﺎﻫVLP
ﯿ تﺎ
ﺖﺨﯾر ﯽﺳﺎﻨﺷ نآ ﻣ طﻮﺑﺮﻣ (ﻞﮑﺷ و هزاﺪﻧا) ﺎﻫ ﯽ
و دﻮﺷ
ﺘﻧ ﯿ ﻪﺠ ي ﺮﺛﺆﻣ بﺬﺟ نآ ﻂﺳﻮﺗ
لﻮﻠﺳ ﺎﻫ ي هﺪﻨﻫد ﻪﺋارا
ﯽﺘﻧآ نژ ﺑ،
ﻪ وﯾ هﮋ لﻮﻠﺳ ﺎﻫ ي رﺪﻧد ﯾﺘ ﮏﯿ ﻣ ﯽ ﺪﺷﺎﺑ هوﻼﻋ .
ﺮﺑ
اﯾ ﻦ د فﻼﺧ ﺮﺑ ، ﯾ
ﺮﮕ ﺘﻧآ ﯽ نژ ﺎﻫ ي ﯽﺟرﺎﺧ
، ﻤﻧ ﻪﮐ ﯽ ﻪﺑ ﺪﻨﻧاﻮﺗ
ﺴﻣ ﯿﺮ ﻤﺠﻣ رﺎﮔزﺎﺳ ﻪﻋﻮ ي
ﺘﻓﺎﺑ ﯽ ﻠﺻا ﯽ سﻼﮐ )
Major -
histocompatibility complex; MHC
( ،ﺪﻨﺳﺮﺑ I
ﯽﺘﻧآ نژ ﺎﻫ ي ﻂﺳﻮﺗ هﺪﺷ ﻪﺋارا ﻟد ﻪﺑ ﺎﻫ VLP
ﯿ ﻞ دﻮﺟو مﺪﻋ
ﺖﻧﻮﻔﻋ ﯾﺎ ﺜﮑﺗ ﯿﺮ ﻟﻮﻠﺳ ﻞﺧاد ﯽ
ﺮﻫ ﺎﺑ طﺎﺒﺗرا رد سﻼﮐ ود
ﺎﻫ ي
، MHC
سﻼﮐ سﻼﮐ وI
ﻣ ﻪﺋاراII
ﯽ ﺪﻧﻮﺷ ) 2،52 (.
ﺳ ﯿ ﻢﺘﺴ اﯾ ﻨﻤ ﯽ نﺪﺑ
، وﯾ سوﺮ و ﺎﻫ ﺎﻫVLP
سﺎﺳا ﺮﺑ ار
ﺻﻮﺼﺧ ﯿ تﺎ ز ﯾﺮ ﺨﺸﺗ ﯿ ﺺ ﻣ ﯽ ﺪﻫد ) 4 ( ﺎﺑ ﻪﮐ ، ﯾﺪ آﺮﻓ رد ﯾ ﺪﻨ
:ﺪﻧﻮﺷ ﻪﺘﻓﺮﮔ ﺮﻈﻧ رد ﻦﺴﮐاو ﺖﺧﺎﺳ 1
( و حﻮﻄﺳ ﯾ ﺳوﺮ ﯽ و
ﺎﻫ VLP
رﺎﺘﺧﺎﺳ ﺮﻈﻧ زا ي
ﺴﺑ ﯿ رﺎ نﺎﻣزﺎﺳ ﯾ ﻪﺘﻓﺎ وﺎﺣ و ﺪﻧا ي
يﺎﻫﺪﯿﺳاﻮﻨﯿﻣآ راﺮﮑﺗ
ي ناراﺰﻫ ﺎﺗ ﺪﺻ ﺪﻨﭼ زا ﻪﮐ ﺪﻨﺘﺴﻫ
لﻮﮑﻟﻮﻣ وCP
ﯾ ﺳوﺮ ﯽ .ﺪﻧا هﺪﺷ ﻪﺘﺧﺎﺳ اﯾ
ﻦ ﺎﻫرﺎﺘﺧﺎﺳ ي
راﺮﮑﺗ ي ﻣ ﯽ ﮔ ﺪﻨﻧاﻮﺗ ﯿ هﺪﻧﺮ ﺎﻫ ي لﻮﻠﺳ ﻞﺼﺘﻣ ﻢﻫ ﻪﺑ ار B
