H AMAD A LANAZI
Date of Birth: Nov, 1st 1990 Phone: +966560860041
Email: [email protected]
Al Qurayyat, Jouf KSA 77217
CURRENT POSITION
Faculty member at Al Jouf University, College of Applied Medical Sciences at Al Qurayyat.
EDUCATION PhD UT Health San Antonio, Immunology, Microbiology and Molecular Genetics, 2021
Dissertation: “Innate Sensing of Aeroallergen-associated Immunogenic RNA Modulates Type 2 Lung Inflammation”
Committee: Dr. Xiao-Dong Li (chair), Dr. Guanming Zhong, Dr. Ann Griffith, Dr. Shamimunisa Begum Mustafa, Dr. Anne Sperling
MS UT Health San Antonio, Immunology and Infection, 2017 Thesis: “Determination of DNA-Dependent Activator of Interferons Regulatory Factors (DAI) During Herpesviruses Infection”
Advisor: Dr. William Kaiser
BS University of Tabuk, Medical Laboratory Technology, 2012
Undergraduate project title “Presence of Food-borne Microorganisms in The Street Food of Tabuk City”
Overall GPA: 4.52/5.0 HONORS AND
AWARDS B.S. Second Class Honor, 2013
Awarded Second Class Honor during undergraduate studies at college of Applied Medical Sciences at University of Tabuk.
Saudi Arabian Cultural Mission scholarship for MS degree, 2014 Awarded Saudi Arabian Cultural Mission scholarship for studying MS degree at one of the top universities in the US.
Saudi Arabian Cultural Mission scholarship for PhD degree, 2018 Awarded Saudi Arabian Cultural Mission scholarship for studying PhD degree at one of the top universities in the US.
RESEARCH AND WORK
EXPERIENCE
Innate Sensing of Aeroallergen-associated Immunogenic RNA Modulates Type 2 Lung Inflammation, UT Health San Antonio, USA, 2015-2021
Advisor: Dr. William Kaiser, Dr. Xiao-Dong Li
Conventional and quantitative PCR
Clustered regularly interspaced short palindromic repeats (CRISPR) technique
Molecular cloning
Transfection
Western blotting
Cell Culture
Flow cytometry
Immunohistochemistry, immunofluorescence techniques
Medical Laboratory, Haqel General Hospital, KSA, 2012-2013 Position: Medical Laboratory Scientist
Managed and performed experimental techniques in various lab departments including Hematology, Serology, Microbiology and Blood Bank.
Performed blood tests and blood counts.
Screened cells and cultures for abnormalities.
Performed, calibrated, and tested maintenance of medical laboratory equipment.
Analyzed and recorded results
Prepared routine laboratory reagents
PUBLICATIONS
Journal Publications
H. H. Alanazi, X. D. Li. Modulation of Type 2 Inflammation by Sensing Immunomodulatory RNA in House Dust Mite and Viruses. J Allergy Infect Dis 2021; 2(1):17-23.
She, L., G. D. Barrera, L. Yan, H. H. Alanazi, E. G. Brooks, P. H. Dube, Y. Sun, H. Zan, D. P. Chupp, N. Zhang, X. Zhang, Y. Liu and X. D. Li (2021). "STING activation in alveolar macrophages and group 2 innate lymphoid cells suppresses IL-33-driven type 2 immunopathology." JCI Insight 6(3).
She, L*., H. H. Alanazi*, L. Yan, E. G. Brooks, P. H. Dube, Y. Xiang, F. Zhang, Y. Sun, Y. Liu, X.
Zhang and X. D. Li (2020). "Sensing and signaling of immunogenic extracellular RNAs restrain group 2
Alanazi, H. H., L. She and X. D. Li (2020). "Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation." J Vis Exp(159).
She, L., H. H. Alanazi, L. Yan, Y. Zou, Y. Sun, P. H. Dube, E. G. Brooks, G. D. Barrera, Z. Lai, Y.
Chen, Y. Liu, X. Zhang and X. D. Li (2019). "Immune Sensing of Aeroallergen-Associated Double- Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation." J Immunol 203(9): 2520-2531.
