2012年西太平洋区域登革热流行病学进展

a Ϫ⬠ि⫳㒘㒛㽓໾ᑇ⋟ऎඳࡲ݀ᅸˈि⫳ᅝܼ੠さথџӊ໘ˈᮄথ⮒⮙ⲥ⌟੠ᑨᇍ㒘ˈ偀ሐᢝˈ㧆ᕟᆒDŽ ᡩ〓᮹ᳳ˖2014ᑈ10᳜4᮹˗থ㸼᮹ᳳ˖2015ᑈ4᳜20᮹

䖥

ᑈᴹˈ೼㽓໾ᑇ⋟ऎඳⱏ䴽⛁Ꮖ㒣៤Ўϔ ϾЏ㽕ⱘ݀݅ि⫳݇⊼䯂乬ˈᇐ㟈њ໻䞣 ⱘথ⮙ǃ⅏ѵ੠㒣⌢ᤳ༅^[1-3]DŽϡҙ೑ᆊ ⲥ⌟᭄᥂ԧ⦄њ䖭ḋⱘ݀݅ि⫳੠㒣⌢䋳ᢙᏆ㒣বᕫ 䴲ᐌᯢᰒˈ㗠Ϩᮼ೼Ԅ䅵ⱏ䴽⛁⮒⮙䋳ᢙⱘ䖤ㅍᄺг ড᯴њ䖭ḋⱘ䯂乬^[4]DŽⱏ䴽⛁ⱘ⌕㸠⮙ᄺ੠⮙↦ᄺ೼

㸔⏙ൟⳌѦ԰⫼ǃᡫԧձ䌪ᗻ๲ᔎ԰⫼੠Ѹঝܡ⭿ǃ

⇨׭੠ᰒ㨫ⱘᗻ߿੠ᑈ啘ߚᏗㄝᮍ䴶ᣕ㓁ᰒ⼎ߎ໡

ᴖⱘ⡍ᕕ^[5–8]DŽⱏ䴽⛁⮙՟ⱘ᡹ਞüü䴲ᐌৃ㛑ԢԄ

њⳳℷⱘ⮒⮙䋳ᢙ^[4,9]üü೼䖛এ

10

ᑈЁ᳝᠔๲ࡴˈ Ң

2007

ᑈᓔྟˈ㽓໾ᑇ⋟ऎඳ↣ᑈ䛑᡹ਞ

200 000

໮

՟⮙՟^[1,2]ˈ

2011

ᑈ䆹ऎඳ᡹ਞњ᥹䖥

250 000

՟ⱏ䴽

⛁⮙՟^[2]DŽ

ᴀ⃵ߚᵤ᡹ਞњ2012ᑈᑺ㽓໾ऎⱏ䴽⛁ⲥ⌟᭄

᥂ˈ䆹᡹ਞ㒣䖛Ϫ⬠ि⫳㒘㒛˄WHO˅㽓໾ᑇ⋟ऎඳ

ࡲ݀ᅸḌᇍDŽ

ᮍ⊩

Ң㽓໾ᑇ⋟ऎඳݙ೑ᆊ੠ഄऎⱘ෎Ѣᣛᷛⱘⲥ⌟㋏㒳 Ёᬊ䲚2012ᑈऎඳⱘⱏ䴽⛁᭄᥂DŽ᭄᥂⬅৘೑ि⫳䚼 থ䗕㟇WHOˈ៪Ң৘೑ि⫳䚼㔥キ㦋ᕫDŽ

▇໻߽Ѯǃ㗕ᣱҎ⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃ 㧆ᕟᆒǃᮄࡴവ੠䍞फᦤկњ乱໪ⱘ᭄᥂DŽߚᵤ᡹ਞ Ёࣙᣀњⱏ䴽⛁ⲥ⌟㋏㒳ǃ⮙՟ᅮНǃᅲ偠ᅸ䞛ḋ ᮍ⊩੠㸔⏙ൟ᭄᥂ⱘᘏ㒧DŽা᳝偀ᴹ㽓Ѯ੠㧆ᕟᆒ 䖭ϸϾ೑ᆊᰃ2011ᑈᑈᑺ᡹ਞПৢথ⫳ᬍবⱘ೑ᆊ

