⮙՟ਞ
WPSAR Vol 6, No 1, 2015 | doi: 10.5365/wpsar.2014.5.003
www.wpro.who.int/wpsar
1
a ᮄ㽓݄ᆊ⫳⠽ᅝܼӴᶧ⮙Ёᖗˈ⦃๗⾥ᄺⷨお᠔ˈᮄ㽓݄ढ㦅࿕ᇨDŽ
b 0LGGOHPRUHए䰶ˈᮄ㽓༹݄ܟ݄DŽ
ᡩ〓᮹ᳳ˖2014ᑈ10᳜23᮹˗থ㸼᮹ᳳ˖2015ᑈ2᳜10᮹ doi: 10.5365/wpsar.2014.5.4.003
ᮄ㽓݄佪থ⦄ C105 ൟ㙴䘧⮙↦
Angela Todd
aˈSusan Taylor
bQ Sue Huang
a䗮䆃㗙˖Angela Todd (e-mail: [email protected])DŽ
Ўᮄ㽓݄㙴䘧⮙↦ⲥ⌟㔥㒰ⱘ៤ਬऩԡˈ ᮄ㽓݄ᆊ⫳⠽ᅝܼӴᶧ⮙Ёᖗ⦃๗⾥ᄺⷨお᠔ESRϟሲⱘᆊ㛞♄⮙↦㙴䘧
⮙↦䆞ᮁখ↨ᅲ偠ᅸˈҢܼಯᆊЏ㽕ए䰶ߚ߿ԡѢ
༹ܟ݄ǃᗔवᠬǃᚴ♉乓ⴷජᐌ㾘ᬊẔߚൟ㙴 䘧⮙↦ⱘЈᑞᷛᴀঞ㒚㚲ݏߚ⾏᷾DŽ䆹ⲥ⌟㔥㒰Ѣ ϞϪ㑾ܿकᑈҷᓔྟ䖤㸠ˈᑇഛ↣ᑈᬊ䲚ᷛᴀ㑺150 ӑDŽⲥ⌟㔥㒰ⱘЏ㽕Ⳃⱘᰃ1њ㾷㙴䘧⮙↦ൟⱘ
⌕㸠ᓣЏ㽕↦᷾˗2ᦣ䗄ᔧࠡ⌕㸠ൟ᠔ᇐ㟈 ⱘЈᑞ⮒⮙ⱘЏ㽕⡍ᕕ˗3থ⦄㙴䘧⮙↦ᲈথˈᓔሩ
݀݅ि⫳ᑆ乘˗ҹঞ4฿㸹ᆊ㛞♄⮙↦ⲥ⌟乍Ⳃⱘ ぎⱑDŽ䖭ಯᆊᅲ偠ᅸESRᆊᅲ偠ᅸЎᮄ㽓݄ܼ
ᦤկⳌ݇ᅲ偠ᅸ᳡ࡵDŽ㙴䘧⮙↦ⲥ⌟ܼᑈᓔሩˈ᭄
ᴹ⑤Ѣᙷ㗙ⱘᐌ㾘䆞ᮁ᳡ࡵਞDŽESR↣਼ᬊ䲚㙴䘧
⮙↦Ẕ⌟ਞˈ䖯㸠᭄ܼ∛ᘏথᏗ[1]DŽℸˈ
ߚൟ㙴䘧⮙↦䖬䳔䗕㟇ESR䖯㸠䖯ϔℹẔ⌟ߚᵤDŽ
C105
ൟ 㙴 䘧 ⮙ ↦EV-C105
ሲ Ѣ Ҏ 㙴 䘧 ⮙ ↦C
㕸ˈ2010
ᑈᑩ佪থ⦄Ѣ߮ᵰ˄䞥˅ˈҢϔ䍋㛞♄ᲈথ⭿ᚙЁⱘϔ՟ᗹᗻ偄㓧ᗻ咏⯍⅏ѵ⮙՟ⱘ㉾֓ᷛ
ᴀЁẔߎ[2]DŽ⬅Ѣ㔎У䖭⾡⮙↦ⱘ⸔ᑣ᭄߫ˈ᳔
߱㹿Ẕ⌟Ўൟ㙴䘧⮙↦
EV-109
[3]DŽ2012
ᑈˈ 䖯ϔℹⱘᑣ߫⌟ᅮথ⦄䆹⮙↦া᳝74.7%
ⱘḌ㣋䝌82.5%
ⱘ⇼䝌ϢEV-109
ϔ㟈ˈℸᇚ݊ߦߚЎᮄⱘ 㙴䘧⮙↦㸔⏙ൟ[4]DŽ䱣ৢˈ⾬剕า⌺䏃ᮃߚ߿Ң䘧⮙՟Ёߚ⾏ߎ
EV-C105
[5,6]DŽ䇈ᯢ㱑✊ᘏԧথ⮙⥛ᕜԢˈԚ䆹⮙↦ܼ⧗㣗ೈݙഛ᳝ߚᏗDŽࡴᔎᇍ
EV- C105
ⱘ䅸䆚ৃ᳝ࡽѢ䆹⮙↦ⱘথ⦄ˈњ㾷䆹⮙↦ൟ⮙ॳᄺЈᑞϞⱘ⡍ᕕDŽ
៥Ӏℸਞϔ՟ᮄ㽓݄佪՟C105ൟ㙴䘧⮙↦ᛳ ᶧˈ䆹⮙՟Ўϔৡ᳝䕏ᖂ䘧⮛⢊ⱘ52ቕ⬋ᗻ⮙
՟ˈ༹ܟ݄ए䰶ԣ䰶⊏⭫ˈ䗮䖛ᆊ㙴䘧⮙↦ⲥ⌟
㔥㒰থ⦄ਞDŽ
⮙՟ਞ
䆹⮙՟Ў52ቕ↯߽ᮣ⬋ᗻˈ2013ᑈ10༹᳜ܟ݄ϔ ᆊए䰶ԣ䰶⊏⭫DŽϢᔧᯊⱘܹ䰶ॳϡৠⱘᰃˈ䆹⮙
՟ܹ䰶ৢѠߎ⦄њઇ୬ᙃ⮛⢊ˈ䞛䲚њ唏 ઑᣁᄤᷛᴀ䖯㸠䘧⮙↦Ẕ⌟DŽ⮙՟᮴থ⛁⮛⢊DŽ 唏ઑᣁᄤᷛᴀ㒣⌕ᛳ⮙↦ǃ㝎⮙↦ǃ䘧ড়㚲⮙
↦ǃҎأ㚎⮙↦ǃࡃ⌕ᛳ⮙↦1-3ൟϢ唏⮙↦Ẕ⌟ഛ䰈 ᗻ[7]DŽReal-time PCRẔߎ㙴䘧⮙↦RNA[8]DŽᇍ375bp 䭓ⷁⱘऎඳ䖯㸠ᠽৢ㦋ᕫ䚼ߚVP1ᑣ߫[9]DŽ䞛⫼
tblastxᡔᴃˈᇚ݊ϢGenBankЁVP1ᑣ߫䖯㸠↨䕗
[10]ˈ থ⦄䆹⮙↦ᑣ߫Ϣ2012ᑈา⌺䏃ᮃⱘEV-C105↦᷾ⱘ⇼䝌99%ϔ㟈ˈᑣ߫㡖↉100%ϔ㟈GenBank㓪ⷕ
