Selected Publications
2022
Ayman Abo Elmaaty, Wagdy M. Eldehna, Muhammad Khattab, Omnia Kutkat, Radwan Alnajjar, Ahmed N.
El-Taweel, Sara T. Al-Rashood, Mohammed A. S. Abourehab, Faizah A. Binjubair, Mohamed A. Saleh, Amany Belal and Ahmed A. Al-Karmalawy. Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies. International Journal of Molecular Sciences 2022, 23(20), 12235; https://doi.org/10.3390/ijms232012235
Antar, S.A., Saleh, M.A., Al-Karmalawy, A.A. Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2 (2022) Life Sciences, 309, art. no. 121048, DOI: 10.1016/j.lfs.2022.121048
Gupta, A., Jayakumar, M.N., Saleh, M.A., Kannan, M., Halwani, R., Qaisar, R., Ahmad, F. SARS-CoV-2 infection- induced growth factors play differential roles in COVID-19 pathogenesis. (2022) Life Sciences, 304, art. no. 120703, DOI: 10.1016/j.lfs.2022.120703
El-Huneidi, W., Anjum, S., Saleh, M.A., Bustanji, Y., Abu-Gharbieh, E., Taneera, J. Carnosic Acid Protects INS-1 β-Cells against Streptozotocin-Induced Damage by Inhibiting Apoptosis and Improving Insulin Secretion and Glucose Uptake. (2022) Molecules, 27 (7), art. no. 2102, DOI: 10.3390/molecules27072102
Saleh, M.A., Antar, S.A., Abdo, W., Ashour, A., Zaki, A.A. Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice (2022) Environmental Science and Pollution Research, DOI: 10.1007/s11356-022-22268-6
Hazem, R.M., Antar, S.A., Nafea, Y.K., Al-Karmalawy, A.A., Saleh, M.A., El-Azab, M.F. Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor (2022) Life Sciences, 288, art. no. 120185, DOI: 10.1016/j.lfs.2021.120185
Khan, A.A., Gul, M.T., Karim, A., Ranade, A., Azeem, M., Ibrahim, Z., Ramachandran, G., Nair, V.A., Ahmad, F., Elmoselhi, A., Qaisar, R. Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice (2022) npj Microgravity, 8 (1), art. no. 24, DOI: 10.1038/s41526-022-00211-w
Karim, A., Iqbal, M.S., Muhammad, T., Ahmad, F., Qaisar, R. Elevated plasma zonulin and CAF22 are correlated with sarcopenia and functional dependency at various stages of Alzheimer's diseases
(2022) Neuroscience Research, 184, pp. 47-53. DOI: 10.1016/j.neures.2022.08.004
Gupta, A., Qaisar, R., Halwani, R., Kannan, M., Ahmad, F. TFPI and FXIII negatively and S100A8/A9 and Cystatin C positively correlate with D-dimer in COVID-19 (2022) Experimental Biology and Medicine, 247 (17), pp. 1570-1576. DOI: 10.1177/15353702221102117
Al-Tamimi, A.O., Yusuf, A.M., Jayakumar, M.N., Ansari, A.W., Elhassan, M., AbdulKarim, F., Kannan, M., Halwani, R., Ahmad, F. SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19 (2022) International Journal of Laboratory Hematology, 44 (4), pp. 712- 721. DOI: 10.1111/ijlh.13829
Gupta, A., Al-Tamimi, A.O., Halwani, R., Alsaidi, H., Kannan, M., Ahmad, F. Lipocalin-2, S100A8/A9, and cystatin C: Potential predictive biomarkers of cardiovascular complications in COVID-19
(2022) Experimental Biology and Medicine, 247 (14), pp. 1205-1213. DOI: 10.1177/15353702221091990
Yusuf, A.M., Qaisar, R., Al-Tamimi, A.O., Jayakumar, M.N., Woodgett, J.R., Koch, W.J., Ahmad, F.
Cardiomyocyte-GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms (2022) Journal of Cellular Physiology, 237 (3), pp. 1804-1817. DOI:
10.1002/jcp.30644
Ahmad, F., Kannan, M., Ansari, A.W. Role of SARS-CoV-2 -induced cytokines and growth factors in coagulopathy and thromboembolism (2022) Cytokine and Growth Factor Reviews, 63, pp. 58-68.
