PERSONAL DATA
Name: Sherine Ahmed Nabil Khattab Date of Birth: January, 20, 1965 Place of Birth: Alexandria, Egypt.
Professor of Organic Chemistry focusing on synthesis and characterization of peptides and proteins as well as synthesis of biologically active heterocyclic compounds.
Nationality: Egyptian
Current status at Alexandria University: Professor of Organic Chemistry Work address:
Faculty of Science-Alexandria University-Chemistry Department P.O. Box 426, Ibrahimia, 21321 Alexandria, EGYPT
Work Tel: 203-5922352.
Home address:
Barbar str. 6, Zizinia, Alexandria-Egypt.
Phone: + (203) 584 18 66, + (20122) 3140924.
E-mail: [email protected]
ACADEMIC QUALIFICATIONS
Ph.D. degree
Thesis title: Synthesis of some Biodegradable Peptides for Possible use as Sequestering Agents”
Alexandria University, 2000.
M.Sc. degree
Thesis title: Synthesis of Optically Active Cobalt-Complexes for Enantioselective Reactions.
University, Year: University of Zürich-Irchel, Switzerland, 1990.
“Dipl. Org. Chem., Uni. Zürich”
University of Alexandria, Faculty of Science (1987-1988).
B.Sc. degree
Degree: Chemistry major Alexandria University, 1987.
School
Deutsche Schule der Boromärinnen, Alexandria, German private school (1969 – 1983).
Languages written and spoken: Arabic, German, English, and French.
QUALIFICATIONS
Executive Manager of the NMR Laboratory, Faculty of Science, Alexandria University,
Executive Manager of the Central Laboratory. Faculty of Science, Alexandria University, since 2011.
Head of the student's chemical society in the Chemistry Department since September 2010.
Head of the student's science society at the Faculty of Science since September 2010.
Coordinator of the Faculty of Science in the joint collaboration with "Nahdet El Mahrousa"
Organization, which supports the students graduation projects
Supervision of 9 Master students and 4 Ph.D. students.
23 years of bench research experience in Synthetic Organic, Peptide, and Heterocyclic Chemistry.
Hands-on skills in multi-step Organic Synthesis, Solid and Solution-Phase Organic and Peptide Synthesis.
Proficient in NMR (1H, 13C), FT-IR, HPLC, UV-VIS.
Member of the organizing committee of the Development of the Student's Assessment program.
Reviewer of several journals, Ex: Molecules and Letters in Drug Design & Discovery.
Honors and Awards
Alexandria University Award for Science 2008 (In Chemistry).
Patent application
Sherine Ahmed Nabil Khattab, Ayman Sadek Ahmed El-Faham, Mona Ibrahim Massoud, Yahya El Sayed Jad, "Production of new sweeteners from stevioside extracted from stevia plant" - Patent application No.
1545 / 2012
FUNDED PROJECTS
PI: Agencia Espanola De Cooperacion Internacional (AECI) “Reactivos Para La Sintesis De Peptidos Con Actividad Terapeutica” 2008-2010.
Co-PI: Academy of Science and Technology and NSF (China) "Design, Synthesis and Evaluation of Novel Nucleosides as Antileishmanial Agents" 2009-2011.
PI: Science and Technology Development Fund (STDF) funded project "Coupling Reagents:
Applications in Solution and Solid-Phase. Synthesis of Biologically Active Peptide" 2012.
EXPERIENCES 1987-1988
Research Assistant, University of Alexandria, Chemistry Department, Faculty of Science, Alexandria-Egypt, M. Sc. dissertation research.
1988-1990.
Research Assistant, University of Zürich, Organic Chemistry Department, Irchel, Switzerland, and “Dipl. Org. Chem., Uni. Zurich”.
1991-2001.
Research Assistant, University of Alexandria, Chemistry Department, Faculty of Science, Alexandria-Egypt, Ph. D. dissertation research.
2001-2007.
Lecturer Research Associate, University of Alexandria, Chemistry Department, Faculty of Science, Alexandria-Egypt
2007-2012.
Associate Professor of Organic and Peptide Chemistry
University of Alexandria, Faculty of Science, Chemistry Department, Alexandria, Egypt.