[2]DŽ೼偀ᴹ㽓Ѯˈ᠔᳝ヺড়ⱏ䴽⛁Јᑞᷛޚⱘ⮙՟៪

ᅲ偠ᅸ⹂䆞䰇ᗻⱘ⮙՟ഛ䳔㽕᡹ਞ˗䴲㒧ᵘ㲟ⱑൟ

˄NS1˅ᡫॳẔ⌟佪⃵㹿ࣙᣀ೼Ẕ⌟ᮍ⊩ЁDŽ೼㧆ᕟ

2012 ᑈ㽓໾ᑇ⋟ऎඳⱏ䴽⛁⌕㸠⮙ᄺ䖯ሩ

Yuzo Arima

^a

ˈ May Chiew

^a

੠ Tamano Matsui

^a

ҷ㸼ᮄথ⮒⮙ⲥ⌟੠ᑨᇍ㒘ˈि⫳ᅝܼ੠さথџӊ໘ˈϪ⬠ि⫳㒘 㒛㽓໾ᑇ⋟ऎඳࡲ݀ᅸ

䗮䆃԰㗙˖ᮄথ⮒⮙ⲥ⌟੠ᑨᇍ㒘˄䚂ㆅ˖outbreak@wpro.who.int˅DŽ

ᆒˈ2012ᑈᇍഄऎǃⳕ੠Ꮦ㑻ि⫳䚼䮼ᓔሩ෍䆁П

ৢˈ㒻㓁᥼ᑓՓ⫼2009ᑈⱏ䴽⛁⮙՟ߚ㉏㋏㒳DŽԚᰃ

⬅Ѣ෍䆁ᣕ㓁ࠄ2012ᑈᑈᑩˈ಴ℸⳈࠄᑈᑩᯊᮄⱘ⮙

՟ᅮНг᳾㛑೼ܼ೑㣗ೈݙᑨ⫼DŽ

㒧ᵰ

㽓໾ᑇ⋟ऎඳⱘⱏ䴽⛁

2012

ᑈˈ㽓໾ᑇ⋟ऎඳ៤ਬ೑݅᡹ਞњ

356 838

՟ⱏ 䴽 ⛁ ⮙ ՟ ˈ ݊ Ё

1248

՟ ⅏ ѵ ˈ ⮙ ⅏ ⥛ Ў

0.34%

˄೒

1

˅DŽ೼Ѯ⌆ഄऎˈⱏ䴽⛁⮙՟᡹ਞ⥛੠㒱ᇍ᭄䞣

᳔催ⱘᰃ㧆ᕟᆒ˄㸼

1

˅DŽ೼໾ᑇ⋟ߚऎˈϢ

2011

ᑈ Ⳍ ↨ ˈ 㒑 ඗ ǃ ᭤ ⌢ ੠ ᮄ ࡴ ࢦ ໮ ሐ Ѯ ᡹ ਞ ⥛ ໻ ᐙ ᑺ Ϟछ^[2]DŽ㱑✊▇໻߽Ѯ᡹ਞњ

1500

໮՟ᅲ偠ᅸ⹂䆞⮙

՟˄㸼

2

˅ˈԚᰃ໻໮᭄ᰃ䕧ܹᗻ⮙՟DŽ

ሑㅵ৘೑ᅲ偠ᅸ䞛ḋᮍḜ੠⹂䆞ᮍ⊩ϡৠˈᴀ᡹ਞЁ ⱘ໮᭄೑ᆊ೼2012ᑈՓ⫼њ᳈ᮄⱘ˄2009˅ⱏ䴽⛁

⮙՟ߚ㉏㋏㒳˄㸼3˅DŽ

䙷ѯᦤկ乱໪᭄᥂ⱘ೑ᆊЁˈ䰸ᮄࡴവП໪ˈ݊Ҫ೑

ᆊ೼

2012

ᑈ᡹ਞⱘ⮙՟᭄ഛ䖰催Ѣ

2011

ᑈ᡹ਞⱘ⮙

՟᭄˄㸼

1

˅DŽᘏԧᴹ䇈ˈ

2012

ᑈ᡹ਞⱘ⮙՟᭄↨

2011

ᑈ催

40%

^[2]DŽ Ѯ⌆ߚऎ

᷀ඨᆼ

2012

ᑈˈ᷀ඨᆼ᡹ਞњ

42 362

՟Јᑞⱏ䴽⛁⮙՟

189

՟⅏ѵˈᰒ㨫䍙䖛Ϟϔᑈᑺ᡹ਞⱘ

15 980

՟㸼

3

DŽ

⮙ ՟ ᡹ ਞ ⱘ 催 ዄ ᳳ ೼7᳜ ӑ ㄀

27਼ ˄n=2447

՟ ˅

˄೒2˅ˈϢ2011ᑈ催ዄᳳ೼7᳜੠2010ᑈ˄催ዄ

ᳳ೼8᳜㉏ԐDŽ೼15ቕҹϞⱘ⮙՟Ёˈ⬋ᗻ↨՟᳈催

˄ ⬋ ཇ ↨ Ў

1.2:1˅ DŽ ೼500

ৡ ᅲ 偠 ᅸ Ẕ ⌟ ⱘ ⮙ ՟ Ёˈ463՟˄93%˅ᕫࠄ⹂䆞DŽ3⾡㸔⏙ൟ೼ᔧഄ⌕

㸠ˈ݊Ё᳔Џ㽕ⱘ㸔⏙ൟЎⱏ䴽⛁1ൟ˄DEN-1˅

˄DEN-1ˈ

n=368 [98%]˗DEN-2

ˈ

n=5 [1%]˗

DEN-4ˈ n=3 [1%]˅DŽ

㗕ᣱҎ⇥⇥Џ݅੠೑

2012

ᑈ ˈ ᡹ ਞ њ

9952

՟ Ј ᑞ ⱏ 䴽 ⛁ ⮙ ՟ ˄

22

՟

⅏ ѵ ˅ ˈ 䍙 䖛

2011

ᑈ ᡹ ਞ ⮙ ՟ ᭄ ⱘ

2

ס ˄㸼

2

˅ DŽ

⮙՟᡹ਞⱘ催ዄᳳ೼

10

᳜ӑ㄀

40

਼˄

n = 555

՟˅

˄೒

2

˅ˈᰮѢ

2011

ᑈ˄催ዄᳳ೼

9

᳜˅੠

2010

ᑈ

˄ 催 ዄ ᳳ ೼

8

᳜ ˅ DŽ ೼

871

՟ ᅲ 偠 ᅸ Ẕ ⌟ ⱘ ⮙ ՟ Ёˈ

449

՟˄

52%

˅ᕫࠄ⹂䆞DŽሑㅵಯ⾡㸔⏙ൟ䛑໘ Ѣ⌕㸠⢊ᗕˈԚЏ㽕ⱘ㸔⏙ൟЎ

DEN-3

ൟ˄

DEN-3

ˈ

n = 164 [80%]

˗

DEN-1

ˈ

n = 23 [11%]

˗

DEN-2 n = 18 [9%]

˗

DEN-4

ˈ

n = 1 [<1%]

˅DŽ

偀ᴹ㽓Ѯ

2012

ᑈˈ偀ᴹ㽓Ѯ᡹ਞњ

21 900

՟⮙՟

35

՟⅏ѵˈ Ϣ

2011

ᑈⳌԐˈԚϢ

2011

ᑈПࠡⱘᑈӑⳌ↨Ⳍᇍ 㽕 Ԣ ˄㸼

3

˅ DŽ ✊ 㗠 ˈ 䖭 ᰃ ㄀ ϔ ᑈ ᇚ 䙷 ѯ ᮴ 䆎 ᰃ ৺

᳝ Ј ᑞ 㸼 ⦄ ⱘ ᅲ 偠 ᅸ ⹂ 䆞 ⮙ ՟ ࣙ ᣀ ೼ ݙ ˄㸼

3

˅ DŽ

⮙՟᡹ਞⱘ催ዄᳳ೼

2

᳜ӑ㄀

8

਼˄

n=602

˅˗

12

᳜

ӑ㟇2᳜ӑᳳ䯈㾖ᆳࠄ䕗໮ⱘ᡹ਞ⮙՟᭄˄೒2˅ˈϢ

2011ᑈ催ዄߎ⦄೼1᳜ӑⱘᚙމ㉏ԐDŽ೼7797՟ᅲ

偠ᅸẔ⌟⮙՟Ёˈ

6506˄83%˅ᕫࠄ⹂䆞DŽẔ⌟ࠄ

᠔᳝ⱘ4⾡㸔⏙ൟˈߚᏗ෎ᴀϔ㟈˄

DEN-3ˈn = 263 [31%]˗DEN-1ˈn = 222 [26%]˗DEN-4ˈn = 185 [22%]˗DEN-2ˈn = 184 [22%]˅DŽ