AFG25720DŽϢℸⳌԐⱘϟϔϾൟЎEV-109ˈϢ GenBankЁ㓪ⷕADK22861ⱘ⇼䝌ᑣ߫89%ϔ㟈DŽ
䅼䆎
ᴀ᭛ਞⱘ
52
ቕ䘧ᛳᶧ⬋ᗻ⮙՟ЎѮഄऎথ⦄ⱘ佪՟
EV-C105
ᛳᶧDŽПࠡҙ᳝߮ᵰ˄䞥˅ǃ⾬剕า⌺䏃ᮃㄝᵕᇥᆊਞ䖛
EV-C105
DŽਞ䆹EV- C105
⮙՟ࠡˈᮄ㽓݄᳒⬅ϔ՟ᗹᗻ䖳㓧ᗻ咏⯍ⱘ㉾֓ᷛᴀ᭄՟ܓ⾥ᙷ㗙䘧ᷛᴀЁẔߎ䖛
EV-C105
⮙↦DŽ
EV-C105
ᮄൟ㙴䘧⮙↦ⱘথ⦄Ϣ⹂䅸ݡ䇈ᯢњᣕ㓁ᓔሩ㙴䘧⮙↦ⲥ⌟ᇍѢথ⦄ᮄথݡথⱘ㙴䘧⮙
↦ൟ᳝䞡㽕ᛣНˈЎᓔሩ݀݅ि⫳ᑆ乘ᦤկњ 䞡㽕ֵᙃDŽᦤ催ᇍ
EV-C105
ⱘ䅸䆚ৃҹࡴᔎ⮙↦ⱘথ⦄ẔߎDŽЎњ㾷䖭⾡ᇥ㾕⮙↦ⱘ⮙ॳᄺ⡍ᕕǃϢЈ ᑞ⮒⮙ⱘ݇㘨ǃӴ᪁ᓣҹঞ݀݅ि⫳ᛣНˈҡ䳔ᓔ ሩ䖯ϔℹⷨおDŽ
߽Ⲟކさ ᮴DŽ
WPSAR Vol 6, No 1, 2015 | doi: 10.5365/wpsar.2014.5.4.003 www.wpro.who.int/wpsar
2
Toddㄝ ᮄ㽓݄থ⦄C105ൟ㙴䘧⮙↦
3. Lukashev AN et al. Novel serotypes 105 and 116 are members of distinct subgroups of human enterovirus C. The Journal of General Virology, 2012, 93:2357–2362. doi:10.1099/vir.0.043216-0 pmid:22894922
4. Oberste MS et al. Molecular evolution of the human enteroviruses:
correlation of serotype with VP1 sequence and application to picornavirus classification. Journal of Virology, 1999, 73:1941–
1948. pmid:9971773
5. Richter J et al. Newly emerging C group enteroviruses may elude diagnosis due to a divergent 5′-UTR. International Journal of Infectious Diseases, 2013, 17:e1245–1248. doi:10.1016/j.
ijid.2013.07.010 pmid:24080070
6. Tokarz R et al. Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru.
The Journal of General Virology, 2013, 94:120–127.
doi:10.1099/vir.0.046250-0 pmid:23034595
7. Centers for Disease Control and Prevention (CDC). CDC Real-Time RT-PCR Assays for Non-Influenza Respiratory Viruses. Atlanta, Centers for Disease Control and Prevention, 2010.