DOI: 10.1016/j.cytogfr.2021.10.007
Shahzadi, S.K., Marzook, H., Qaisar, R., Ahmad, F. Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload (2022) Clinical science (London, England : 1979), 136 (2), pp. 181-196. DOI: 10.1042/CS20210964
Gupta, A., Marzook, H., Ahmad, F. Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview (2022) Clinical and Experimental Medicine. DOI: 10.1007/s10238-022-00821-4
Qaisar, R., Karim, A. A comparison of international and national references to measure the prevalence of stunting in Pakistani school-age girls (2022) Scientific Reports, 12 (1), art. no. 5501, . DOI: 10.1038/s41598- 022-09511-3
Karim, A., Muhammad, T., Shah, I., Khan, J., Qaisar, R. A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure (2022) Journal of Cardiology, 80 (5), pp. 449-455. DOI: 10.1016/j.jjcc.2022.06.006
Ahmed, Z., Qaisar, R. Nanomedicine for Treating Muscle Dystrophies: Opportunities, Challenges, and Future Perspectives (2022) International Journal of Molecular Sciences, 23 (19), art. no. 12039. DOI:
10.3390/ijms231912039
Shama, S., Qaisar, R., Khan, N.A., Tauseef, I., Siddiqui, R. The Role of 4-Phenylbutyric Acid in Gut Microbial Dysbiosis in a Mouse Model of Simulated Microgravity (2022) Life, 12 (9), art. no. 1301. DOI:
10.3390/life12091301
Karim, A., Muhammad, T., Shahid Iqbal, M., Qaisar, R. A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial (2022) Archives of Gerontology and Geriatrics, 102, art. no. 104721. DOI: 10.1016/j.archger.2022.104721
Ibrahim, Z., Ramachandran, G., El-Huneidi, W., Elmoselhi, A., Qaisar, R. Suppression of endoplasmic reticulum stress prevents disuse muscle atrophy in a mouse model of microgravity (2022) Life Sciences in Space Research, 34, pp. 45-52. DOI: 10.1016/j.lssr.2022.06.005
Karim, A., Bajbouj, K., Qaisar, R., Hall, A.C., Hamad, M. The role of disrupted iron homeostasis in the development and progression of arthropathy (2022) Journal of Orthopaedic Research, 40 (6), pp. 1243- 1250. DOI: 10.1002/jor.25323
Hawliczek, A., Brix, B., Al Mutawa, S., Alsuwaidi, H., Du Plessis, S., Gao, Y., Qaisar, R., Siddiqui, R., Elmoselhi, A.B., Goswami, N. Hind-limb unloading in rodents: Current evidence and perspectives (2022) Acta Astronautica, 195, pp. 574-582. DOI: 10.1016/j.actaastro.2022.03.008
Karim, A., Muhammad, T., Shah, I., Khan, J., Qaisar, R. Relationship of Haptoglobin Phenotypes With Sarcopaenia in Patients With Congestive Heart Failure (2022) Heart Lung and Circulation, 31 (6), pp. 822- 831. DOI: 10.1016/j.hlc.2022.01.003
Bajbouj, K., Qaisar, R., Alshura, M.A., Ibrahim, Z., Alebaji, M.B., Al Ani, A.W., Janajrah, H.M., Bilalaga, M.M., Omara, A.I., Assaleh, R.S.A., Saber-Ayad, M.M., Elmoselhi, A.B. Synergistic Anti-Angiogenic Effect of Combined VEGFR Kinase Inhibitors, Lenvatinib, and Regorafenib: A Therapeutic Potential for Breast Cancer (2022) International Journal of Molecular Sciences, 23 (8), art. no. 4408. DOI:
10.3390/ijms23084408
Karim, A., Iqbal, M.S., Muhammad, T., Qaisar, R. Evaluation of Sarcopenia Using Biomarkers of the Neuromuscular Junction in Parkinson’s Disease (2022) Journal of Molecular Neuroscience, 72 (4), pp. 820- 829. DOI: 10.1007/s12031-022-01970-7
Karim, A., Bajbouj, K., Shafarin, J., Qaisar, R., Hall, A.C., Hamad, M. Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes (2022) Frontiers in Cell and Developmental Biology, 10, art. no. 821014. DOI: 10.3389/fcell.2022.821014
Qaisar, R., Ustrana, S., Muhammad, T., Shah, I. Sarcopenia in pulmonary diseases is associated with elevated sarcoplasmic reticulum stress and myonuclear disorganization (2022) Histochemistry and Cell Biology, 157 (1), pp. 93-105. DOI: 10.1007/s00418-021-02043-3
Abdulsalam R, Alsadah A, Alkhuboli M, Muala D, Hussein A, Elmoselhi AB. Hydration status assessment and impinging factors among university students in the UAE. Eur Rev Med Pharmacol Sci. 2022 Sep;26(18):6451-6458. doi: 10.26355/eurrev_202209_29744. PMID: 36196695.
