nblib.library.kz - /elib/library.kz/jurnal/b_2006_1/

. 2006. 1

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1,1-

IN VITRO

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74,7 %.

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1,1- -

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0,65

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5%.

1,1- 130 -

79%,

650 -

– 82%.

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65 130 -

– 3,9 33,5% .

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. 2006. 1

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– , %

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, 1,1-

26 69,7% -

, 65

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130 650 .

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1,1- -

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-451.2 ISNC.

1. ., ., ., -

,. . -

- // . . 2001. 1(21). .54-56.

2. ., ., . .

- // . .134-137.

3. Hess E.V. Environmental chemicals and autoimmune disease:

cause and effect // Toxicology. 2002. V.181-182. P.65-70.

4. Zelnick SD., Mattie DR., Stepaniak PC. Occupational exposure to hydrazines: treatment of acute central nervous system toxicity // Aviat Space Environ Med. 2003. V.74, N 12. P.1285- 1291.

5. Choudhary G., Hansen H., Links. Human health perspective on environmental exposure to hydrazines: a review // Chemosphere.

1998. V. 37, N 5. .801-843.

6. Morgenstern H., Ritz B. Effects of radiation and chemical exposures on cancer mortality among Rocketdyne workers: a review of three cohort studies // Occup Med. 2001. V.16, N 2. P.219-237.

7. . . .: , 1982.

192 .

. 2006. 1

8. ., .

. .: , 1989.

272 .

9. ., ., . -

// . . 2001. 1(21). .67-69.

10. ., .

( ) -

// .

1982. .54, 2. .59-62.

11. ., ., . -

// . 1991. 10. .9-13.

12. .X.

.

-

// . 1990. .53, 1. .70-73.

1,1- (1,1- )

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, i

. Summary

In fluen ce of 1 ,1-dimethylhydrazine (1,1 -DMH) on the hemolysis in isotonic and hypotonic environments, peroxyde resistance of red blood cells, permeability of erythrocyte membranes, activity of catalase of erythrocytes has been investigated at in vitro conditions. Increasing of hemolysis in isotonic and hypotonic solutions of sodium chloride under action of toxicant was shown. It is established that low concentrations of 1,1-DMH decrease permeability of eryth rocyte membran es, in crease peroxyde resistance of erythrocyte and activity of catalase of red blood cells, and high concentrations cause opposite effects.

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