8. Oberste MS et al. Comparative evaluation of Taqman real-time PCR and semi-nested VP1 PCR for detection of enteroviruses in clinical specimens. Journal of Clinical Virology, 2010, 49:73–74.
doi:10.1016/j.jcv.2010.06.022 pmid:20667767
9. Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. Journal of Clinical Microbiology, 2006, 44:2698–2704. doi:10.1128/
JCM.00542-06 pmid:16891480
10. Altschul SF et al. Basic local alignment search tool. Journal of Molecular Biology, 1990, 215:403–410. doi:10.1016/S0022- 2836(05)80360-2 pmi d:2231712
䌘䞥ᴹ⑤
ᆊ㛞♄㙴䘧⮙↦ⲥ⌟⬅ᮄ㽓݄ि⫳䚼ᦤկ䌘䞥ᬃ
ᣕˈᑊ㦋᭄থ㸼䆌ৃDŽ 㟈䇶
ᛳ䇶㕢
CDC
㒚Ḍ䝌⮙↦ᅲ偠ᅸⱘW Allan Nix
㙴䘧⮙↦ߚൟᎹ䆎᭛ׂᬍЁᦤկⱘᐂࡽDŽ ᓩ⫼ᴀ᭛ഄഔ˖
Todd A et al. Identification of Enterovirus C105 for the first time in New Zealand. Western Pacific Surveillance and Response Journal, 2015, 6(1):60–61. doi:10.5365/
wpsar.2014.5.4.003
খ㗗᭛⤂
1. Public Health Surveillance: Information for New Zealand Public Health Action [Internet]. Wellington, Institute of Environmental Science and Research Limited, 2014 (https://surv.esr.cri.nz/virology/virology_weekly_report.php, accessed 20 November 2014).
2. Grard G et al. Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October–November 2010. Eurosurveillance: European Communicable Disease Bulletin, 2010, 15(47):pii:19723. pmid:21144443