ﺮﺤﺗ ﻪﺑ ﺮﺠﻨﻣ و ،ﺪﻨﻨﮐ ﯾ
ﮏ ﺪﺷ ﯾﺪ ﺎﻫ لﻮﻠﺳ ي ءﺎﻘﻟا و B
ﺦﺳﺎﭘ ﺎﻫ ي ﻧﻻﻮﻃ ﯽ تﺪﻣ ﺘﻧآ ﯽ دﺎﺑ ي ﻣ ﯽ .ﺪﻧﻮﺷ ﺖﺧﺎﺳ ﺮﻈﻧ زا
و تارذ ،ﻦﺴﮐاو ﯾ
ﺳوﺮ ﯽ و ﺎﺑ ﺎﻫ VLP
ﯾﺪ ﯽﺳﺎﻨﺷ ﺖﺨﯾر
وﯾ ﺳوﺮ ﯽ ﻟﻮﻤﻌﻣ ﯽ رﺎﮑﺘﺳد ﻪﻤﻫ زا ﺲﭘ ار دﻮﺧ ي
ﻆﻔﺣ ﺎﻫ
.ﺪﻨﻨﮐ 2 ( ا و ﻞﮑﺷ ، هزاﺪﻧا رﺎﺘﺧﺎﺳ مﺎﮑﺤﺘﺳ
ﯽﯾﺎﻀﻓ ﻦﺴﮐاو
ﻧﯿ ﺰ ﻣ ﯽ ا ﺦﺳﺎﭘ رد ﺪﻧاﻮﺗ ﯾ
ﻨﻤ ﯽ ﺛﺄﺗ ﯿﺮ .دراﺬﮕﺑ و ﯾ سوﺮ و ﺎﻫ
اراد ﺎﻫVLP
ي هزاﺪﻧا ﺎﻫ ي ﻬﺑ ﯿ ﻪﻨ ) 20-200 ﺪﻨﺘﺴﻫ (ﺮﺘﻣﻮﻧﺎﻧ
نآ ﻪﺑ و ﺳ ﻪﺑ دورو هزﺎﺟا ﺎﻫ ﯿ
ﻢﺘﺴ وﺎﻔﻨﻟ ي ﻣ ار ﯽ و ﺪﻨﻫد
لﻮﻠﺳ ﻂﺳﻮﺗ ﺎﻫ
ي هﺪﻨﻫد ﻪﺋارا ﯽﺘﻧآ
نژ ﻣ ﻪﺘﻓﺮﮔ ﯽ .ﺪﻧﻮﺷ اﺮﺑ ي
ﻤﻃا ﯿ نﺎﻨ زا لﺎﻘﺘﻧا رﺎﮐ ﺳ رد ﺪﻣآ ﯿ ﻢﺘﺴ وﺎﻔﻨﻟ ي ﺎﺑ ، ﯾﺪ ﻊﻤﺠﺗ زا
هدﺮﺘﺴﮔ ﺎﻫVLP
زﺎﺳ هدﺎﻣآ رد ي
ﮔﻮﻠﺟ ﻦﺴﮐاو ﯿﺮ
ي .دﻮﺷ
3 ( وﯾ سوﺮ و ﺎﻫ وﺎﺣ ﺎﻫVLP
ي ﺌﻠﮐﻮﻧ ﯿ ﮏ ﺳا ﯿ ﺎﻫﺪ ي
ﯽﺻﺎﺼﺘﺧا ﻣ
ﯿ نﺎﺑﺰ ﻪﮐ ﺪﻨﺘﺴﻫ هﺪﻨﻨﮐ لﺎﻌﻓ
ﮔﯿ هﺪﻧﺮ ﺎﻫ ي
ﻦﻔﻠﺗ - ﺪﻨﻧﺎﻣ لﻮﻠﺳ رد ﯽﺘﻧآ هﺪﻨﻫد ﻪﺋارا يﺎﻫ .ﺪﻨﺘﺴﻫ نژ
رد
،موﺰﻟ ترﻮﺻ ﻣ ﺎﻫVLP
ﯽ ترﻮﺻ ﻪﺑ ﺪﻨﻧاﻮﺗ آ
ﯽﻫﺎﮕﺸﯾﺎﻣز ﺎﺑ
ﯾﺎDNA
ﺪﻧﻮﺷ ﺮﭘ ﺮﻈﻧ درﻮﻣRNA
) 18 (.
