Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in
West Africa recently gave rise to American and Asian populations of this major disease vector
Item Type Article
Authors Crawford, Jacob E.;Alves, Joel M.;Palmer, William J.;Day, Jonathan P.;Sylla, Massamba;Ramasamy, Ranjan;Surendran, Sinnathamby N.;Black, William C., IV;Pain, Arnab;Jiggins, Francis M.
Citation Crawford JE, Alves JM, Palmer WJ, Day JP, Sylla M, et al. (2017) Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector. BMC Biology 15. Available: http://dx.doi.org/10.1186/
s12915-017-0351-0.
Eprint version Publisher's Version/PDF
DOI 10.1186/s12915-017-0351-0
Publisher Springer Nature
Journal BMC Biology
Rights This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://
creativecommons.org/licenses/by/4.0/), which permits
unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/
publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Link to Item http://hdl.handle.net/10754/622961
A
- Mean FSTvalues for1000bp non-overlapping windows for each population pairwise comparison.The x-axis represents a physical map (bp) made by arranging scaffolds along the genetic map with scaffolds mapping to the same genetic map position being ordered randomly. Scaffolds according to Juneja et al (2015 PLoS Pathogens. 11:
e1004765). All positions with less than 10 individuals in each population
comparison were excluded. Only windows contained at least 10 SNPs were plotted.
Mexico vs. Senegal Forest
Mexico vs. Senegal Urban
Mexico vs. Sri Lanka
Mexico vs. Uganda
Senegal Forest vs. Senegal Urban
Senegal Forest vs. Sri Lanka
Senegal Forest vs. Uganda
Senegal Urban vs. Sri Lanka
Senegal Urban vs. Uganda
Sri Lanka vs. Uganda
0.00.40.80.00.40.80.00.40.80.00.40.8
UGA SEN1 SEN2 SRI MEX
Chr. 1
Uganda Senegal Forest
Senegal Urban
Sri
Lanka Mexico
B
- Ancestry proportions for Ae. aegyptiindividuals from five populations calculated for each of the chromosomes separately.Ancestry is conditional on the number of genetic clusters (K=2–5), and is inferred from all sites in our dataset.
0.00.40.80.00.40.80.00.40.80.00.40.8
UGA SEN1 SEN2 SRI MEX
0.00.40.80.00.40.80.00.40.80.00.40.8
UGA SEN1 SEN2 SRI MEX
Chr. 2
Chr. 3
Uganda Senegal Forest
Senegal Urban
Sri
Lanka Mexico
Uganda Senegal Forest
Senegal Urban
Sri
Lanka Mexico
Chr. 1
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PC1
PC2
Pop
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MEX SEN1 SEN2 SRI UGA
PC1 (11.6%) / PC2 (5.59%)
Mexico Senegal Forest Senegal Urban Sri Lanka Uganda
C
- Principal components analysis of Ae. aegypti exome sequences from five populations calculated for each chromosome separately.The PCA was calculated from a covariance matrix calculated from all variants in the dataset and accounting for genotype uncertainty. The percentage of the variance explained by each component is shown on the top of the plot.
Chr. 3
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PC1
PC2
Pop
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MEX SEN1 SEN2 SRI UGA
PC1 (12%) / PC2 (5.03%)
Mexico Senegal Forest Senegal Urban Sri Lanka Uganda
Chr. 2
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PC1
PC2
Pop
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MEX SEN1 SEN2 SRI UGA
PC1 (11.5%) / PC2 (5.11%)
Mexico Senegal Forest Senegal Urban Sri Lanka Uganda