07/2011-09/2011.
Visiting Professor, University of Barcelona (Barcelona Science Park) Barcelona, Spain.
12/2011- Now.
Executive Manager of the NMR Lab (Nuclear Magnetic Resonance Lab). Alexandria University, Faculty of Science, Alexandria, Egypt.
6/2012- Now.
Executive Manager of the Central Laboratory. Faculty of Science, Alexandria University.
11/2012
Professor of Organic and Peptide Chemistry
University of Alexandria, Faculty of Science, Chemistry Department, Alexandria, Egypt.
TEACHING EXPERIENCES
2012 - Now, Professor in Organic Chemistry and Peptides, University of Alexandria, Faculty of Science, Chemistry Department, Alexandria-Egypt
2007 - 2012, Associate Professor in Organic Chemistry and Peptides, University of Alexandria, Faculty of Science, Chemistry Department, Alexandria-Egypt.
2001-2007, Assistant Professor in Organic Chemistry, Alexandria University, Faculty of Science, Chemistry Department, Alexandria-Egypt.
1991-2001, Assistant Lecturer in Organic Chemistry, Alexandria University, Faculty of Science, Chemistry Department, Alexandria-Egypt.
1988-1991, Demonstrator in Chemistry, Alexandria University, Faculty of Science, Chemistry Department, Alexandria-Egypt.
Teaching Courses Experiences:
For Undergraduates and Postgraduates
Organic Chemistry for undergraduate students - Spectroscopic Identification of Organic Compounds for undergraduates and postgraduates - Amino Acids, Peptides, Proteins and Nucleic Acid for undergraduates and postgraduates. Heterocyclic Chemistry. Organic Synthesis.
Attended Workshops
Organized by the Faculty and Leadership Development Center, Alexandria University Certified by International Board of Certified Trainers (IBCT)-European Division
o Code of Ethics 17-19 September, 2005
o Teaching with Technology 21-24 January, 2006
o Credit hours 25-26 January, 2006
o Writing Scientific Paper & International Publication 12-14 September, 2006
o Curriculum Design 26-28 May, 2007
o Thinking Skills 12-14 June, 2007
o Communication Skills 4-5 February, 2012
o Presentation Skills 2-3 January, 2012
o Research Team Management 13-14 February, 2012
o Research Ethics 25-26 February, 2012
o University Management 27-28 February, 2012
o Student Evaluation and Examination Techniques 10-11 March, 2012 Organized by the Development of Student's Assessment Systems Project o Development of Students Assessment 9-10 March, 2010
25-26 May, 2010 22-24 August, 2010 Organized by the University of Alexandria (QAC & D)
o Internal Evaluation of Students Assessment 8-9 January 2013 Organized by DAAD Kairo Akademie
Project Management 21 March 2013
Activities:
Organization of the student's conference for all Science Faculties in the Faculty of Science, Alexandria University (18-19/5/2011).
Invitation and organization of the 14th Arab conference of Innovation of the Arab Undergraduate Students' (in collaboration with the Arab Council for Training Students of Arab Universities), in Alexandria University, in the Faculty of Science (1-5/10/2011).
Council of the Students Project "Environmental Development through Solid waste Management and Recycling"
Council of "Sonaa El Haya" student organization at the Faculty of Science
Supervision of school students in ISEF projects organized by Bibliotheca of Alexandria.
Supervision of Undergraduates and graduates in research projects.
LIST OF PUBLICATIONS
1. Sh. N. Khattab, A. El-Faham, A. M. El-Massry, E. M. E. Mansour and M. M. Abd El-Rahman
“Coupling of Iminodiacetic acid with amino Acid Derivatives in Solution and Solid Phase.” Lett. In Pept. Sci., 7, 331-345 (2001).
2. M. Abdul-Ghani, Sh. N. Khattab, A. M. El-Massry, A. El-Faham and Adel Amer “A Novel and Direct Method For Preparation of 4-Amino-1,1,3,3-Tetra- substituted Guanidines as well as [1,2,4]
Triazolo Fused Heterocyclic Derivatives.”, Organic Preparations And Procedures Int., 36 (2), 121- 127 (2004).
