nblib.library.kz - /elib/library.kz/jurnal/v_2007_2/

28

2007. 2

- - // . . . 1984. . 58, 10. . 2597-2599.

6. Demarco P.V., Parkas E., Doddrell D.et al. Pyridine induced solvent shifts in the nuclear magnetic resonance spectra of hydroxylic compounds // J. Amer. Chem. Soc. 1968. V. 90.

P. 5480-5486.

7. ., . 1,1- -

4- -2- -1 // . . .

1960. . 30. . 1197-1202.

8. ., .

1,2- -4- -4-

// . . . . 1969. 2. . 69-74.

i

i 2- -3- -5-

-5- -2- [4.4.0]

.

: -

i

i.

i .

Summary

With the purpose of modification of acetylene alcohol with the participation of a hydroxyl group there has been carried out acetylation of stereoisomeric 2-methyl-3-phenyl-5-ethinyl-5- oxy-2-azabicyclo[4.4.0]decanes. There has been also studied a reaction of Mannich aminomethylation in the solution of dry dioxane in the presence of catalytic quantities of copper (I) chloride with the help of paraform and secondary amines:

diethylamine and piperidine. It has been established that the nature of secondary amines does not produce a significant effect upon the course of the reaction.

547.831.8+547.314

. . . ,

. 13.09.06 .

.

- h.

- -

. -

. - :

r z, -

,

( . .).

r, z -

x, :

a r ,

a

z , (1)

a – , -

-

, . . 5–6 ,

.

z r = a -

,

z, – , z –

. -

h, . .

b – :

h

0

z

2 b

q z

z 2 a

, (

, _z )

29

1

x 1 a

b ,

a

0 h . (2) - - b

₀

b

₃

*, . .:

0

0

2

b ,

²

b

₃

0 . (3)

2 2 2

2

2

1

x

x x . (4)

b

₀

, b

₃

- :

x b x

a b

u

^{0 3}

,

x b x

b b a

w 3 4

₃ ^{0 3}

, (5)

–

2 3 2 2

0 2

2

3

2

x b x

b v b

r

G ,

2 3 2 2

0 2

1

3

2 2

x b x

b v b

z

G ,

x b x

b v b

G

³

1

^{0 3}

2

2 ,

x b x

b x

v b

rz

G

3 2 0

2

2

3

1

2 . (6)

b

₀

, b

₃

:

x

b 2 3 ln

2

1

_{3 2}

0

,

x D C

b 2 ln

2

1

2 2

3

, (7)

A, B, C, D – -

. , (7),

(5):

x D a x

u 3 ,

C x B x A

a

w ln 2

2

3

²

3

^{2 2}

x D

x 3 4 ln

2 2 4 1

3

^{2 2}

(8)

–

2

2

4 1

3 2

x D x

G B

r

,

2 1 2 6

z

2G ,

2

2

4 1

3

2 x

D x

G B , (9)

x x D

x x B

rz

G

2 2 1

1 3

2 .

: x = 1:

_r

,

_rz

0 ,

x = x

₁

:

_r

0 ,

_rz

0 . (10) (9)

(10), -

- A, B, C, D:

G D a

1 2 4

3 ,

0 2 1 2

1

3 D ,

0 1

4

3

2

1 2

1

x

D x

B , (11)

2 0 2 1

1 3

1 1

1

1

x

x D x

x B .

, -

:

A

1

, B

²

, C

³

, D

⁴

, (12)

a

ij

, (13)

11

3

a , a

₁₂

1 , a

₁₃

4 1 , a

₁₄

1 ,

21

3

a , a

₂₂

1 , a

₂₃

1 2 , a

₂₄

1 2 ,

* . . ., 1970. 939 .

30

2007. 2

31

3

a ,

₂

1 32

1 x

a , a

₃₃

4 1 ,

₂

1 34

1 a x ,

1

41

3x

a ,

1 42

1

a x ,

1

43

1 2 x

a ,

1 44

2 1

a x ; (14)

44 43 42

34 33 32

24 23 22

1

2

a a a

a a a

a a a

G , (15)

44 43 41

34 33 31

24 23 21

2

2

a a a

a a a

a a a

G , (16)

44 42 41

34 32 31

24 22 21

3

2

a a a

a a a

a a a

G , (17)

43 42 41

33 32 31

23 22 21

4

2

a a a

a a a

a a a

G . (18)

, -

.

- -

(9), (12)–(18) -

:

2, 7 3

; = 0,3;

5

0, 62 10 3

; a = 12 ; b = 2 z = 50 .

. -

:

=0,3, 2 , 7 10

³

; 0 , 62 10

⁵

;

1 2

G E ; b 200 ; a

₁

1200 ;

1

1

a

x b .

11

3

a , a

₁₂

1 , a

₁₃

4 1 , a

₁₄

1 ,

21

3

a , a

₂₂

1 , a

₂₃

1 2 , 2

24

1

a ,

31

3

a ,

2 1 32

a 1 , a

₃₃

4 1 ,

₂

1 34

a 1 ,

1

41

3x

a ,

1 42

1

a x , a

₄₃

1 2 x

₁

,

1 44

2 1

a x .

44 43 42

34 33 32

24 23 22

1

2

1200

a a a

a a a

a a a

G ^,

44 43 41

34 33 31

24 23 21

2

2

1200

a a a

a a a

a a a

G ^,

44 42 41

34 32 31

24 22 21

3

2

1200

a a a

a a a

a a a

G ^,

43 42 41

33 32 31

23 22 21

4

2

1200

a a a

a a a

a a a

G ^.

1 848 ,

1

6 ,

₂

3 , 655 10

³

,

06 ,

3

0 ,

₄

5 , 775 10

⁴

.

10

3

181 , 2

det .

44 43 42 41

34 33 32 31

24 23 22 21

14 13 12 11

det

a a a a

a a a a

a a a a

a a a a

,

det A

1

,

det B

2

,

det

C

3

,

det D

4

, 10

6

141 , 3

A ^, 1 , 676 10

⁶

^, 10

5

748 ,

2 ^, D 2 , 648 10

⁷

^, a

1

z ,

2 1 2

1

1 4 3

2

x D x

G B

r

,

31

2

1 2 6

z

2G ,

2 1 2

1

1 4 3

2

x D x

G B ,

1 1

1 1

2 2 1

1 3

2 x

x D x

x B

rz

G .

k = 1, z k 5000 , = 0,3.

r

=0,

_z

=-0,472, =-27,771,

_rz

=0.

=0,5;

_{r z rz}

0 ,

27, 771 ₂

.

(9) -

.

i

i .

. Summary

The article reveals tense condition around vertical mining pit in the form of a round cylinder. The mine without support has been considered.

539.3 + 528.22

4.03.07 .

. .

, -

-

, :

;

, -

-

;

- - ,

–

– -

;

- ,

-

;

, -

-

,

;

; - -

, -

, -

- [1, . 10–11].

, -

: -

, , -

- -

: ,

- .

.

-