㧆ᕟᆒ

2012

ᑈˈ㧆ᕟᆒ᡹ਞњ

187 031

՟Јᑞ⮙՟˄

921

՟

⅏ѵ˅ˈϢ

2011

ᑈⳌ↨๲ࡴњ

48%

˄㸼

2

˅ˈ

8

᳜ӑ ߎ⦄⮙՟᡹ਞ催ዄ˄

n = 31 999

˅˄೒

2

˅DŽ

5–14

ቕ ᑈ啘㒘ᰃ⮙՟᳔᭄໮ⱘᑈ啘㒘DŽ೼

165

՟ᅲ偠ᅸẔ

⌟ ⱘ ⮙ ՟ Ё ˈ

142

˄

85%

˅ ᕫ ࠄ ⹂ 䆞 ˈ ೼ 㸔 ⏙ ൟ ߚൟⱘ⮙՟Ёˈ

DEN-1

ᰃЏ㽕ⱘ㸔⏙ൟ˄

DEN-1

ˈ

n = 128 [90%]

˗

DEN-2

ˈ

n = 10 [3%]

˅DŽ

ᮄࡴവ

2012

ᑈ ˈ ᮄ ࡴ വ ᡹ ਞ њ

4632

՟ ᅲ 偠 ᅸ ⹂ 䆞 ⱏ 䴽

⛁ ⮙ ՟ ˄

2

՟ ⅏ ѵ ˅ ˈ ↨

2011

ᑈ ੠

2010

ᑈ ᡹ ਞ ⱘ

⮙ ՟ ᭄ ᇥ ˄㸼

2

˅ ˈ ⮙ ՟ ᡹ ਞ ⱘ 催 ዄ ᳳ ೼

6

᳜ ӑ ㄀

26

਼˄

n = 152

՟˅˄೒

2

˅ˈϢ

2011

ᑈ೼

7

᳜ӑߎ⦄

催 ዄ ㉏ Ԑ DŽ 㱑 ✊ Ẕ ⌟ ࠄ ᠔ ᳝ ⱘ

4

⾡ 㸔 ⏙ ൟ ˈ Ԛ ᰃ

1 3 3 3

՟ 䖯 㸠 㸔 ⏙ ൟ ߚ ൟ ⱘ ⮙ ՟ Ё ˈ Џ 㽕 㸔⏙ൟᰃ

DEN-2

˄

DEN-2

ˈ

n = 988 [74%]

˗

DEN-1

ˈ

n = 258 [19%]

˗

DEN-3

ˈ

n = 76 [6%]

˗

DEN-4

ˈ

n = 11 [1%]

˅DŽ

೒

1. 2000

ᑈ㟇

2012

ᑈ㽓໾ᑇ⋟ऎඳⱏ䴽⛁᡹ਞ⮙՟᭄੠⮙⅏⥛

*

ᴹ⑤˖Ϫ⬠ि⫳㒘㒛㽓໾ᑇ⋟ऎඳࡲ݀ᅸDŽ

* ⱏ䴽⛁ⲥ⌟੠᡹ਞ㋏㒳಴೑ᆊ㗠ϡৠDŽ

CFR⮙⅏⥛DŽ

0 0.1 0.2 0.3 0.4 0.5 0.6

0 50 100 150 200 250 300 350 400

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 ᠔᳝⮙՟ⱘ᠔᳝⮙՟ⱘCFR˄%˅

᡹ਞ⮙՟᭄˄᡹ਞ⮙՟᭄˄/1000˅

ᑈӑ ᑈӑ

ᚲ᦭∛଀⊛CFR (%) ᡹๔∛଀ᢙ(/1000)

˄1000˅

˄1000˅

㸼

1. 2012

ᑈ㽓໾ᑇ⋟ऎඳ᡹ਞⱘⱏ䴽⛁⮙՟˄ࣙᣀ䕧ܹᗻ⮙՟೼ݙ˅੠ⱏ䴽⛁ᇐ㟈ⱘ⅏ѵ᭄

*

೑ᆊഄऎ^噛 ⮙՟ ᡹ਞ⥛˄˅ ⅏ѵ ⮙⅏⥛˄%˅ Ҏষ᭄˄ग˅

Ѯ⌆ߚऎ

᭛㦅䖒剕㧼݄ 290 71.43 0 0.00 406

᷀ඨᆼ 42 362 316.23 189 0.45 13 396

Ё೑ 575 0.04 0 0.00 1 370 537

Ё೑佭␃⡍߿㸠ᬓऎ 53 0.75 0 0.00 7068

Ё೑▇䮼⡍߿㸠ᬓऎ 24 4.35 0.00 552

᮹ᴀ 220 0.17 0 0.00 128 056

䶽೑ 145 0.30 0.00 48 875

㗕ᣱҎ⇥⇥Џ݅੠೑ 9952 162.40 22 0.22 6128

偀ᴹ㽓Ѯ 21 900 77.52 35 0.16 28 251

㩭স 0 0.00 0 – 2780

㧆ᕟᆒ 187 031 198.94 921 0.49 94 013

ᮄࡴവ 4632 89.35 2 0.04 5184

䍞फ 86 026 100.00 79 0.09 86 025

ߚऎড়䅵 353 210 19.72 1248 0.35 1 791 271

໾ᑇ⋟ߚऎ

▇໻߽Ѯ 1542 6.90 0 0 22 342

᭤⌢ 705 82.55 0 0 854

෎䞠Ꮘᮃ 243 240.59 0 0 101

偀㒡ᇨ㕸ቯ 182 337.04 0 0 54

ᆚܟ㔫ሐ㽓Ѯ˄㘨䙺˅ 273 265.05 0 0 103

ᮄࡴࢦ໮ሐѮ 478 194.31 0 0 246

ᮄ㽓݄ 77 1.86 0 0 4 143

㒑඗ 128 8556.00 0 0 1.5

ߚऎড়䅵 3 628 13.03 0 0 27 845

ড়䅵 356 838 19.62 1248 0.35 1 819 116

ᴹ⑤˖Ϫ⬠ि⫳㒘㒛㽓໾ᑇ⋟ऎඳࡲ݀ᅸDŽ

ⱏ䴽⛁ⲥ⌟੠᡹ਞ㋏㒳಴೑ᆊ㗠ϡৠDŽ

噛 ϟ䴶೑ᆊ੠ഄऎ≵᳝᡹ਞⱏ䴽⛁᭄᥂˖㕢ሲ㧼ᨽѮǃᑧܟ㕸ቯǃ⊩ሲ⊶䞠ሐ㽓Ѯǃ݇ቯǃ⨭剕ǃ࣫偀䞠Ѯ㒇㕸ቯ݅੠೑ǃᏩࢇˈᏈᏗѮᮄ޴ݙѮǃⲂ

⡍߃ᘽ㕸ቯǃ㧼ᨽѮǃ᠔㔫䮼㕸ቯǃᠬܟࢇǃ∸ࡴǃ೒⪺शǃ⪺ࡾ䰓೒੠≗߽ᮃǃҹঞᆠ೒㒇DŽ

㸼2. 2008-2012ᑈ᷀ඨᆼǃ㗕ᣱҎ⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃᮄࡴവǃ䍞फ੠▇໻߽Ѯⱏ䴽⛁᡹ਞ⮙՟᭄ǃ