3. Sh. N. Khattab, A. M. El-Massry, A. El-Faham, A. A. Bekhit and Adel Amer “Coupling Reaction of Hydralazine with Amino Acids and their Adducts for Antihypertensive Activities.”, J.
Heterocyclic Chem., 41, 387-392 (2004).
4. Sh. N. Khattab “Synthesis and Biological Activity of Novel Amino Acid-(N`-Benzoyl) Hydrazide and Amino Acid-(N`-Nicotinoyl) Hydrazide Derivatives.”, Molecules, 10, 1218-1228 (2005).
5. S. Y. Hassan, Sh. N. Khattab, A. A. Bekhit and Adel Amer " Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.”, Bioorganic & Medicinal Chemistry Letters, 16, 1753-1756 (2006)
6. A. El-Faham, Sh. N. Khattab, M. Abdul-Ghani and Fernando Albericio “Design and Synthesis of New Immonium-Type Coupling Reagents.", Eur. J. Org. Chem., 1563-1573 (2006).
7. A. El-Faham, Sh. N. Khattab, M. Abdul-Ghani “Tetramethyl-fluoroformamidinium Hexafluorophosphate (TFFH)/ Benzyltri-phenylphosphonium Dihydrogen Trifluoride (PTF): A Unique Reagent for the Conversion of Carboxylic Acids to the Corresponding Alcohols as well as Hydroxamic Acids.” Arkivoc, Xiii, 57-63 (2006).
8. Sh. N. Khattab, S. Y. Hassan, A. El-Faham, A. M. El-Massry, and Adel Amer “ Reaction of Phthalaldehydic Acid with Different Substituted Aniline as well as Hydrazine Derivatives.” J.
Heterocyclic Chem., 44, 617-626 (2007).
9. Sh. N. Khattab, S. Y. Hassan, E. A. Hamed, A. El-Faham “Synthesis and Morpholinolysis of N,N- Diethyl Carbamate Derivatives of 4-HOBt, 7-HOAt and HOBt.” J. Chem. Research, April, 247-251 (2007)
10. Sh. N. Khattab, A. M. El-Massry, A. El-Faham “Synthesis of Some Biologically Active Peptides Containing Iminodiacetic Acid” 7th IBN SINA International Conference on Pure and Applied Heterocyclic Chemistry, 25-28 March 2000, p-340.
11. M. M. Abd El-Rahman, E. M. E. Mansour, A. M. El-Massry, A. El-Faham, and Sh. N. Khattab,
“Synthesis of Amino Acid Derivatives of Iminodiacetic Acid”, 40th Science Week Conference, proceeding of Basic Sciences, University of Tachreen, 4-9 November 2000, Book 2-part 2, p 525- 537.
12. E. S. H. El Ashry, A. A. Kassem, H. Adel-Hamid, F. F. Louis, Sh. A. N. Khattab and M. R. Aouad, Synthesis of 4-amino-5-(3-chlorobenzo[b]thien-2-yl)-3-mercapto-1,2,4-triazolo[3,4-b]thiadiazoles and triazolo[3,4,b][1,3,4]thiadiazines under classical and microwave conditions.” Arkivoc, xiv, 119- 132 (2006).
13. E. S. H. El Ashry, A. A. Kassem, H. Adel-Hamid, F. F. Louis, Sh. A. N. Khattab and M. R. Aouad,
“Synthesis and Alkylation of 5-(3-chlorobenzo[b]thien-2-yl)-4H-1,2,4-triazole-3-thiol under classical and microwave conditions. AM1 Semiemperical Calculations for Investigating the Regioselectivity of Alkylation.” J. Heterocyclic Chem., 43, 1421-1429 (2006).
14. S. Y. Hassan, Sh. N. Khattab, Ayman El-Faham, “Microwave Synthesis of some 4-amino-1,2,4-
15. E. S. H. El Ashry, A. A. Kassem, H. Adel-Hamid, F. F. Louis, Sh. A. N. Khattab and M. R. Aouad,
“Novel Regioselective Formation of S- and N-Hydroxy-Alkyls of 5-(3-Chlorobenzo[b]Thien-2-yl)- 3-Mercapto-4H-1,2,4-Triazole and a Facile Synthesis of Triazolo-Thiazoles and Thiazolo-Triazoles.