Bajbouj, K., Al-Ali, A., Shafarin, J., Sahnoon, L., Sawan, A., Shehada, A., Elkhalifa, W., Saber-Ayad, M., Muhammad, J., Elmoselhi, A.B., Guraya, S., Hamad, M. Vitamin D Exerts Significant Antitumor Effects by Suppressing Vasculogenic Mimicry in Breast Cancer Cells (2022) Frontiers in Oncology, 12, art. no. 918340.
DOI: 10.3389/fonc.2022.918340
Siddiqui, R., Mungroo, M.R., Anuar, T.S., Alharbi, A.M., Alfahemi, H., Elmoselhi, A.B., Khan, N.A.
Antiamoebic Properties of Laboratory and Clinically Used Drugs against Naegleria fowleri and Balamuthia mandrillaris (2022) Antibiotics, 11 (6), art. no. 749. DOI: 10.3390/antibiotics11060749
Hawliczek, A., Brix, B., Al Mutawa, S., Alsuwaidi, H., Du Plessis, S., Gao, Y., Qaisar, R., Siddiqui, R., Elmoselhi, A.B., Goswami, N. Hind-limb unloading in rodents: Current evidence and perspectives (2022) Acta Astronautica, 195, pp. 574-582. DOI: 10.1016/j.actaastro.2022.03.008
Jalaleddine, N., Hachim, M., Al-Hroub, H., Saheb Sharif-Askari, N., Senok, A., Elmoselhi, A., Mahboub, B., Samuel Kurien, N.M., Kandasamy, R.K., Semreen, M.H., Halwani, R., Soares, N.C., Al Heialy, S. N6-Acetyl- L-Lysine and p-Cresol as Key Metabolites in the Pathogenesis of COVID-19 in Obese Patients
(2022) Frontiers in Immunology, 13, art. no. 827603. DOI: 10.3389/fimmu.2022.827603
Mdkhana, B., Goel, S., Saleh, M.A., Siddiqui, R., Khan, N.A., Elmoselhi, A.B. Role of oxidative stress in angiogenesis and the therapeutic potential of antioxidants in breast cancer (2022) European Review for Medical and Pharmacological Sciences, 26 (13), pp. 4677-4692. DOI: 10.26355/eurrev_202207_29192
Riedhammer, K.M., Burgemeister, A.L., Cantagrel, V., Amiel, J., Siquier-Pernet, K., Boddaert, N., Hertecant, J., Kannouche, P.L., Pouvelle, C., Htun, S., Slavotinek, A.M., Beetz, C., Diego-Alvarez, D., Kampe, K., Fleischer, N., Awamleh, Z., Weksberg, R., Kopajtich, R., Meitinger, T., Suleiman, J., El-Hattab, A.W.
