Article FRONTIERS Number: 544794 IN PHARMACOLOGY

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Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated FromDatura metelLinnaeus (Angel's Trumpet) Fruits

By: Bawazeer, S (Bawazeer, Saud) ;Rauf, A (Rauf, Abdur) ; Bawazeer, S (Bawazeer, Sami)

FRONTIERS IN PHARMACOLOGY Volume: 11

Article Number: 544794 DOI: 10.3389/fphar.2020.544794 Published: SEP 25 2020 Document Type: Article Jump to

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Datura metelLinn is used traditionally for the treatment of various diseases including relaxation of smooth muscles, relief of fever, as well as

gastrointestinal disorder. This study deals with the bio-guided isolation of an active, amyrin-type triterpenoid, namely 3-oxo-6-beta-hydroxy-beta-amyrin (daturaolone;1), from the chloroform fraction ofDatura metelL. (Angel's trumpet) fruits and its gastrointestinal motility, antipyretic, and muscle relaxation effects in animal models. The chemical structure of daturaolone (1) was elucidated by NMR spectroscopy and crystallography techniques. The chloroform fraction and daturaolone (1) were assessed for the GIT motility test. Data exhibited in charcoal meal GI transit test show that chloroform fraction and daturaolone (1) significantly reduce GIT motility and increased intestinal transit time, comparable to the standard (atropine), a muscarinic receptor blocking agent. Muscle relaxant potency of the extract and daturaolone (1) was assessed in various animal paradigms. In the inclined plane screening test, it produced a significant (P < 0.05) muscle relaxation potential in a dose-dependent manner a er 30, 60, and 90 min. Likewise, the muscle relaxation potential of the extract and daturaolone (1) was strongly complemented by the chimney and traction test, representing a dominant effect a er 60 min of sample administration. The chloroform fraction showed good antipyretic activity, and while daturaolone (1) exhibited significant activity at a higher dose, the maximum effect (84.64%) was at 20 mg/kg i.p. In acute toxicity screening test, the chloroform extract (100, 250, 500, and 1,000 mg/kg) and daturaolone (1) (5, 10, 20, and 50 mg/kg) were found safe. In conclusion, the chloroform extract and daturaolone (1) exhibited strong

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FRONTIERS IN PHARMACOLOGY

Journal Impact Factor ™ 2020

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Keywords

Author Keywords: Datura metel;daturaolone;gastrointestinal motility;

antipyretic activity;muscle relaxation activity

Keywords Plus: IN-VIVO;METEL;ANTIOXIDANT;EXTRACTS;LEAVES Author Information

Corresponding Address: Bawazeer, Saud(corresponding author)

Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut Chem, Mecca, Saudi Arabia

Corresponding Address: Rauf, Abdur(corresponding author) Univ Swabi, Dept Chem, Swabi, Pakistan

Addresses:

1 Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut Chem, Mecca, Saudi Arabia

2 Univ Swabi, Dept Chem, Swabi, Pakistan

3 Umm Al Qura Univ, Fac Pharm, Dept Pharmacognosy, Mecca, Saudi Arabia

E-mail Addresses: [email protected];[email protected] Categories/Classification

Research Areas: Pharmacology & Pharmacy Funding

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FRONTIERS IN PHARMACOLOGY ISSN:1663-9812

Current Publisher: FRONTIERS MEDIA SA,AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE CH-1015, SWITZERLAND

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diﬀerent animal models and intestinally, was found safe at higher tested doses.

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14- MED333- 10 National Science, Technology and Innovation Plan

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King Abdul-Aziz City for Science and Technology (KACST), Kingdom of Saudi Arabia

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