Journal Papers in Review
Li She, HamadH. Alanazi, Jingwei Wang, DanielP. Chupp, Yijiang Xu, Hong Zan, Zhenming Xu, Yil un Sun, Na Xiong, Nu Zhang, Xin Zhang, Yong Liu, Xiao-Dong Li (2020). "Non-canonical Activation of Human Group 2 Innate Lymphoid Cells by TLR4 Signaling." BioRxiv
H. H. Alanazi, She, L., L. Yan, Y. Zou, Y. Sun, P. H. Dube and X. D. Li (2021). “Immunogenic RNA of House Dust Mites Restrain Group 2 Innate Lymphoid Cell-Driven Acute Lung Inflammation in Interferon Independent Manner”.
Conference Papers
Hamad Alanazi, Li She, Liping Yan, Yilun Sun, Yi Zou, Peter Dube, Edward Brooks, Gema
Barrera, Zhao Lai, Yidong Chen, Yong Liu, Xin zhang and Xiao-Dong Li., “Immune Sensing of Aeroallergen-Associated Double-Stranded RNA Triggers an IFN Response and Modulates Type 2 Lung Inflammation." J Immunol May 1, 2020, 204 (1 Supplement) 147.35;
Li She, Gema Barrera, Liping Yan, Hamad Alanazi, Edward Brooks, Peter Dube, Yilun Sun, Yong
Liu, Nu Zhang, Xin zhang and Xiao-Dong Li.,“Inhibition of Acute Type-2 Lung Inflammation by 2′3′- cyclic Guanosine Monophosphate-Adenosine Monophosphate (2′3′-cGAMP)." J Immunol May 1, 2020, 204 (1 Supplement) 234.13;
PRESENTATIONS AND INVITED
LECTURES
Oral and Poster Presentation of Identification and characterization of immunogenic dsRNA in House Dust Mite, “Immunogenic RNA of House Dust Mites Restrain Group 2 Innate Lymphoid Cell-Driven Acute Lung Inflammation in Interferon Independent Manner” 5th Annual MIMG Spring Conference, April 2019.
Oral and Poster Presentation of Identification and characterization of immunogenic dsRNA in House Dust Mite, “Determining The Microbial Compositions of HDM Allergen by RNA-seq” 7th Annual Vaccine Development Center of San Antonio Conference, November 2018.
CONFERENCES 4th International Congress on Bacteriology and Infectious Diseases at San Antonio, TX USA. (May 16-18, 2016)
Infection, Immunity, and Vaccines at San Antonio, TX USA. (Nov 10- 12, 2016)
8th world Congress on Virology at San Antonio, TX USA. (Nov 28-30, 2016)
21st Annual Conference: HIV Update Contemporary Issues in Management at Harvard Medical School of Medicine in Boston, MA USA. (Jun 1-3, 2017)
PROFESSIONAL
TRAINING
Genes and The Human Condition University of Maryland, Online, Aug 2015 Bacteria and Chronic Diseases
University of Copenhagen, Online, Jun 2015 Introduction to the Biology of Cancer Johns Hopkins University, Online, Jun 2015
Cardiopulmonary resuscitation (CPR) Certification, 2013.
PROFESSIONAL
AFFILIATIONS
The American Association of Immunologists, 2019-Present
AAI is dedicated to advancing the knowledge of Immunology, fostering the interchange of ideas and information among investigators, and addressing the potential integration of immunologic principles into clinical practice.
COMMUNITY
SERVICE Science Fair Judge
Science and Engineering Fair at John Jay Science and Engineering Academy, San Antonio, USA, December 2018
LANGUAGES
Arabic: Native English: Advanced
Applications: G-Power, GraphPad Prism, R studio
REFERENCES Dr. Xiao Dong-Li, M.D., PhD
Director of Immunology & Inflammation at Melior discovery
pharmaceuticals, Department of Immunology, Microbiology & Molecular Genetics
Melior discovery pharmaceuticals, UT Health San Antonio Phone: +1(469) 260-9180#
Email: [email protected] Dr. William Kaiser, PhD
Inzen Therapeutics, Department of Immunology, Microbiology & Molecular Genetics
Inzen Therapeutics, UT Health San Antonio Phone: +1(404) 583-0910 #
Email: [email protected]
Dr. Zhong Guanming, M.D., PhD
Dielmann Chair of Genetic and Environmental Risk, Department of Immunology, Microbiology & Molecular Genetics
UT Health San Antonio Phone: +1 210 464 3656 # Email: [email protected]