Suleiman-El-Hattab syndrome: a histone modification disorder caused by TASP1 deficiency (2022) Human molecular genetics, 31 (18), pp. 3083-3094. DOI: 10.1093/hmg/ddac098
Almannai, M., Marafi, D., El-Hattab, A.W. WIPI proteins: Biological functions and related syndromes (2022) Frontiers in Molecular Neuroscience, 15, art. no. 1011918. DOI: 10.3389/fnmol.2022.1011918
Al Ojaimi, M., Salah, A., El-Hattab, A.W. Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders (2022) Membranes, 12 (9), art. no. 8930. DOI:
10.3390/membranes12090893
Almannai, M., El-Hattab, A.W., Azamian, M.S., Ali, M., Scaglia, F. Mitochondrial DNA maintenance defects:
potential therapeutic strategies (2022) Molecular Genetics and Metabolism, 137 (1-2), pp. 40-48. DOI:
10.1016/j.ymgme.2022.07.003
Al Ojaimi, M., Banimortada, B.J., Othman, A., Riedhammer, K.M., Almannai, M., El-Hattab, A.W. Disorders of histone methylation: Molecular basis and clinical syndromes (2022) Clinical Genetics, 102 (3), pp. 169- 181. DOI: 10.1111/cge.14181
Almannai, M., Salah, A., El-Hattab, A.W. Mitochondrial Membranes and Mitochondrial Genome:
Interactions and Clinical Syndromes (2022) Membranes, 12 (6), art. no. 625, . DOI:
10.3390/membranes12060625
Almannai, M., Marafi, D., Abdel-Salam, G.M.H., Zaki, M.S., Duan, R., Calame, D., Herman, I., Levesque, F., Elbendary, H.M., Hegazy, I., Chung, W.K., Kavus, H., Saeidi, K., Maroofian, R., AlHashim, A., Al-Otaibi, A., Al Madhi, A., Abou Al-Seood, H.M., Alasmari, A., Houlden, H., Gleeson, J.G., Hunter, J.V., Posey, J.E., Lupski, J.R., El-Hattab, A.W. El-Hattab-Alkuraya syndrome caused by biallelic WDR45B pathogenic variants:
Further delineation of the phenotype and genotype (2022) Clinical Genetics, 101 (5-6), pp. 530-540. DOI:
10.1111/cge.14132
Salah, A., Almannai, M., Al Ojaimi, M., Radefeldt, M., Gulati, N., Iqbal, M., Alawbathani, S., Al-Ali, R., Beetz, C., El-Hattab, A.W. A homozygous frame-shift variant in PROSER1 is associated with developmental delay, hypotonia, genitourinary malformations, and distinctive facial features (2022) Clinical Genetics, 101 (5-6), pp. 565-570. DOI: 10.1111/cge.14126
2021
Ashry, N.A., Abdеlaziz, R.R., Suddеk, G.M., Saleh, M.A. Canagliflozin ameliorates aortic and hepatic dysfunction in dietary-induced hypercholesterolemia in the rabbit (2021) Life Sciences, 280, art. no.
119731. DOI: 10.1016/j.lfs.2021.119731
El-Huneidi, W., Bajbouj, K., Muhammad, J.S., Vinod, A., Shafarin, J., Khoder, G., Saleh, M.A., Taneera, J., Abu-Gharbieh, E. Carnosic acid induces apoptosis and inhibits akt/mtor signaling in human gastric cancer cell lines (2021) Pharmaceuticals, 14 (3), art. no. 230. DOI: 10.3390/ph14030230
Qaisar, R., Karim, A. BMI status relative to international and national growth references among Pakistani school-age girls (2021) BMC Pediatrics, 21 (1), art. no. 535. DOI: 10.1186/s12887-021-03017-z
Qaisar, R., Karim, A., Muhammad, T., Shah, I., Khan, J. Prediction of sarcopenia using a battery of circulating biomarkers (2021) Scientific Reports, 11 (1), art. no. 8632. DOI: 10.1038/s41598-021-87974-6
Karim, A., Muhammad, T., Ustrana, S., Qaisar, R. Intestinal permeability marker zonulin as a predictor of sarcopenia in chronic obstructive pulmonary disease (2021) Respiratory Medicine, 189, art. no. 106662.