⅏ѵ᭄੠⮙⅏⥛*

೑ᆊ

2008 2009 2010 2011 2012

⮙՟ ⅏ѵ ⮙⅏⥛

˄˅ ⮙՟ ⅏ѵ ⮙⅏⥛

˄˅ ⮙՟ ⅏ѵ ⮙⅏⥛

˄˅ ⮙՟ ⅏ѵ ⮙⅏⥛

˄˅ ⮙՟ ⅏ѵ ⮙⅏⥛

˄˅

᷀ඨᆼ 9 542 65 0.68 11 699 38 0.32 12 500 58 0.30 15 980 73 0.46 42 362 189 0.45

㗕ᣱҎ⇥⇥Џ

݅੠೑ 4 149 21 0.51 7 214 12 0.17 22 929 46 0.20 3 905 7 0.18 9 952 22 0.22

偀ᴹ㽓Ѯ 49 335 112 0.23 41 486 88 0.21 46 171 134 0.29 19 884 36 0.18 21 900 35 0.16

㧆ᕟᆒ 39 620 373 0.94 57 819 548 0.95 135 355 793 0.59 125 975 654 0.52 187 031 921 0.49

ᮄࡴവ 7 031 10 0.14 4 497 8 0.18 5 363 6 0.11 5 330 6 0.11 4 632 2 0.04

䍞फ 96 451 97 0.10 105 370 87 0.08 128 831 55 0.04 69 680 61 0.09 86 026 79 0.09

▇໻߽Ѯ 563 0 0 1 401 0 0 1 171 0 0 820 0 0 1 542 0 0

ড়䅵 206 692 678 0.33 229 486 781 0.34 352 321 1070 0.30 241 574 837 0.35 353 445 1 248 0.35

ᴹ⑤˖Ϫ⬠ि⫳㒘㒛㽓໾ᑇ⋟ऎඳࡲ݀ᅸDŽ

* ⱏ䴽⛁ⲥ⌟੠᡹ਞ㋏㒳಴೑ᆊ㗠ϡৠDŽ CFRˈ⮙⅏⥛DŽ

ৡᴀഄᛳᶧⱘⱏ䴽⛁⮙՟ЁˈЏ㽕㸔⏙ൟᰃ

DEN-1

˄

14

՟

DEN-1

ˈ

7

՟

DEN-3

ˈ

1

՟

DEN-2

੠

6

՟ ᳾ ߚ ൟ˅˗

28

՟⮙՟Ё

13

՟ᰃ⬋ᗻDŽ೼

41

՟䕧ܹᗻ⮙՟

Ёˈ

22

՟ᰃ

DEN-2

ˈ

13

՟ᰃ

DEN-1

ˈ

3

՟ᰃ'

EN-3

ˈ

1

՟ᰃ

DEN-4

ˈ

2

՟᳾ߚൟ˄ϾҎѸ⌕ˈᯚ຿݄ᬓᑰ ߃ᘽᮃ੠咥⡍݄ए䰶੠ि⫳᳡ࡵ䚼ˈᆊᒁि⫳੠ع ᒋ

1

໘ˈ߃ᘽᮃ⛁ᏺ݀݅ि⫳᳡ࡵ㒘ˈ

Sonia Harman

म

຿˅DŽ

೼ ໾ ᑇ ⋟ ߚ ऎ ˈ 㒑 ඗ ᡹ ਞ থ ⮙ ⥛ ᳔ 催

˄8556/100 000˗128՟˅ˈ᭤⌢᡹ਞњ䍙䖛700՟

⮙՟˄82.6/100 000˅DŽϢ2011ᑈҙ᡹ਞ՟⮙՟Ⳍ

↨ ˄㸼

1˅ ˈ ᮄ ࡴ ࢦ ໮ ሐ Ѯ ೼ 2012ᑈ ㄀ ಯ ᄷ ᑺ ᡹

ਞ ⮙ ՟ ᭄ ໻ 䞣 ๲ ࡴ ˄೒

2

˅ ˈ ᡹ ਞ њ 㑺

500

՟ ⮙

՟˄194.3/100 000˅DŽ೼ᮄ㽓݄ˈⱏ䴽⛁ϡᰃഄᮍ

⮙ˈ2012ᑈ᡹ਞњ77՟⮙՟ˈ݊Ё76՟Ў䕧ܹᗻ⮙

՟DŽ 䍞फ

2012

ᑈˈ䍞फ᡹ਞњ

86 026

՟Јᑞ⮙՟

79

՟⅏ѵˈ

↨

2011

ᑈ᡹ਞⱘ⮙՟᭄໮˄㸼

3

˅DŽ೼

13 222

՟ᅲ偠 ᅸẔ⌟⮙՟Ёˈ

5317

՟˄

40%

˅ᕫࠄ⹂䆞DŽẔ⌟ࠄ ᠔᳝⾡㸔⏙ൟˈ

DEN-1

ᰃ᳔ᐌ㾕ⱘ㸔⏙ൟ˄

DEN-1

ˈ

n=319 [32%]

˗

DEN-2

ˈ

n=262 [26%]

˗

DEN-4

ˈ

n=235 [23%]

˗

DEN-3

ˈ

n=188 [19%]

˅DŽ

໾ᑇ⋟ߚऎ

▇໻߽Ѯ

2012ᑈˈ▇໻߽Ѯ᡹ਞњ1542՟ᅲ偠ᅸ⹂䆞ⱏ䴽⛁

⮙՟˄0՟⅏ѵ˅ˈᰃ䖛এ5ᑈЁ᡹ਞ⮙՟᳔᭄໮ⱘ ϔᑈ˄㸼2˅ˈ⮙՟᡹ਞⱘ催ዄᳳ೼

1᳜ӑ˄n=267

՟⮙՟˅˄೒2˅ˈϢ2011ᑈ㉏ԐDŽ೼࣫ᯚ຿݄28

㸼

3. 2012

ᑈ᷀ඨᆼǃ㗕ᣱҎ⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃ㧆ᕟᆒǃᮄࡴവǃ䍞फ੠▇໻߽Ѯⱏ䴽⛁ⲥ⌟ⱘ⮙՟

