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Potent In Vitro alpha-Glucosidase and beta-Secretase Inhibition of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus (Angel's Trumpet) Fruits

By: Bawazeer, S (Bawazeer, Saud) ;Rauf, A (Rauf, Abdur) ; Bawazeer, S (Bawazeer, Sami)

BIOMED RESEARCH INTERNATIONAL Volume: 2020

Article Number: 8530165 DOI: 10.1155/2020/8530165 Published: AUG 25 2020 Document Type: Article Jump to

Keywords

Keywords Plus: PISTAGREMIC ACID;INSIGHTS;BIOLOGY;LEAVES Author Information

Corresponding Address: Bawazeer, Saud(corresponding author)

Umm Al Qura Univ, Dept Pharmaceut Chem, Fac Pharm, POB 42, Mecca, Saudi Arabia

Corresponding Address: Rauf, Abdur(corresponding author) Univ Swabi, Dept Chem, Swabi Anbar 23430, Kpk, Pakistan Addresses:

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Enriched Cited References Abstract

This study deals with alpha-glucosidase and beta-secretase inhibitory screening of extract/fractions and isolated daturaolone (1), namely, 3-oxo-6- beta-hydroxy-beta-amyrin (daturaolone) from chloroform fraction ofDatura metelL. Among entire fractions, the chloroform soluble fraction showed excellent activity against alpha-glucosidase with % inhibition 90.8 with IC(50)160.2 +/- 1.85 mu g and daturaolone (1) with 98.7% inhibition with IC(50)840.4 +/- 1.74 mu M, respectively. Similarly, extract and daturaolone (1) also exhibited significant activity against the beta-secretase enzyme (BACE1) with % activities 88.27 and 95.19 and with IC(50)values304.21 +/- 2.98 mu g and260.70 +/- 1.87 mu M, respectively, as compared to the standard inhibitor (Ans670, Sta671, Val672)-amyloid-beta/A4 precursor protein 770 fragments 662-675) with % activity 94.21 and IC(50)value289.24 +/- 1.60 mu M. This finding encourages and opens a new window for further detail phytochemical investigation onD.metelin order to isolate novel compounds with promising enzyme inhibitory potential.

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BIOMED RESEARCH INTERNATIONAL

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3.62

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BIOTECHNOLOGY & APPLIED MICROBIOLOGY

in SCIE edition

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MEDICINE, RESEARCH &

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1 Umm Al Qura Univ, Dept Pharmaceut Chem, Fac Pharm, POB 42, Mecca, Saudi Arabia

2 Univ Swabi, Dept Chem, Swabi Anbar 23430, Kpk, Pakistan

3 Umm Al Qura Univ, Dept Pharmacognosy, Fac Pharm, POB 42, Mecca, Saudi Arabia

E-mail Addresses: [email protected];[email protected]; [email protected]

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Research Areas: Biotechnology & Applied Microbiology;Research &

Experimental Medicine

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BIOMED RESEARCH INTERNATIONAL ISSN:2314-6133

eISSN:2314-6141

Current Publisher: HINDAWI LTD,ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON W1T 5HF, ENGLAND

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Research Areas: Biotechnology & Applied Microbiology;Research

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Web of Science Categories: Biotechnology & Applied Microbiology;Medicine, Research & Experimental

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