DOI: 10.1016/j.rmed.2021.106662
Qaisar, R., Karim, A., Muhammad, T., Shah, I., Iqbal, M.S. The coupling between sarcopenia and COVID-19 is the real problem (2021) European Journal of Internal Medicine, 93, pp. 105-106. DOI:
10.1016/j.ejim.2021.09.009
Karim, A., Muhammad, T., Qaisar, R. Prediction of sarcopenia using multiple biomarkers of neuromuscular junction degeneration in chronic obstructive pulmonary disease (2021) Journal of Personalized Medicine, 11 (9), art. no. 919. DOI: 10.3390/jpm11090919
Qaisar, R. CELLULAR AND MOLECULAR MECHANISMS OF MUSCLE REGENERATION (2021) Khyber Medical University Journal, 13 (3), pp. 173-178. DOI: 10.35845/kmuj.2021.20319
Qaisar, R., Qayum, M., Muhammad, T. Reduced sarcoplasmic reticulum Ca2+ ATPase activity underlies skeletal muscle wasting in asthma (2021) Life Sciences, 273, art. no. 119296. DOI:
10.1016/j.lfs.2021.119296
Azeem, M., Qaisar, R., Karim, A., Ranade, A., Elmoselhi, A. Signature molecular changes in the skeletal muscle of hindlimb unloaded mice (2021) Biochemistry and Biophysics Reports, 25, art. no. 100930. DOI:
10.1016/j.bbrep.2021.100930
Ranade, A., Qaisar, R., Karim, A., Elmoselhi, A., Nair, V., Jose, J., Ramachandran, G., Ibrahim, Z., Gul, M.T., Hassan, W.A.-R., Azeem, M., Khan, A. PHARMACOLOGICAL INHIBITION OF ER STRESS MITIGATES TESTICULAR PATHOLOGY IN HIND-LIMB UNLOADED MICE (2021) Proceedings of the International Astronautical Congress, IAC, A2.
Khan, N.A., Qaisar, R., Siddiqui, R., Elmoselhi, A. Effect of microgravity on the gut microbiota bacterial composition in a hindlimb unloading model (2021) Proceedings of the International Astronautical Congress, IAC, A1.
Qaisar, R., Karim, A., Muhammad, T., Shah, I., Khan, J. Circulating MicroRNAs as biomarkers of accelerated sarcopenia in chronic heart failure (2021) Global Heart, 16 (1), art. no. 56. DOI: 10.5334/GH.943
Qaisar, R., Pharaoh, G., Bhaskaran, S., Xu, H., Ranjit, R., Bian, J., Ahn, B., Georgescu, C., Wren, J.D., Van Remmen, H. Restoration of sarcoplasmic reticulum Ca2+ atpase (SERCA) activity prevents age-related muscle atrophy and weakness in mice (2021) International Journal of Molecular Sciences, 22 (1), art. no.
37, pp. 1-14. DOI: 10.3390/ijms22010037
Karim, A., Qaisar, R., Hussain, M.A. Growth and socio-economic status, influence on the age at menarche in school going girls (2021) Journal of Adolescence, 86, pp. 40-53. DOI: 10.1016/j.adolescence.2020.12.001
Siddiqui, R., Maciver, S., Elmoselhi, A., Soares, N.C., Khan, N.A. Longevity, cellular senescence and the gut microbiome: lessons to be learned from crocodiles (2021) Heliyon, 7 (12), art. no. e08594. DOI:
10.1016/j.heliyon.2021.e08594
Bajbouj, K., Ramakrishnan, R.K., Saber-Ayad, M., Omar, H.A., Sharif-Askari, N.S., Shafarin, J., Elmoselhi, A.B., Ihmaid, A., Al Haj Ali, S., Alalool, A., Abdullah, R., Hamid, Q. Prmt5 selective inhibitor enhances therapeutic efficacy of cisplatin in lung cancer cells (2021) International Journal of Molecular Sciences, 22 (11), art. no. 6131. DOI: 10.3390/ijms22116131
Almannai, M., El-Hattab, A.W. Nitric Oxide Deficiency in Mitochondrial Disorders: The Utility of Arginine and Citrulline (2021) Frontiers in Molecular Neuroscience, 14, art. no. 682780. DOI:
10.3389/fnmol.2021.682780
Almannai, M., Al Mahmoud, R.A., Mekki, M., El-Hattab, A.W. Metabolic Seizures (2021) Frontiers in Neurology, 12, art. no. 640371. DOI: 10.3389/fneur.2021.640371
Ballout, R.A., El-Hattab, A.W. The int22h1/int22h2-mediated xq28 duplication syndrome: An intersection between neurodevelopment, immunology, and cancer (2021) Genes, 12 (6), art. no. 860. DOI:
10.3390/genes12060860
Arora, V., Khan, S., El-Hattab, A.W., Puri, R.D., Rocha, M.E., Merdzanic, R., Paknia, O., Beetz, C., Rolfs, A., Bertoli-Avella, A.M., Bauer, P., Verma, I.C. Biallelic pathogenic GFRA1 variants cause autosomal recessive bilateral renal agenesis (2021) Journal of the American Society of Nephrology, 32 (1), pp. 223-228. DOI:
10.1681/ASN.2020040478