ᅮНǃᅲ偠ᅸ䞛ḋ੠Ẕ⌟ᮍ⊩

*

೑ᆊ ⮙՟ᅮН

ᅲ偠ᅸ䞛ḋ੠Ẕ⌟ᮍ⊩

Јᑞᷛޚ^† ᅲ偠ᅸ⹂䆞

᷀ඨᆼ 2009ᑈⱏ䴽⛁⮙՟ߚ㉏^† ৺ 5Ͼ઼⚍↣᳔਼໮䗕ӑḋᴀ䖯㸠Ẕ⌟ˈ䞡⚍ЎܓスDŽ⹂䆞ᰃ෎Ѣ䝊㘨

ܡ⭿਌䰘䆩偠˄ELISA˅ˈ㘮ড়䝊䫒ডᑨ˄PCR˅੠៪⮙↦ߚ⾏DŽབ ᵰথ⮙᮹ᳳ੠䞛ḋ᮹ᳳ䯈䱨ᇣѢ5໽ˈ䖯㸠ELISAǃ㸔㒚㚲ޱ䲚ᡥࠊ䆩 偠ǃPCR੠⮙↦ߚ⾏˗བᵰ䯈䱨>5໽ˈ߭া䖯㸠ELISA੠㸔㒚㚲ޱ䲚 ᡥࠊ䆩偠DŽ

㗕ᣱҎ⇥⇥Џ

݅੠೑

2009ᑈⱏ䴽⛁⮙՟ߚ㉏^† ৺ ᇍϔᅮ↨՟ⱘⱏ䴽⛁⮙՟Փ⫼ELISA䖯㸠Ẕ⌟ˈབЈᯊথ⫳ⱘᲈথ⮙՟

ḋᴀ੠ᴹ㞾ⳕ㑻ए䰶ⱘḋᴀDŽ

ᇚথ⮙᮹ᳳ੠䞛ḋᯊ䯈䯈䱨<5໽ⱘ,J0䰇ᗻḋᴀᣥ䗝ߎᴹˈ೼ϔᆊᴎᵘ 䖯㸠㸔⏙ߚൟˈԚ᠔᳝ⱘḋᴀ䛑䖯㸠঺໪ϔ⾡㸔⏙ߚൟẔ⌟DŽ 偀ᴹ㽓Ѯ থ⛁៪থ⛁৆ˈҹঞı2乍ϟ߫

㸼⦄˖༈⮯ǃⴐⴊ⮯ǃ㙠⮯ǃ

݇㡖⮯ǃߎ⮍ǃߎ㸔㸼⦄ǃⱑ 㒚㚲ޣᇥˈ៪᳝䰇ᗻᅲ偠ᅸ㒧 ᵰⱘ⮙՟

৺ ≵᳝䞛ḋᮍḜ˖⹂䆞ձ䴴㸔⏙ᄺ˄IgM˅៪㗙ᡫॳẔ⌟˄䴲㒧ᵘ㲟ⱑ 1ൟˈNS1˅DŽ

㧆ᕟᆒ 2009ᑈⱏ䴽⛁⮙՟ߚ㉏^†

ᗹᗻ䍋⮙থ⛁2–7໽ˈᑊ᳝ı2 乍ϟ߫㸼⦄˖༈⮯ǃⴐⴊ⮯ǃ 㙠⮯ǃ݇㡖⮯ǃߎ⮍ǃߎ㸔㸼

⦄ǃⱑ㒚㚲ޣᇥ

৺ ᇍϔᅮ↨՟ⱘ⭥Ԑⱏ䴽⛁⮙՟䖯㸠㸔⏙ᄺ˄IgM˅៪PCRẔ⌟DŽ

ᮄࡴവ ᗹᗻ䍋⮙থ⛁2–7໽ˈᑊ᳝ı2 乍ϟ߫㸼⦄˖༈⮯ǃ㚠⮯ǃ㙠

⮯ǃߎ⮍ǃⴐⴊ⮯ǃ݇㡖⮯ǃ ߎ㸔ǃⱑ㒚㚲ޣᇥ

㽕∖ ᇍ᠔᳝ⱘЈᑞ䆞ᮁ⮙՟䖯㸠ᅲ偠ᅸẔ⌟ˈাⱏ䆄㸔⏙ᄺ˄IgM˅៪

PCR/NS1䰇ᗻⱘ⮙՟DŽ

䍞फ 2009ᑈⱏ䴽⛁⮙՟ߚ㉏^† ৺ ϔ䚼ߚⱏ䴽⛁⮙՟䞛⫼㸔⏙ᄺẔ⌟ˈᇥ᭄⮙՟ᷛᴀ䖯㸠⮙↦ߚ⾏DŽ

▇໻߽Ѯ থ⛁ǃ༈⮯ǃ݇㡖⮯ǃ㙠⮯ǃ ߎ⮍ǃᙊᖗ੠਩৤

㽕∖ ᠔᳝Јᑞ䆞ᮁ⮙՟䳔㽕䖯㸠ᅲ偠ᅸẔ⌟ˈԚাᇍϟ߫ᮍ⊩⹂䆞ⱘ⮙՟䖯 㸠ⱏ䆄˖ߚ⾏Ẕ⌟ࠄⱏ䴽⛁⮙↦៪IgG㸔⏙ᄺ䰇䕀៪ᡫԧ∈ᑇᰒ㨫छ 催៪ⱏ䴽⛁⮙↦ᡫԧⓈᑺ∈ᑇıסछ催៪೼㛥㛞⎆ЁẔ⌟ࠄⱏ䴽⛁⮙