Role of Catalyst and Microwave.” Nucleosides, Nucleotides, and Nucleic Acids, 26, 437-451 (2007).
16. Sh. N. Khattab, A. A. Bekhit, A. El-Faham, A. M. El-Massry and Adel Amer, “Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors” Chem.
Pharm. Bull., 56, 1717-1721 (2008).
17. Sh. N. Khattab, A. El-Faham, “Utilization of N, N, N׳, N׳-Tetramethylfluoroformamidinium Hexafluorophosphate (TFFH) in Peptide and Organic Synthesis” Synlett, 6, 886-904 (2009).
18. E. S. H. El Ashry, A. A. Kassem, H. Adel-Hamid, F. F. Louis, Sh. A. N. Khattab and M. R. Aouad,
“Regioselectivity in the glycosylation of 5-(3-chlorobenzo[b]thien-2-yl)-4H-1,2,4-triazole-3-thiol”
Carbohydrate Research, 344, 725-733 (2009).
19 Sherine N. Khattab, Seham Y. Hassan, Ezzat A. Hamed, Fernando Albericio and Ayman. El- Faham, "Synthesis and aminolysis of N, N, Diethyl Carbamic ester of HOBt derivatives" Bull.
Korean Chem. Soc., 31, 75-81 (2010).
20 Sherine N. Khattab, Ramon Subirós-Funosas, Ayman El-Faham, Fernando Albericio, “Oxime Carbonates: Novel Reagents for the Introduction of Fmoc and Alloc Protecting Groups, Free of Side- Reactions” Eur. J. Org. Chem. 3275-3280 (2010).
21 Sherine N. Khattab, “Sulfonate Esters of 1-Hydroxypyridin-2(1H)-one and Ethyl 2-Cyano-2- (hydroxyimino)acetate (Oxyma) as Effective Peptide Coupling Reagents for Replacing HOBt and HOAt” Chem. Pharm. Bull., 58 (4) 501-506 (2010).
22 Sherine N. Khattab, Seham Y.Hassan, Adnan A. Bekhit, Abdel Moneim El Massry, Vratislav Langer and Adel Amer, “Synthesis of New Series of quinoxaline Based MAO-Inhibitors and Docking Studies” Eur. J. Med. Chem., 45, 4479-4489 (2010).
23 Sherine N. Khattab, “2-Cyano-2-(hydroxyimino)acetate (Oxyma): An Efficient and Convenient Additive used with Tetramethylfluoroformamidinium hexafluorophosphate (TFFH) to Replace 1- Hydroxybenzotriazole (HOBt) and 1-Hydroxy-7-Azabenzotriazole (HOAt) during Peptide Synthesis”, Bull. Chem. Soc. Japan, 83, No. 11, 1374-1379 (2010).
24 Adel Amer *, Mohamed Salah, Sherine Nabil Khattab, Seham Yassen Hassan, Vratislav Langer, Samir Senior, Abdel Moneim El Massry, A regio- and stereo-controlled approach to triazoloquinoxalinyl C-nucleosides, Carbohydrate Research, 345, 2474-2484, (2010).
25 Magda F. Fathalla, Sherine N. Khattab, “Spectrophotometric Determination of pKa’s of 1- Hydroxybenzotriazole and Oxime Derivatives in 95% acetonitrile-water” J. Chem. Soc. Pakistan, 33, 324-332 (2011).
26 Sherine N. Khattab,Ezzat A. Hamed, Fernando Albericio and Ayman. El-Faham, "Synthesis and Aminolysis of 2,4-Dinitrophenyl and 5-Nitropyridine N-Hydroxy Oxime Derivatives" Bull. Chem.
Soc. Japan, 84, No. 6, 633-639 (2011).
27 Sherine N. Khattab, 2-cyano-2-(hydroxyimino)acetate (Oxyma): An efficient reagent for coupling of N-Protected Amino acids", Current Medicinal Chemistry, Special Issue, 170-171 (2011). 3rd International Conference on Drug Discovery & Therapy, Dubai, UAE.