ﻢﺘﺴﯿﺳ ﻪﮐ ﯽﻧﺎﻣز زا هﺪﺷ ﯽﻓﺮﻌﻣ ﯽﻫﺎﯿﮔ ﯽﻧﺎﯿﺑ يﺎﻫ
ﺪﻧا
ﻦﯾﺪﻨﭼ نﻮﻨﮐ ﺎﺗ سوﺮﯾو زا VLP
ﻪﻠﻤﺟ زا ﻒﻠﺘﺨﻣ يﺎﻫ
ﺖﯿﺗﺎﭙﻫ سوﺮﯾو سوﺮﯾو ،ﯽﻧﺎﺴﻧا يﺎﻣﻮﻠﯿﭘﺎﭘ سوﺮﯾو ،B
سوﺮﯾو ،اﺰﻧﻻﻮﻔﻧآ ﺪﯾوﻮﮐ
- 19 )
SARS-CoV-2
سوﺮﯾو ،(
كاورﻮﻧ )
Norwalk virus
( و ،نﺎﻫد و ﺎﭘ يرﺎﻤﯿﺑ سوﺮﯾو ،
ﺖﯿﺗﺎﭙﻫ سوﺮﯾو هﺪﺷ ﺪﯿﻟﻮﺗ ﻦﺴﮐاو ﺐﻠﻃواد ناﻮﻨﻋ ﻪﺑ C
ﺖﺳا ) 5 ، 53 ، 54 ( هداد نﺎﺸﻧ ﻪﺳ زﺎﻓ تﺎﺸﯾﺎﻣزآ رد اﺮﯿﺧا .
ﻪﮐ هﺪﺷ ﯽﻫﺎﯿﮔ ﻢﺘﺴﯿﺳ رد ﻪﮐ اﺰﻧﻻﻮﻔﻧآ سوﺮﯾو يﺎﻫVLP
هﺪﺷ ﺪﯿﻟﻮﺗ و ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ،ﺪﻧا
ﻦﺴﮐا ﻪﮐ اﺰﻧﻻﻮﻔﻧآ يرﺎﺠﺗ يﺎﻫ
ﯽﻣ ﺪﯿﻟﻮﺗ غﺮﻣ ﻢﺨﺗ رد رد ار يﺮﺘﻬﺑ ﺖﻈﻓﺎﺤﻣ ،ﺪﻧﻮﺷ
ﯽﻣ دﺎﺠﯾا اﺰﻧﻻﻮﻔﻧآ سوﺮﯾو ﺮﺑاﺮﺑ رد نﻻﺎﺴﮔرﺰﺑ ﺪﻨﻨﮐ
) 55 ( . ﺪﯿﻟﻮﺗ رد ﺖﯿﻘﻓﻮﻣ زا ﺲﭘ
ﻂﺳﻮﺗ اﺰﻧﻻﻮﻔﻧآ سوﺮﯾو يﺎﻫVLP
ﻪﺑﺮﺠﺗ و ﺶﻧاد سﺎﺳا ﺮﺑ ﺖﮐﺮﺷ ﻦﯾا ،ﻮﮔﺎﮑﯾﺪﻣ ﺖﮐﺮﺷ ي
ﺪﯿﻟﻮﺗ ﻪﺑ ماﺪﻗا هﺪﺷ ﺐﺴﮐ يﺎﻫVLP
SARS-CoV-2
رد
ًﻼﻣﺎﮐ ﻞﮑﺷ و هزاﺪﻧا ﺮﻈﻧ زا ﻪﮐ دﺮﮐ هﺎﯿﮔ هﺮﮑﯿﭘ ﻪﺑﺎﺸﻣ
يﺎﻫ
ﯽﻌﯿﺒﻃ
SARS-CoV-2
ﻦﯾا ﻪﮐ ،ﺪﻧدﻮﺑ هﺪﺷ ﺪﯿﻟﻮﺗVLP
ﻪﺑ
ار ﯽﻨﯿﻟﺎﺑ تﺎﺸﯾﺎﻣزآ ﮏﯾ ﻪﻠﺣﺮﻣ ﺐﻠﻃواد ﻦﺴﮐاو ﮏﯾ ناﻮﻨﻋ ﺖﺤﺗ ﺮﺿﺎﺣ لﺎﺣ رد و ﺖﺳا ﻪﺘﺷاﺬﮔ ﺮﺳ ﺖﺸﭘ ﺖﯿﻘﻓﻮﻣ ﺎﺑ ﯽﻣ ﻪﺳ و ود ﻪﻠﺣﺮﻣ ﯽﻨﯿﻟﺎﺑ تﺎﺸﯾﺎﻣزآ ﯽﻨﯿﺑ ﺶﯿﭘ ﻪﮐ ﺪﺷﺎﺑ
ﯽﻣ ناﺰﯿﻣ ﻪﺑ دﻮﺷ 10
ﻦﺴﮐاو عﻮﻧ ﻦﯾا زا هﺎﻣ رد زود نﻮﯿﻠﯿﻣ
دﻮﺷ ﺪﯿﻟﻮﺗ )
54،56 (.
يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
) ﯽﺳوﺮﯾو ﻪﺒﺷ تارذ ﺪﯿﻟﻮﺗ ياﺮﺑ ﯽﻨﺷور هﺪﻨﯾآ (VLP
ﻦﺴﮐاو ﯽﻣ نﺎﺸﻧ ﺎﻣ ﻪﺑ ار ﺪﯾﺪﺟ ﻞﺴﻧ يﺎﻫ ﺪﻨﻫد
نآ.
ﻫ ﻪﯿﺒﺷ ﺎ
ﺪﻨﺘﺴﻫ سوﺮﯾو ﯽﻌﻗاو رﺎﺘﺧﺎﺳ ﯽﻨﻤﯾا ﺦﺳﺎﭘ ﺚﻋﺎﺑ ﻪﮐ
ﯽﻣ ﯽﻟﻮﻠﺳ و لارﻮﻣﻮﻫ ﺪﻧﻮﺷ
نآ ،ﻦﯾا ﺮﺑ هوﻼﻋ.
ﭻﯿﻫ يوﺎﺣ ﺎﻫ
ﯿﺘﻧژ هدﺎﻣ نآ ﯽﮔﮋﯾو ﻦﯾا ﻪﮐ ،ﺪﻨﺘﺴﯿﻧ ﯽﺳوﺮﯾو ﯽﮑ ياﺮﺑ ار ﺎﻫ
و ﺪﻨﺘﺴﻫ ﻦﺴﮐاو ﺎﺑ سﺎﻤﺗ رد ﻪﮐ ﻦﺴﮐاو نﺎﮔﺪﻨﻨﮐ ﺪﯿﻟﻮﺗ ﯽﻣ ﺮﻄﺧ ﯽﺑ ،ﻦﺴﮐاو نﺎﮔﺪﻨﻨﮐ ﺖﻓﺎﯾرد ﺮﻄﺧ اﺮﯾز ،دزﺎﺳ
دراﺪﻧ دﻮﺟو ﯽﻗﺎﻔﺗا ﺖﻧﻮﻔﻋ ﻪﯿﻬﺗ ياﺮﺑ ﯽﻔﻠﺘﺨﻣ يﺎﻫ شور.
ي
شور ﻪﻠﻤﺟ زا دراد دﻮﺟو ﺎﻫVLP
شور ،ﯽﮑﯿﺘﻧژ يﺎﻫ يﺎﻫ
ﯽﻤﯾﺰﻧآ و ﯽﯾﺎﯿﻤﯿﺷ زا هدﺎﻔﺘﺳا شور و ﯽﮑﯾﺰﯿﻓ يﺎﻫ شور ،
عﻮﻧ سﺎﺳا ﺮﺑ ﯽﻧﺎﯿﺑ يﺎﻫ ﻢﺘﺴﯿﺳ ﻪﮐ ﯽﻧﺎﯿﺑ يﺎﻫ ﻢﺘﺴﯿﺳ زا ﯽﻔﻠﺘﺨﻣ يﺎﻫ شور ﻞﻣﺎﺷ دﻮﺧ هدﺎﻔﺘﺳا درﻮﻣ يﺎﻫ لﻮﻠﺳ ،ﺎﻫﺮﻤﺨﻣ ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ ،ﺎﻫ يﺮﺘﮐﺎﺑ ﯽﻧﺎﯿﺑ يﺎﻫ ﻢﺘﺴﯿﺳ ﻪﻠﻤﺟ يﺎﻫ لﻮﻠﺳ ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ ،تاﺮﺸﺣ لﻮﻠﺳ ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ ﻫﺎﯿﮔ ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ و ناراﺪﻧﺎﺘﺴﭘ ﺎﻫ شور ﻦﯾا زا ماﺪﮐﺮﻫ .نﺎ
ﻢﺘﺴﯿﺳ ﯽﯾﺎﻬﻧ بﺎﺨﺘﻧا و ﺪﻨﺘﺴﻫ ﺰﯿﻧ ﯽﺒﯾﺎﻌﻣ و ﺎﯾاﺰﻣ ياراد ﯽﮔﮋﯾو ﻪﺑ نﺎﯿﺑ نﻮﻨﮐ ﺎﺗ .دراد ﯽﮕﺘﺴﺑ زﺎﯿﻧ درﻮﻣ ﻦﺴﮐاو يﺎﻫ
سﺎﺳا ﺮﺑ ﻪﮐ ﯽﺑﻮﺧ يرﺎﺠﺗ يﺎﻫ ﻦﺴﮐاو هﺪﺷ ﻪﺘﺧﺎﺳ ﺎﻫVLP
ﻞﺜﻣ ﺖﺳا هﺪﺷ رازﺎﺑ دراو ،ﺪﻧا
Recombivax®
،
Energix®
،
Gardasil®
و
™
Cervarix
د ﻪﮐ نﺎﯿﺑ ﻖﯾﺮﻃ زا لوا يﺎﺗو
يﺎﻫVLP
نﺎﯿﺑ ﻖﯾﺮﻃ زا يﺪﻌﺑ ﻦﺴﮐاو ود وHBV
يﺎﻫVLP
ﻢﺘﺴﯿﺳ ردHPV
لﻮﻠﺳ و يﺮﻤﺨﻣ ﯽﻧﺎﯿﺑ يﺎﻫ هﺮﺸﺣ يﺎﻫ
يا
هﺪﺷ ﺪﯿﻟﻮﺗ ﺪﻧا
) 5 ( ﻪﻤﻫ رد . ﺎﻧوﺮﮐ سوﺮﯾو ﻪﺑ طﻮﺑﺮﻣ يﺮﯿﮔ
ﺷﺰﮐﺮﻤﺗ ﻮﮔﺎﮑﯾﺪﻣ ﺖﮐﺮﺷ ﻪﻠﻤﺟ زا گرﺰﺑ ﺖﮐﺮﺷ ﻦﯾﺪﻨﭼ نﺎ
ﺪﯿﻟﻮﺗ ﺮﺑ نآ زا ﯽﺧﺮﺑ و هدﻮﺑ سوﺮﯾو VLP
تﺎﺸﯾﺎﻣزآ ﺎﻫ
هدﺮﮐ يﺮﭙﺳ ﺖﯿﻘﻓﻮﻣ ﺎﺑ ار دﻮﺧ ﯽﻨﯿﻟﺎﺑ ﺪﻧا