↦⡍ᓖᗻIgMᡫԧ៪೼㸔⏙ЁẔ⌟ࠄⱏ䴽⛁⮙↦⡍ᓖᗻIgMᡫԧDŽ

* 䖭䞠াࣙᣀヺড়Јᑞⱏ䴽⛁⮙՟ᅮН᠔䳔㽕ⱘ᳔Ԣᷛޚ˗ᇍѢ᳈Ϲ䞡ⱘᚙމ˄བ˖ⱏ䴽⛁ߎ㸔⛁ǃⱏ䴽⛁ӥܟ㓐ড়ᕕ˅᠔䳔㽕ⱘ݊Ҫԧᕕ੠⮛⢊䖭䞠

≵᳝߫ߎDŽ

噛 ⱏ䴽⛁ৃ㛑⮙՟ᅮНЎӏԩߎ⦄থ⛁੠ҹϟϸ乍៪᳈໮㸼⦄㗙˖ᙊᖗǃ਩৤ǃߎ⮍ǃ⮐੠⮯ǃℶ㸔ᏺ䆩偠䰇ᗻǃⱑ㒚㚲ޣᇥ੠ӏԩ䄺⼎ԧᕕDŽߎ⦄䄺

⼎ԧᕕⱘ⮙՟ᅮНЎЈᑞ䆞ᮁ⮙՟ߎ⦄ϟ߫ӏԩϔ乍㗙˖㝍⮯៪㝍䚼य़⮯ǃᣕ㓁਩৤ǃЈᑞ⿃⎆ǃ㉬㝰ߎ㸔ǃரⴵǃ䑕ࡼǃ㙱㚓໻>2६㉇ˈ㑶㒚㚲 य़⿃๲ࡴৠᯊԈ㸔ᇣᵓᖿ䗳䰡ԢDŽϹ䞡ⱏ䴽⛁ᅮНЎϹ䞡㸔⌚϶༅ᇐ㟈ҹϟӏԩϔ乍㗙˖ӥܟǃ⿃⎆Ԉ੐਌ぬ䖿៪Јᑞए⫳䆘ԄⱘϹ䞡ߎ㸔៪఼ᅬߎ

⦄Ϲ䞡䯂乬ˈࣙᣀ㙱㛣˄໽ހ⇼䝌⇼෎䕀⿏䝊៪ϭ⇼䝌⇼෎䕀⿏䝊ı1000˅ǃЁᵶ⼲㒣㋏㒳˄ᛣ䆚ᤳᆇ˅៪㗙ᖗ㛣੠݊Ҫ఼ᅬDŽ

՟᭄ै䰡Ԣᕜ໮DŽ✊㗠ˈ᭤⌢੠㒑඗᳝໻䞣ⱘⱏ䴽⛁

᡹ਞ⮙՟ˈ೼ᮄࡴࢦ໮ሐѮⱘ᡹ਞ⮙՟᭄г೼๲ࡴˈ 䖭ᰃ䆹ऎඳ᳝৆ҹᴹ᡹ਞⱘ᳔໻ᲈথⱘᓔྟ䰊↉^[10]DŽ ሑㅵ೼ᏈᏗѮᮄ޴ݙѮ≵᳝ϧ䮼ᓔሩ䩜ᇍⱏ䴽⛁ⱘⲥ

⌟ˈԚᰃ䗮䖛ᇍ▇໻߽Ѯ੠݊Ҫഄऎⱘ䕧ܹᗻ⮙՟ⱘ

⌕㸠⮙ᄺ੠㋏㒳䖯࣪ߚᵤˈৃҹᕜདⱘ䆚߿⌕㸠ⱘ⮙

↦㉏ൟ^[11]DŽ

2011

ᑈҹᴹߎ⦄ⱘ᡹ਞথ⮙⥛ᯢᰒᬍবҹঞ㸔⏙

ൟߚᏗⱘ䕀বˈݡϔ⃵ᔎ䇗њ䳔㽕ᣕ㓁ᓔሩⲥ⌟ǃֵ

ᙃ݅ѿ੠ᓔሩ䆘ԄDŽ೼ഄᮍሖ䴶Ϟˈ⮙՟ⱘঞᯊ᡹ਞ

ৃҹਃࡼᮽᳳᑨᇍˈ՟བၦҟ᥻ࠊ੠ᲈথ䇗ᶹ䰏ᮁᴀ

ഄӴ᪁DŽ೼೑ᆊ៪ഄऎሖ䴶Ϟˈᐌ㾘੠ঞᯊⱘֵᙃ݅

ѿৃࡴᔎᇍᔶ࢓ⱘњ㾷ˈᑊЎ亢䰽䆘Ԅ੠ᑨᇍޚ໛ᦤ կֵᙃˈ↨བ䇈ᇍ䚏೑៪䙷ѯ᳝㋻ᆚ䌌ᯧᮙ␌ᕔᴹⱘ

೑ᆊ䖯㸠亢䰽≳䗮˄՟བˈⱏ䴽⛁Ꮖ㒣ҢѮ⌆㹿ᓩܹ

ᇕ䯁ⱘ໾ᑇ⋟ቯ೑^[12]˅DŽ䞡㽕ⱘᰃˈҢ

2010

ᑈᓔྟ䖯

䅼䆎

ⱏ䴽⛁೼

2012

ᑈ㒻㓁೼㽓໾ᑇ⋟ഄऎ䗴៤䋳ᢙˈᘏ᡹

ਞ⮙՟᭄໮ѢϞϔᑈᑺDŽ▇໻߽Ѯǃ᷀ඨᆼǃ㗕ᣱҎ

⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃ㧆ᕟᆒǃᮄࡴവ੠䍞फ᡹

ਞ⮙՟᭄䛑䍙䖛

1000

՟DŽ䰸ᮄࡴവ໪ˈ݊ԭ೑ᆊϢ

2011

ᑈⳌ↨᡹ਞ⮙՟᭄䛑᳝᠔๲ࡴDŽⱏ䴽⛁ⱘᄷ㡖ᗻ

⡍ᕕҡ✊Ϣ᮶ᕔ῵ᓣϔḋˈ೼᷀ඨᆼǃ㗕ᣱҎ⇥⇥Џ

݅੠೑ǃ㧆ᕟᆒ੠䍞फ䛑ᰃ೼䲼ᄷ๲ࡴᑊ䖒ࠄ催ዄDŽ ሑㅵ᳝ѯ೑ᆊ˄᷀ඨᆼǃ偀ᴹ㽓Ѯǃᮄࡴവ੠䍞फ˅

Џ㽕㸔⏙ൟϢϞϔᑈᑺⳌৠˈԚᰃ೼঺໪ϔѯ೑ᆊ߭

থ⫳њব࣪ˈࣙᣀ▇໻߽Ѯ੠㗕ᣱҎ⇥⇥Џ݅੠೑ˈ 䖭ϸϾ೑ᆊ೼

2012

ᑈⱘЏ㽕㸔⏙ൟЎ

DEN-3

ൟˈ㗠೼

2010

ᑈ^[1]੠

2011

ᑈ^[2]Џ㽕㸔⏙ൟЎ

DEN-1

ൟDŽ

೼໾ᑇ⋟ߚऎˈ㱑✊2011ᑈ೼ᆚܟ㔫ሐ㽓Ѯ㘨䙺

੠偀㒡ᇨ㕸ቯথ⦄໻㾘῵ᲈথˈԚᰃ2012ᑈⱘ᡹ਞ⮙

೒2. 2012ᑈᣝ᮹ग़਼˄᷀ඨᆼǃ㗕ᣱҎ⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃᮄࡴࢦ໮ሐѮ੠ᮄࡴവ˅੠᳜ӑ˄▇໻߽

