Design and Synthesis of Different Aryl Substituted 1,3,4-Oxadiazole-imidazo[1,5-a]pyridine Derivatives
as Anticancer Agents
Dandamudi Srilaxmi
a, Alugubelli Gopi Reddy
b, Reddymasu Sireesha
c, Pasupuleti Visweswara Rao
d, M. Ravi Kiran
e,
Deepti Kolli
f, and Mandava Venkata Basaveswara Rao
a,*
a Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001 India
b Department of Pharmacy, Sana College of Pharmacy, Kodad, Telangana, 508206 India
c Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510 India
d Department of Biomedical Sciences and Therapeutics, Faculty of Medical and Health Sciences, University Malaysia Sabah, Kota Kinabalu, Sabah, 88400 Malaysia
e Department of Educational Technology, State Council of Educational Research & Training, Vijayawada, Andhra Pradesh, 521456 India
f Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Andhra Pradesh, 522502 India
*e-mail: [email protected]
Received December 14, 2020; revised February 13, 2021; accepted February 22, 2021
Abstract—A new series of 1,3,4-oxadiazole incorporated imidazo[1,5-a]pyridine derivatives was prepared.
Anticancer activity of all the obtained compounds was investigated by employing MTT assay. Among them, six compounds showed most prominent anticancer activity than etoposide.
Keywords: Alpidem, imidazo[1,5-a]pyridine, 1,3,4-oxadiazole, Zibotentan, anticancer activity DOI: 10.1134/S107036322205019X