28 Gamal Abdel-Nasser Gohar, Sherine Nabil Khattab, Omaima Osman Farahat, and Hosam Hassan Khalil, "Kinetic studies of the reaction of phenacyl bromide derivatives with sulfur nucleophiles", J.
Phys. Org., 25, 343-350 (2012).
29 Sherine N. Khattab, Ramon Subirós-Funosas, Ayman El-Faham, and Fernando Albericio, "
Cyanoacetamide-based oxime carbonates: an efficient, simple alternative for the introduction of Fmoc with minimal dipeptide formation", Tetrahedron, 68, 3056-3062 (2012).
30 Abdel Moneim EL Massry, Ahmed Mosaad Asal, Sherine Nabil Khattab, Nesreen Saied Haiba, Hala A. Awney, Mohamed Helmy, Vratislav Langer and Adel Amer, "Synthesis and structure elucidation of novel fused 1,2,4-triazine derivatives as potent inhibitors targeting CYP1A1 activity", Bioorg. Med. Chem. 20, 2624-2637 (2012).
31 Sherine N. Khattab, Ramon Subirós-Funosas, Ayman El-Faham, and Fernando Albericio,
"Screening of N-alkyl-cyanoacetamido oximes as Substitutes for N-Hydroxysuccinimide", Chemistry Open, 1, 147-152, (2012).
32 Sherine N. Khattab, Mohamed A. H. Kharaba, Amal El-Hawary, Ayman El-Faham, Ezzat A.
Hamed, "Aminolysis of 1-(1-hydroxybenzotriazolyl)-2,4- dinitrobenzene and 2-(1- hydroxybenzotriazolyl)-5-nitro-pyridine", Open J. Phys. Chem., 2, 156-168, (2012).
33 Yahya El-Sayed Jad, Sherine N. Khattab, Ayman El-Faham, Fernando Albericio, " Oxime-Based Carbonates as Useful Reagents for Both N-Protection and Peptide Coupling", Molecules, 17, 14361- 14376 (2012).
34 Ayman El-Faham, Hammed H.A.M. Hassan, Sherine N. Khattab, "Synthesis and characterization of new polyamides derived from alanine and valine derivatives" Chemistry Central Journal, 6, 128, (2012).
35 R. Subirós-Funosas,Sh. N. Khattab,L. Nieto-Rodriguez, Ayman El-Faham, F. Albericio" Advances in Acylation Methodologies Enabled by Oxyma-Based Reagents " Aldrichimica, 46, 20-40 (2013).
36 Ahmed Mosaad Asal, Abdel Moneim EL Massry, Sherine Nabil Khattab,Nesreen Said Haiba,Hala A. Awney,Samir Senior and Adel Amer, "Synthesis and Structure Elucidation of Novel 1,2,4- triazine Derivatives: Potential Chemo-preventive Anticancer Agents." Am. J. Chem, 3, 44-50 (2013).
37 Mohamed Ghazzali, Sherine Nabil Khattab, Ayman El-Faham, "Synthesis, structure, theoretical calculations and biological activity of sulfonate active ester new derivatives". J. Mol. Struct., XXX, 147-152 (2013).
38 Mahmoud F. Ibrahim, Hanaa A. Abdel-Reheem, Sherine N. Khattab, Ezzat A. Hamed,
"Nucleophilic Substitution Reactions of 2,4-Dinitrobenzene derivatives with Hydrazine: Leaving Group and Solvent Effects", International Journal of Chemistry, 5, 33-45, 2013.
39 Prabhakar Cherkupally, Gerardo A. Acosta, Lidia Nieto-Rodriguez, Hortensia Rodriguez, Sherine N. Khattab, Ayman El-Faham, Jan Spengler, Marima Shamis, YoaLuxembourg, Rafel Prohens, Ramon Subiros-Funosas, Fernando Albericio, "K-Oxyma: a strong acylation-promoting, 2-CTC resin-friendly coupling additive". Eur. J. Org. Chem. 2013 in press.