Ѯ੠㧆ᕟᆒ˅ⱘⱏ䴽⛁᡹ਞ⮙՟᭄

᷀ඨᆼ 㗕ᣱҎ⇥⇥Џ݅੠೑ 偀ᴹ㽓Ѯ

0 500 1000 1500 2000 2500

1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52

Number of cases

Epidemiological week

0 100 200 300 400 500 600

1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52

Number of cases

Epidemiological week

0 100 200 300 400 500 600 700

1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52

Number of cases

Epidemiological week

0 20 40 60 80 100 120 140 160

1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52

Number of cases

Epidemiological week 0

10 20 30 40 50 60 70 80 90

1 4 7 10 13 16 19 22 25 28 31 34 37 40 43 46 49 52

Number of cases

Epidemiological week

ᮄࡴࢦ໮ሐѮ ᮄࡴവ

0 50 100 150 200 250 300

1 2 3 4 5 6 7 8 9 10 11 12

Number of cases

Month

0 5000 10000 15000 20000 25000 30000 35000

1 2 3 4 5 6 7 8 9 10 11 12

Number of cases

Month

▇໻߽Ѯ 㧆ᕟᆒ

਼ ਼ ਼

਼ ਼

᳜ ᳜

⮙՟᭄ ⮙՟᭄

⮙՟᭄ ⮙՟᭄

⮙՟᭄ ⮙՟᭄ ⮙՟᭄

䌘ࡽ

᮴DŽ 㟈䇶

ᛳ䇶㽓໾ᑇ⋟ऎඳ᠔᳝Ϫ⬠ि⫳㒘㒛偏৘೑ࡲ݀

ᅸਬᎹ੠៤ਬ೑೼ⲥ⌟᭄᥂ᬊ䲚੠᡹ਞᮍ䴶㒭ќⱘण

ࡽDŽ

ᓩ⫼ᴀ᭛ഄഔ˖

Arima Y et al. Epidemiological update of the dengue situation in the Western Pacific Region. Western Pacific Surveillance and Response Journal, 2015, 6(2):82–89.

doi:10.5365/wpsar.2014.5.4.002

খ㗗᭛⤂

1. Arima Y, Matsui T. Epidemiologic update of dengue in the Western Pacific Region, 2010. Western Pacific Surveillance and Response Journal, 2011, 2:4–8. doi:10.5365/wpsar.2011.2.2.005 pmid:23908882

2. Arima Y et al. Epidemiologic update on the dengue situation in the Western Pacific Region, 2011. Western Pacific Surveillance and Response Journal, 2013, 4(2):47–54. doi:10.5365/

wpsar.2012.3.4.019 pmid:24015372

3. Shepard DS, Undurraga EA, Halasa YA. Economic and disease burden of dengue in Southeast Asia. PLoS Neglected Tropical Diseases, 2013, 7:e2055. doi:10.1371/journal.pntd.0002055 pmid:23437406

4. Vong S et al. Under-recognition and reporting of dengue in Cambodia:

a capture-recapture analysis of the National Dengue Surveillance System. Epidemiology and Infection, 2012, 140:491–499.

doi:10.1017/S0950268811001191 pmid:21733251

5. Duong V et al. Complex dynamic of dengue virus serotypes 2 and 3 in Cambodia following series of climate disasters. Infection, Genetics and Evolution, 2013, 15:77–86. doi:10.1016/j.

meegid.2012.05.012

6. Reich NG et al. Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity. Journal of the Royal Society, Interface, 2013, 10:20130414. doi:10.1098/

rsif.2013.0414 pmid:23825116

7. Anker M, Arima Y. Male-female differences in the number of reported incident dengue fever cases in six Asian countries. Western Pacific Surveillance and Response Journal, 2011, 2(2):17–23.

doi:10.5365/wpsar.2011.2.1.002 pmid:23908884

8. Prasith N et al. Assessment of gender distribution in dengue surveillance data, the Lao People’s Democratic Republic. Western Pacific Surveillance and Response Journal, 2013, 4(2):17–24.

doi:10.5365/wpsar.2012.3.4.020 pmid:24015367

9. Undurraga EA, Halasa YA, Shepard DS. Use of expansion factors to estimate the burden of dengue in Southeast Asia: a systematic analysis. PLoS Neglected Tropical Diseases, 2013, 7:e2056.