) 54 ( ﻦﯾا ﻪﮐ ،
ﯽﻣ نﺎﺸﻧ ﺖﯿﻘﻓﻮﻣ ﯽﻣ ﻦﺴﮐاو ﺪﯿﻟﻮﺗ ﻢﺘﺴﯿﺳ ﻦﯾا ﺪﻫد
ﺎﺗ ﺪﻧاﻮﺗ
ﻘﻧ ﯽﺘﺣ و ﻦﯿﻣﺎﺗ ار ﻦﺴﮐاو زﺎﯿﻧ يدﺎﯾز دوﺪﺣ ﺺ
يﺎﻫ
ﻦﺴﮐاو ﻦﺴﮐاو ﺪﻨﭼﺮﻫ .دزﺎﺳ فﺮﻃﺮﺑ ار ﯽﻠﺒﻗ يﺎﻫ ﻪﮐ يﺎﻫ
هﺪﺷ ﺪﯿﻟﻮﺗ نﻮﻨﮐﺎﺗ هدﺮﮐ ﻞﻤﻋ ﯽﺑﻮﺧ ﻪﺑ ﺪﻧا
ناﺪﻨﻤﺸﻧاد ﺎﻣا ،ﺪﻧا
ﻢﺘﺴﯿﺳ ﻦﯾﺮﺘﻬﺑ لﺎﺒﻧد ﻪﺑ ﻪﺸﯿﻤﻫ ﺪﯿﻟﻮﺗ و نﺎﯿﺑ ياﺮﺑ ﺎﻫ
ﻦﺴﮐاو هدﻮﺑ ﺎﻫ ﻪﻨﯾﺰﻫ ﺮﻈﻧ زا ﻪﭼ ،ﺪﻧا ﺮﻈﻧ زا ﻪﭼ و ﺪﯿﻟﻮﺗ يﺎﻫ
ﻪﻫد رد .يروآﺮﻓ و ﺪﯿﻟﻮﺗ ﯽﮔدﺎﺳ ﺳ ﻪﺘﺷﺬﮔ ي
نﺎﯿﺑ ﻢﺘﺴﯿ
ﯽﮔﮋﯾو ﻞﯿﻟد ﻪﺑ ﯽﻫﺎﯿﮔ ﻪﺘﻓﺮﮔ راﺮﻗ ﻪﺟﻮﺗ درﻮﻣ صﺎﺧ يﺎﻫ
ﺪﻧا
ﯽﻣ ﺮﻈﻧ ﻪﺑ و هﺪﻨﯾآ رد ﺪﺳر
زا ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ ﻢﺠﺣ ﮏﯾدﺰﻧ يا
ﻦﺴﮐاو ﻦﯿﺌﺗوﺮﭘ و ﺎﻫ ﯽﻧﺎﯿﺑ ﻢﺘﺴﯿﺳ ﻦﯾا رد ﺐﯿﮐﺮﺗﻮﻧ يﺎﻫ
.ﺪﺷ ﺪﻫاﻮﺧ ﺪﯿﻟﻮﺗ
ﺮﮑﺸﺗ ﯽﻧادرﺪﻗ و
هﺎﯿﮔ هوﺮﮔ زا ﻪﻠﯿﺳﻮﻨﯾﺪﺑ ﺮﯿﺷ هﺎﮕﺸﻧاد ﯽﮑﺷﺰﭘ
ﺮﮔ و زا هو
ﺑ ﯽﻤﯿﺷﻮﯿﺑ هﺎﮕﺸﻧاد ﯽﻨﯿﻟﺎ
زاﺮﯿﺷ ﯽﮑﺷﺰﭘ مﻮﻠﻋ ﺮﻃﺎﺧ ﻪﺑ
ﺖﯾﺎﻤﺣ ﺎﻫ مزﻻ ي ﺮﮑﺸﺗ و ﺮﯾﺪﻘﺗ ﻪﺑ
ﯽﻣ ﻞﻤﻋ ﺪﯾآ .
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Employment of virus-like particles in vaccines production
Hemmati-Dinarvand F1, Malekshahi A2, Afsharifar A3, Hemmati-Dinarvand M4*
1. PhD Student of Plant Virology, Plant Virology Research Center, College of Agriculture, Shiraz University, Shiraz, Iran
2. MSc of Medical Virology, Department of Medical Virology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
3.Professor of Plant Virology, Plant Virology Research Center, College of Agriculture, Shiraz University, Shiraz, Iran 4. PhD Studen of Clinical Biochemistry, Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, [email protected].
Received: 4 Sep 2021 Accepted: 24 Nov 2021
Abstract
Background: Virus-Like Particles (VLPs) are nanostructures that are similar to their native virus in shape, size, and other morphological features, except that virus-like particles lack a genome.
Virus-Like Particles cause a high humoral and cellular immune response due to repetitive structures in their body. Therefore, the use of these particles increases the body's immunity during production and consumption because they lack genomic materials. Several systems may be used to generate VLPs. The choice of production platform depends on several factors, including cost and the need for Post-Translational Modifications that may be necessary to generate an optimal immune response. In addition, plant viruses, due to their structure, are well able to stimulate the mammalian immune system; on the other hand, since they are not able to infect mammals, they can be considered a subset of VLPs. Some VLP-based vaccines and plant viruses have been designed and tested to prevent several infectious diseases; however, some are in the clinical or research phase.
Interest in using VLPs to produce vaccines has recently increased due to its advantages over conventional vaccines. In this review, an attempt has been made to compare the advantages and disadvantages of VLP production systems.
Keywords: Expression system, Plant virus, Vaccine, Virus-Like Particle.
*Citation: Hemmati-Dinarvand F, Malekshahi A, Afsharifar A, Hemmati-Dinarvand M. Comparison of virus-like particles (VLPs) in the production vaccines. Yafte. 2022; 23(5):52-64.