KFMRC Position:
Assistant Professor
Coordinator - Acquired & Inherited Disease Unit Fundamental & Applied Biology Group
Specialty: Cancer Biology, Cell Signaling, Gene Expression Degree: PhD in Biotechnology
Brief Bio:
Dr. Mohammad Sarwar Jamal, Joined King Fahd Medical Research Center, King Abdulaziz University, Jeddah as Assistant Professor. He completed his PhD in Biotechnology from International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
His research work focused on Systems biology oriented study of cancers and hematological disorders. During his Doctorate program, he studied the G1 phase of cell cycle arrest at the level of signaling, transcription factors and gene expression using systems biology approach. During his postdoctoral program in Cincinnati Children’s Hospital Medical Center (CCHMC), Cincinnati, he worked on leukemic humanized mouse model. Later in Human Oncology Department, Wisconsin Institute for Medical Research (WIMR), University of Wisconsin, USA, as Research Associate he worked on skin and prostate cancer. He has explored the activation of transcription factors (TFs) (GATA and PAX family) and microRNAs in responses to UVR exposure of mouse skin. In the continuum of that at KFMRC, KAU, Jeddah, KSA, he is investigating the role of TFs and miRs in the development of skin, prostate, breast cancer and hematological disorders using systems biology approach.
Area(s) of Research:
Cancer Biology and Hematological disorders
Dr. Mohammad Sarwar Jamal
Email: [email protected]
Publications:
Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways.Hafeez BB, Jamal MS, Fischer JW, Mustafa A, Verma AK.Int J Cancer.
2012 Nov 1;131(9):2175-86. doi: 10.1002/ijc.27478. Epub 2012 Mar 20.
Plumbagen(5-hydroxy-2-methyl-1,4 naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Sand JM, Bin Hafeez B, Jamal MS, Witkowsky O, Siebers EM, Fischer J, Verma AK, Carcinogenesis, 2012 Jan; 33(1):184-90. Epub 2011 Nov9
Genetic Ablation of PKC Epsilon Inhibits Prostate Cancer Development and Metastasis in Transgenic Mouse Model of Prostate Adenocarcinoma.Hafeez BB, Zhong W, Weichert J, Dreckschmidt NE, Jamal MS, Verma AK (Cancer Research. 2011 Mar 15;71(6):2318-27)
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes. Jamal MS, Ravichandran S, Jailkhani N, Chatterjee S, Dua R, Rao KV (BMC Syst Biol. 2010 Dec 9;4:169)
Integration of signals from the B-cell antigen receptor and the IL-4 receptor leads to a cooperative shift in the cellular response axis.
Aflakian N, Ravichandran S, Jamal MS, Jarvenpaa H, Lahesmaa R, Rao KV (Mol Biosyst. 2009 Dec;5(12):1661-71. Epub 2009 May 5)
Sperm membrane lipid liposomes can evoke an effective immune response against encapsulated antigen in BALB/c mice. Atif SM, Salam N, Ahmad N, Hasan IM, Jamal HS, Sudhanshu A, Azevedo V, Owais M.
(Vaccine. 2008 Oct 29;26(46):5874-82. Epub 2008 Oct 1)