㸠њᐌ㾘ⱘ↣2਼ϔ⃵ⱘഄऎⱏ䴽⛁ᔶ࢓᡹ਞˈֵᙃ䗮 䖛᳈ᑓ⊯ⱘ݀݅ि⫳ⲥ⌟㔥㒰˄՟བϪ⬠ि⫳㔥^[13]˅ 㹿ᅮᳳ݅ѿˈ㗠ϨЎњᦤ催ᮙ␌㗙عᒋ^[14]ⱘᛣ䆚ˈ⬅

៤ਬ೑䖯㸠㗏䆥կᴀഄՓ⫼DŽഄऎֵᙃ݅ѿ֗䖯њᮽ

ᳳᑨᇍˈ䖭ϢϪ⬠ि⫳㒘㒛ⱘѮ໾ഄऎᮄথӴᶧ⮙ᑨ ᇍㄪ⬹ḚᶊⳌϔ㟈ˈⳂⱘᰃЎњ๲ᔎ೑ᆊ੠ഄऎⲥ⌟

੠ᑨᇍⱘ㛑࡯DŽ

Ϣҹࠡⱘⱏ䴽⛁ഄऎߚᵤϔḋ^[1,2]ˈᴀ⃵ⲥ⌟᭄

᥂ߚᵤгᄬ೼䕗໻ⱘሔ䰤ᗻˈ᮶ࣙᣀᇍⱏ䴽⛁ⳳᅲ⮒

⮙䋳ᢙ㾷䞞ⱘሔ䰤ᗻ˄՟བˈⓣ᡹˅ˈгࣙᣀᇍ䱣 ᯊ䯈ব࣪䍟࢓㾷䞞ⱘሔ䰤ᗻ˄՟བˈ⮒⮙ⱘᛣ䆚ǃ䆞

ᮁẔ⌟᡹ਞ㸠Ўⱘব࣪˅DŽ՟བˈ

2012

ᑈ偀ᴹ㽓 Ѯᇚ

NS1

ᡫॳ䰇ᗻḋᴀ԰Ўϔ⾡⹂䆕ᅲ偠ᅸẔ⌟ᮍ⊩

⫼Ѣⲥ⌟ˈ᮴䆎⮙՟ᰃ৺݋᳝Јᑞ⮛⢊ˈᅲ偠ᅸ⹂䆞 ⱘ⮙՟㹿ࣙᣀ೼⮙՟ЁDŽ೼㧆ᕟᆒˈ㒻㓁᥼ᑓ

2009

ⱏ 䴽⛁ߚ㉏㋏㒳ˈҹ᳓ҷ೼

2011

ᑈҡᑓ⊯Փ⫼ⱘЈᑞ

⮙՟ᅮНDŽℸ໪ˈ೑ᆊ䯈ⱘ↨䕗г䳔㽕䇼ᜢ䖯㸠ˈ಴

Ў▇໻߽Ѯ੠ᮄࡴവা᡹ਞᅲ偠ᅸ⹂䆞⮙՟ˈ㗠᷀ඨ ᆼǃ㗕ᣱҎ⇥⇥Џ݅੠೑ǃ偀ᴹ㽓Ѯǃ㧆ᕟᆒ੠䍞फ

᡹ਞⱘ߭Џ㽕ЎЈᑞ⭥Ԑ⮙՟˗䖭ѯخ⊩ৃ㛑ᇐ㟈ⓣ

᡹៪䖛ᑺ᡹ਞDŽ䞡㽕ⱘᰃˈ⮙⅏⥛ϡҙফࠄЈᑞㅵ⧚

ⱘᕅડˈ䖬ফࠄ∖ए㸠ЎǃЈᑞए⫳᡹ਞ㸠Ўǃ⮙՟

ᅮНǃ᡹ਞᯊ䯈ǃ⮙՟䱣䆓੠⹂䅸䖛⿟ⱘᕅડ˗䖭ѯ

಴㋴೼៤ਬ೑П䯈ҹঞϡৠᯊᳳ䛑ৃ㛑ϡৠDŽᅲ偠ᅸ

⹂䆞ⱘ䞛ḋᮍḜ೼៤ਬ೑П䯈гϡৠˈৃ㛑ϡᰃ㋏㒳 ⱘ៪᳝ҷ㸼ᗻⱘˈ䖭г┰೼ഄ䰤ࠊњᇍ᡹ਞ㸔⏙ൟߚ Ꮧⱘ㾷䞞DŽ᳔ৢˈϔѯ៤ਬ೑೼

2011

ᑈ੠

2012

ᑈᳳ

䯈ᇚ

2009

ⱏ䴽⛁⮙՟ߚ㉏ᮍḜᭈড়ࠄⱏ䴽⛁ⲥ⌟㋏㒳 Ёˈ䖭ӮᕅડϢПࠡᑈӑ᡹ਞ᭄᥂ⱘৃ↨ᗻDŽ

㱑✊ᄬ೼䖭ѯሔ䰤ᗻˈҡ✊㒻㓁䳔㽕೼ᐌ㾘੠

ঞᯊⱘ෎⸔Ϟᓔሩഄऎ㣗ೈݙⱘⱏ䴽⛁᭄᥂݅ѿDŽᑨ 䆹䙓ܡⳈ᥹↨䕗೑ᆊП䯈ⱘ᡹ਞথ⮙⥛੠⮙⅏⥛ˈԚ ᰃ೼ৠϔϾ೑ᆊݙˈৃҹ㾖ᆳࠄग़৆ᗻҹঞϔ㟈ᗻⱘ ᄷ㡖䍟࢓ˈৠᯊгৃҹⳟࠄ䇌བ㸔⏙ൟߚᏗ䖭⾡┰೼

ⱘ䞡㽕ব࣪DŽ䖭ѯⲥ⌟᭄᥂гৃҹ⫼Ѣ᭄ᄺ῵ൟ^[6]ˈ ᔧⱏ䴽⛁⭿㢫䖯ܹᏖഎᯊৃҹᦤկ෎㒓ⱏ䴽⛁ⲥ⌟᭄

᥂DŽ᳔ৢˈ೼䖭Ͼᖿ䗳থሩ੠ⳌѦ㘨㋏ⱘऎඳˈ⮙՟

ϡᮁഄ䕧ܹࠄ䴲⌕㸠ऎඳ㸼ᯢњ᠔᳝೑ᆊᇍⱏ䴽⛁ᓔ ሩⲥ⌟ᑊ݅ѿֵᙃⱘ䞡㽕ᗻ^[15]DŽ

߽Ⲟކさ ᮴DŽ

13. ProMED. Published Date: 2012–09–17 16:43:48.

Subject: PRO/EDR> Dengue/DHF update 2012 (43): Asia Archive Number: 20120917.1297396 (http://www.

promedmail.org/direct.php?id=20120917.1297396, accessed 26 February 2015).

14. Quarantine Information - dengue situation updates – Asia [in Japanese]. Tokyo, Office Ministry of Health, Labour and Welfare Japan, 2014.

15. Nakamura N et al. Incidence of dengue virus infection among Japanese travellers, 2006 to 2010. Western Pacific Surveillance and Response Journal, 2012, 3(2):39–45. doi: 10.5365/

wpsar.2011.2.3.002 pmi d:23908911 10. Dupont-Rouzeyrol M et al. Epidemiological and molecular features

of dengue virus type-1 in New Caledonia, South Pacific, 2001–

2013. Virology Journal, 2014, 11:61. doi:10.1186/1743- 422X-11-61 pmid:24684835

11. Warrilow D, Northill JA, Pyke AT. Sources of dengue viruses imported into Queensland, Australia, 2002–2010. Emerging Infectious Diseases, 2012, 18:1850–1857. doi:10.3201/

eid1811.120014 pmid:23092682

12. Wilder-Smith A, Gubler DJ. Geographic expansion of dengue:

the impact of international travel. The Medical Clinics of North America, 2008, 92:1377–1390, x. doi:10.1016/j.

mcna.2008.07.002 pmid:19061757