Contents lists available atScienceDirect
Progress in Materials Science
journal homepage:www.elsevier.com/locate/pmatsci
Dendrimer-entrapped gold nanoparticles as promising nanocarriers for anticancer therapeutics and imaging
Prashant Kesharwani
a,⁎, Hira Choudhury
b, Jaya Gopal Meher
c, Manisha Pandey
b, Bapi Gorain
d,⁎⁎aDepartment of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India
bDepartment of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
cCSIR-Central Drug Research Institute, Lucknow, UP 226031, India
dSchool of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Selangor 47500, Malaysia
A R T I C L E I N F O
Keywords:
Dendrimer Gold nanoparticle Drug delivery Cancer CT imaging Theranostic
A B S T R A C T
Theranostic nanotherapeutic strategy has been widely emphasized now a day to develop next- generation nanomedicine. Dendrimer-entrapped gold nanoparticles (DE-Au-NP) have acquired emerging application in therapeutic, imaging as well as in theranostics sciences. DE-Au-NP de- corated with a specific ligand for cancer cells could deliver contrast agents at target sites for imaging as well as chemotherapeutics for anticancer activity. Entrapped Au in DE-Au-NP com- plex could serve as an excellent contrast agent for CT imaging with better signal intensity to identify initial stages of cancer, whereas its photothermal effect can kill cancerous cells effec- tively. Although, reported nonspecific binding of DE-Au-NP due to free amine groups and asso- ciated toxicities of dendrimer complex could be minimized through PEGylation or acetylation of such surface amines. Recent research on gene delivery also revealed DE-Au-NP as an active tool to deliver plasmids to cancer cells to express/suppress particular protein(s) to combat against cancer.
1. Introduction
Recent statistics on incidence of cancer in the United States showed a slight drop in male cases whereas it is stable in female (from 2009 to 2012), although annual statistics report from American Cancer Society showed that the occurrence of death in the USA due to cancer has decreased tremendously by 23% from its peak in 1991 to 2012[1]. Thesefindings suggest a great progress in thefield of cancer research aiming towards novel diagnostic techniques and treatments, however, to increase the percentage of recovery of cancer patients, scientists all over the world are still combating against this dreadful disease. Advancement of nanotechnology with potentially transformative progresses in various medicalfield including preventive, diagnostic, therapeutic and theranostic can create this dream into reality, by surmounting the barrier in achieving the ultimate goal with improved therapeutic efficacy, trustworthy diagnosis and minimal toxicity by improving biodistribution of administered chemotherapeutics and impeding recognition to the normal/healthy tissue[2,3]. Therefore, application of miniaturized delivery systems through nanotechnology in cancer medicine claim potential advantages over conventional dosage forms, which includes therapeutics, acting through cytosolic compartment (via
https://doi.org/10.1016/j.pmatsci.2019.03.003
Received 18 April 2018; Received in revised form 5 February 2019; Accepted 6 March 2019
⁎Corresponding author.
⁎⁎Corresponding author.
E-mail addresses:prashantdops@gmail.com,prashant@jamiahamdard.ac.in(P. Kesharwani),bapi.gorain@taylors.edu.my(B. Gorain).
URL:https://scholar.google.com/citations?user=DJkvOAQAAAAJ&hl=en(P. Kesharwani).
Progress in Materials Science 103 (2019) 484–508
Available online 07 March 2019
0079-6425/ © 2019 Elsevier Ltd. All rights reserved.
